Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Integrating hypertension phenotype and genotype with hybrid non-negative matrix factorization. 2019
2019 Distracted Driving and Risk of Crash or Near-Crash Involvement among Older Drivers Using Naturalistic Driving Data with a Case-Crossover Study Design 2019
2019 Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data 2019
2019 Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data 2019
2019 Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry 2019
2019 A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019
2019 Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits 2019
2019 Clinical correlates and heritability of cardiac mechanics: The HyperGEN study 2019
2019 Integrating hypertension phenotype and genotype with hybrid non-negative matrix factorization 2019
2018 Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries 2018
2018 Deep-coverage whole genome sequences and blood lipids among 16,324 individuals 2018
2018 Erratum to: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w) 2018
2018 GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes 2018
2018 Association of sickle cell trait with ischemic stroke among African americans a meta-analysis 2018
2018 Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium 2018
2018 Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study 2018
2018 Epigenome-wide association study of metabolic syndrome in African-American adults 2018
2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes 2018
2018 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure 2018
2018 General cognitive impairment as a risk factor for motor vehicle collision involvement: a prospective population-based study. 2018
2018 PCSK9 variants, low-density lipoprotein cholesterol, and neurocognitive impairment reasons for geographic and racial differences in stroke study (REGARDS) 2018
2018 The association of nocturnal hypertension and nondipping blood pressure with treatment-resistant hypertension: The Jackson Heart Study 2018
2018 Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI 2018
2018 A DNA methylation biomarker of alcohol consumption 2018
2018 APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke 2018
2018 An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort 2018
2018 West African ancestry and nocturnal blood pressure in African Americans: The Jackson Heart Study 2018
2017 DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation 2017
2017 Genome-wide admixture and association study of subclinical atherosclerosis in the Women’s Interagency HIV Study (WIHS) 2017
2017 Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities 2017
2017 Chronic kidney disease and incident apparent treatment-resistant hypertension among blacks: Data from the Jackson Heart Study 2017
2017 Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage 2017
2017 An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network 2017
2017 Interleukin–6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men 2017
2017 Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the HyperGEN Study. 2017
2017 PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data from 9 Studies of Blacks and Whites 2017
2017 Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array 2017
2017 Sickle cell trait and the risk of ESRD in blacks 2017
2017 Genetics of Blood Pressure: New Insights Into a Complex Trait 2017
2017 Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) 2017
2017 Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction 2017
2017 Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci 2017
2017 Visual sensory and visual-cognitive function and rate of crash and near-crash involvement among older drivers using naturalistic driving data 2017
2017 Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function 2017
2017 Stroke in Indigenous Africans, African Americans, and European Americans: Interplay of Racial and Geographic Factors 2017
2017 Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study 2017
2017 Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events among African Americans in 2 Large Cohort Studies 2017
2017 Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium 2017
2017 National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension 2017
2017 CPT1A methylation is associated with plasma adiponectin 2017
2017 Epigenetic Patterns in Blood Associated with Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results from Genome-Wide Association Studies 2017
2017 Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations 2017
2017 Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach 2017
2017 D-dimer in african americans whole genome sequence analysis and relationship to cardiovascular disease risk in the Jackson Heart Study 2017
2017 Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies. 2017
2016 Hemostasis biomarkers and risk of sepsis: the REGARDS cohort 2016
2016 Epigenetic Signatures of Cigarette Smoking 2016
2016 Epigenetics of Lipid Phenotypes 2016
2016 Heritable DNA methylation in CD4+ Cells among complex families displays genetic and non-genetic effects 2016
2016 The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study 2016
2016 Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits 2016
2016 Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin 2016
2016 Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study 2016
2016 Association of Central Adiposity with Adverse Cardiac Mechanics; Findings from the Hypertension Genetic Epidemiology Network Study 2016
2016 APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans 2016
2016 Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study 2016
2016 Driving with pets and motor vehicle collision involvement among older drivers: A prospective population-based study 2016
2016 Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: A meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium 2016
2016 The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter 2016
2016 A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies 2016
2016 Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study 2016
2016 Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge 2016
2015 Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: A pharmacogenomics study from the CHARGE consortium 2015
2015 A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network 2015
2015 Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci 2015
2015 Apparent treatment-resistant hypertension among individuals with history of stroke or transient ischemic attack 2015
2015 Apparent Treatment-resistant Hypertension Among Individuals with History of Stroke or Transient Ischemic Attack 2015
2015 Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals 2015
2015 Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference 2015
2015 Genetic loci associated with circulating phospholipid trans fatty acids: A meta-analysis of genome-wide association studies from the CHARGE consortium 2015
2015 Genetic variants modify the effect of age on APOE methylation in the genetics of lipid lowering drugs and diet network study 2015
2015 Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study 2015
2015 PCSK9 variation and association with blood pressure in African Americans: Preliminary findings from the HyperGEN and REGARDS studies 2015
2014 Diastolic wall strain: A simple marker of abnormal cardiac mechanics 2014
2014 Multi-ethnic fine-mapping of 14 central adiposity loci 2014
2014 Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study 2014
2014 Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study 2014
2014 Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study 2014
2014 Determination of prevalence, risk factors, and comorbidities in a large, population-based cohort 2014
2014 CPT1A: The future of heart disease detection and personalized medicine? 2014
2014 Epigenome-wide association study of fasting measures of glucose, insulin, and homa-ir in the genetics of lipid lowering drugs and diet network study 2014
2014 HIV, inflammation, and calcium in atherosclerosis 2014
2014 Apparent treatment-resistant hypertension and risk for stroke, coronary heart disease, and all-cause mortality 2014
2014 Association of comorbidity burden with abnormal cardiac mechanics: Findings from the HyperGEN study 2014
2014 Association of low-grade albuminuria with adverse cardiac mechanics: Findings from the hypertension genetic epidemiology network (hypergen) study 2014
2014 Healthy lifestyle factors and risk of cardiovascular events and mortality in treatment-resistant hypertension: The Reasons for Geographic and Racial Differences in Stroke study 2014
2014 Incident ESRD and treatment-resistant hypertension: The reasons for geographic and racial differences in stroke (REGARDS) study 2014
2014 RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS) 2014
2014 Response to should more significance be granted to medication response to antihypertensives in patients with resistant hypertension? 2014
2014 The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study. 2014
2013 Genetic and adverse health outcome associations with treatment resistant hypertension in GenHAT 2013
2013 Fine mapping and identification of BMI loci in African Americans 2013
2013 Prevalence of apparent treatment-resistant hypertension among individuals with CKD 2013
2013 Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci 2013
2013 RYR3 gene polymorphisms and cardiovascular disease outcomes in the context of antihypertensive treatment 2013
2013 A431: Epigenetics of Fasting Insulin and Glucose Concentrations 2013
2013 A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry 2013
2013 Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies 2013
2013 A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study 2013
2013 Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network 2013
2013 SNPs located at CpG sites modulate genome-epigenome interaction 2013
2012 Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy 2012
2012 Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate 2012
2012 Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study 2012
2012 A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the genetics of lipid lowering drug and diet network 2012
2012 Prevalence and Correlates of Low Medication Adherence in Apparent Treatment-Resistant Hypertension 2012
2011 Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men 2011
2011 A data-driven method for identifying rare variants with heterogeneous trait effects 2011
2011 Genome-wide detection of allele specific copy number variation associated with insulin resistance in african americans from the hyperGEN study 2011
2011 Response to letter regarding article, "Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the GOLDN study" 2011
2010 Apolipoprotein e polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the genetics of lipid lowering and diet network (GOLDN) study 2010
2010 Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study 2010
2010 A genome-wide association study of carotid atherosclerosis in HIV-infected men 2010
2009 Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder 2009
2009 Linkage analysis of schizophrenia in African-American families 2009
2008 Barriers to genetic testing among persons at risk for alpha-1 antitrypsin deficiency 2008
2008 A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH genetic initiative 2008
2007 Does genetic testing result in behavioral health change? Changes in smoking behavior following testing for alpha-1 antitrypsin deficiency 2007
2006 Results of a survey of patients with alpha-1 antitrypsin deficiency 2006
2005 Association studies of transforming growth factor-β1 and Alzheimer's disease 2005
2005 Delay in Diagnosis of α1-Antitrypsin Deficiency 2005
2004 Genetic testing for alpha1-antitrypsin deficiency. 2004
2001 Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells 2001

Chapter

Year Title Altmetric
2014 Cardiovascular Genetics and Genomics in Clinical Practice. Part 1: Toolbox for Genetics and Genomics: The Basics 2014
2011 Gene-environment Interactions: Gene-environment interactions in human traits 2011

Principal Investigator On

  • Identification of the Role of HDL Function in Human Cardiovascular Disease through Proteomics and Genetics  awarded by Oregon Health & Science University 2018 - 2022
  • Metabolic Predictors of Stroke in REGARDS  awarded by MASSACHUSETTS GENERAL HOSPITAL 2016 - 2021
  • Genomic Background of Blood Pressure Response to Thiazide Diuretic in African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Genetic Underpinnings of Cardiorenal risk in Africans and African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • How Inflammation and High Density Lipoproteins Affect the Relationship Between APOL 1 and Outcomes  awarded by American Heart Association 2018 - 2020
  • Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics  awarded by Northwestern University 2016 - 2020
  • Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat  awarded by University of Kentucky 2016 - 2020
  • Characterizing Pleitropy in Cardiometabolic Phenotypes Among Diverse Populations  awarded by University of North Carolina at Chapel Hill 2019 - 2020
  • Trace Mineral Levels, the Trajectory of Cognitive Decline and Telomere Attrition  awarded by Indiana University 2017 - 2019
  • Genomics of Lipidomic Phenotypes in a Postprandial Intervention Dietary Study  awarded by American Heart Association 2015 - 2019
  • UAB Center for AIDS Research - Lipidomic Profiling in HIV Patients Newly Initiating Antiretroviral Treatment  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • HyperGEN: Genetics of Left Ventricular Hypertrophy  awarded by University of Kentucky 2016 - 2019
  • Prospective Meta-Analyses of Drug-gene Interactions: CHARGE GWAS  awarded by UNIVERSITY OF WASHINGTON 2016 - 2017
  • Epigenetic Determinants of Left Ventricular Structure and Function in Hypertensive African Americans  awarded by University of Kentucky 2016 - 2017
  • Investigator On

  • VCID and Stroke in Bi-Racial National Cohort  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2019 - 2023
  • VCID and Stroke in a Bi-racial National Cohort  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Incorporation of a Hypertension Working Group into the Jackson Heart Study  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • Transitions to Family Caregiving and Its Impact on Health Indicators  awarded by Johns Hopkins University 2016 - 2021
  • Use of High Density Lipoprotein Proteome in the Prediction of Cognitive Impairment and Alzheimer’s Disease (REGARDS)  awarded by Mount Sinai School of Medicine 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Stroke Investigative Research & Educational Network  awarded by UNIVERSITY OF IBADAN 2015 - 2018
  • Epigenetic Regulation of Lipids in Response to Dietary Fat and Fenofibrate  awarded by University of Kentucky 2016 - 2018
  • Incorporation of a Hypertension Working Group into the Jackson Heart Study  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2017
  • Prospective Meta-Analyses of Drug-Gene Interactions: CHARGE GWAS Consortium  awarded by UNIVERSITY OF WASHINGTON 2011 - 2016
  • Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015
  • HyperGEN: Genetics of Left Ventricular Hypertrophy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2015
  • Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2015
  • Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2008 - 2014
  • Hypergen: Genetics of Left Ventricular Hypertrophy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2006 - 2013
  • Teaching Activities

  • EPI799 - Dissertation Research (Fall Term 2019) 2019
  • EPI799 - Dissertation Research (Summer Term 2019) 2019
  • EPI710 - Analysis Case Control Studies (Spring Term 2019) 2019
  • EPI798 - Doctoral Directed Research (Spring Term 2019) 2019
  • EPI798 - Doctoral Directed Research (Fall Term 2018) 2018
  • EPI697 - Internship (Summer Term 2018) 2018
  • EPI798 - Doctoral Directed Research (Summer Term 2018) 2018
  • EPI697 - Internship (Spring Term 2018) 2018
  • EPI710 - Analysis Case Control Studies (Spring Term 2018) 2018
  • EPI798 - Doctoral Directed Research (Spring Term 2018) 2018
  • EPI699 - Project Research (Fall Term 2017) 2017
  • EPI798 - Doctoral Directed Research (Fall Term 2017) 2017
  • EPI697 - Internship (Summer Term 2017) 2017
  • EPI699 - Project Research (Summer Term 2017) 2017
  • EPI710 - Analysis Case Control Studies (Spring Term 2017) 2017
  • EPI799 - Dissertation Research (Spring Term 2017) 2017
  • EPI799 - Dissertation Research (Fall Term 2016) 2016
  • EPI697 - Internship (Summer Term 2016) 2016
  • EPI699 - Project Research (Summer Term 2016) 2016
  • EPI799 - Dissertation Research (Summer Term 2016) 2016
  • EPI710 - Analysis Case Control Studies (Spring Term 2016) 2016
  • EPI798 - Doctoral Directed Research (Spring Term 2016) 2016
  • EPI698 - Directed Research (Fall Term 2015) 2015
  • EPI798 - Doctoral Directed Research (Fall Term 2015) 2015
  • EPI697 - Internship (Summer Term 2015) 2015
  • EPI798 - Doctoral Directed Research (Summer Term 2015) 2015
  • EPI710 - Analysis Case Control Studies (Spring Term 2015) 2015
  • EPI798 - Doctoral Directed Research (Spring Term 2015) 2015
  • EPI798 - Doctoral Directed Research (Fall Term 2014) 2014
  • EPI697 - Internship (Summer Term 2014) 2014
  • EPI798 - Doctoral Directed Research (Summer Term 2014) 2014
  • EPI798 - Doctoral Directed Research (Spring Term 2013) 2013
  • Full Name

  • Marguerite Irvin