Selected Publications

Academic Article

Year Title Altmetric
2021 Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like TumorTranslational Oncology.  14. 2021
2021 Serine-threonine kinase receptor-associated protein (Strap) knockout decreases the malignant phenotype in neuroblastoma cell linesCancers.  13. 2021
2021 Understanding the effect of mechanical forces on ovarian cancer progressionGynecologic Oncology.  162:154-162. 2021
2021 Differential and overlapping effects of melatonin and its metabolites on keratinocyte function: Bioinformatics and metabolic analysesAntioxidants.  10. 2021
2021 Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitorsCancer Research.  81:2220-2233. 2021
2021 Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing IL-12, in pet dogs with sporadic gliomasNeurosurgical Focus.  50:1-11. 2021
2021 Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγEndocrinology.  162. 2021
2021 Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ.Endocrinology.  162. 2021
2021 Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ.Endocrinology.  162. 2021
2021 CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cellsCancer Gene Therapy2021
2021 Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic diseaseLaboratory Investigation2021
2021 Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cellsJournal of Biological Chemistry.  296. 2021
2021 Human gut microbial communities dictate efficacy of anti-PD-1 therapy in a humanized microbiome mouse model of glioma. 2021
2020 Assigning immunoglobulin class from single-cell transcriptomes in IgA1-secreting versus membrane subpopulations 2020
2020 Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancyNature Communications.  11. 2020
2020 STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cellsNature Communications.  11. 2020
2020 Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.Journal of Biological Chemistry.  296:100034. 2020
2020 CHD7 regulates cardiovascular development through ATP-dependent and -independent activities 2020
2020 Strain Tracking to Identify Individualized Patterns of Microbial Strain Stability in the Developing Infant Gut EcosystemFrontiers in Pediatrics.  8. 2020
2020 DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologiesHuman Molecular Genetics.  29:2855-2871. 2020
2020 The One Health Consortium: Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Combination With a Checkpoint Inhibitor in Canine Patients With Sporadic High Grade GliomasFrontiers in Surgery.  7. 2020
2020 Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetesJCI insight.  5. 2020
2020 Genome-wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress 2020
2020 RNASeq analysis reveals upregulation of complement C3 in the offspring gut following prenatal stress in miceImmunobiology.  225. 2020
2020 Photoprotective Properties of Vitamin D and Lumisterol HydroxyderivativesCell Biochemistry and Biophysics.  78:165-180. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory NeuronsNeuroscience.  435:73-94. 2020
2020 Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progressionOncogene.  39:4077-4091. 2020
2020 Profiling and quantification of pluripotency reprogramming reveal that WNT pathways and cell morphology have to be reprogramed extensivelyHeliyon.  6. 2020
2020 An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cellsActa Biomaterialia.  107:65-77. 2020
2020 An individualized mosaic of maternal microbial strains is transmitted to the infant gut microbial communityRoyal Society Open Science.  7. 2020
2020 The impact of Lactococcus lactis (probiotic nasal rinse) co-culture on growth of patient-derived strains of Pseudomonas aeruginosaInternational Forum of Allergy and Rhinology.  10:444-449. 2020
2020 Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathiesHuman Genetics.  139:483-498. 2020
2020 Utilizing genome-wide mrna profiling to identify the cytotoxic chemotherapeutic mechanism of triazoloacridone C-1305 as direct microtubule stabilizationCancers.  12. 2020
2020 Transcriptomic profiling of DAF-7/TGFΒ pathway mutants in C. ElegansGenes.  11. 2020
2020 Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody SelectionFrontiers in Immunology.  11. 2020
2020 A state-based approach to genomics for rare disease and population screeningGenetics in Medicine2020
2020 Identification of DNA methylation associated enrichment pathways in adults with non-specific chronic low back painMolecular Pain.  16. 2020
2019 Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis InfectionCell Reports.  29:3564-3579.e5. 2019
2019 Individualized recovery of gut microbial strains post antibioticsnpj Biofilms and Microbiomes.  5. 2019
2019 Sharing of gut microbial strains between selected individual sets of twins cohabitating for decadesPLoS ONE.  14. 2019
2019 STAT4 directs a protective innate lymphoid cell response to gastrointestinal infectionJournal of Immunology.  203:2472-2484. 2019
2019 Individualized recovery of gut microbial strains post antibiotics.npj Biofilms and Microbiomes.  5:30. 2019
2019 KSRP modulates melanoma growth and efficacy of vemurafenib 2019
2019 Multi-Omics Profiling for NF1 Target Discovery in Neurofibromin (NF1) Deficient CellsProteomics.  19. 2019
2019 Podocyte-specific expression of cre recombinase promotes glomerular basement membrane thickening 2019
2019 Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across speciesJournal of the American Society of Nephrology.  30:767-781. 2019
2019 Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failureLaboratory Investigation.  99:371-386. 2019
2019 Non-obstructive vas deferens and epididymis loss in cystic fibrosis ratsMechanisms of Development.  155:15-26. 2019
2019 Resident macrophages reprogram toward a developmental state after acute kidney injuryJCI insight.  4. 2019
2019 Rapid bladder interleukin-10 synthesis in response to uropathogenic Escherichia coli is part of a defense strategy triggered by the major bacterial flagellar filament fliC and contingent on TLR5mSphere.  4. 2019
2019 Tissue-resident macrophages promote renal cystic diseaseJournal of the American Society of Nephrology.  30:1841-1856. 2019
2018 Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancerClinical Cancer Research.  24:6433-6446. 2018
2018 Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cellsScientific Reports.  8. 2018
2018 New microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tractHuman Microbiome Journal.  10:37-42. 2018
2018 PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cellsScientific Reports.  8. 2018
2018 Differential and overlapping effects of 20,23(OH)2 D3 and 1,25(OH)2 D3 on gene expression in human epidermal keratinocytes: Identification of AHR as an alternative receptor for 20,23(OH)2 D3International Journal of Molecular Sciences.  19. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosisNeurobiology of Disease.  114:85-94. 2018
2018 Gene-expression analysis identifies IGFBP2 dysregulation in dental pulp cells from Human Cleidocranial dysplasiaFrontiers in Genetics.  9. 2018
2018 Molecular response to neoadjuvant chemotherapy in high-grade serous ovarian carcinoma 2018
2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairment 2018
2018 High-Throughput Tabular Data Processor – Platform independent graphical tool for processing large data setsPLoS ONE.  13. 2018
2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genomeJournal of Virology.  92. 2018
2017 Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficilenpj Biofilms and Microbiomes.  3. 2017
2017 The Human Blood-Nerve Barrier TranscriptomeScientific Reports.  7. 2017
2017 Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumorsScientific Reports.  7. 2017
2017 Identification of transcriptome signature for myocardial reductive stressRedox Biology.  13:568-580. 2017
2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene ProgramsImmunity.  47:251-267.e7. 2017
2017 Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencingDevelopmental Biology.  426:429-441. 2017
2017 HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseasesGlia.  65:945-963. 2017
2017 Erratum: Author Correction: Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile.npj Biofilms and Microbiomes.  3:29. 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targetsOncotarget.  8:21710-21718. 2017
2017 RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndromeMolecular Autism.  8:56. 2017
2016 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary FibrosisScientific Reports.  6. 2016
2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling 2016
2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelatesHuman Molecular Genetics.  25:1619-1636. 2016
2016 The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosisNature Communications.  7. 2016
2016 Uropathogenic Escherichia coli engages CD14-dependent signaling to enable bladder-macrophage-dependent control of acute urinary tract infectionJournal of Infectious Diseases.  213:659-668. 2016
2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficileBMC Microbiology.  16. 2016
2016 Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signaling or bacterial killing in human olfactory ensheathing cellsInfection and Immunity.  84:1941-1956. 2016
2016 Somatic mutations modulate autoantibodies against galactose-deficient IgA1 in IgA nephropathyJournal of the American Society of Nephrology.  27:3278-3284. 2016
2015 Alterations in gene expression and DNA methylation during murine and human lung alveolar septationAmerican Journal of Respiratory Cell and Molecular Biology.  53:60-73. 2015
2015 Analysis of the Human Proteome in Subcutaneous and Visceral Fat Depots in Diabetic and Non-diabetic Patients with Morbid Obesity.Journal of Proteomics and Bioinformatics.  8:133-141. 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4FBiochemical Journal.  467:517-527. 2015
2015 Hypomagnesemia due to two novel TRPM6 mutationsJournal of Pediatric Endocrinology and Metabolism.  28:1373-1378. 2015
2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupusJournal of Clinical Investigation.  125:2877-2890. 2015
2015 Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction 2015
2014 Differential gene expression landscape of co-existing cervical pre-cancer lesions using RNA-seqFrontiers in Oncology.  4. 2014
2014 Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomasNature Genetics.  46:182-187. 2014
2014 Getting started with microbiome analysis: Sample acquisition to bioinformaticsCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.].  2014:18.8.1-18.8.29. 2014
2013 Real-time methylomic aberrations during initiation and progression of induced human mammary epithelial cell tumorigenesisEpigenomics.  5:155-165. 2013
2013 WNT5A Inhibits Metastasis and Alters Splicing of Cd44 in Breast Cancer CellsPLoS ONE.  8. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F 2012
2012 Altered DNA methylation profile in idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  186:525-535. 2012
2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant functionKidney International.  82:304-313. 2012
2011 The Unfolded Protein Response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genesJournal of Biological Chemistry.  286:41862-41870. 2011
2011 Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group 2011
2010 Abundant lipid and protein components of drusenPLoS ONE.  5. 2010
2010 Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspAJournal of Bacteriology.  192:326-335. 2010
2009 Mycobacterium tuberculosis WhiB3 Maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage responsePLoS Pathogens.  5. 2009
2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulonJournal of Biological Chemistry.  283:18032-18039. 2008
2000 High color-vision sensitivity in macaque and humansVisual Neuroscience.  17:119-125. 2000
“DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies”

Investigator On

  • MicroRNA Correlates of Childhood Maltreatment and Suicidality  awarded by National Institute of Mental Health/NIH/DHHS 2021 - 2026
  • Combinatorial Epigenetic-Based Prevention of Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2021 - 2025
  • Epigenetic Regulation of Kidney Fibrosis following AKI  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2021 - 2025
  • Bromodomain-Containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2021 - 2025
  • Characterizing the Negative Signaling in Dendritic Cells and Macrophages to Attenuate Inflammation and Bone Destruction in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2020 - 2024
  • Epitranscriptomic Mapping of Novel N6-Adenosine-based RNA Methylation in MDD Brain  awarded by National Institute of Mental Health/NIH/DHHS 2019 - 2024
  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Mechanism of Ultraviolet Radiation Induced Immune Tolerance  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Mechanism of Action and Function of Novel Secosteroid 20(OH)D3 in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Cytokine Immunoregulatory Strategy to Target SLE Autoreactive B Cells  awarded by LUPUS RESEARCH ALLIANCE 2019 - 2022
  • Canine Immuno Neurotherapeutics  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Significance of Metabolic Activation of Lumisterol in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Histone H4 Lysine16 Acetylation in Aging and Lung Fibrosis  awarded by National Institute on Aging/NIH/DHHS 2016 - 2022
  • Transcriptional Regulation of Metabolism in Neurons  awarded by SOUTHERN RESEARCH INSTITUTE 2017 - 2022
  • Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back Pain  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2021 - 2022
  • Genetic Prediction for Treatment Resistance in Kawasaki Disease  awarded by SEATTLE CHILDREN'S RESEARCH INSTITUTE 2018 - 2021
  • Cervical Cancer Derived Xenografts (PDX) and Organoid Raft Cultures to Evaluate Pathway Specific Therapeutic Agents.  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Brain Tumor Recurrence Via Signals From Vascular Endothelial Cells  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2019 - 2020
  • Network Medicine Approaches to Cachexia in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Chromatin Remodeling Mechanisms of Gene Transcription in Memory  awarded by National Institute of Mental Health/NIH/DHHS 2012 - 2018
  • Transcriptional Regulation of Metabolism in Neurons  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017
  • DHA Mechanisms in Obesity-Mediated Cardiac Remodeling Post-Myocardial Infarction  awarded by NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH/NIH/DHHS 2013 - 2016
  • Completed - Comprehensive Genomics Shared Facility - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Completed - Comprehensive Cancer Center Core Support Grant - Micro Array SF  awarded by National Cancer Institute/NIH/DHHS 2011 - 2013
  • Education And Training

  • University Of Alabama at Birmingham Surgery, Postdoctoral Research 2011
  • University of Alabama at Birmingham Microbiology, Postdoctoral Research 2009
  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 2007
  • Bachelor of Science or Mathematics in Biology, Samford University 1998
  • Full Name

  • David Crossman