Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 The editorialist repliesNew England Journal of Medicine.  383:1692. 2020
2020 Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN StudyKidney International Reports.  5:1679-1689. 2020
2020 Reply to ‘The case for evidence-based medicine for the association between hyperuricaemia and CKD’Nature Reviews Nephrology.  16:422-423. 2020
2020 Uric acid and hypertension: An update with recommendationsAmerican Journal of Hypertension.  33:583-594. 2020
2020 Urate-lowering therapy and chronic kidney disease progressionNew England Journal of Medicine.  382:2567-2568. 2020
2020 Persistent Disease Activity in Patients With Long-Standing Glomerular DiseaseKidney International Reports.  5:860-871. 2020
2020 Hyperuricemia is associated with a lower glomerular filtration rate in pediatric sickle cell disease patientsPediatric Nephrology.  35:883-889. 2020
2019 The case for uric acid-lowering treatment in patients with hyperuricaemia and CKDNature Reviews Nephrology.  15:767-775. 2019
2019 Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir ProphylaxisPediatric Transplantation.  23. 2019
2019 Health-related quality of life in glomerular diseaseKidney International.  95:1209-1224. 2019
2019 Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathyAmerican Journal of Hematology.  94:417-423. 2019
2019 Phase I study of single-dose pharmacokinetics and pharmacodynamics of belatacept in adolescent kidney transplant recipientsAmerican Journal of Transplantation.  19:1218-1223. 2019
2019 CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular DiseaseAmerican Journal of Kidney Diseases.  73:218-229. 2019
2019 CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipientsPediatric Transplantation.  23. 2019
2018 Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature 2018
2018 Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN StudyKidney International Reports.  3:1373-1384. 2018
2018 Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantationAmerican Journal of Transplantation.  18:2189-2199. 2018
2017 Effect of Febuxostat on ambulatory blood pressure in subjects with hyperuricemia and hypertension: A Phase 2 randomized placebo-controlled study 2017
2017 Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemiaPediatric Nephrology.  32:1565-1573. 2017
2017 Added sugars and cardiovascular disease risk in children: A scientific statement from the American Heart AssociationCirculation.  135:e1017-e1034. 2017
2017 Severe anemia early in life as a risk factor for sickle-cell kidney diseaseBlood.  129:385-387. 2017
2017 Uric Acid Excretion Predicts Increased Blood Pressure Among American Adolescents of African DescentAmerican Journal of the Medical Sciences.  353:336-341. 2017
2016 The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationaleContemporary Clinical Trials.  50:238-244. 2016
2016 Prevalence of acute kidney injury during pediatric admissions for acute chest syndromePediatric Nephrology.  31:1363-1368. 2016
2016 Smaller circuits for smaller patients: improving renal support therapy with Aquadex™Pediatric Nephrology.  31:853-860. 2016
2016 Obstructive sleep apnea and periodic limb movement disorder in a population of children with hypertension and/or nocturnal nondipping blood pressuresJournal of the American Society of Hypertension.  10:101-107. 2016
2015 Serum uric acid and risk of CKD in type 2 diabetesClinical Journal of the American Society of Nephrology.  10:1921-1929. 2015
2015 Pharmacokinetics, pharmacodynamics, and safety of lisinopril in pediatric kidney transplant patients: Implications for starting dose selectionClinical Pharmacology and Therapeutics.  98:25-33. 2015
2014 Serum uric acid and the risk of hypertension and chronic kidney diseaseCurrent Opinion in Rheumatology.  26:176-185. 2014
2013 Serum urate: A biomarker or treatment target in pediatric hypertension?Current Opinion in Cardiology.  28:433-438. 2013
2013 The utility of cortical-sparing adrenalectomy in pheochromocytomas associated with genetic syndromesJournal of Pediatric Surgery.  48:1422-1425. 2013
2013 Uric acid and the origins of hypertensionJournal of Pediatrics.  162:896-902. 2013
2013 What are the key arguments against uric acid as a true risk factor for hypertension?Hypertension.  61:948-951. 2013
2012 Hyperuricemia and HypertensionAdvances in Renal Replacement Therapy.  19:377-385. 2012
2012 Uric acid reduction rectifies prehypertension in obese adolescentsHypertension.  60:1148-1156. 2012
2012 The Role of Uric Acid in the Pathogenesis of Hypertension in the YoungJournal of Clinical Hypertension.  14:346-352. 2012
2012 Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduriaAmerican Journal of Human Genetics.  90:836-846. 2012
2012 Association between left ventricular mass index and cardiac function in pediatric dialysis patientsPediatric Nephrology.  27:835-841. 2012
2011 Uric acid: A clinically useful marker to distinguish preeclampsia from gestational hypertensionHypertension.  58:548-549. 2011
2011 Uric Acid and HypertensionSeminars in Nephrology.  31:441-446. 2011
2011 Serum uric acid is associated with high blood pressure in pediatric hemodialysis patientsPediatric Nephrology.  26:1123-1128. 2011
2011 Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small childrenPediatric Critical Care Medicine.  12:28-32. 2011
2010 Sugar-sweetened beverages and hypertensionFuture Cardiology.  6:773-776. 2010
2010 Uric acid and hypertension: Cause or effect?Current Rheumatology Reports.  12:108-117. 2010
2010 Pediatrics: Uncontrolled hypertension in children on hemodialysisNature Reviews Nephrology.  6:7-8. 2010
2009 Uric acid: A novel mediator and marker of risk in chronic kidney disease?Current Opinion in Nephrology and Hypertension.  18:526-530. 2009
2009 A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid 2009
2009 Sour Notes on Sweet DrinksJournal of Pediatrics.  154:783-784. 2009
2009 Prenatal programming: Maybe not so hopeless after all?American Journal of Hypertension.  22:348. 2009
2009 Minimal change disease with IgM+ immunofluorescence: A subtype of nephrotic syndromePediatric Nephrology.  24:1187-1192. 2009
2009 Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes? 2009
2009 Letter to the editorsNew England Journal of Medicine.  360:540-541. 2009
2008 Cost-effectiveness of ambulatory blood pressure monitoring in the initial evaluation of hypertension in childrenPediatrics.  122:1177-1181. 2008
2008 Medical progress: Uric acid and cardiovascular riskNew England Journal of Medicine.  359:1811-1821. 2008
2008 Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trial 2008
2008 Frequent hemodialysis with NxStage™ system in pediatric patients receiving maintenance hemodialysisPediatric Nephrology.  23:129-135. 2008
2008 Pathogenesis of essential hypertension: Historical paradigms and modern insightsJournal of Hypertension.  26:381-391. 2008
2007 Recent advances in the diagnosis and treatment of pheochromocytoma in children 2007
2007 Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease1-3American Journal of Clinical Nutrition.  86:899-906. 2007
2007 Coincident activation of Th2 T cells with onset of the disease and differential expression of GRO-gamma in peripheral blood leukocytes in minimal change diseaseAmerican Journal of Nephrology.  27:253-261. 2007
2007 Inaccuracy in pediatric outpatient blood pressure measurementPediatrics (Spanish Edition).  119. 2007
2007 The Role of Uric Acid in Pediatric HypertensionJournal of Renal Nutrition.  17:79-83. 2007
2006 Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertensionHypertension.  48:25-26. 2006
2006 Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular diseaseKidney International.  69:1722-1725. 2006
2006 Uric acid and hypertensionCurrent Hypertension Reports.  8:111-115. 2006
2006 Childhood hypertension is not a silent diseasePediatric Nephrology.  21:527-532. 2006
2006 Serum uric acid: A risk factor and a target for treatment?Journal of the American Society of Nephrology.  17. 2006
2006 A causal role for uric acid in fructose-induced metabolic syndrome 2006
2006 3-5 year longitudinal follow-up of pediatric patients after acute renal failureKidney International.  69:184-189. 2006
2006 Hormonal and cytokine effects of uric acidCurrent Opinion in Nephrology and Hypertension.  15:30-33. 2006
2005 Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertensionHypertension.  45:326-330. 2005
2005 A unifying pathway for essential hypertensionAmerican Journal of Hypertension.  18:431-440. 2005
2005 Resurrection of uric acid as a causal risk factor in essential hypertensionHypertension.  45:18-20. 2005
2005 Uric acid and hypertension in adolescentsSeminars in Nephrology.  25:32-38. 2005
2004 Does asymptomatic hyperuricaemia contribute to the development of renal and cardiovascular disease? An old controversy renewedNephrology.  9:394-399. 2004
2004 Calcium oxalate deposition in renal allografts: Morphologic spectrum and clinical implicationsAmerican Journal of Transplantation.  4:1338-1344. 2004
2004 Diuretic-induced hyperuricemia does not decrease cardiovascular risk.Journal of Hypertension.  22:1415-1417. 2004
2004 Management of a Severe Carbamazepine Overdose Using Albumin-Enhanced Continuous Venovenous HemodialysisPediatrics.  113:406-409. 2004
2004 Diuretic-induced hyperuricemia does not decrease cardiovascular risk [2] (multiple letters)Journal of Hypertension.  22:1415-1419. 2004
2004 Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertensionKidney International.  66:281-287. 2004
2003 Hyperuricemia in childhood primary hypertensionHypertension.  42:247-252. 2003
2003 Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?Hypertension.  41:1183-1190. 2003
1994 Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA 1994
1994 Reactive oxygen species in tumorigenesis.Cancer Research.  54:1890s-1894s. 1994
1994 Oxygen radical induced mutagenesis is DNA polymerase specificJournal of Molecular Biology.  235:33-41. 1994
1994 Mutagenesis by metal-induced oxygen radicalsEnvironmental Health Perspectives.  102:57-61. 1994
1993 Mechanisms of Mutation by Oxidative DNA Damage: Reduced Fidelity of Mammalian DNA Polymerase βBiochemistry.  32:4466-4473. 1993
1988 The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sitesMolecular and Cellular Biology.  8:4477-4483. 1988

Chapter

Year Title Altmetric
2018 Uric acid in the pathogenesis of hypertension.  73-90. 2018
2013 Uric acid in the pathogenesis of hypertension.  67-82. 2013
2012 Renal Urate Metabolism inthe Fetus and Newborn.  75-83. 2012
2012 Hypertension.  123-157. 2012

Research Overview

  • Childhood hypertension
    Sickle cell nephropathy
    FSGS
    Renal transplantation
  • Principal Investigator On

  • CUREGN 2.0 - Midwest Pediatric Nephrology Consortium - PCC  awarded by NATIONWIDE CHILDREN'S 2019 - 2021
  • ESTaBLISH: Impact of Early Life STressors on the BLood Pressure and Vascular Function In AdoleScents and cHildren  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2018 - 2020
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2016 - 2019
  • Cure Glomerulonephropathy (CureGN): Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers  awarded by NATIONWIDE CHILDREN'S HOSPITAL 2014 - 2019
  • Cure Glomerulonephropathy (CureGN): Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers  awarded by NATIONWIDE CHILDREN'S HOSPITAL 2015 - 2018
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2014 - 2018
  • Pharmacogenomics of Tacrolimus in Pediatric Kidney Transplant Recipients  awarded by American Kidney Fund 2016 - 2017
  • Private Grant  awarded by RETROPHIN, INC. 2014 - 2017
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2013 - 2017
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2013 - 2015
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2014 - 2015
  • Steering Committee for Safety and Pharmacokinetics of Lisinopril in Pediatric Kidney Transplant Patients  awarded by Duke University 2012 - 2014
  • Safety and Pharmacokinetics of Multiple Dose Lisinopril in Pediatric Kidney Transplant Recipients  awarded by Duke University 2012 - 2014
  • Viral Triggers of Alioimmunity and Autoimmunity in Pediatric Lung Transplantation  awarded by Washington University 2012 - 2013
  • (Protocol Development Team) for Safety and Pharmacokinetics of Lisinopril in Pediatric Kidney Transplant Patients  awarded by Duke University 2012 - 2013
  • Novel Therapies for Chronic Allograft Dysfunction in Children  awarded by CHILDREN'S HOSPITAL (BOSTON) 2012 - 2013
  • Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Project 4: Protecting Renal Function with Urate-Lowering Drugs  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2020 - 2022
  • Private Grant  awarded by Genentech 2018 - 2021
  • Private Grant  awarded by Sanofi US Services Inc 2017 - 2021
  • Chronic Kidney Disease in Children CKID IV  awarded by CHILDREN'S MERCY HOSPITAL 2018 - 2021
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Chronobiology and Chronopharmacology to Prevent Sickle Cell Nephropathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2020
  • The Child-Centered Outcomes in Practice and Research (COPR) Center of Excellence: Strengthing the Clinical Validity Evidence Base for PROMIS Measures in Chronically Ill Children  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2015 - 2019
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Private Grant  awarded by VIFOR 2016 - 2019
  • Phase 2 Study of Selective Cytopheretic Device for the Treatment of Pediatric Patients with Acute Kidney Injury  awarded by CINCINNATI CHILDREN'S HOSPITAL 2015 - 2019
  • Private Grant  awarded by OCTAPHARMA - NEW 2016 - 2019
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2016 - 2018
  • Chronic Kidney Disease in Children (CKiD III)  awarded by CHILDREN'S MERCY HOSPITAL 2013 - 2018
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Centers of Research Translation (CoRT) - Project 2  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC 2016 - 2017
  • International Pediatric Peritoneal Biopsy Study in Children  awarded by UNIVERSITY OF HEIDELBERG 2015 - 2016
  • Private Grant  awarded by ROCKWELL MEDICAL, INC. 2015 - 2016
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2014 - 2016
  • The Genetic Contribution to Drug Induced Renal lnjury:The Drug Induced Renal Injury Consortium (DIRECT)  awarded by INTERNATIONAL SAE CONSORTIOUM, LTD 2013 - 2016
  • Private Grant  awarded by ABBVIE INC 2013 - 2015
  • Private Grant  awarded by AMGEN, INC. 2010 - 2014
  • Chronic Kidney Disease in Children  awarded by CHILDREN'S MERCY HOSPITAL 2010 - 2013
  • Randomized Intervention for Children with Vesicoureteral Reflux  awarded by Wayne State University 2010 - 2013
  • Education And Training

  • Master of Science in Public Health, Baylor College of Medicine 2014
  • Doctor of Medicine, University of Washington 1995
  • Doctor of Philosophy in Biochemistry, University of Washington 1993
  • Bachelor of Science or Mathematics in Molecular Biology, Princeton University 1987
  • University of Washington Medical Center, Internship 1996
  • University of Washington Medical Center, Residency 1998
  • Children's Hospital Boston, Postdoctoral Fellowship 2001
  • Full Name

  • Daniel Feig