Selected Publications

Academic Article

Year Title Altmetric
2020 TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.Science Immunology.  5. 2020
2020 Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in AutoimmunityImmunity.  52:650-667.e10. 2020
2020 Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammationScience Advances.  6. 2020
2020 One road to the TH17 pathway: how TH1 led to TH17 (and vice versa), and first came lastNature Immunology2020
2020 Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosisEuropean Journal of Immunology2020
2019 Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsisNature Medicine.  25:1772-1782. 2019
2019 Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of CtcfCell Reports.  29:1203-1220.e7. 2019
2019 Natural tr1-like cells do not confer long-term tolerogenic memoryeLife.  8. 2019
2019 Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial InfectionCell.  178:1176-1188.e15. 2019
2018 IL-1R signaling promotes STAT3 and NF-B factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcriptionJournal of Biological Chemistry.  293:15790-15800. 2018
2018 Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cellsScience.  361. 2018
2018 Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infectionJournal of Experimental Medicine.  215:1823-1838. 2018
2017 Citrobacter rodentium: A model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunityMucosal Immunology.  10:1108-1117. 2017
2017 Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHDJCI insight.  2. 2017
2017 T Cell-derived IL-10 impairs host resistance to mycobacterium tuberculosis infectionJournal of Immunology.  199:613-623. 2017
2017 Selective induction of homeostatic Th17 cells in the murine intestine by cholera toxin interacting with the microbiotaJournal of Immunology.  199:312-322. 2017
2016 Cytomegalovirus-Specific IL-10-Producing CD4+T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus PersistencePLoS Pathogens.  12. 2016
2016 IL-6 IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cellsJournal of Experimental Medicine.  213:2281-2291. 2016
2016 Determining immune system suppression versus CNS protection for pharmacological interventions in autoimmune demyelinationJournal of Visualized Experiments.  2016. 2016
2016 A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host diseaseJournal of Clinical Investigation.  126:3541-3555. 2016
2016 Regulation of Effector Treg Cells in Murine LupusArthritis and Rheumatology.  68:1454-1466. 2016
2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficileBMC Microbiology.  16. 2016
2015 IRF4-dependent and IRF4-independent pathways contribute to DC dysfunction in lupusPLoS ONE.  10. 2015
2015 Skin-resident memory CD4+ T cells enhance protection against Leishmania major infectionJournal of Experimental Medicine.  212:1405-1414. 2015
2015 Daughter's Tolerance of Mom Matters in Mate ChoiceCell.  162:467-469. 2015
2015 Inhibition of system Xc- transporter attenuates autoimmune inflammatory demyelinationJournal of Immunology.  195:450-463. 2015
2015 TH17 cells transdifferentiate into regulatory T cells uring resolution of inflammationNature.  523:221-225. 2015
2015 T-cell expression of IL10 is essential for tumor immune surveillance in the small intestineCancer Immunology Research.  3:806-814. 2015
2015 Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis 2015
2015 Ligation of TLR7 on CD19+CD1dhi B cells suppresses allergic lung inflammation via regulatory T cellsEuropean Journal of Immunology.  45:1842-1854. 2015
2015 PD-L1hi B cells are critical regulators of humoral immunityNature Communications.  6. 2015
2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iT reg cell balanceNature Immunology.  16:286-295. 2015
2014 Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1Journal of Clinical Investigation.  124:3455-3468. 2014
2014 The transcription factors T-bet and runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cellsImmunity.  40:355-366. 2014
2014 Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene TranscriptionPLoS Genetics.  10. 2014
2014 Development and survival of th17 cells within the intestines: The influence of microbiome-and diet-derived signalsJournal of Immunology.  193:4769-4777. 2014
2013 IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanismJournal of Leukocyte Biology.  94:1103-1112. 2013
2013 IL-2 coordinates IL-2-producing and regulatory T cell interplayJournal of Experimental Medicine.  210:2707-2720. 2013
2013 Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cellsCancer Research.  73:5905-5913. 2013
2013 Antiapoptotic McI-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cellsNature Immunology.  14:959-965. 2013
2013 Linking vitamin D deficiency to inflammatory bowel diseaseInflammatory Bowel Diseases.  19:2245-2256. 2013
2013 Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in miceJournal of Immunology.  191:2780-2795. 2013
2013 IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis 2013
2013 Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine SignalsImmunity.  39:148-159. 2013
2013 Allogeneic th1 cells home to host bone marrow and spleen and mediate ifnγ-dependent aplasiaBiology of Blood and Marrow Transplantation.  19:876-887. 2013
2013 Dwelling on T cell fate decisionsCell.  153:739-741. 2013
2013 Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrantsJournal of Immunology.  190:2603-2613. 2013
2013 The Th17 family: Flexibility follows functionImmunological Reviews.  252:89-103. 2013
2013 Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to porphyromonas gingivalisJournal of Leukocyte Biology.  93:21-31. 2013
2013 The Th17 pathway and inflammatory diseases of the intestines, lungs, and skinAnnual Review of Pathology: Mechanisms of Disease.  8:477-512. 2013
2012 Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic BacteriaImmunity.  37:1061-1075. 2012
2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22Journal of Immunology.  189:3653-3660. 2012
2012 γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 ResponseImmunity.  37:524-534. 2012
2012 Reciprocal interactions of the intestinal microbiota and immune systemNature.  489:231-241. 2012
2012 Noninvasive bioluminescence imaging in small animals 2012
2012 Stem-cell-like qualities of immune memory; CD4 + T cells join the partyCell Stem Cell.  10:107-108. 2012
2012 Developmental regulation of Th17-cell capacity in human neonatesEuropean Journal of Immunology.  42:311-319. 2012
2012 Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivoJournal of Immunology.  188:1036-1048. 2012
2012 Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity 2012
2012 B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas lpr miceJournal of Immunology.  188:678-685. 2012
2012 Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatusInfection and Immunity.  80:410-417. 2012
2011 Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal ImmunityImmunity.  35:997-1009. 2011
2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infectionInfection and Immunity.  79:3966-3977. 2011
2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsivenessMucosal Immunology.  4:503-518. 2011
2011 Immunology: Context is key in the gutNature.  471:169-170. 2011
2011 Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cellsJournal of Biological Chemistry.  286:997-1004. 2011
2011 IL-12 converts Foxp3(+) regulatory T cells to Foxp3(+)IFN-γ(+) T cells with inhibitory functions during induction of colitisGastroenterology.  140:2031-43. 2011
2011 Interleukin-12 converts Foxp3+ regulatory T cells to interferonγ-producing Foxp3+ T cells that inhibit colitisGastroenterology.  140:2031-2043. 2011
2010 Regulation of the Ifng locus in the context of T-lineage specification and plasticityImmunological Reviews.  238:216-232. 2010
2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levelsJournal of Immunology.  185:3643-3651. 2010
2010 Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuliImmunity.  33:35-47. 2010
2010 Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineageImmunity.  32:616-627. 2010
2010 Autoimmunity: Increasing suspects in the CD4 + T cell lineupNature Immunology.  11:36-40. 2010
2009 Interplay between the TH 17 and TReg cell lineages: A (co-)evolutionary perspectiveNature Reviews Immunology.  9:883-889. 2009
2009 Intestinal Effector T Cells in Health and DiseaseImmunity.  31:389-400. 2009
2009 Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic modelBMC Immunology.  10. 2009
2009 IL-9 as a mediator of Th17-driven inflammatory diseaseJournal of Experimental Medicine.  206:1653-1660. 2009
2009 MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airwaysEuropean Journal of Immunology.  39:2281-2292. 2009
2009 The AP-1 transcription factor Batf controls T H 17 differentiationNature.  460:405-409. 2009
2009 TGF-β promotes Th17 cell development through inhibition of SOCS3Journal of Immunology.  183:97-105. 2009
2009 Th17: The ascent of a new effector T-cell subsetEuropean Journal of Immunology.  39:634-636. 2009
2009 Developmental plasticity of Th17 and Treg cellsCurrent Opinion in Immunology.  21:274-280. 2009
2009 Editorial overviewCurrent Opinion in Immunology.  21:119-120. 2009
2009 Contrasting roles for all-trans retinoic acid in TGF-β-mediated induction of Foxp3 and Il10 genes in developing regulatory T cellsJournal of Experimental Medicine.  206:343-357. 2009
2009 Duality in the Th17-Treg developmental decision.F1000 biology reports.  1:5. 2009
2009 Late Developmental Plasticity in the T Helper 17 LineageImmunity.  30:92-107. 2009
2009 Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitisJournal of Neuroimmunology.  206:22-27. 2009
2008 Chapter 5 Emergence of the Th17 Pathway and Its Role in Host DefenseAdvances in Immunology.  99:115-163. 2008
2008 Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulationImmunological Reviews.  226:219-233. 2008
2008 III. Report of adaptive and regulatory immune responses workgroupInflammatory Bowel Diseases.  14:694-696. 2008
2008 X. Challenges update workgroupsInflammatory Bowel Diseases.  14:706-708. 2008
2008 Memory CD4 T cells emerge from effector T-cell progenitorsNature.  452:356-360. 2008
2008 Noninvasive bioluminescence imaging in small animals 2008
2007 The central role of the Th17 lineage in regulating the inflammatory/autoimmune axisSeminars in Immunology.  19:351-352. 2007
2007 Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporterInternational Immunology.  19:1165-1173. 2007
2007 Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Nature Immunology.  8:931-941. 2007
2007 Immunology: Narcissistic helpersNature.  448:416-418. 2007
2007 IL-17 family cytokines and the expanding diversity of effector T cell lineagesAnnual Review of Immunology.  25:821-852. 2007
2007 T-Cell Subsets: The More the MerrierCurrent Biology.  17. 2007
2007 Monoclonal Anti-Interleukin 23 Reverses Active Colitis in a T Cell-Mediated Model in MiceGastroenterology.  132:2359-2370. 2007
2007 The Genetics of Inflammatory Bowel DiseaseGastroenterology.  133:1327-1339. 2007
2006 Alterations of T lymphocytes in inflammatory bowel diseasesAdvances in Experimental Medicine and Biology.  579:133-148. 2006
2006 A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK CellsImmunity.  25:717-729. 2006
2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineageCurrent Opinion in Immunology.  18:349-356. 2006
2006 Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell TiesImmunity.  24:677-688. 2006
2006 Transforming growth factor-β induces development of the T H17 lineageNature.  441:231-234. 2006
2006 Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in miceAmerican Journal of Pathology.  168:1425-1434. 2006
2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesNature Immunology.  6:1123-1132. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-276. 2005
2005 Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome functionJournal of Immunology.  174:2787-2795. 2005
2005 Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endotheliumAmerican Journal of Pathology.  167:1661-1675. 2005
2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-76. 2005
2005 P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculatureAmerican Journal of Pathology.  167:1647-1660. 2005
2004 Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cellsJournal of Immunology.  173:7249-7258. 2004
2004 New developments in experimental models of inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-367. 2004
2004 Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytesInternational Immunology.  16:345-351. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionAnnals of the New York Academy of Sciences.  1029:319-320. 2004
2004 Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionAnnals of the New York Academy of Sciences.  1029:319-20. 2004
2004 Gene disruption and immunity in experimental colitisInflammatory Bowel Diseases.  10. 2004
2004 New developments in experimental inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-7. 2004
2003 T-bet or Not T-betScience.  302:993-994. 2003
2003 IFN-γ-Inducible Chemokines Enhance Adaptive Immunity and ColitisJournal of Interferon and Cytokine Research.  23:591-600. 2003
2003 Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cellsJournal of Experimental Medicine.  198:123-132. 2003
2003 Psoriasiform dermatitis susceptibility in Itgb2tm1Bay PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe diseaseAmerican Journal of Pathology.  163:197-202. 2003
2003 Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgeneArthritis and Rheumatism.  48:1602-1611. 2003
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferationJournal of Experimental Medicine.  197:751-762. 2003
2002 Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric floraJournal of Immunology.  169:6112-6119. 2002
2002 Cutting-edge technology IV. Genomic engineering for studies of the gastrointestinal tract in mice 2002
2002 Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice. 2002
2002 Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenoviral transductionImmunologic Research.  26:131-141. 2002
2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigensJournal of Immunology.  169:2337-2345. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic modelBMC Immunology.  3. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model.BMC Immunology.  3:4. 2002
2002 Vitamin A enhances in vitro Th2 development via retinoid X receptor pathwayJournal of Immunology.  168:4495-4503. 2002
2002 T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitisJournal of Experimental Medicine.  195:71-84. 2002
2002 Inhibition of T cell responses by transferrin-coupled competitor peptidesImmunologic Research.  26:77-85. 2002
2001 Unexpected characteristics of the IFN-γ reporters in nontransformed T cellsJournal of Immunology.  167:855-865. 2001
2001 Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family membersJournal of Immunology.  166:4534-4542. 2001
2001 Immno-bacterial homeostasis in the gut: new insights into an old enigmaSeminars in Immunology.  13:187-94. 2001
2001 Immuno-bacterial homeostasis in the gut: New insights into an old enigmaSeminars in Immunology.  13:187-194. 2001
2000 Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12Journal of Immunology.  165:2173-2182. 2000
1999 Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCRInternational Immunology.  11:1253-1263. 1999
1999 Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector functionImmunity.  11:271-280. 1999
1998 Experimental models to study molecular mechanisms underlying intestinal disease. Proceedings of Symposium Intestinal Plasticity in Health and DiseaseAnnals of the New York Academy of Sciences.  859:85-95. 1998
1998 Experimental models to study molecular mechanisms underlying intestinal inflammationAnnals of the New York Academy of Sciences.  859:85-95. 1998
1998 Heterogeneity in the clonal T cell response: Implications for models of T cell activation and cytokine phenotype developmentImmunologic Research.  17:279-302. 1998
1998 Regional differences in L-selectin expression in murine intestinal lymphocytesGastroenterology.  114:965-974. 1998
1997 The Mucosal Adjuvanticity of Cholera Toxin Involves Enhancement of Costimulatory Activity by Selective Up-Regulation of B7.2 ExpressionJournal of Immunology.  159:5301-5308. 1997
1997 Single-cell analyses of CD4+ T cells from αβ T cell receptor-transgenic mice: A distinct mucosal cytokine phenotype in the absence of transgene-specific antigenEuropean Journal of Immunology.  27:1774-1781. 1997
1997 Visualization of Antigen-Specific T Cell Activation and Cytokine Expression in VivoJournal of Immunology.  158:649-657. 1997
1997 Evaluation of pathologic criteria for acute renal allograft rejection: Reproducibility, sensitivity, and clinical correlationJournal of the American Society of Nephrology.  8:1930-1941. 1997
1996 Anti-LFA-1 mAb drives naive CD4 T cells to A TH2-like phenotypeThe FASEB Journal.  10. 1996
1996 Differences in phenotypes and activation markers in different compartments of the intestineThe FASEB Journal.  10. 1996
1996 Direct alloantigen stimulation of T cells in vitro (MLR) shows inhibition characteristics of low TCR avidity responsesThe FASEB Journal.  10. 1996
1996 Heterogenity of fas-ligand expression during CD4+ T cell phenotype development detected by single-cell analysisThe FASEB Journal.  10. 1996
1996 In vivo analysis of CD4+ T cell responses to oral immunizationThe FASEB Journal.  10. 1996
1996 In vivo cytokine production and antibody isotype profiles reflect the TR1 or TN2 phenotype of adoptivley transferred αβ-tcr transgenic cellsThe FASEB Journal.  10. 1996
1996 Tolerization of ovalbumin-specific αβ-tcr transgenic cells in adoptively transferred mice by the feeding of ovalbuminThe FASEB Journal.  10. 1996
1996 Visualization of T cell activation and cytokine expression in vivoThe FASEB Journal.  10. 1996
1996 Oral antigen delivery via a multiple emulsion system enhances oral toleranceAnnals of the New York Academy of Sciences.  778:156-62. 1996
1996 Oral-antigen delivery by way of a multiple emulsion system enhances oral toleranceAnnals of the New York Academy of Sciences.  778:156-162. 1996
1996 Regulation of mucosal immune responses - The missing link in IBD?Canadian Journal of Gastroenterology.  10:105-109. 1996
1995 Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development 1995
1995 In situ hybridization for cytokine mRNA with digoxigenin-labeled riboprobes Sensitivity of detection and double label applicationsJournal of Immunological Methods.  182:93-106. 1995
1994 Heterogeneity of single cell cytokine gene expression in clonal T cell populationsJournal of Experimental Medicine.  180:1251-1262. 1994
1994 T cells of staphylococcal enterotoxin B‐tolerized autoimmune MRL‐lpr/lpr mice require co‐stimulation through the B7‐CD28/CTLA‐4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co‐stimulatory signalEuropean Journal of Immunology.  24:1019-1025. 1994
1993 Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide 1993
1993 Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cellJournal of Immunology.  150:3832-3842. 1993
1992 CD45: A transmembrane protein tyrosine phosphatase involved in the transduction of antigenic signalsBiochemical Society Transactions.  20:169-174. 1992
1991 CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.Molecular and Cellular Biology.  11:4415-4422. 1991
1991 CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuliMolecular and Cellular Biology.  11:4415-4422. 1991
1990 Reply 1990
1990 The costimulatory function of antigen-presenting cells 1990
1990 Costimulatory function of APCs (I: Reply)Immunology Today (Reference Edition).  11:304. 1990
1990 Reply 1990
1990 The costimulatory function of antigen-presenting cellsImmunology Today (Reference Edition).  11:49-55. 1990
1990 The costimulatory function of antigen-presenting cells 1990
1989 Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: Evidence against a clonal-deletion mechanism 1989
1989 A new murine CD4+ T cell subset with an unrestricted cytokine profileJournal of Immunology.  143:518-525. 1989
1989 Nonopiate active proenkephalin-derived peptides are secreted by T helper cellsThe FASEB Journal.  3:2401-2407. 1989
1989 T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of T(H)1 and T(H)2 subsetsJournal of Immunology.  142:3469-3476. 1989
1988 T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells 1988
1987 Membrane IL-1: A key protein in antigen presentationAnnales de l'Institut Pasteur. Immunology.  138:489-492. 1987
1986 T cell induction of membrane IL 1 on macrophagesJournal of Immunology.  137:3868-3873. 1986


Year Title Altmetric
2015 Effector CD4+ T Cells in the Intestines.  721-732. 2015
2010 In Vivo Models of Inflammatory Bowel Disease.  25-51. 2010
2006 Experimental mouse models of inflammatory bowel disease: New insights into pathogenic mechanisms.  67-99. 2006
2005 Disease induction and prevention in experimental models of inflammatory bowel disease.  1237-1254. 2005
2004 Regulatory T cells in animal models: therapeutic potential.  100-6. 2004
2003 Are lessons from experimental models relevant for human IBD? 2003
2000 Aetiopathogenesis 1999- How to put it all together.  133-41. 2000
2000 Induced mutant mouse models of inflammatory bowel disease: new insights into disease pathogenesis.  47-55. 2000
1998 Animal models to study molecular mechanisms underlying intestinal disease 1998
1998 Cytokines and anti-cytokines in the therapy of inflammatory bowel disease.  232-8. 1998
1998 Experimental models of inflammatory bowel disease: Old hypotheses confirmed and new paradigms generated.  35-42. 1998
1998 What can we learn from animal models?.  65-72. 1998
1997 Genetic and chemical models of IBD. In Proc. of Falk Symposium No. 96.  21-6. 1997
1995 Regulation of mucosal immune responses - the missing link in IBD?.  81-81. 1995

Education And Training

  • Doctor of Medicine, University of Florida 1984
  • Bachelor of Science or Mathematics in Biochemistry, University of Florida 1979
  • Jewish Hospital of St. Louis, Internship 1985
  • Barnes Hospital, Residency 1988
  • Full Name

  • Casey Weaver