Positions

Overview

  • My research has focused on the metabolism of Nicotinamide Adenine Dinucleotide (NAD), the bioactive form of the vitamin niacin, and the roles that NAD-utilizing enzymes and NAD-derived molecules play in modulating cellular life/death decisions and inflammatory responses following oxidative stress. My interests are in basic and translational research aimed at (i) validating NAD metabolism as a therapeutic target, and (ii) discovering new therapies for the treatment of diseases as diverse as cancer, chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis (IPF), influenza, acute respiratory distress syndrome (ARDS), Alzheimer’s Disease, and schistosomiasis.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tractsHuman Vaccines and Immunotherapeutics.  18. 2022
    2021 Lung dendritic cells migrate to the spleen to prime long-lived TCF1hi memory CD8+ T cell precursors after influenza infectionScience Immunology.  6. 2021
    2021 Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challengeVaccines.  9. 2021
    2021 Evaluation of immunologic parameters in canine glioma patients treated with an oncolytic herpes virus. 2021
    2020 Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice. 2020
    2020 Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survivalPLoS Pathogens.  16. 2020
    2019 Ifnγ induces epigenetic programming of human t-bethi b cells and promotes tlr7/8 and il-21 induced differentiationeLife.  8. 2019
    2018 CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanismScientific Reports.  8. 2018
    2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infectionNature Immunology.  18:1249-1260. 2017
    2017 Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of MetalACS Chemical Biology.  12:1787-1795. 2017
    2010 Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase.Biochemistry.  49:7674-7682. 2010

    Full Name

  • Davide Botta