Positions

Overview

  • Following his postdoctoral fellowship at the University of Rochester, Dr. Graves joined the faculty in the Department of Chemistry and Biochemistry at the University of Mississippi in 1984. He rose through the ranks of assistant, associate, and full professor at the University of Mississippi and was awarded the title of Distinguished Faculty Fellow from the University of Mississippi College of Liberal Arts in 2001. In 2003, Dr. Graves was recruited to become the chair of the Department of Chemistry at the University of Alabama at Birmingham. He served as chair of the department from May 2003 to July 2015.
  • Research Overview

  • The focus of my research involves the biophysical characterization of nucleic acid structures and stabilities as related to both base sequence effects as well as complex formation with small molecules and proteins. My initial research efforts focused on DNA as a target for small molecules such as anticancer agents including intercalating and groove binders and the mechanistic processes of molecular recognition. An understanding of the forces that govern DNA base sequence-specific interactions for small molecules and/or proteins is fundamental towards our comprehension of basic processes associated with gene expression such as transcription, recombination, DNA repair, as well as the recognition of DNA cleavage sites for nuclear enzymes such as topoisomerase I and topoisomerase II.

    More recently, our research has focused on the structural, stability, and protein-binding properties of G-quadruplex DNA fragments. Recent studies in my laboratory have demonstrated that small deoxyribonucleotides can act as modulators of a number of toll-like receptor (TLR) mediated biological responses, including cancer cell invasion. Although the nature of the TLR9-mediated cell invasion is not understood, the key determinant seems to reside in the stable nuclease-resistant structure(s) of the oligonucleotides either for binding to the target protein or protection from nuclease invasion. We continue to use a multifaceted approach of calorimetry and high-resolution NMR to discern the structure and stability of nucleic acids and protein-nucleic acid complexes.
  • Teaching Overview

  • Research Methods in Chemistry and Biochemistry, Concepts in Biochemistry, Advanced Biochemistry, Biophysical Chemistry, Biochemistry Laboratory
  • Teaching Activities

  • CH297 - Research Experiences (Fall Term 2015) 2015
  • CH297 - Research Experiences (Fall Term 2015) 2015
  • CH497 - Undergraduate Research (Fall Term 2015) 2015
  • CH497 - Undergraduate Research (Fall Term 2015) 2015
  • CH691 - Seminar (Fall Term 2015) 2015
  • CH790 - Intro to Graduate Research (Fall Term 2015) 2015
  • CH791 - Seminar (Fall Term 2015) 2015
  • CH798 - Non-Dissertation Research (Fall Term 2015) 2015
  • CH799 - Dissertation Research (Fall Term 2015) 2015
  • CH297 - Research Experiences (Summer Term 2015) 2015
  • CH497 - Undergraduate Research (Summer Term 2015) 2015
  • CH798 - Non-Dissertation Research (Summer Term 2015) 2015
  • CH799 - Dissertation Research (Summer Term 2015) 2015
  • CH201 - Research Methods in Chem (Spring Term 2015) 2015
  • CH297 - Research Experiences (Spring Term 2015) 2015
  • CH297 - Research Experiences (Spring Term 2015) 2015
  • CH461 - Advanced Biochemistry I (Spring Term 2015) 2015
  • CH464 - Physical Biochemistry Lab (Spring Term 2015) 2015
  • CH497 - Undergraduate Research (Spring Term 2015) 2015
  • CH561 - Advanced Biochemistry I (Spring Term 2015) 2015
  • CH761 - Biochemistry II (Spring Term 2015) 2015
  • CH791 - Seminar (Spring Term 2015) 2015
  • CH792 - Seminar Presentation (Spring Term 2015) 2015
  • CH798 - Non-Dissertation Research (Spring Term 2015) 2015
  • CH799 - Dissertation Research (Spring Term 2015) 2015
  • CH297 - Research Experiences (Fall Term 2014) 2014
  • CH297 - Research Experiences (Fall Term 2014) 2014
  • CH497 - Undergraduate Research (Fall Term 2014) 2014
  • CH790 - Intro to Graduate Research (Fall Term 2014) 2014
  • CH791 - Seminar (Fall Term 2014) 2014
  • CH792 - Seminar Presentation (Fall Term 2014) 2014
  • CH798 - Non-Dissertation Research (Fall Term 2014) 2014
  • CH799 - Dissertation Research (Fall Term 2014) 2014
  • CH297 - Research Experiences (Summer Term 2014) 2014
  • CH297 - Research Experiences (Summer Term 2014) 2014
  • CH497 - Undergraduate Research (Summer Term 2014) 2014
  • CH698 - Graduate Research (Summer Term 2014) 2014
  • CH798 - Non-Dissertation Research (Summer Term 2014) 2014
  • CH799 - Dissertation Research (Summer Term 2014) 2014
  • CH201 - Research Methods in Chem (Spring Term 2014) 2014
  • CH297 - Research Experiences (Spring Term 2014) 2014
  • CH297 - Research Experiences (Spring Term 2014) 2014
  • CH461 - Advanced Biochemistry I (Spring Term 2014) 2014
  • CH464 - Physical Biochemistry Lab (Spring Term 2014) 2014
  • CH497 - Undergraduate Research (Spring Term 2014) 2014
  • CH561 - Advanced Biochemistry I (Spring Term 2014) 2014
  • CH761 - Biochemistry II (Spring Term 2014) 2014
  • CH791 - Seminar (Spring Term 2014) 2014
  • CH792 - Seminar Presentation (Spring Term 2014) 2014
  • CH798 - Non-Dissertation Research (Spring Term 2014) 2014
  • CH799 - Dissertation Research (Spring Term 2014) 2014
  • CH297 - Research Experiences (Fall Term 2013) 2013
  • CH297 - Research Experiences (Fall Term 2013) 2013
  • CH460 - Fundamentals of Biochemistry (Fall Term 2013) 2013
  • CH497 - Undergraduate Research (Fall Term 2013) 2013
  • CH497 - Undergraduate Research (Fall Term 2013) 2013
  • CH560 - Fundamentals of Biochemistry (Fall Term 2013) 2013
  • CH760 - Fundamentals of Biochemistry (Fall Term 2013) 2013
  • CH790 - Intro to Graduate Research (Fall Term 2013) 2013
  • CH791 - Seminar (Fall Term 2013) 2013
  • CH792 - Seminar Presentation (Fall Term 2013) 2013
  • CH798 - Non-Dissertation Research (Fall Term 2013) 2013
  • CH799 - Dissertation Research (Fall Term 2013) 2013
  • CH297 - Directed Studies (Summer Term 2013) 2013
  • CH297 - Directed Studies (Summer Term 2013) 2013
  • CH497 - Undergraduate Research (Summer Term 2013) 2013
  • CH698 - Graduate Research (Summer Term 2013) 2013
  • CH792 - Seminar Presentation (Summer Term 2013) 2013
  • CH798 - Non-Dissertation Research (Summer Term 2013) 2013
  • CH799 - Dissertation Research (Summer Term 2013) 2013
  • CH201 - Research Methods in Chem (Spring Term 2013) 2013
  • CH297 - Directed Studies (Spring Term 2013) 2013
  • CH297 - Directed Studies (Spring Term 2013) 2013
  • CH461 - Advanced Biochemistry I (Spring Term 2013) 2013
  • CH464 - Physical Biochemistry Lab (Spring Term 2013) 2013
  • CH497 - Undergraduate Research (Spring Term 2013) 2013
  • CH498 - Chemistry Teaching Methods (Spring Term 2013) 2013
  • CH499 - Honors Thesis - RES (Spring Term 2013) 2013
  • CH561 - Biochemistry I (Spring Term 2013) 2013
  • CH691 - Seminar (Spring Term 2013) 2013
  • CH761 - Biochemistry II (Spring Term 2013) 2013
  • CH791 - Seminar (Spring Term 2013) 2013
  • CH792 - Seminar Presentation (Spring Term 2013) 2013
  • CH798 - Non-Dissertation Research (Spring Term 2013) 2013
  • CH799 - Dissertation Research (Spring Term 2013) 2013
  • CH297 - Directed Studies (Fall Term 2012) 2012
  • CH460 - Fundamentals of Biochemistry (Fall Term 2012) 2012
  • CH497 - Undergraduate Research (Fall Term 2012) 2012
  • CH560 - Fundamentals of Biochemistry (Fall Term 2012) 2012
  • CH760 - Fundamentals of Biochemistry (Fall Term 2012) 2012
  • CH790 - Intro to Graduate Research (Fall Term 2012) 2012
  • CH791 - Seminar (Fall Term 2012) 2012
  • CH792 - Seminar Presentation (Fall Term 2012) 2012
  • CH798 - Non-Dissertation Research (Fall Term 2012) 2012
  • CH799 - Dissertation Research (Fall Term 2012) 2012
  • CH297 - Directed Studies (Summer Term 2012) 2012
  • CH497 - Undergraduate Research (Summer Term 2012) 2012
  • CH698 - Graduate Research (Summer Term 2012) 2012
  • CH798 - Non-Dissertation Research (Summer Term 2012) 2012
  • CH799 - Dissertation Research (Summer Term 2012) 2012
  • CH201 - Research Methods in Chem (Spring Term 2012) 2012
  • CH297 - Directed Studies (Spring Term 2012) 2012
  • CH461 - Advanced Biochemistry I (Spring Term 2012) 2012
  • CH464 - Physical Biochemistry Lab (Spring Term 2012) 2012
  • CH497 - Undergraduate Research (Spring Term 2012) 2012
  • CH498 - Chemistry Teaching Methods (Spring Term 2012) 2012
  • CH499 - Honors Thesis - RES (Spring Term 2012) 2012
  • CH691 - Seminar (Spring Term 2012) 2012
  • CH761 - Biochemistry II (Spring Term 2012) 2012
  • CH764 - Biophysical Chemistry (Spring Term 2012) 2012
  • CH791 - Seminar (Spring Term 2012) 2012
  • CH792 - Seminar Presentation (Spring Term 2012) 2012
  • CH798 - Non-Dissertation Research (Spring Term 2012) 2012
  • CH799 - Dissertation Research (Spring Term 2012) 2012
  • CH297 - Directed Studies (Fall Term 2011) 2011
  • CH297 - Directed Studies (Fall Term 2011) 2011
  • CH497 - Undergraduate Research (Fall Term 2011) 2011
  • CH498 - Chemistry Teaching Methods (Fall Term 2011) 2011
  • CH499 - Honors Thesis - RES (Fall Term 2011) 2011
  • CH691 - Seminar (Fall Term 2011) 2011
  • CH790 - Intro to Graduate Research (Fall Term 2011) 2011
  • CH791 - Seminar (Fall Term 2011) 2011
  • CH792 - Seminar Presentation (Fall Term 2011) 2011
  • CH798 - Non-Dissertation Research (Fall Term 2011) 2011
  • CH799 - Dissertation Research (Fall Term 2011) 2011
  • CH297 - Directed Studies (Summer Term 2011) 2011
  • CH297 - Directed Studies (Summer Term 2011) 2011
  • CH497 - Senior Research (Summer Term 2011) 2011
  • CH798 - Non-Dissertation Research (Summer Term 2011) 2011
  • CH799 - Dissertation Research (Summer Term 2011) 2011
  • CH201 - Research Methods in Chem (Spring Term 2011) 2011
  • CH297 - Directed Studies (Spring Term 2011) 2011
  • CH297 - Directed Studies (Spring Term 2011) 2011
  • CH461 - Advanced Biochemistry I (Spring Term 2011) 2011
  • CH497 - Senior Research (Spring Term 2011) 2011
  • CH761 - Biochemistry II (Spring Term 2011) 2011
  • CH791 - Seminar (Spring Term 2011) 2011
  • CH792 - Seminar Presentation (Spring Term 2011) 2011
  • CH798 - Non-Dissertation Research (Spring Term 2011) 2011
  • CH799 - Dissertation Research (Spring Term 2011) 2011
  • CH297 - Directed Studies (Fall Term 2010) 2010
  • CH497 - Senior Research (Fall Term 2010) 2010
  • CH497 - Senior Research (Fall Term 2010) 2010
  • CH790 - Intro to Graduate Research (Fall Term 2010) 2010
  • CH791 - Seminar (Fall Term 2010) 2010
  • CH792 - Seminar Presentation (Fall Term 2010) 2010
  • CH798 - Non-Dissertation Research (Fall Term 2010) 2010
  • CH799 - Dissertation Research (Fall Term 2010) 2010
  • CH297 - Directed Studies (Summer Term 2010) 2010
  • CH497 - Senior Research (Summer Term 2010) 2010
  • CH499 - Honors Thesis - RES (Summer Term 2010) 2010
  • CH798 - Non-Dissertation Research (Summer Term 2010) 2010
  • CH799 - Dissertation Research (Summer Term 2010) 2010
  • CH201 - Chemical Research Approaches I (Spring Term 2010) 2010
  • CH297 - Directed Studies (Spring Term 2010) 2010
  • CH297 - Directed Studies (Spring Term 2010) 2010
  • CH461 - Advanced Biochemistry I (Spring Term 2010) 2010
  • CH497 - Senior Research (Spring Term 2010) 2010
  • CH497 - Senior Research (Spring Term 2010) 2010
  • CH661 - Biochemistry II (Spring Term 2010) 2010
  • CH761 - Biochemistry II (Spring Term 2010) 2010
  • CH791 - Seminar (Spring Term 2010) 2010
  • CH792 - Seminar Presentation (Spring Term 2010) 2010
  • CH798 - Non-Dissertation Research (Spring Term 2010) 2010
  • CH799 - Dissertation Research (Spring Term 2010) 2010
  • CH297 - Directed Studies (Fall Term 2009) 2009
  • CH297 - Directed Studies (Fall Term 2009) 2009
  • CH497 - Senior Research (Fall Term 2009) 2009
  • CH497 - Senior Research (Fall Term 2009) 2009
  • CH614 - Intro Biochem for Teachers (Fall Term 2009) 2009
  • CH615 - Intro Biochem for Teachers II (Fall Term 2009) 2009
  • CH669 - Special Topics in Biochemistry (Fall Term 2009) 2009
  • CH790 - Intro to Graduate Research (Fall Term 2009) 2009
  • CH791 - Seminar (Fall Term 2009) 2009
  • CH792 - Seminar Presentation (Fall Term 2009) 2009
  • CH798 - Non-Dissertation Research (Fall Term 2009) 2009
  • CH799 - Dissertation Research (Fall Term 2009) 2009
  • CH297 - Directed Studies (Summer Term 2009) 2009
  • CH469 - Special Topics in Biochemistry (Summer Term 2009) 2009
  • CH497 - Senior Research (Summer Term 2009) 2009
  • CH669 - Special Topics in Biochemistry (Summer Term 2009) 2009
  • CH798 - Non-Dissertation Research (Summer Term 2009) 2009
  • CH799 - Dissertation Research (Summer Term 2009) 2009
  • CH297 - Directed Studies (Spring Term 2009) 2009
  • CH462 - Advanced Biochemistry II (Spring Term 2009) 2009
  • CH497 - Senior Research (Spring Term 2009) 2009
  • CH562 - Biochemistry II (Spring Term 2009) 2009
  • CH698 - Graduate Research (Spring Term 2009) 2009
  • CH798 - Non-Dissertation Research (Spring Term 2009) 2009
  • CH799 - Dissertation Research (Spring Term 2009) 2009
  • CH297 - Directed Studies (Fall Term 2008) 2008
  • CH497 - Senior Research (Fall Term 2008) 2008
  • CH497 - Senior Research (Fall Term 2008) 2008
  • CH614 - Intro Biochem for Teachers (Fall Term 2008) 2008
  • CH615 - Intro Biochem for Teachers II (Fall Term 2008) 2008
  • CH790 - Intro to Graduate Research (Fall Term 2008) 2008
  • CH798 - Non-Dissertation Research (Fall Term 2008) 2008
  • CH799 - Dissertation Research (Fall Term 2008) 2008
  • CH297 - Directed Studies (Summer Term 2008) 2008
  • CH497 - Senior Research (Summer Term 2008) 2008
  • CH798 - Non-Dissertation Research (Summer Term 2008) 2008
  • CH799 - Dissertation Research (Summer Term 2008) 2008
  • CH297 - Directed Studies (Spring Term 2008) 2008
  • CH462 - Biochemistry II (Spring Term 2008) 2008
  • CH497 - Senior Research (Spring Term 2008) 2008
  • CH562 - Biochemistry II (Spring Term 2008) 2008
  • CH798 - Non-Dissertation Research (Spring Term 2008) 2008
  • CH799 - Dissertation Research (Spring Term 2008) 2008
  • CH297 - Directed Studies (Fall Term 2007) 2007
  • CH497 - Senior Research (Fall Term 2007) 2007
  • CH614 - Intro Biochem for Teachers (Fall Term 2007) 2007
  • CH615 - Intro Biochem for Teachers II (Fall Term 2007) 2007
  • CH790 - Intro to Graduate Research (Fall Term 2007) 2007
  • CH798 - Non-Dissertation Research (Fall Term 2007) 2007
  • CH799 - Dissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 1979
  • Bachelor of Science or Mathematics in Chemistry, University of Alabama at Birmingham 1974
  • Full Name

  • David Graves