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Stijn De Langhe Ph.D.
Associate Professor
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E-mail
delanghe@uab.edu
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Stijn De Langhe Ph.D.
Associate Professor
Positions
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Associate Professor (P)
,
Medicine - Pulmonary, Allergy, & Critical Care Medicine
,
Department of Medicine
2017 -
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2017 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration
.
Frontiers in Pharmacology
. 11.
2020
2020
The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy
.
Theranostics
. 10:4422-4436.
2020
2019
FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury
.
Stem Cell Reports
. 12:1041-1055.
2019
2019
Developmental pathways in the pathogenesis of lung fibrosis
.
Molecular Aspects of Medicine
. 65:56-69.
2019
2019
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
2019
2018
Protein tyrosine phosphatase-N13 promotes myofibroblast resistance to apoptosis in idiopathic pulmonary fibrosis
.
American Journal of Respiratory and Critical Care Medicine
. 198:914-927.
2018
2018
Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury.
.
Frontiers in Genetics
. 9:418.
2018
2017
Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells
.
Developmental Cell
. 43:48-59.e5.
2017
2017
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction
.
Journal of Clinical Investigation
. 127:2262-2276.
2017
2017
Erratum: Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis (Cell Stem Cell (2017) 20(2) (261–273) (S1934590916303447) (10.1016/j.stem.2016.10.004))
.
Cell Stem Cell
. 20:571.
2017
2017
Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis
.
Cell Stem Cell
. 20:261-273.e3.
2017
2016
Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis
.
Scientific Reports
. 6.
2016
2015
Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development
2015
2015
Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm
.
STEM CELLS
. 33:999-1012.
2015
2015
Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development
.
Developmental Dynamics
. 244:342-366.
2015
2014
miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development
2014
2014
General parity between trio and pairwise breeding of laboratory mice in static caging
.
Journal of Immunology
. 193:4757-4760.
2014
2014
Lung epithelial stem cells and their niches: Fgf10 takes center stage
2014
2013
Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
2013
2013
c-Myc Regulates Proliferation and Fgf10 Expression in Airway Smooth Muscle after Airway Epithelial Injury in Mouse
.
PLoS ONE
. 8.
2013
2013
Erratum: Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner (Endocrine-Related Cancer 19 (111-122) DOI:10.1530/ERC-10-0327)
.
Endocrine-Related Cancer
. 20.
2013
2012
Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype
.
Journal of Clinical Investigation
. 122:3862-3872.
2012
2012
Characterization of a novel Fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development
.
PLoS ONE
. 7.
2012
2012
Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner
.
Endocrine-Related Cancer
. 19:111-122.
2012
2011
Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury
.
Journal of Clinical Investigation
. 121:4409-4419.
2011
2011
Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling
2011
2011
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
2011
2011
Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo
.
STEM CELLS
. 29:206-216.
2011
2010
β-Catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis
.
Journal of Surgical Research
. 164:276-285.
2010
2010
Corrigendum to "Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis" [Mol. Cell. Neurosci. 37 (2008) 857-868] (DOI:10.1016/j.mcn.2008.01.008)
.
Molecular and Cellular Neuroscience
. 43:259.
2010
2010
Lung organogenesis
.
Current Topics in Developmental Biology
. 90:73-158.
2010
2009
Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of apert syndrome
.
Pediatric Research
. 66:386-390.
2009
2009
Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
.
American Journal of Respiratory and Critical Care Medicine
. 180:701-712.
2009
2009
Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease
.
Anatomical Record
. 292:1045-1061.
2009
2009
miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution
.
Developmental Biology
. 333:238-250.
2009
2008
Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages
.
STEM CELLS
. 26:2902-2911.
2008
2008
Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling
.
Developmental Biology
. 317:121-131.
2008
2008
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by β-catenin signaling
.
PLoS ONE
. 3.
2008
2008
Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis
.
Molecular and Cellular Neuroscience
. 37:857-868.
2008
2008
Wnt signaling in lung organogenesis
.
Organogenesis
. 4:100-108.
2008
2007
Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via β-catenin activation
.
Hepatology
. 46:1187-1197.
2007
2007
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
.
Developmental Biology
. 307:237-247.
2007
2006
Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung
.
Developmental Biology
. 299:52-62.
2006
2006
Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung
.
Developmental Biology
. 293:77-89.
2006
2006
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia
.
Journal of Pediatric Surgery
. 41:132-136.
2006
2005
Wnt5a regulates Shh and Fgf10 signaling during lung development
.
Developmental Biology
. 287:86-97.
2005
2005
A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis
.
Developmental Biology
. 282:422-431.
2005
2005
Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
2005
2005
Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
.
Developmental Biology
. 277:316-331.
2005
2005
Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway
.
Journal of Pediatric Surgery
. 40:390-396.
2005
2005
Fibroblast growth factor-10 serves a regulatory role in duodenal development
.
Journal of Pediatric Surgery
. 40:313-316.
2005
2005
Molecular Mechanisms of Early Lung Specification and Branching Morphogenesis
.
Pediatric Research
. 57:26R-37R.
2005
2004
A genetic mechanism for cecal atresia: The role of the Fgf10 signaling pathway
.
Journal of Surgical Research
. 120:201-209.
2004
2004
Fibroblast growth factor receptor 2 IIIb invalidation - A potential cause of familial duodenal atresia
.
Journal of Pediatric Surgery
. 39:872-874.
2004
2004
Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse
.
Developmental Biology
. 265:61-74.
2004
2002
Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.
.
International Journal of Molecular Medicine
. 9:451-459.
2002
Research
Principal Investigator On
Epithelial Stem Cell Hippo Signaling In Pulmonary Fibrosis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2023
HL-Lung Stem Cells and Their Niches
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2017 - 2020
HL-Role of c-Myc in Myofibroblast Differentiation in Pulmonary Fibrosis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2017 - 2020
Epithelial Mesenchymal Interactions in Lung Development and Fibrosis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2020
Private Grant
awarded by
Genentech
2019
Role of Integrin linked Kinase in Regulating Epithelial Cell Lineage Commitment during Lung Development.
awarded by
March of Dimes
2017 - 2018
Investigator On
Therapeutic Targeting of MUC5B in a Novel Ferret Model of Idiopathic Pulmonary Fibrosis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2020 - 2024
Teaching
Teaching Activities
BME798 - Non-Dissertation Research (Fall Term 2020)
2020
BME798 - Non-Dissertation Research (Summer Term 2020)
2020
BME798 - Non-Dissertation Research (Spring Term 2020)
2020
BME798 - Non-Dissertation Research (Summer Term 2019)
2019
Background
Education And Training
Ghent University, Other
USC Keck School of Medicine, Postdoctoral Research
Doctor of Philosophy in Biotechnology,
Ghent University
2005
Bachelor of Science or Mathematics in Biotechnology,
Ghent University
1998
Contact
Full Name
Stijn
De Langhe