Selected Publications

Academic Article

Year Title Altmetric
2022 Ataluren suppresses a premature termination codon in an MPS I-H mouseJournal of Molecular Medicine.  100:1223-1235. 2022
2021 A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletionNature Communications.  12. 2021
2016 Discovery of clinically approved agents that promote suppression of cystic fibrosis transmembrane conductance regulator nonsense mutationsAmerican Journal of Respiratory and Critical Care Medicine.  194:1092-1103. 2016
2014 Characterization of defects in ion transport and tissue development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-knockout ratsPLoS One.  9. 2014
2014 Long-term nonsense suppression therapy moderates MPS I-H disease progressionMolecular Genetics and Metabolism.  111:374-381. 2014
2014 Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftorAmerican Journal of Respiratory Cell and Molecular Biology.  50:805-816. 2014
2011 IL-21 is an antitolerogenic cytokine of the late-phase alloimmune responseDiabetes.  60:3223-3234. 2011
2009 A vital role for Interleukin-21 in the control of a chronic viral infectionScience.  324:1572-1576. 2009
2009 Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis Mouse modelJournal of Biological Chemistry.  284:6885-6892. 2009
2008 Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation TerminationMolecular Cell.  30:599-609. 2008
2008 PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model 2008
2006 Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse modelJournal of Molecular Medicine.  84:573-582. 2006
2004 Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiaeRNA.  10:691-703. 2004
2002 Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgeneJournal of Molecular Medicine.  80:595-604. 2002
2002 Synergistic cytotoxic effect between serine-threonine phosphatase inhibitors and 5-fluorouracil: A novel concept for modulation of cytotoxic effectCancer Chemotherapy and Pharmacology.  49:111-118. 2002
1999 Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to phosphorylation.International Journal of Oncology.  15:293-299. 1999
1997 Promotion of proliferation of murine BALB/c 3T3 fibroblasts mediated by nitric oxide at lower concentrationsIUBMB Life.  41:625-631. 1997

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Chiba University 1997
  • Full Name

  • Ming Du