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Ming Du
Assistant Professor
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dalian@uab.edu
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Ming Du
Assistant Professor
Positions
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
Assistant Professor (P)
,
Biochemistry & Molecular Genetics
,
Academic Joint Departments
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Ataluren suppresses a premature termination codon in an MPS I-H mouse
.
Journal of Molecular Medicine
. 100:1223-1235.
2022
2021
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
.
Nature Communications
. 12.
2021
2016
Discovery of clinically approved agents that promote suppression of cystic fibrosis transmembrane conductance regulator nonsense mutations
.
American Journal of Respiratory and Critical Care Medicine
. 194:1092-1103.
2016
2014
Characterization of defects in ion transport and tissue development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-knockout rats
.
PLoS One
. 9.
2014
2014
Long-term nonsense suppression therapy moderates MPS I-H disease progression
.
Molecular Genetics and Metabolism
. 111:374-381.
2014
2014
Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor
.
American Journal of Respiratory Cell and Molecular Biology
. 50:805-816.
2014
2011
IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response
.
Diabetes
. 60:3223-3234.
2011
2009
A vital role for Interleukin-21 in the control of a chronic viral infection
.
Science
. 324:1572-1576.
2009
2009
Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis Mouse model
.
Journal of Biological Chemistry
. 284:6885-6892.
2009
2008
Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation Termination
.
Molecular Cell
. 30:599-609.
2008
2008
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
2008
2006
Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model
.
Journal of Molecular Medicine
. 84:573-582.
2006
2004
Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae
.
RNA
. 10:691-703.
2004
2002
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene
.
Journal of Molecular Medicine
. 80:595-604.
2002
2002
Synergistic cytotoxic effect between serine-threonine phosphatase inhibitors and 5-fluorouracil: A novel concept for modulation of cytotoxic effect
.
Cancer Chemotherapy and Pharmacology
. 49:111-118.
2002
1999
Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to phosphorylation.
.
International Journal of Oncology
. 15:293-299.
1999
1997
Promotion of proliferation of murine BALB/c 3T3 fibroblasts mediated by nitric oxide at lower concentrations
.
IUBMB Life
. 41:625-631.
1997
Research
Investigator On
Assay to Discover Compounds that Block eRF1/eRF3 Binding
awarded by
Cystic Fibrosis Foundation ^
Epigenome Editing Approaches for Gene Therapy
awarded by
UNIVERSITY OF ALABAMA (HUNTSVILLE)
Evaluation of Approved Drug Libraries for Translational Readthrough Activity
awarded by
Cystic Fibrosis Foundation ^
Exploring Nonsense Suppression as a Treatment for FOXG1 Syndrome
awarded by
FOXG1 RESEARCH FOUNDATION
Exploring Nonsense Suppression as a Treatment for NF1
awarded by
GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI)
Identify Drugs to Treat MPS-IH Caused by Nonsense Mutations
awarded by
University of Pennsylvania
Private Grant
awarded by
MONTE ROSA THERAPEUTICS AG
The Identification of New Treatments for Cystic Fibrosis Caused by Premature Termination Codons
awarded by
SOUTHERN RESEARCH INSTITUTE
UAB CF Research and Translation Core Center
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
UAB CF Research and Translation Core Center - Core B: Animal Models Core
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Background
Education And Training
Doctor of Philosophy Level Degree in Biochemistry,
Chiba University
1997
Contact
Full Name
Ming
Du