Positions

Overview

  • David Bedwell, Professor and Chairman of the Department of Biochemistry and Molecular Genetics, completed his undergraduate studies in Microbiology at Purdue University (B.S. with Honors, 1979). His graduate work in Molecular Biology was done with Dr. Masayasu Nomura at the University of Wisconsin-Madison, (Ph.D., 1985). He then carried out a postdoctoral fellowship in Dr. Scott Emr's laboratory at Caltech. Dr. Bedwell joined the faculty at UAB in 1988. At the national level, he is in a second 5 year term on the Editorial Board of the Journal of Biological Chemistry, and has served as chair of both the Molecular Genetics B (MGB) and Molecular Genetics C (MGC) Study Sections of the National Institutes of Health. He has reviewed manuscripts for >60 scientific journals (including Science, Nature, and Cell). He was elected Fellow of the American Academy of Microbiology in 2011. At the institutional level, he has served as chair of the UAB School of Medicine Faculty Council (2016) and also currently serves as the Co-Director of the UAB structural Biology Program. He previously served as Director the the UAB Cell and Molecular Biology (CMB) Graduate Program (1996-2002).
  • Selected Publications

    Chapter

    Year Title Altmetric
    2005 Therapies of Nonsense-Associated Diseases.  121-136. 2005

    Research Overview

  • The Bedwell lab seeks to understand the mechanistic details of translation termination in eukaryotes, and to use that knowledge to develop therapeutic strategies for a range of genetic diseases caused by premature translation termination mutations (PTCs). In addition, other important cellular processes also intersect with the process of translation termination. For example, conserved cellular machineries also regulate the abundance of mRNAs based on the location of stop codons through the process of Nonsense-Mediated mRNA Decay (NMD). We are using a combination of genetics, biochemistry, and cell biology to better understand the molecular details of these processes.

    Two diseases we are applying our findings to are cystic fibrosis (CF) and the lysosomal storage disease MPS I-H (Hurler syndrome). CF is caused by mutations in the CFTR gene. Roughly 10% of CF patients carry a premature stop mutation in the CFTR gene. We are working to identify drugs that suppress premature stop mutations in the CFTR gene in various experimental models, including cultured CF cells, transgenic and knock-in CF mice, and CF patients. We have also recently identified the amino acids inserted during the suppression of various stop codons in mammalian cells, and are using that informationto develop strategies to enhance the CFTR activity obtained by PTC suppression.

    Similarly, 70% of Mucopolysaccharidosis Type I-H (MPS I-H) patients carry a premature stop mutation in the IDUAgene. We have shown that PTC suppression can alleviate the primary biochemical defect in primary cells and a knock-in Hurler mouse. In addition, we have shown that this approach can also moderate long-term progression of this disease in the brain, bone and heart. Ultimately, this therapeutic approach could be usedto treat a broad range of human genetic diseases caused by premature stop mutations.

    Currently, our research is provided by the NIH, The University of Pennsylvania, and the Cystic Fibrosis Foundation.
  • Principal Investigator On

  • UAB CF Research and Translation Core Center - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Exploring Nonsense Suppression as a Treatment for NF1  awarded by GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI) 2018 - 2021
  • The Identification of New Treatments for Cystic Fibrosis Caused by Premature Termination Codons-Bedwell Subcontract  awarded by SOUTHERN RESEARCH INSTITUTE 2015 - 2021
  • A Reporter System to Monitor the Association of eRF1 and eRF3  awarded by Cystic Fibrosis Foundation ^ 2020 - 2021
  • Amino Acids Incorporated at CFTR Nonsense Mutations During Readthrough  awarded by Cystic Fibrosis Foundation ^ 2019 - 2021
  • Private Grant  awarded by MONTE ROSA THERAPEUTICS AG 2020 - 2021
  • Private Grant  awarded by ZIKANI THERAPEUTICS, INC 2019 - 2020
  • Exploring Nonsense Suppression as a Treatment for FOXG1 Syndrome  awarded by FOXG1 RESEARCH FOUNDATION 2019 - 2020
  • Identify Drugs to Treat MPS-IH Caused by Nonsense Mutations  awarded by University of Pennsylvania 2016 - 2019
  • Epigenome Editing Approaches for Gene Therapy  awarded by UNIVERSITY OF ALABAMA (HUNTSVILLE) 2018
  • UAB CF Research and Translation Core Center - Core B: Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2018
  • New Nonsense Suppression Drugs to Treat MPS I  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2017
  • UAB CF Research and Translation Core Center - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2016
  • Tuning Aminoglycosides for Treatment of Genetic Diseases  awarded by Technion Israel Institute of Technology 2011 - 2015
  • Investigating Suppression Therapy to Treat MPS I-H  awarded by University of Pennsylvania 2011 - 2013
  • Suppression of the Idua-W402X Mutation in an MPS I-H Mouse  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2007 - 2013
  • Mechanism of Eukaryotic Translation Termination  awarded by National Institute of General Medical Sciences/NIH/DHHS 2007 - 2012
  • UAB CF Research and Translation Core Center - Core B - Mouse Model Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2007 - 2012
  • Assay of Aminoglycosides in a CF Mouse Model  awarded by Technion Israel Institute of Technology 2010 - 2011
  • Teaching Activities

  • GBSC720 - Journal Club 2 (Spring Term 2020) 2020
  • GBSC720 - Journal Club 2 (Fall Term 2019) 2019
  • GBSC720 - Journal Club 2 (Spring Term 2019) 2019
  • GBSC720 - Journal Club 2 (Fall Term 2018) 2018
  • GBSC720 - Journal Club 2 (Spring Term 2018) 2018
  • GBSC720 - Journal Club 2 (Fall Term 2017) 2017
  • GBSC720 - Journal Club 2 (Spring Term 2017) 2017
  • GBSC720 - Journal Club 2 (Fall Term 2016) 2016
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2016) 2016
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2015) 2015
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2015) 2015
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2014) 2014
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2014) 2014
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2013) 2013
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2013) 2013
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2012) 2012
  • GBS795 - Lab Rotation I (Summer Term 2012) 2012
  • GBS797 - Lab Rotation 3 (Summer Term 2012) 2012
  • GBS798 - Non dissertation Research (Summer Term 2012) 2012
  • GBS799 - Dissertation Research (Summer Term 2012) 2012
  • GBS796 - Lab Rotation II (Spring Term 2012) 2012
  • GBS797 - Lab Rotation 3 (Spring Term 2012) 2012
  • GBS798 - Non dissertation Research (Spring Term 2012) 2012
  • GBS799 - Dissertation Research (Spring Term 2012) 2012
  • GBS795 - Lab Rotation I (Fall Term 2011) 2011
  • GBS798 - Non dissertation Research (Fall Term 2011) 2011
  • GBS799 - Dissertation Research (Fall Term 2011) 2011
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2011) 2011
  • GBS797 - Lab Rotation 3 (Summer Term 2011) 2011
  • GBS798 - Non dissertation Research (Summer Term 2011) 2011
  • GBS799 - Dissertation Research (Summer Term 2011) 2011
  • GBS796 - Lab Rotation II (Spring Term 2011) 2011
  • GBS798 - Non dissertation Research (Spring Term 2011) 2011
  • GBS799 - Dissertation Research (Spring Term 2011) 2011
  • MIC743 - Post-Trns Mech Adv Course (Spring Term 2011) 2011
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2011) 2011
  • GBS795 - Lab Rotation I (Fall Term 2010) 2010
  • GBS798 - Non dissertation Research (Fall Term 2010) 2010
  • GBS799 - Dissertation Research (Fall Term 2010) 2010
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2010) 2010
  • GBS798 - Non dissertation Research (Summer Term 2010) 2010
  • MIC785 - Post-Transcription Reg Mech (Spring Term 2010) 2010
  • MIC785 - Post-Transcription Reg Mech (Fall Term 2009) 2009
  • 01-125 - CMB2 GENETICS (Fall Term 2009) 2009
  • MIC785 - Post-Transcription Reg Mech (Spring Term 2009) 2009
  • CMB720 - CMB II Genes (Fall Term 2008) 2008
  • MIC759 - Adv Post-Trans Reg Mech (Fall Term 2008) 2008
  • MIC785 - Post-Transcription Reg Mech (Fall Term 2008) 2008
  • 01-125 - CMB2 GENETICS (Fall Term 2008) 2008
  • MIC785 - Post-Transcription Reg Mech JC (Spring Term 2008) 2008
  • CMB720 - CMB II Genes (Fall Term 2007) 2007
  • MIC785 - Post-Transcription Reg Mech JC (Fall Term 2007) 2007
  • 01-125 - CMB2 GENETICS (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Molecular Biology, University of Wisconsin System : Madison 1985
  • Bachelor of Science or Mathematics in Microbiology, Purdue University System : Purdue University 1979
  • Full Name

  • David Bedwell