Positions

Overview

  • Dr. Chaplin completed his undergraduate education at Harvard University in 1973, then undertook graduate training in the MD/PhD program at Washington University, graduating in 1980. He completed two years of Internal Medicine Residency at U of Texas/Southwestern Medical School, Parkland Memorial Hospital. His post-doctoral research training was with Dr. J.G. Seidman in the Department of Genetics at Harvard Medical School, studying the genetics of the murine major histocompatibility complex. In 1984, he accepted a position as Associate Investigator of the Howard Hughes Medical Institute and Assistant Professor of Medicine, Molecular Microbiology, and Genetics at Washington University in St. Louis. He was promoted to Associate Professor in 1992, and Professor in 1995. He was Director of the Division of Allergy and Immunology from 1994-2001. In July 2001, he joined the faculty of UAB as Charles H. McCauley Professor and Chairman of the Department of Microbiology. In 2012, he stepped down from his position as Department Chair and assumed the position of Associate Dean for Faculty Development in the School of Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
    2018 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipientsThe Journal of heart transplantation.  37:206-216. 2018
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2015 IL-1β in eosinophil-mediated small intestinal homeostasis and IgA productionMucosal Immunology.  8:930-942. 2015
    2014 Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707.Journal of Immunology.  192:2010-2014. 2014
    2013 IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitisProceedings of the National Academy of Sciences.  110:12768-12773. 2013
    2013 A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropismGene Therapy.  20:733-741. 2013
    2013 Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of miceBritish Journal of Pharmacology.  169:462-476. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2012 Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathwaysAmerican Journal of Respiratory Cell and Molecular Biology.  46:790-796. 2012
    2012 Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4 + T cells and γδ T cellsJournal of Immunology.  188:3107-3115. 2012
    2012 Regulatory role of antigen-induced interleukin-10, produced by CD4 + T cells, in airway neutrophilia in a murine model for asthmaEuropean Journal of Pharmacology.  677:154-162. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.Molecular Medicine.  18:659-668. 2012
    2011 AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophilsFederation proceedings.  25:4358-4368. 2011
    2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infectionInfection and Immunity.  79:3966-3977. 2011
    2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsivenessMucosal Immunology.  4:503-518. 2011
    2011 Inhibition of neutrophil apoptosis by PAI-1AJP - Lung Cellular and Molecular Physiology.  301. 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 miceArthritis and Rheumatism.  63:2038-2048. 2011
    2011 Important role of neutrophils in the late asthmatic response in miceLife Sciences.  88:1127-1135. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2010 Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniaePLoS ONE.  5. 2010
    2010 Follicular dendritic cell makes environmental senseImmunity.  33:2-4. 2010
    2010 Tumor immune evasionScience.  328:697-698. 2010
    2010 Overview of the immune responseJournal of Allergy and Clinical Immunology.  125. 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunityJournal of Immunology.  184:442-451. 2010
    2009 MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airwaysEuropean Journal of Immunology.  39:2281-2292. 2009
    2009 The Lymphotoxin LTα1β2 Controls Postnatal and Adult Spleen Marginal Sinus Vascular Structure and FunctionImmunity.  30:408-420. 2009
    2008 Intraclonal competition inhibits the formation of high-affinity antibody-secreting cellsJournal of Immunology.  181:6027-6037. 2008
    2008 Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiologyProceedings of the National Academy of Sciences.  105:6720-6724. 2008
    2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceNature Immunology.  9:166-175. 2008
    2006 1. Overview of the human immune responseJournal of Allergy and Clinical Immunology.  117. 2006
    2006 Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in miceAmerican Journal of Pathology.  168:1425-1434. 2006
    2006 Taking control of follicular dendritic cellsImmunity.  24:13-15. 2006
    2005 CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosaNature Immunology.  6:698-706. 2005
    2005 Induction of a late asthmatic response associated with airway inflammation in miceEuropean Journal of Pharmacology.  521:144-155. 2005
    2003 Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph nodeAJP - Heart and Circulatory Physiology.  284. 2003
    2003 Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.AJP - Heart and Circulatory Physiology.  284:H2213-H2226. 2003
    2003 Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin β receptor, and TNF receptor I functionJournal of Immunology.  170:5475-5482. 2003
    2003 1. Overview of the immune responseJournal of Allergy and Clinical Immunology.  111. 2003
    2003 Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin.The Scientific World Journal.  3:484-496. 2003
    2002 Regulation of spleen white pulp structure and function by lymphotoxinAdvances in Experimental Medicine and Biology.  512:49-56. 2002
    2002 Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthmaJournal of Immunology.  169:5458-5467. 2002
    2002 IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigenJournal of Immunology.  169:5468-5476. 2002
    2002 Cell cooperation in development of eosinophil-predominant inflammation in airwaysImmunologic Research.  26:55-62. 2002
    2002 Nonhematopoietic expression of Janus Kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammationJournal of Immunology.  168:2475-2482. 2002
    2002 T helper type 1 cells in asthma: Friend or foe?Current Opinion in Allergy and Clinical Immunology.  2:31-37. 2002
    2001 Visualization of early APC/T cell interactions in the mouse lung following intranasal challengeJournal of Immunology.  167:6756-6764. 2001
    2001 Confocal fluorescent intravital microscopy of the murine spleenJournal of Immunological Methods.  256:55-63. 2001
    2001 Induction, distribution and modulation of upper airway allergic inflammation in miceClinical and Experimental Allergy.  31:1048-1059. 2001
    2001 Interleukin-1β promotes repair of the CNSJournal of Neuroscience.  21:7046-7052. 2001
    2001 A role for IL-1α in inducing pathologic inflammation during bacterial infectionProceedings of the National Academy of Sciences.  98:10880-10885. 2001
    2001 Signaling through TNF receptor p55 in TNF-α-deficient mice alters the CXCL13/CCL19/CCL21 ratio in the spleen and induces maturation and migration of anergic B cells into the B cell follicleJournal of Immunology.  167:1920-1928. 2001
    2001 IL-1β is essential for langerhans cell activation and antigen delivery to the lymph nodes during contact sensitization: Evidence for a dermal source of IL-1βCellular Immunology.  211:105-112. 2001
    2001 Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-α-deficient miceJournal of Experimental Medicine.  193:1227-1238. 2001
    2000 Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulinEuropean Journal of Immunology.  30:2226-2234. 2000
    2000 Lymphotoxin-α-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activationJournal of Immunology.  164:2508-2514. 2000
    2000 Could asthma be worsened by stimulating the T-helper type 1 immune response?American Journal of Respiratory Cell and Molecular Biology.  22:143-146. 2000
    1999 The role of CCR7 in T(H)1 and T(H)2 cell localization and delivery of B cell help in vivoScience.  286:2159-2162. 1999
    1999 Dysregulated myelopoiesis in mice lacking Jak3Blood.  94:932-939. 1999
    1999 Development and maturation of secondary lymphoid tissuesAnnual Review of Immunology.  17:399-433. 1999
    1999 Requirement for membrane lymphotoxin in natural killer cell developmentProceedings of the National Academy of Sciences.  96:6336-6340. 1999
    1999 Modulation of airway inflammation by passive transfer of allergen- specific Th1 and Th2 cells in a mouse model of asthmaJournal of Immunology.  162:2375-2383. 1999
    1999 Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammationJournal of Clinical Investigation.  104:1021-1029. 1999
    1998 B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin α-dependent fashionJournal of Experimental Medicine.  187:1009-1018. 1998
    1998 B lymphocytes deliver lymphotoxin-dependent signals for the development of follicular dendritic cell clustersFederation proceedings.  12. 1998
    1998 Modulation of allergic airway inflammation by transferred Th1 and Th2 cellsFederation proceedings.  12. 1998
    1998 Cytokine regulation of secondary lymphoid organ developmentCurrent Opinion in Immunology.  10:289-297. 1998
    1997 Distinct roles of lymphotoxin α and the type i tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non- bone marrow-derived cellsJournal of Experimental Medicine.  186:1997-2004. 1997
    1997 Targets in cytokine activationAgents and actions. Supplements.  49:1-3. 1997
    1997 Abrogation of the alternative complement pathway by targeted deletion of murine factor BProceedings of the National Academy of Sciences.  94:8720-8725. 1997
    1997 Lymphotoxin-α (LTα) supports development of splenic follicular structure that is required for IgG responsesJournal of Experimental Medicine.  185:2111-2120. 1997
    1997 Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph nodeProceedings of the National Academy of Sciences.  94:5739-5743. 1997
    1997 Lymphotoxin-α-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centersImmunological Reviews.  156:137-144. 1997
    1996 Affinity maturation in the absence of germinal centers in lymphotoxin-α deficient miceFederation proceedings.  10. 1996
    1996 Mean multidimentional functionДоклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 Polymorphic marker from there tumor necrosis factor receptor p75 gene: Application for the disease association studiesДоклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 [A polymorphic markers for the p75 tumor necrosis factor receptor gene: use for analyzing disease linkage].Доклады Академии Наук / Doklady Biological Sciences.  351:558-560. 1996
    1996 Affinity maturation without germinal centres in lymphotoxin-α- deficient miceNature.  382:462-466. 1996
    1996 Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2Proceedings of the National Academy of Sciences.  93:3357-3361. 1996
    1996 Mice deficient in IL-1β manifest impaired contact hypersensitivity to trinitrochlorobenzeneJournal of Experimental Medicine.  183:1427-1436. 1996
    1996 Role of lymphotoxin and the type I TNF receptor in the formation of germinal centersScience.  271:1289-1291. 1996
    1995 Restriction map of a 35-kb HLA fragment constructed by nested deletion 'drop-out' mappingGene.  164:335-339. 1995
    1995 Molecular Dissection of the Murine IL-1beta Promoter.American Journal of Therapeutics.  2:677-686. 1995
    1995 Construction of a genomic DNA 'feature map' by sequencing from nested deletions: Application to the HLA class I regionNucleic Acids Research.  23:117-122. 1995
    1995 A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1β geneMolecular and Cellular Biology.  15:112-119. 1995
    1995 A novel creb family gene telomeric of HLA-DRA in the HLA complexGenomics.  30:149-156. 1995
    1995 Absence of lymph nodes in lymphotoxin-α(LTα)-deficient mice is due to abnormal organ development, not defective lymphocyte migrationJournal of inflammation.  45:72-78. 1995
    1995 Feature mapping of the HLA class I region: Localization of the POU5F1 and TCF19 genesGenomics.  30:53-58. 1995
    1995 Macrophage apoptosis in the absence of active interleukin-1β-converting enzymeJournal of Leukocyte Biology.  58:717-724. 1995
    1994 Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1β geneJournal of Immunology.  153:143-152. 1994
    1994 Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxinScience.  264:703-707. 1994
    1994 An NFIL-6 Sequence Near the Transcriptional Initiation Site Is Necessary for the Lipopolysaccharide Induction of Murine Interleukin-lβDNA (Mary Ann Liebert, Inc.).  13:561-569. 1994
    1994 Fluorescent automated sequencing of supercoiled high molecular weight double-stranded DNABioTechniques.  17:854-857. 1994
    1994 P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 lociImmunogenetics.  39:48-55. 1994
    1993 Genes in one megabase of the HLA class I regionProceedings of the National Academy of Sciences.  90:11870-11874. 1993
    1993 Identification in the HLA class I region of a gene expressed late in keratinocyte differentiationProceedings of the National Academy of Sciences.  90:9470-9474. 1993
    1993 Chromosomal Localization of Five Murine HSP70 Gene Family Members: Hsp70.1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78Genomics.  16:193-198. 1993
    1993 IDENTIFICATION IN THE HLA CLASS-I REGION OF A NOVEL GENE EXPRESSED IN TERMINALLY DIFFERENTIATING KERATINOCYTESJournal of Investigative Dermatology.  100:501-501. 1993
    1993 IDENTIFICATION IN THE HLA CLASS-I REGION OF A NOVEL GENE EXPRESSED IN TERMINALLY DIFFERENTIATING KERATINOCYTESClinical research.  41:A487-A487. 1993
    1993 RELEASE OF INTERLEUKIN-1 FROM ACTIVATED MOUSE MACROPHAGES BY ANTIGEN-SPECIFIC HELPER T-LYMPHOCYTE CLONESClinical research.  41:A184-A184. 1993
    1993 CHARACTERIZATION AND ACTIVATION OF THE MURINE INTERLEUKIN-1-BETA (IL-1-BETA) CONVERTING ENZYMEJournal of Cellular Biochemistry.  117-117. 1993
    1993 Highly informative typing of the human TNF locus using six adjacent polymorphic markersGenomics.  16:180-186. 1993
    1993 Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. I. Development and initial characterisation of the modelAgents and actions.  38:247-254. 1993
    1993 Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugsAgents and actions.  38:255-264. 1993
    1993 Regulation of IL-1 gene expression: Differential responsiveness of murine macrophage linesCytokine.  5:327-335. 1993
    1993 Simultaneous transfer of four functional genes from the HLA class II region into mammalian cells by fusion with yeast spheroplasts carrying an artificial chromosomeJournal of Immunology.  150:5371-5378. 1993
    1992 Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomesProceedings of the National Academy of Sciences.  89:2669-2673. 1992
    1992 Molecular cloning of the murine IL-1β converting enzyme cDNAJournal of Immunology.  149:3254-3259. 1992
    1991 Interleukin 1 is processed and released during apoptosisProceedings of the National Academy of Sciences.  88:8485-8489. 1991
    1991 Generation of monoclonal antibodies to murine IL-1β and demonstration of IL-1 in vivoJournal of Immunology.  146:1534-1540. 1991
    1991 Different isozymes of mouse 11/β-hydroxylase produce mineralocorticoids and glucocorticoidsMolecular Endocrinology -Baltimore-.  5:1853-1861. 1991
    1991 IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1αJournal of Immunology.  147:2964-2969. 1991
    1991 Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C lociProceedings of the National Academy of Sciences.  88:1676-1680. 1991
    1991 Molecular linkage of the HLA-DR, HLA-DQ, and HLA-DO genes in yeast artificial chromosomesGenomics.  11:577-586. 1991
    1991 Release of IL-1 from mononuclear phagocytesJournal of Immunology.  147:2181-2186. 1991
    1991 cDNA selection: Efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragmentsProceedings of the National Academy of Sciences.  88:9623-9627. 1991
    1990 The B144-H-2Dbinterval and the location of a mouse homologue of the human D6S81E locusImmunogenetics.  32:200-204. 1990
    1990 Compartmentalization of mammalian proteins produced in Escherichia coliJournal of Biological Chemistry.  265:13066-13073. 1990
    1990 Identification and sequence analysis of four complement factor H-related transcripts in mouse liverJournal of Biological Chemistry.  265:3193-3201. 1990
    1990 Structure and Chromosome Assignment of the Murine p36 (Calpactin I Heavy Chain) GeneBiochemistry.  29:1226-1232. 1990
    1990 A novel enhancer in the immunoglobulin λ locus is duplicated and functionally independent of NFκBGenes and Development.  4:978-992. 1990
    1990 Factor H.Current Topics in Microbiology and Immunology.  153:147-162. 1990
    1990 Genetic variability at the human tumor necrosis factor lociJournal of Immunology.  145:1278-1285. 1990
    1990 Genomic organization of mouse Fc(γ) receptor genesProceedings of the National Academy of Sciences.  87:2856-2860. 1990
    1989 Molecular Analysis of the Murine C4b-Binding Protein Gene. Chromosome Assignment and Partial Gene OrganizationBiochemistry.  28:8312-8317. 1989
    1989 Molecular biology and genetics of interleukin-1.The Year in immunology.  5:21-37. 1989
    1989 Regulation of the human chorionic gonadotrophin beta subunit genes.Journal of Reproduction and Fertility -Supplement-.  37:1-10. 1989
    1988 Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1α cDNAProceedings of the National Academy of Sciences.  85:5649-5653. 1988
    1988 Identification of a promoter region in the CGβ gene clusterJournal of Biological Chemistry.  263:7322-7329. 1988
    1988 Monoclonal antibodies to murine IL-1α. Production, characterization, and inhibition of membrane-associated IL-1 activityJournal of Immunology.  141:2643-2650. 1988
    1988 Structure of the murine complement factor H geneJournal of Biological Chemistry.  263:16720-16724. 1988
    1988 The major histocompatibility complex and autoimmunity.The Year in immunology.  3:179-198. 1988
    1987 Interleukin-1 α and β genes: linkage on chromosome 2 in the mouseImmunogenetics.  26:339-343. 1987
    1987 Human complement C3b/C4b receptor (CRI) mRNA polymorphism that correlates with the CRI allelic molecular weight polymorphismProceedings of the National Academy of Sciences.  84:2459-2463. 1987
    1987 Cosmid mapping of the human chorionic gonadotropin β subunit genes by field-inversion gel elect rophoresisNucleic Acids Research.  15:4437-4448. 1987
    1987 Anaphylaxis to intravenous furosemideJournal of Allergy and Clinical Immunology.  80:538-541. 1987
    1987 Deletion of C4A genes in patients with systemic lupus erythematosusArthritis and Rheumatism.  30:1015-1022. 1987
    1987 Germline organization of the murine T cell receptor β-chain genesScience.  238:545-548. 1987
    1987 Membrane IL-1: A key protein in antigen presentationAnnales de l'Institut Pasteur. Immunology.  138:489-492. 1987
    1987 Regulation of interleukin 1 gene expression by adherence and lipopolysaccharideJournal of Immunology.  138:3799-3802. 1987
    1986 Characterization of a regulatory region of the steroid 21-hydroxylase geneJournal of Biological Chemistry.  261:15353. 1986
    1986 Molecular analysis of 21-hydroxylase gene expression in mouse adrenal cellsEndocrine Research.  12:409-427. 1986
    1986 Nucleotide sequence analysis of murine 21-hydroxylase genes: Mutations affecting gene expressionProceedings of the National Academy of Sciences.  83:9601-9605. 1986
    1985 Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cellsProceedings of the National Academy of Sciences.  82:7860-7864. 1985
    1985 Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in bb and bbn ratsJournal of Experimental Medicine.  162:444-458. 1985
    1985 Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in manProceedings of the National Academy of Sciences.  82:1089-1093. 1985
    1985 Expression of complement proteins C2 and factor B in transfected L cellsJournal of Clinical Investigation.  76:1449-1454. 1985
    1985 Molecular Organization and in vitro Expression of Murine Class III GenesImmunological Reviews.  87:61-80. 1985
    1985 Molecular linkage of the genes encoding adrenal steroid 21-hydroxylase to the S region of the murine major histocompatibility complex (MHC)Federation proceedings.  44. 1985
    1984 Two steroid 21-hydroxylase genes are located in the murine S regionNature.  312:465-467. 1984
    1984 Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker.Proceedings of the National Academy of Sciences.  81:4879-4883. 1984
    1984 Class I, II and III major histocompatibility complex gene polymorphisms in BB ratsDiabetologia.  27:77-79. 1984
    1984 Eukaryotic chromosome transfer: Linkage of the murine major histocompatibility complex to an inserted dominant selectable markerProceedings of the National Academy of Sciences.  81:4879-4883. 1984
    1984 Expression of hemolytically active murine fourth component of complement in transfected L cellsCell.  37:569-576. 1984
    1983 Molecular map of the murine S region.Proceedings of the National Academy of Sciences.  80:6947-6951. 1983
    1983 Molecular map of the murine S regionProceedings of the National Academy of Sciences.  80:6947-6951. 1983
    1980 Early activation events in lectin-stimulated human lymphocytes: Evidence that wheat germ agglutinin and mitogenic lectins cause similar early changes in lynphocyte metabolismJournal of Immunology.  125:1544-1550. 1980
    1980 Protein phosphorylation in human peripheral blood lymphocytes: Mitogen-induced increases in protein phosphorylation in intact lymphocytesJournal of Immunology.  124:2390-2398. 1980
    1979 Protein phosphorylation in human peripheral blood lymphocytes. Phosphorylation of endogenous plasma membrane and cytoplasmic proteinsBiochemical Journal.  182:537-546. 1979
    1979 Protein phosphorylation in human peripheral blood lymphocytes. Subcellular distribution and partial characterization of adenosine 3':5'-cyclic monophosphate-dependent protein kinaseBiochemical Journal.  182:525-536. 1979
    1979 Stimulation by mitogens of phosphorylation of a 65,000 MW protein in intact human lymphocytesFederation proceedings.  38. 1979
    1978 Inhibition of lectin-induced lymphocyte activation by diamide and other sulfhydryl reagentsCellular Immunology.  36:303-311. 1978
    1977 Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP in human peripheral lymphocytesCellular Immunology.  28:338. 1977
    1974 The effects of thrombin on phytohemagglutinin receptor sites in human plateletsJournal of Cell Biology.  60:541-553. 1974

    Chapter

    Year Title Altmetric
    2007 Overview of Immunology in the Mouse: Molecular and Cellular Immunology.  1-55. 2007
    2001 Analysis of isolated YAC clones. 2001
    2001 Overview of strategies for screening YAC libraries and analyzing YAC clones. 2001

    Research Overview

  • Interplay between innate and adaptive immunity in asthmatic inflammation - Dr. Chaplin’s laboratory aims to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifest in tissues through the action of the adaptive immune response. He has a special interest in the ways commensal and pathogenic microbes that are present in the lung alter allergic inflammatory responses such as those that underlie asthmatic inflammation. He is testing the hypothesis that airway microbes impact the quality and quantity of asthmatic inflammation largely through their induction of myeloid-derived regulatory cells (MDRC). Lung and airway MDRC, defined by Dr. Chaplin’s laboratory in 2011, constitute several discrete populations of cells that determine the overall inflammatory tone in the tissues through their production of cytokines, chemokines, and reactive nitrogen and oxygen free radical species. Dr. Chaplin’s laboratory demonstrated in studies using a mouse model that superoxide-producing MDRC dramatically accentuate airway hyperresponsiveness after exposure to aerosolized antigen. In contrast, populations of nitric oxide-producing MDRC blunt airway hyperresponsiveness, suggesting that the nitric oxide/superoxide axis may be a valuable target for future development of novel anti-asthmatic therapeutics.
  • Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Asthma Cohort Support Contract  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2013 - 2023
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • UAB Skin Disease Research Center - Administrative Core - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • Second-Hand Smoke and Myeloid Cells in Asthma  awarded by Flight Attendant Medical Research Institute 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) KL2 Component  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) T32 (TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Dental Academic Research Training - DART  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2012
  • Teaching Overview

  • Course Director for GBS 730-01 Respiratory Tract Pathogens 2010, 2012, 2015, 2017
    Course Co-Director for MIC 788 Primary Immunodeficiency Diseases 2008, 2011
    Course Director for EPI 680 Clinical and Translational Science Training Program 2015, 2016, 2017, 2018
  • Education And Training

  • Doctor of Medicine in Developmental Biology and Embryology, Washington University/St. Louis 1980
  • Doctor of Philosophy in Cell / Cellular Biology and Anatomical Sciences, Washington University/St. Louis 1980
  • University of Texas Southwestern Medical School Internal Medicine, Internship 1982
  • Harvard Medical School Genetics, Postdoctoral Fellowship 1984
  • Full Name

  • David Chaplin
  • Fax

  • 205-996-4008