Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammationScience Advances.  6. 2020
2019 Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsisNature Medicine.  25:1772-1782. 2019
2019 Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of CtcfCell Reports.  29:1203-1220.e7. 2019
2019 Natural tr1-like cells do not confer long-term tolerogenic memoryeLife.  8. 2019
2019 Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial InfectionCell.  178:1176-1188.e15. 2019
2018 Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cellsScience.  361. 2018
2018 Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infectionJournal of Experimental Medicine.  215:1823-1838. 2018
2018 IL-1R signaling promotes STAT3 and NF-B factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcriptionJournal of Biological Chemistry.  293:15790-15800. 2018
2017 Citrobacter rodentium: A model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunityMucosal Immunology.  10:1108-1117. 2017
2017 Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHDJCI insight.  2. 2017
2017 T Cell-derived IL-10 impairs host resistance to mycobacterium tuberculosis infectionJournal of Immunology.  199:613-623. 2017
2017 Selective induction of homeostatic Th17 cells in the murine intestine by cholera toxin interacting with the microbiotaJournal of Immunology.  199:312-322. 2017
2016 Cytomegalovirus-Specific IL-10-Producing CD4+T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus PersistencePLoS Pathogens.  12. 2016
2016 Determining immune system suppression versus CNS protection for pharmacological interventions in autoimmune demyelinationJournal of Visualized Experiments.  2016. 2016
2016 A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host diseaseJournal of Clinical Investigation.  126:3541-3555. 2016
2016 Regulation of Effector Treg Cells in Murine LupusArthritis and Rheumatology.  68:1454-1466. 2016
2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficileBMC Microbiology.  16. 2016
2016 IL-6 IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cellsJournal of Experimental Medicine.  213:2281-2291. 2016
2015 IRF4-dependent and IRF4-independent pathways contribute to DC dysfunction in lupusPLoS ONE.  10. 2015
2015 Daughter's Tolerance of Mom Matters in Mate ChoiceCell.  162:467-469. 2015
2015 Inhibition of system Xc- transporter attenuates autoimmune inflammatory demyelinationJournal of Immunology.  195:450-463. 2015
2015 TH17 cells transdifferentiate into regulatory T cells uring resolution of inflammationNature.  523:221-225. 2015
2015 T-cell expression of IL10 is essential for tumor immune surveillance in the small intestineCancer Immunology Research.  3:806-814. 2015
2015 Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitisProceedings of the National Academy of Sciences.  112:7061-7066. 2015
2015 Ligation of TLR7 on CD19+CD1dhi B cells suppresses allergic lung inflammation via regulatory T cellsEuropean Journal of Immunology.  45:1842-1854. 2015
2015 PD-L1hi B cells are critical regulators of humoral immunityNature Communications.  6. 2015
2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iT reg cell balanceNature Immunology.  16:286-295. 2015
2015 Skin-resident memory CD4+ T cells enhance protection against Leishmania major infectionJournal of Experimental Medicine.  212:1405-1414. 2015
2014 Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1Journal of Clinical Investigation.  124:3455-3468. 2014
2014 The transcription factors T-bet and runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cellsImmunity.  40:355-366. 2014
2014 Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene TranscriptionPLoS Genetics.  10. 2014
2014 Development and survival of th17 cells within the intestines: The influence of microbiome-and diet-derived signalsJournal of Immunology.  193:4769-4777. 2014
2013 IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanismJournal of Leukocyte Biology.  94:1103-1112. 2013
2013 IL-2 coordinates IL-2-producing and regulatory T cell interplayJournal of Experimental Medicine.  210:2707-2720. 2013
2013 Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cellsCancer Research.  73:5905-5913. 2013
2013 Antiapoptotic McI-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cellsNature Immunology.  14:959-965. 2013
2013 Linking vitamin D deficiency to inflammatory bowel diseaseInflammatory Bowel Diseases.  19:2245-2256. 2013
2013 Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in miceJournal of Immunology.  191:2780-2795. 2013
2013 IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitisProceedings of the National Academy of Sciences.  110:12768-12773. 2013
2013 Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine SignalsImmunity.  39:148-159. 2013
2013 Allogeneic th1 cells home to host bone marrow and spleen and mediate ifnγ-dependent aplasiaBiology of Blood and Marrow Transplantation.  19:876-887. 2013
2013 Dwelling on T cell fate decisionsCell.  153:739-741. 2013
2013 Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrantsJournal of Immunology.  190:2603-2613. 2013
2013 The Th17 family: Flexibility follows functionImmunological Reviews.  252:89-103. 2013
2013 Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to porphyromonas gingivalisJournal of Leukocyte Biology.  93:21-31. 2013
2013 The Th17 pathway and inflammatory diseases of the intestines, lungs, and skinAnnual Review of Pathology: Mechanisms of Disease.  8:477-512. 2013
2012 Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic BacteriaImmunity.  37:1061-1075. 2012
2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22Journal of Immunology.  189:3653-3660. 2012
2012 γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 ResponseImmunity.  37:524-534. 2012
2012 Reciprocal interactions of the intestinal microbiota and immune systemNature.  489:231-241. 2012
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2012 Stem-cell-like qualities of immune memory; CD4 + T cells join the partyCell Stem Cell.  10:107-108. 2012
2012 Developmental regulation of Th17-cell capacity in human neonatesEuropean Journal of Immunology.  42:311-319. 2012
2012 Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivoJournal of Immunology.  188:1036-1048. 2012
2012 Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunityProceedings of the National Academy of Sciences.  109:1210-1215. 2012
2012 B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas lpr miceJournal of Immunology.  188:678-685. 2012
2012 Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatusInfection and Immunity.  80:410-417. 2012
2011 Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal ImmunityImmunity.  35:997-1009. 2011
2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infectionInfection and Immunity.  79:3966-3977. 2011
2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsivenessMucosal Immunology.  4:503-518. 2011
2011 Immunology: Context is key in the gutNature.  471:169-170. 2011
2011 Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cellsJournal of Biological Chemistry.  286:997-1004. 2011
2011 IL-12 converts Foxp3(+) regulatory T cells to Foxp3(+)IFN-γ(+) T cells with inhibitory functions during induction of colitisGastroenterology.  140:2031-43. 2011
2011 Interleukin-12 converts Foxp3+ regulatory T cells to interferonγ-producing Foxp3+ T cells that inhibit colitisGastroenterology.  140:2031-2043. 2011
2010 Regulation of the Ifng locus in the context of T-lineage specification and plasticityImmunological Reviews.  238:216-232. 2010
2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levelsJournal of Immunology.  185:3643-3651. 2010
2010 Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuliImmunity.  33:35-47. 2010
2010 Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineageImmunity.  32:616-627. 2010
2010 Autoimmunity: Increasing suspects in the CD4 + T cell lineupNature Immunology.  11:36-40. 2010
2009 Interplay between the TH 17 and TReg cell lineages: A (co-)evolutionary perspectiveNature Reviews Immunology.  9:883-889. 2009
2009 Intestinal Effector T Cells in Health and DiseaseImmunity.  31:389-400. 2009
2009 Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic modelBMC Immunology.  10. 2009
2009 IL-9 as a mediator of Th17-driven inflammatory diseaseJournal of Experimental Medicine.  206:1653-1660. 2009
2009 MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airwaysEuropean Journal of Immunology.  39:2281-2292. 2009
2009 The AP-1 transcription factor Batf controls T H 17 differentiationNature.  460:405-409. 2009
2009 TGF-β promotes Th17 cell development through inhibition of SOCS3Journal of Immunology.  183:97-105. 2009
2009 Th17: The ascent of a new effector T-cell subsetEuropean Journal of Immunology.  39:634-636. 2009
2009 Developmental plasticity of Th17 and Treg cellsCurrent Opinion in Immunology.  21:274-280. 2009
2009 Editorial overviewCurrent Opinion in Immunology.  21:119-120. 2009
2009 Contrasting roles for all-trans retinoic acid in TGF-β-mediated induction of Foxp3 and Il10 genes in developing regulatory T cellsJournal of Experimental Medicine.  206:343-357. 2009
2009 Duality in the Th17-Treg developmental decision.F1000 biology reports.  1:5. 2009
2009 Late Developmental Plasticity in the T Helper 17 LineageImmunity.  30:92-107. 2009
2009 Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitisJournal of Neuroimmunology.  206:22-27. 2009
2008 Chapter 5 Emergence of the Th17 Pathway and Its Role in Host DefenseAdvances in Immunology.  99:115-163. 2008
2008 Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulationImmunological Reviews.  226:219-233. 2008
2008 III. Report of adaptive and regulatory immune responses workgroupInflammatory Bowel Diseases.  14:694-696. 2008
2008 X. Challenges update workgroupsInflammatory Bowel Diseases.  14:706-708. 2008
2008 Memory CD4 T cells emerge from effector T-cell progenitorsNature.  452:356-360. 2008
2008 Noninvasive bioluminescence imaging in small animalsILAR news.  49:103-115. 2008
2007 The central role of the Th17 lineage in regulating the inflammatory/autoimmune axisSeminars in Immunology.  19:351-352. 2007
2007 Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporterInternational Immunology.  19:1165-1173. 2007
2007 Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Nature Immunology.  8:931-941. 2007
2007 Immunology: Narcissistic helpersNature.  448:416-418. 2007
2007 IL-17 family cytokines and the expanding diversity of effector T cell lineagesAnnual Review of Immunology.  25:821-852. 2007
2007 T-Cell Subsets: The More the MerrierCurrent Biology.  17. 2007
2007 Monoclonal Anti-Interleukin 23 Reverses Active Colitis in a T Cell-Mediated Model in MiceGastroenterology.  132:2359-2370. 2007
2007 The Genetics of Inflammatory Bowel DiseaseGastroenterology.  133:1327-1339. 2007
2006 Alterations of T lymphocytes in inflammatory bowel diseasesAdvances in Experimental Medicine and Biology.  579:133-148. 2006
2006 A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK CellsImmunity.  25:717-729. 2006
2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineageCurrent Opinion in Immunology.  18:349-356. 2006
2006 Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell TiesImmunity.  24:677-688. 2006
2006 Transforming growth factor-β induces development of the T H17 lineageNature.  441:231-234. 2006
2006 Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in miceAmerican Journal of Pathology.  168:1425-1434. 2006
2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesNature Immunology.  6:1123-1132. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-276. 2005
2005 Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome functionJournal of Immunology.  174:2787-2795. 2005
2005 Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endotheliumAmerican Journal of Pathology.  167:1661-1675. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-76. 2005
2005 P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculatureAmerican Journal of Pathology.  167:1647-1660. 2005
2004 Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cellsJournal of Immunology.  173:7249-7258. 2004
2004 New developments in experimental models of inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-367. 2004
2004 Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytesInternational Immunology.  16:345-351. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionAnnals of the New York Academy of Sciences.  1029:319-320. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionAnnals of the New York Academy of Sciences.  1029:319-20. 2004
2004 Gene disruption and immunity in experimental colitisInflammatory Bowel Diseases.  10. 2004
2004 New developments in experimental inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-7. 2004
2003 T-bet or Not T-betScience.  302:993-994. 2003
2003 IFN-γ-Inducible Chemokines Enhance Adaptive Immunity and ColitisJournal of Interferon and Cytokine Research.  23:591-600. 2003
2003 Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cellsJournal of Experimental Medicine.  198:123-132. 2003
2003 Psoriasiform dermatitis susceptibility in Itgb2tm1Bay PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe diseaseAmerican Journal of Pathology.  163:197-202. 2003
2003 Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgeneArthritis and Rheumatism.  48:1602-1611. 2003
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferationJournal of Experimental Medicine.  197:751-762. 2003
2002 Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric floraJournal of Immunology.  169:6112-6119. 2002
2002 Cutting-edge technology IV. Genomic engineering for studies of the gastrointestinal tract in miceAJP - Gastrointestinal and Liver Physiology.  283. 2002
2002 Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice.AJP - Gastrointestinal and Liver Physiology.  283:G1232-G1237. 2002
2002 Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenoviral transductionImmunologic Research.  26:131-141. 2002
2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigensJournal of Immunology.  169:2337-2345. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic modelBMC Immunology.  3. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model.BMC Immunology.  3:4. 2002
2002 Vitamin A enhances in vitro Th2 development via retinoid X receptor pathwayJournal of Immunology.  168:4495-4503. 2002
2002 T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitisJournal of Experimental Medicine.  195:71-84. 2002
2002 Inhibition of T cell responses by transferrin-coupled competitor peptidesImmunologic Research.  26:77-85. 2002
2001 Unexpected characteristics of the IFN-γ reporters in nontransformed T cellsJournal of Immunology.  167:855-865. 2001
2001 Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family membersJournal of Immunology.  166:4534-4542. 2001
2001 Immno-bacterial homeostasis in the gut: new insights into an old enigmaSeminars in Immunology.  13:187-94. 2001
2001 Immuno-bacterial homeostasis in the gut: New insights into an old enigmaSeminars in Immunology.  13:187-194. 2001
2000 Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12Journal of Immunology.  165:2173-2182. 2000
1999 Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCRInternational Immunology.  11:1253-1263. 1999
1999 Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector functionImmunity.  11:271-280. 1999
1998 Experimental models to study molecular mechanisms underlying intestinal disease. Proceedings of Symposium Intestinal Plasticity in Health and DiseaseAnnals of the New York Academy of Sciences.  859:85-95. 1998
1998 Experimental models to study molecular mechanisms underlying intestinal inflammationAnnals of the New York Academy of Sciences.  859:85-95. 1998
1998 Heterogeneity in the clonal T cell response: Implications for models of T cell activation and cytokine phenotype developmentImmunologic Research.  17:279-302. 1998
1998 Regional differences in L-selectin expression in murine intestinal lymphocytesGastroenterology.  114:965-974. 1998
1997 The Mucosal Adjuvanticity of Cholera Toxin Involves Enhancement of Costimulatory Activity by Selective Up-Regulation of B7.2 ExpressionJournal of Immunology.  159:5301-5308. 1997
1997 Single-cell analyses of CD4+ T cells from αβ T cell receptor-transgenic mice: A distinct mucosal cytokine phenotype in the absence of transgene-specific antigenEuropean Journal of Immunology.  27:1774-1781. 1997
1997 Visualization of Antigen-Specific T Cell Activation and Cytokine Expression in VivoJournal of Immunology.  158:649-657. 1997
1997 Evaluation of pathologic criteria for acute renal allograft rejection: Reproducibility, sensitivity, and clinical correlationJournal of the American Society of Nephrology.  8:1930-1941. 1997
1996 Anti-LFA-1 mAb drives naive CD4 T cells to A TH2-like phenotypeFederation proceedings.  10. 1996
1996 Differences in phenotypes and activation markers in different compartments of the intestineFederation proceedings.  10. 1996
1996 Direct alloantigen stimulation of T cells in vitro (MLR) shows inhibition characteristics of low TCR avidity responsesFederation proceedings.  10. 1996
1996 Heterogenity of fas-ligand expression during CD4+ T cell phenotype development detected by single-cell analysisFederation proceedings.  10. 1996
1996 In vivo analysis of CD4+ T cell responses to oral immunizationFederation proceedings.  10. 1996
1996 In vivo cytokine production and antibody isotype profiles reflect the TR1 or TN2 phenotype of adoptivley transferred αβ-tcr transgenic cellsFederation proceedings.  10. 1996
1996 Tolerization of ovalbumin-specific αβ-tcr transgenic cells in adoptively transferred mice by the feeding of ovalbuminFederation proceedings.  10. 1996
1996 Visualization of T cell activation and cytokine expression in vivoFederation proceedings.  10. 1996
1996 Oral antigen delivery via a multiple emulsion system enhances oral toleranceAnnals of the New York Academy of Sciences.  778:156-62. 1996
1996 Oral-antigen delivery by way of a multiple emulsion system enhances oral toleranceAnnals of the New York Academy of Sciences.  778:156-162. 1996
1996 Regulation of mucosal immune responses - The missing link in IBD?Canadian Journal of Gastroenterology.  10:105-109. 1996
1995 Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype developmentProceedings of the National Academy of Sciences.  92:7565-7569. 1995
1995 In situ hybridization for cytokine mRNA with digoxigenin-labeled riboprobes Sensitivity of detection and double label applicationsJournal of Immunological Methods.  182:93-106. 1995
1994 Heterogeneity of single cell cytokine gene expression in clonal T cell populationsJournal of Experimental Medicine.  180:1251-1262. 1994
1994 T cells of staphylococcal enterotoxin B‐tolerized autoimmune MRL‐lpr/lpr mice require co‐stimulation through the B7‐CD28/CTLA‐4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co‐stimulatory signalEuropean Journal of Immunology.  24:1019-1025. 1994
1993 Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicideProceedings of the National Academy of Sciences.  90:4409-4413. 1993
1993 Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cellJournal of Immunology.  150:3832-3842. 1993
1992 CD45: A transmembrane protein tyrosine phosphatase involved in the transduction of antigenic signalsBiochemical Society Transactions.  20:169-174. 1992
1991 CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.Molecular and Cellular Biology.  11:4415-4422. 1991
1991 CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuliMolecular and Cellular Biology.  11:4415-4422. 1991
1990 ReplyImmunology Today.  11:304. 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today.  11:55-59. 1990
1990 Costimulatory function of APCs (I: Reply)Immunology Today (Reference Edition).  11:304. 1990
1990 ReplyImmunology Today.  11:304. 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today (Reference Edition).  11:49-55. 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today.  11:55-59. 1990
1989 Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: Evidence against a clonal-deletion mechanismProceedings of the National Academy of Sciences.  86:10034-10038. 1989
1989 A new murine CD4+ T cell subset with an unrestricted cytokine profileJournal of Immunology.  143:518-525. 1989
1989 Nonopiate active proenkephalin-derived peptides are secreted by T helper cellsFederation proceedings.  3:2401-2407. 1989
1989 T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of T(H)1 and T(H)2 subsetsJournal of Immunology.  142:3469-3476. 1989
1988 T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cellsProceedings of the National Academy of Sciences.  85:8181-8185. 1988
1987 Membrane IL-1: A key protein in antigen presentationAnnales de l'Institut Pasteur. Immunology.  138:489-492. 1987
1986 T cell induction of membrane IL 1 on macrophagesJournal of Immunology.  137:3868-3873. 1986

Chapter

Year Title Altmetric
2015 Effector CD4+ T Cells in the Intestines.  721-732. 2015
2010 In Vivo Models of Inflammatory Bowel Disease.  25-51. 2010
2006 Experimental mouse models of inflammatory bowel disease: New insights into pathogenic mechanisms.  67-99. 2006
2005 Disease induction and prevention in experimental models of inflammatory bowel disease.  1237-1254. 2005
2004 Regulatory T cells in animal models: therapeutic potential.  100-6. 2004
2003 Are lessons from experimental models relevant for human IBD? 2003
2000 Aetiopathogenesis 1999- How to put it all together.  133-41. 2000
2000 Induced mutant mouse models of inflammatory bowel disease: new insights into disease pathogenesis.  47-55. 2000
1998 Animal models to study molecular mechanisms underlying intestinal disease 1998
1998 Cytokines and anti-cytokines in the therapy of inflammatory bowel disease.  232-8. 1998
1998 Experimental models of inflammatory bowel disease: Old hypotheses confirmed and new paradigms generated.  35-42. 1998
1998 What can we learn from animal models?.  65-72. 1998
1997 Genetic and chemical models of IBD. In Proc. of Falk Symposium No. 96.  21-6. 1997
1995 Regulation of mucosal immune responses - the missing link in IBD?.  81-81. 1995

Principal Investigator On

  • Agonism of DR3 for Enhanced Treg Cell Function in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2023
  • Specialization of Innate and Adaptive Immune Cells in Intestinal Barrier Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Mechanisms Controlling Regulatory T Cell Effector Function in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Private Grant  awarded by JT PHARMA INC. 2017 - 2020
  • Th17 Pathway Plasticity in the Pathogenesis of Inflammatory Bowel Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Role of Rorgt Positive Innate Lymphoid Cells in Neonatal Intestinal Barrier Development  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Acquisition of a Mainz COLOVIEW System for COLOVIEW Systems for Research Using Animal Models  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • IL-1-Mediated Regulation of the Th17 Developmental Program and Its Role in IBD  awarded by Crohn's & Colitis Foundation of America 2015 - 2018
  • Molecular Regulation of MS Susceptibility Genes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2018
  • HSF-GEF Scholar Award  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Factors Controlling Effector T Cell Maintenance in the Pathogenesis of Colitis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2017
  • Interplay of T Cell Subsets in IBD Pathogenesis  awarded by Crohn's & Colitis Foundation of America 2014 - 2017
  • Private Grant  awarded by JT PHARMA INC. 2013 - 2017
  • Mechanistic Studies of Interleukin 10 Gene Regulation in Intestinal CD4 T Cells  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2017
  • Gene Regulatory Networks Controlling Effector and Regulatory T Cell Balance in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2016
  • Innate and Adaptive Immunity in IBD - Project 3  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Regulation of IL-10 Expression by Intestinal T Cells  awarded by Crohn's & Colitis Foundation of America 2012 - 2014
  • Regulation of IL-22 Induction from Th17 and Non-Th17 CD4 T Cells  awarded by Crohn's & Colitis Foundation of America 2012 - 2014
  • A Critical Role for T Cell-Derived IL-6 in the Pathogenesis of Colitis  awarded by Crohn's & Colitis Foundation of America 2011 - 2014
  • Control of Chromatin Landscapes in Effector T Cell Lineage Specifications  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Mechanisms of Vitamin D-Mediated Protection Against IBD  awarded by Crohn's & Colitis Foundation of America 2009 - 2012
  • Howard Hughes Medical Institute Fellows Award  awarded by Hughes (Howard) Medical Institute 2011 - 2012
  • Post-Thymic T-Cell Functional Repetoire Heterogeneity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2006 - 2012
  • Control of Effector Cytokine Gene Induction in Immunopathogenic T Cells  awarded by Crohn's & Colitis Foundation of America 2009 - 2011
  • Mechanisms Controlling IL-10 Producing Intestinal Regulatory T Cells  awarded by Crohn's & Colitis Foundation of America 2009 - 2011
  • CD4 T Cell Functional Heterogeneity During Multiple Sclerosis  awarded by National Multiple Sclerosis Society 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • UAB Autoimmunity Center for Excellence: Project 4 - Development and Maintenance of Intestinal Regulatory T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2009
  • Investigator On

  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Microbiome and Gnotobiotics Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Biology of Innate IL-22 During Lung Fungal Infection  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Regulation of T Cell Activity during Chronic Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2020
  • Rheumatic Diseases Research Core Centers - Core C: Analytic Imaging and Immunoreagent Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core C: Analytic Imaging and Immunoreagent Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • The Thrombospondin1-TGF-Beta Axis in Multiple Myeloma  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Inflammation, Immunology and Immunotherapeutics Program  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Microbiome and Gnotobiotics Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Immunopathogenesis in Fungal Asthma  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • Pathological TNFR1 Expressing CD4+ T-Cells are Critical for HF Progression  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Glycosylation-Dependent Mechanisms Regulating Ovarian Tumor Cell Survival  awarded by National Institute of General Medical Sciences/NIH/DHHS 2014 - 2018
  • Interactions Between AHR Ligands and the Gut Microbiota in Murine Arthritis  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2014 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Comprehensive Cancer Center Core Support Grant - Microbiome and Gnotobiotics Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Innate and Adaptive Immunity in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Innate and Adaptive Immunity in IBD - Animal Model Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Expansion of the UAB Gnotobiotic-Microbiome Research Facility  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2012 - 2016
  • Developing and Improving the UAB Gnotobiotic Facility  awarded by NIH - OFFICE OF THE DIRECTOR 2013 - 2015
  • New Animal Model for Studies of Mucosal Immunity and IgA Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2013
  • Mucosal HIV and Immunobiology Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • UAB Autoimmunity Center for Excellence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2009
  • Education And Training

  • Doctor of Medicine, University of Florida 1984
  • Bachelor of Science or Mathematics in Biochemistry, University of Florida 1979
  • Jewish Hospital of St. Louis, Internship 1985
  • Barnes Hospital, Residency 1988
  • Full Name

  • Casey Weaver