Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Defining the Hallmarks of Metastasis 2019
2017 Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example 2017
2016 Increased autophagic response in a population of metastatic breast cancer cells 2016
2016 Globular adiponectin enhances invasion in human breast cancer cells 2016
2016 SIN3A and SIN3B differentially regulate breast cancer metastasis 2016
2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cells 2015
2015 Promising oncolytic agents for metastatic breast cancer treatment. 2015
2014 Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix 2014
2014 Linking adiponectin and autophagy in the regulation of breast cancer metastasis 2014
2014 Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells 2014
2014 Linking adiponectin and autophagy in the regulation of breast cancer metastasis 2014
2013 Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1α 2013
2013 Unraveling the 'TGF-β paradox' one metastamir at a time 2013
2013 The C-Terminal Putative Nuclear Localization Sequence of BReast cancer Metastasis Suppressor 1, BRMS1, Is Necessary for Metastasis Suppression 2013
2012 Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes 2012
2012 Clinical significance of KISS1 protein expression for brain invasion and metastasis 2012
2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis 2012
2012 The influence of the cancer microenvironment on the process of metastasis. 2012
2011 Protein signatures in human MDA-MB-231 breast cancer cells indicating a more invasive phenotype following knockdown of human endometase/matrilysin-2 by siRNA 2011
2011 Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression 2011
2011 Heparanase-mediated loss of nuclear syndecan-1 enhances Histone Acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype 2011
2011 Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines 2011
2011 Metastasis suppressors and the tumor microenvironment 2011
2011 Metastasis suppressor genes. At the interface between the environment and tumor cell growth 2011
2010 Linking metastasis suppression with metastamir regulation 2010
2009 Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression 2009
2009 Metastamir: The field of metastasis-regulatory microRNA is spreading 2009
2009 Linking metastasis suppression with metastamiR regulation 2009
2009 Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution 2009
2009 Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone 2009
2009 Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells 2009
2009 Breast cancer metastasis suppressor 1 up-regulates miR-146, Which suppresses breast cancer metastasis 2009
2009 Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model 2009
2008 Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling 2008
2008 Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells 2008
2008 BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process 2008
2007 A MSC-ing link in metastasis? 2007
2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy 2007
2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone 2006
2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1) 2006
2006 Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases 2006
2005 Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors 2005
2004 Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities 2004
2004 Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. 2004
2003 The Intermediate S1′ Pocket of the Endometase/ Matrilysin-2 Active Site Revealed by Enzyme Inhibition Kinetic Studies, Protein Sequence Analyses, and Homology Modeling 2003
2002 Protein engineering and properties of human metalloproteinase and thrombospondin 1 2002
2001 Development and characterization of a new polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 in human breast cancer 2001
2001 Preparation of 2-phenyl-4-(1h-pyrazol-5-yl)quinolines 2001
1999 A new series of proton/charge transfer molecules: Synthesis and spectral studies of 2-(5-Aryl-1-carbomethoxy-1H-pyrazol-3-yl)phenols 1999
1999 Preparation of N-aryl-4-oxo-4H-1-benzothiopyran-2-acetamides from trilithiated acetoacetanilides and lithiated methyl thiosalicylate 1999
1999 The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1H- pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic esters 1999
1999 The preparation of 2-[4,5-dihydro-3-aryl-5-isoxazolyl]-phenols from C(α),O-dilithiooximes and lithiated hydroxyaryl aldehydes 1999
1999 The preparation of 4,5-dihydro-2H-benz[e]indazoles from dilithiated 2- tetralone phenylhydrazone and aromatic esters 1999
1998 Hydroxyaryl-isoxazoles: Synthesis and related studies 1998
1998 A New Preparation of Substituted 4H-1-Benzothiopyran-4-ones from C(α),N-Benzoylhydrazones or C(α),N-Carboalkoxyhydrazones and Methyl Thiosalicylate 1998
1998 The preparation of 2-(4-oxo-4h-1-benzopyran-2-yl)- 1-phenylethanones by the condensation/cyclization of dilithiated 1-benzoylacetone with lithiated methyl salicylates 1998
1998 The preparation of 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides by the condensation/cyclization of trilithiated acetoacetanilides with lithiated methyl salicylates 1998

Chapter

Year Title Altmetric
2016 Beyond the primary tumor: Progression, invasion, and metastasis.  203-216. 2016
2016 Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action.  111-137. 2016

Full Name

  • Douglas Hurst