Selected Publications

Academic Article

Year Title Altmetric
2022 Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signalingNature Communications.  13. 2022
2022 An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinasesJCI Insight.  7. 2022
2022 Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK)Journal of Pediatric Surgery.  57:1026-1032. 2022
2022 Patience Is a Virtue 2022
2022 Understanding Drug Sensitivity and Tackling Resistance in CancerCancer Research.  82:1448-1460. 2022
2022 Factors associated with loss to follow-up after radiation therapy for head and neck cancer 2022
2022 Inhibition of DNA-PK may improve response to neoadjuvant chemoradiotherapy in rectal cancerNeoplasia.  25:53-61. 2022
2022 Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic VirotherapyCancers.  14. 2022
2022 Targeted Extracellular Vesicles Delivered Verrucarin A to Treat GlioblastomaBiomedicines.  10. 2022
2021 Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapynpj Breast Cancer.  7. 2021
2021 PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastomaScientific Reports.  11. 2021
2021 Corrigendum: Statistical Enrichment Analysis of Samples: A General-Purpose Tool to Annotate Metadata Neighborhoods of Biological Samples (Front. Big Data (2021), 4, (725276), 10.3389/fdata.2021.725276)Frontiers in Big Data.  4. 2021
2021 Brain Glucose Metabolism is Reduced After Radiation Therapy for Head and Neck Cancer 2021
2021 Genomic and Transcriptomic Differences at the Pyruvate Kinase M (PKM) Locus in Patient-Derived Glioblastoma Multiforme (GBM) Cell Lines 2021
2021 Mesangioproliferative Kidney Diseases and Platelet-Derived Growth Factor–Mediated AXL PhosphorylationKidney Medicine.  3:1003-1013.e1. 2021
2021 Pain, Weight Loss, and Quality of Life in a Supportive Care Trial for Patients With Advanced Head and Neck Cancer 2021
2021 Patient Factors Associated With Loss to Radiation Oncology Specialty Follow-Up Among Head and Neck Cancer Survivors 2021
2021 The Opioid Crisis and Radiation Therapy: A Patient Survey to Identify Best Practices for Pain Management 2021
2021 Statistical Enrichment Analysis of Samples: A General-Purpose Tool to Annotate Metadata Neighborhoods of Biological SamplesFrontiers in Big Data.  4. 2021
2021 Predictors of In-Hospital Death in Patients with Lung Cancer Admitted for Acute Radiation Pneumonitis: A Healthcare Cost and Utilization Project (HCUP) AnalysisClinical Lung Cancer.  22:e716-e722. 2021
2021 Serine-threonine kinase receptor-associated protein (Strap) knockout decreases the malignant phenotype in neuroblastoma cell linesCancers.  13. 2021
2021 N-cadherin upregulation mediates adaptive radioresistance in glioblastomaJournal of Clinical Investigation.  131. 2021
2021 Transition From Manual to Automated Planning and Delivery of Volumetric Modulated Arc Therapy Stereotactic Radiosurgery: Clinical, Dosimetric, and Quality Assurance ResultsPractical Radiation Oncology.  11:e163-e171. 2021
2021 Cancer Explant ModelsCurrent Topics in Microbiology and Immunology.  430:131-160. 2021
2021 Control and Toxicity in Melanoma Versus Other Brain Metastases in Response to Combined Radiosurgery and PD-(L)1 Immune Checkpoint InhibitionAdvances in Radiation Oncology.  6. 2021
2021 Lipid microsphere bound oxycodone for pain management in patients receiving radiotherapy for head and neck cancerSupportive Care in Cancer.  29:263-269. 2021
2020 Intratumoral spatial heterogeneity of BTK kinomic activity dictates distinct therapeutic response within a single glioblastoma tumorJournal of Neurosurgery.  133:1683-1694. 2020
2020 Surface guided imaging during stereotactic radiosurgery with automated deliveryJournal of Applied Clinical Medical Physics.  21:90-95. 2020
2020 A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastomaOncogene.  39:6961-6974. 2020
2020 Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic PotentialCells.  9. 2020
2020 Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma GrowthFrontiers in Genetics.  11. 2020
2020 Re: Therapeutically Actionable PAK4 is Amplified, Overexpressed, and Involved in Bladder Cancer ProgressionInvestigative urology.  204:622-623. 2020
2020 Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progressionOncogene.  39:4077-4091. 2020
2020 Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy.Kidney Diseases.  6:168-180. 2020
2020 Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancerPLoS One.  15. 2020
2020 Focal Management of Large Brain Metastases and Risk of Leptomeningeal DiseaseAdvances in Radiation Oncology.  5:34-42. 2020
2019 Electromagnetic Transponder Based Tracking and Gating in the Radiotherapeutic Treatment of Thoracic MalignanciesPractical Radiation Oncology.  9:456-464. 2019
2019 Differential escape mechanisms in cetuximab-resistant head and neck cancer cellsBiochemical and Biophysical Research Communications.  517:36-42. 2019
2019 HPAanalyze: An R package that facilitates the retrieval and analysis of the Human Protein Atlas dataBMC Bioinformatics.  20. 2019
2019 A novel assay for profiling GBM cancer model heterogeneity and drug screeningCells.  8. 2019
2019 BEERE: a web server for biomedical entity expansion, ranking and explorationsNucleic Acids Research.  47:W578-W586. 2019
2019 Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastomaInternational Journal of Oncology.  54:2039-2053. 2019
2019 Optical surface guidance for submillimeter monitoring of patient position during frameless stereotactic radiotherapyJournal of Applied Clinical Medical Physics.  20:91-98. 2019
2019 Spleen tyrosine kinase–mediated autophagy is required for epithelial–mesenchymal plasticity and metastasis in breast cancerCancer Research.  79:1831-1843. 2019
2019 Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer *Journal of Drug Targeting.  27:193-200. 2019
2019 Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection 2019
2019 The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumorOncotarget.  10:5534-5548. 2019
2018 Combinatorial drug testing in 3D microtumors derived from GBM patient-derived xenografts reveals cytotoxic synergy in pharmacokinomics-informed pathway interactionsScientific Reports.  8. 2018
2018 Kinomics toolbox—A web platform for analysis and viewing of kinomic peptide array dataPLoS One.  13. 2018
2018 Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucoseBiomarker Research.  6. 2018
2018 Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal diseaseJournal of Clinical Neuroscience.  49:48-55. 2018
2018 Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell deathJournal of Ovarian Research.  11. 2018
2017 Non-coding MIR491 is associated with less EGFr expression and greater radiosensitivity in human head and neck cancer cell linesAnnals of Oncology.  28:x6. 2017
2017 Fractionated stereotactic radiation therapy for intact brain metastasesAdvances in Radiation Oncology.  2:564-571. 2017
2017 Management of metastatic spinal cord compressionSouthern Medical Journal.  110:586-593. 2017
2017 Creation of an Analytical Platform for Integrative Molecular Profiling of Glioblastoma Xenolines.American Journal of Clinical Pathology.  147:S171-S172. 2017
2017 MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell linesOncology Letters.  13:1216-1222. 2017
2017 Hepatitis C virus Genie: A web 2.0 interpretation and analytics platform for the Versant Hepatitis C virus genotype Line Probe Assay version 2.0Journal of Pathology Informatics.  8. 2017
2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA NephropathyKidney International Reports.  2:1194-1207. 2017
2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targetsOncotarget.  8:21710-21718. 2017
2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinomaOncotarget.  8:29220-29232. 2017
2016 Primary Sellar Rhabdomyosarcoma Arising in Association with a Pituitary AdenomaInternational Journal of Surgical Pathology.  24:753-756. 2016
2016 Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndromeSpringerPlus.  5:1-13. 2016
2016 Stereotactic Hypofractionated Radiation Therapy for Intact Brain Metastases. 2016
2016 Correction: Kinomic profiling of electromagnetic navigational bronchoscopy specimens: A new approach for personalized medicine (PLoS ONE (2016) 9:12 (e116388) DOI: 10.1371/journal.pone.0116388)PLoS One.  11. 2016
2016 Generation of microtumors using 3D human biogel culture system and patient-derived glioblastoma cells for kinomic profiling and drug response testingJournal of Visualized Experiments.  2016. 2016
2016 Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays.Journal of Proteomics and Bioinformatics.  9:151-157. 2016
2015 A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded MyocardiumJournal of Cellular Biochemistry.  116:2793-2803. 2015
2015 The effector domain of MARCKS Is a nuclear localization signal that regulates cellular PIP2 levels and nuclear PIP2 localizationPLoS One.  10. 2015
2015 Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 InhibitionBMC Cancer.  15. 2015
2015 Patient-Derived Xenografts as a Model System for Radiation ResearchSeminars in Radiation Oncology.  25:273-280. 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypesPLoS One.  10. 2015
2015 KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA.Medical research archives.  2015. 2015
2015 The protective effect of p16 INK4a in oral cavity carcinomas: p16 Ink4A dampens tumor invasion-integrated analysis of expression and kinomics pathwaysModern Pathology.  28:631-653. 2015
2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivityInternational Journal of Oncology.  46:1079-1088. 2015
2015 Stable phenotypic changes of the host T cells are essential to the long-term stability of latent HIV-1 infectionJournal of Virology.  89:6656-6672. 2015
2014 Kinomic profiling of electromagnetic navigational bronchoscopy specimens: A new approach for personalized medicinePLoS One.  9. 2014
2014 Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: The University of Alabama at Birmingham experienceNeuro-oncology practice.  1:172-177. 2014
2014 Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune DiseaseJournal of Immunology Research.  2014. 2014
2014 Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinomaExpert Opinion on Investigational Drugs.  23:305-315. 2014
2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivationJournal of Virology.  88:364-376. 2014
2014 Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolinesRadiotherapy and Oncology.  111:468-474. 2014
2013 Mini-review: Bmx kinase inhibitors for cancer therapyRecent Patents on Anti-Cancer Drug Discovery.  8:228-238. 2013
2012 Kinomic profiling approach identifies Trk as a novel radiation modulatorRadiotherapy and Oncology.  103:380-387. 2012
2012 MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for gliomaClinical Cancer Research.  18:3030-3041. 2012
2012 Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific mannerPLoS One.  7. 2012
2011 Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiationRadiotherapy and Oncology.  101:183-189. 2011
2011 Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinomaRadiotherapy and Oncology.  99:339-343. 2011
2010 Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation 2010
2009 Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinomaRadiotherapy and Oncology.  92:339-344. 2009
2009 Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitorMolecular Cancer Therapeutics.  8:1270-1279. 2009
2009 Refractory lympho-epithelial carcinoma of the nasopharynx: a case report illustrating a protracted clinical course.Head and Neck Oncology.  1:18. 2009
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium (Cancer Research (2008) 68, (2861-2869))Cancer Research.  68:8189. 2008
2008 STAT3 activation in pressure-overloaded feline myocardium: Role for integrins and the tyrosine kinase BMXInternational Journal of Biological Sciences.  4:184-199. 2008
2008 Differential Efficacy of Combined Therapy With Radiation and AEE788 in High and Low EGFR-Expressing Androgen-Independent Prostate Tumor Models 2008
2008 Bone marrow X kinase-mediated signal transduction in irradiated vascular endotheliumCancer Research.  68:2861-2869. 2008
2007 HIV protease inhibitors enhance the efficacy of irradiationCancer Research.  67:4886-4893. 2007
2007 Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer modelsClinical Cancer Research.  13:3033-3042. 2007
2007 A Phase II Multi-institutional Trial of Chemoradiation Using Weekly Docetaxel and Erythropoietin for High-Risk Postoperative Head and Neck Cancer Patients 2007
2007 Inhibition of Survivin and Aurora B Kinase Sensitizes Mesothelioma Cells by Enhancing Mitotic Arrests 2007
2006 222 Differential Expression of Phosphorylated-EGFR Determines Susceptibility of Prostate Cancer to Combined Radiation and Anti-EGFR Therapy 2006
2006 Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligasesJournal of Molecular and Cellular Cardiology.  41:669-679. 2006
2006 Expression of protein kinase C isoforms in cultured human retinal pigment epithelial cellsGerman journal of ophthalmology.  245:993-999. 2006
2006 A82. Bmx and c-Src mediates phosphorylation of p130Cas during cardiac hypertrophyJournal of Molecular and Cellular Cardiology.  40:891. 2006
2003 Focal complex formation in adult cardiomyocytes is accompanied by the activation of β3 integrin and c-SrcJournal of Molecular and Cellular Cardiology.  35:671-683. 2003
2002 c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cellsJournal of Biological Chemistry.  277:23065-23075. 2002
2000 Integrin activation and focal complex formation in cardiac hypertrophyJournal of Biological Chemistry.  275:35624-35630. 2000


Year Title Altmetric
2015 Interaction of Chemotherapy and Radiation.  63-79.e4. 2015
2012 Interaction of Chemotherapy and Radiation.  65-82. 2012
2008 Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.  23-30. 2008
2000 Integrin-Dependent and -Independent Signaling During Pressure-Overload Cardiac Hypertrophy.  143-164. 2000

Investigator On

  • 3D Printing of PDX for Head and Neck  awarded by Oral and Maxillofacial Surgery Foundation
  • A Phase II Study of Durvalumab (MEDI 4736) with Radiotherapy for the adjuvant treatment of Intermediate Risk Head and Neck Squamous Cell Carcinoma  awarded by University of North Carolina at Chapel Hill
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • ECOG-ACRIN Purchase Service Agreement  awarded by Eastern Cooperative Oncology Group
  • GBM Avatar Screening Paradigm for Rational Pharmacokinomic Glioma Therapy  awarded by National Cancer Institute/NIH/DHHS
  • Integrated Pharmacogenomic/Pharmacokinomic Approach to Optimize GBM Therapy  awarded by National Brain Tumor Society
  • Intra-Tumor Heterogeneity in Colorectal Cancer Progression and Treatment Response  awarded by National Cancer Institute/NIH/DHHS
  • Mechanistic Risk Prediction of Radiation Therapy Cardiotoxicity  awarded by University of Pennsylvania
  • Molecular Basis of Pathogenicity of IgA1-Containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Molecular Predictors of Post-Mastectomy Breast Cancer Loco-Regional Recurrence  awarded by National Cancer Institute/NIH/DHHS
  • NRG Oncology Member Institution Clinical Trial Fixed Price Subaward Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • Private Grant  awarded by ELI LILLY AND COMPANY
  • Private Grant  awarded by Pfizer Pharmaceuticals
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC.
  • Private Grant  awarded by VIVO BIOSCIENCES, INC. ^
  • Private Grant  awarded by ELI LILLY AND COMPANY
  • Private Grant  awarded by SUCAMPO PHARMACEUTICALS
  • Private Grant  awarded by NOVOCURE, INC.
  • Private Grant  awarded by NOVOCURE, INC.
  • Private Grant  awarded by ELI LILLY AND COMPANY
  • Private Grant  awarded by ELI LILLY AND COMPANY
  • Private Grant  awarded by BLUE EARTH DIAGNONSTICS LTD ^
  • RAD 2001 (2012-0825): Phase II/III Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for the Treatment of Oropharyngeal Cancer of the Head and Neck  awarded by UNIVERSITY OF TEXAS (M.D. ANDERSON CANCER CENTER)
  • RTOG Foundation Master Service Agreement for Participation in Foundation Research: RTOG 3501 Tryhard: A Phase II, Randomized, Double Blind, Placebo-Controlled Study of Lapatinib (Tykerb) for Non-HPV Locally Advanced Head and Neck Cancer with Concurrent Chemoradiation  awarded by American College of Radiology
  • Targeting Adaptive Radioresistance of Glioblastoma  awarded by National Cancer Institute/NIH/DHHS
  • Tissue-Regulated Lineage-Specific Splicing in Glioblastoma Pathogenesis  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB NRG Oncology Master Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO
  • Education And Training

  • Spartanburg Regional Medical Center, Internship
  • Vanderbilt University Medical Center, Residency
  • Doctor of Medicine, Medical University of South Carolina 2005
  • Doctor of Philosophy in Medical Scientist, Medical University of South Carolina 2003
  • Bachelor of Science or Mathematics in Biomedical / Medical Engineering, Duke University 1996
  • Full Name

  • Christopher Willey