Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Focal Management of Large Brain Metastases and Risk of Leptomeningeal Disease 2020
2020 Lipid microsphere bound oxycodone for pain management in patients receiving radiotherapy for head and neck cancer 2020
2020 Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer 2020
2020 Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression 2020
2019 Electromagnetic Transponder Based Tracking and Gating in the Radiotherapeutic Treatment of Thoracic Malignancies 2019
2019 Differential escape mechanisms in cetuximab-resistant head and neck cancer cells 2019
2019 HPAanalyze: An R package that facilitates the retrieval and analysis of the Human Protein Atlas data 2019
2019 A Novel Assay for Profiling GBM Cancer Model Heterogeneity and Drug Screening. 2019
2019 BEERE: a web server for biomedical entity expansion, ranking and explorations 2019
2019 Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma 2019
2019 Optical surface guidance for submillimeter monitoring of patient position during frameless stereotactic radiotherapy 2019
2019 Spleen tyrosine kinase–mediated autophagy is required for epithelial–mesenchymal plasticity and metastasis in breast cancer 2019
2019 Cancer Explant Models. 2019
2019 Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer * 2019
2019 Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection 2019
2019 The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor 2019
2018 Combinatorial drug testing in 3D microtumors derived from GBM patient-derived xenografts reveals cytotoxic synergy in pharmacokinomics-informed pathway interactions 2018
2018 Kinomics toolbox—A web platform for analysis and viewing of kinomic peptide array data 2018
2018 Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose 2018
2018 Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease 2018
2018 Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death 2018
2017 Non-coding MIR491 is associated with less EGFr expression and greater radiosensitivity in human head and neck cancer cell lines 2017
2017 Fractionated stereotactic radiation therapy for intact brain metastases 2017
2017 Management of metastatic spinal cord compression 2017
2017 Creation of an Analytical Platform for Integrative Molecular Profiling of Glioblastoma Xenolines. 2017
2017 MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines 2017
2017 Hepatitis C virus Genie: A web 2.0 interpretation and analytics platform for the Versant Hepatitis C virus genotype Line Probe Assay version 2.0 2017
2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets 2017
2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma 2017
2016 Primary Sellar Rhabdomyosarcoma Arising in Association with a Pituitary Adenoma 2016
2016 Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome 2016
2016 Stereotactic Hypofractionated Radiation Therapy for Intact Brain Metastases. 2016
2016 Correction: Kinomic profiling of electromagnetic navigational bronchoscopy specimens: A new approach for personalized medicine (PLoS ONE (2016) 9:12 (e116388) DOI: 10.1371/journal.pone.0116388) 2016
2016 Generation of microtumors using 3D human biogel culture system and patient-derived glioblastoma cells for kinomic profiling and drug response testing 2016
2016 Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays. 2016
2015 A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium 2015
2015 The effector domain of MARCKS Is a nuclear localization signal that regulates cellular PIP2 levels and nuclear PIP2 localization 2015
2015 Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition 2015
2015 Patient-Derived Xenografts as a Model System for Radiation Research 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes 2015
2015 KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA. 2015
2015 Stable phenotypic changes of the host T cells are essential to the long-term stability of latent HIV-1 infection 2015
2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity 2015
2015 The protective effect of p16 INK4a in oral cavity carcinomas: p16 Ink4A dampens tumor invasion-integrated analysis of expression and kinomics pathways 2015
2014 Kinomic profiling of electromagnetic navigational bronchoscopy specimens: A new approach for personalized medicine 2014
2014 Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: The University of Alabama at Birmingham experience 2014
2014 Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease 2014
2014 Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma 2014
2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation 2014
2014 Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines 2014
2013 Mini-review: Bmx kinase inhibitors for cancer therapy 2013
2012 Kinomic profiling approach identifies Trk as a novel radiation modulator 2012
2012 MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma 2012
2012 Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner 2012
2011 Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiation 2011
2011 Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma 2011
2010 Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation 2010
2009 Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma 2009
2009 Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor 2009
2009 Refractory lympho-epithelial carcinoma of the nasopharynx: a case report illustrating a protracted clinical course. 2009
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium (Cancer Research (2008) 68, (2861-2869)) 2008
2008 STAT3 activation in pressure-overloaded feline myocardium: Role for integrins and the tyrosine kinase BMX 2008
2008 Differential Efficacy of Combined Therapy With Radiation and AEE788 in High and Low EGFR-Expressing Androgen-Independent Prostate Tumor Models 2008
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium 2008
2007 HIV protease inhibitors enhance the efficacy of irradiation 2007
2007 Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models 2007
2007 A Phase II Multi-institutional Trial of Chemoradiation Using Weekly Docetaxel and Erythropoietin for High-Risk Postoperative Head and Neck Cancer Patients 2007
2007 Inhibition of Survivin and Aurora B Kinase Sensitizes Mesothelioma Cells by Enhancing Mitotic Arrests 2007
2006 222 2006
2006 Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases 2006
2006 Expression of protein kinase C isoforms in cultured human retinal pigment epithelial cells 2006
2006 A82. Bmx and c-Src mediates phosphorylation of p130Cas during cardiac hypertrophy 2006
2003 Focal complex formation in adult cardiomyocytes is accompanied by the activation of β3 integrin and c-Src 2003
2002 c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells 2002
2000 Integrin activation and focal complex formation in cardiac hypertrophy 2000

Chapter

Year Title Altmetric
2015 Interaction of Chemotherapy and Radiation.  63-79.e4. 2015
2012 Interaction of Chemotherapy and Radiation.  65-82. 2012
2000 Integrin-Dependent and -Independent Signaling During Pressure-Overload Cardiac Hypertrophy.  143-164. 2000
Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.  23-30.

Principal Investigator On

Investigator On

  • Private Grant  awarded by ELI LILLY AND COMPANY 2019 - 2026
  • Private Grant  awarded by ELI LILLY AND COMPANY 2019 - 2024
  • Molecular Basis of Pathogenicity of IgA1-Containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • RTOG Foundation Master Service Agreement for Participation in Foundation Research: RTOG 3501 Tryhard: A Phase II, Randomized, Double Blind, Placebo-Controlled Study of Lapatinib (Tykerb) for Non-HPV Locally Advanced Head and Neck Cancer with Concurrent Chemoradiation  awarded by American College of Radiology 2012 - 2022
  • Private Grant  awarded by NOVOCURE, INC. 2019 - 2022
  • Intra-Tumor Heterogeneity in Colorectal Cancer Progression and Treatment Response  awarded by National Cancer Institute/NIH/DHHS 2019 - 2020
  • Private Grant  awarded by PROSTATE CANCER CLINICAL TRIALS CONSORTIUM, LLC 2017 - 2019
  • UAB NRG Oncology Master Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2019
  • Private Grant  awarded by NOVOCURE, INC. 2017 - 2019
  • Private Grant  awarded by ELI LILLY AND COMPANY 2016 - 2019
  • Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2015 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2014 - 2019
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC. 2014 - 2017
  • Private Grant  awarded by VIVO BIOSCIENCES, INC. 2015 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Private Grant  awarded by SUCAMPO PHARMACEUTICALS 2016
  • Molecular Predictors of Post-Mastectomy Breast Cancer Loco-Regional Recurrence  awarded by National Cancer Institute/NIH/DHHS 2012 - 2016
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO 2014 - 2015
  • Private Grant  awarded by Pfizer Pharmaceuticals 2013 - 2015
  • Private Grant  awarded by ELI LILLY AND COMPANY 2012 - 2015
  • Integrated Pharmacogenomic/Pharmacokinomic Approach to Optimize GBM Therapy  awarded by National Brain Tumor Society 2011 - 2013

    • Education And Training

  • Doctor of Medicine, Medical University of South Carolina 2005
  • Doctor of Philosophy in Medical Scientist, Medical University of South Carolina 2003
  • Bachelor of Science or Mathematics in Biomedical / Medical Engineering, Duke University 1996
  • Spartanburg Regional Medical Center, Internship 2004
  • Vanderbilt University Medical Center, Residency 2008

    • Full Name

  • Christopher Willey