• Powell earned both his Ph.D. in Neuroscience and M.D. with Honor at Baylor College of Medicine in 1994 and 1997 respectively. His graduate work was among the first to measure lasting biochemical changes during long-lasting synaptic plasticity in the hippocampus. After his medical internship year at Baylor College of Medicine, Dr. Powell trained at the University of California San Francisco Neurology Residency Program. In his final year, he was selected as Chief Resident at UCSF. From there, he returned to UT Southwestern Medical Center as a professor and served in several roles before holding his current leadership positions.

    “With my laboratory’s longstanding focus on autism, intellectual disability, and cognitive dysfunction in general, the opportunity to lead the UAB Civitan International Research Center is a great honor,” said Powell. “As a physician and a scientist, I am uniquely poised to leverage the existing clinical research strengths at UAB and Children’s of Alabama to move our neurobiology discoveries out of the laboratory and into the clinics to help patients and their families.”
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments 2019
    2019 Volumetric Analysis of the Basal Ganglia and Cerebellar Structures in Patients with Phelan-McDermid Syndrome 2019
    2018 Pitt-Hopkins Syndrome: A Review of Current Literature, Clinical Approach, and 23-Patient Case Series 2018
    2018 Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background 2018
    2017 Spatial gene expression analysis of neuroanatomical differences in mouse models 2017
    2017 Kctd13 deletion reduces synaptic transmission via increased RhoA 2017
    2017 Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity 2017
    2017 Neuroscience: Mum's bacteria linked to baby's behaviour 2017
    2017 Laquinimod has no effects on brain volume or cellular CNS composition in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease 2017
    2017 Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment 2017
    2017 Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function 2017
    2016 Autism screening or smoke screen and mirrors? 2016
    2016 Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism 2016
    2015 Increased cortical inhibition in Autism-Linked neuroligin-3R451C mice is due in part to loss of endocannabinoid signaling 2015
    2015 Autism-associated insertion mutation (InsG) of shank3 exon 21 causes impaired synaptic transmission and behavioral deficits 2015
    2015 Erratum to "Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome" [Neurosci. Lett., 591 (2015) 86-92], doi: 10.1016/j.neulet.2015.02.008 2015
    2015 Chronic P7C3 treatment restores hippocampal neurogenesis 2015
    2015 3D visualization of the regional differences 2015
    2015 Clustering autism: Using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity 2015
    2015 Neuroligin 1 modulates striatal glutamatergic neurotransmission in a pathway and NMDAR subunit-specific manner 2015
    2014 PTEN knockdown alters dendritic spine/protrusion morphology, not density 2014
    2014 Autism-Related Neuroligin-3 Mutation Alters Social Behavior and Spatial Learning 2014
    2014 Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume 2014
    2013 Loss of predominant shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission 2013
    2013 Pearls and Oy-sters: Acute ischemic stroke caused by atypical thrombotic thrombocytopenic purpura 2013
    2013 Interfering with the reconsolidation of traumatic memory: Sirolimus as a novel agent for treating veterans with posttraumatic stress disorder 2013
    2012 Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule 2012
    2012 Region-specific deletions of RIM1 reproduce a subset of global RIM1α -/- phenotypes 2012
    2012 Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice 2012
    2011 Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice 2011
    2011 Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory 2011
    2011 Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury 2011
    2010 Effects of exogenous glucocorticoid on combat-related PTSD symptoms 2010
    2010 Lowering β-amyloid levels rescues learning and memory in a down syndrome mouse model 2010
    2010 RIM1α and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia 2010
    2010 Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior 2010
    2010 A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons 2010
    2009 Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments 2009
    2009 A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export 2009
    2009 Disparate diseases due to copycat copy number variations 2009
    2009 Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5 2009
    2009 Pharmacological inhibition of mTORCl suppresses anatomical, cellular, and behavioral abnormalities in neural-specific PTEN knock-out mice 2009
    2009 Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2 2009
    2008 RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning 2008
    2008 Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation 2008
    2008 Motor coordination deficits in mice lacking RGS9 2008
    2007 A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice 2007
    2007 Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation 2007
    2007 Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation 2007
    2006 Postreactivation glucocorticoids impair recall of established fear memory 2006
    2006 Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder? 2006
    2006 Pten Regulates Neuronal Arborization and Social Interaction in Mice 2006
    2006 Gene targeting of presynaptic proteins in synaptic plasticity and memory: Across the great divide 2006
    2004 Essential role of brain-derived neurotrophic factor in adult hippocampal function 2004
    2004 Multilevel Intramedullary Spinal Neurocysticercosis with Eosinophilic Meningitis 2004
    2004 The presynaptic active zone protein RIM1α is critical for normal learning and memory 2004
    1994 Autonomously active protein kinase C in the maintenance phase of N-methyl-D-aspartate receptor-independent long term potentiation 1994
    1993 Studies with Synthetic Peptide Substrates Derived from the Neuronal Protein Neurogranin Reveal Structural Determinants of Potency and Selectivity for Protein Kinase C 1993
    1992 Ca2+-induced persistent protein kinase C activation in rat hippocampal homogenates 1992


    Year Title Altmetric
    2012 The Autisms Molecules to Model Systems 2012


    Year Title Altmetric
    2010 Neuroligins and neurexins: Synaptic bridges implicated in autism.  201-215. 2010
    2009 Rab3A Interacting Molecules (RIMs).  7-14. 2009

    Research Overview

  • Autism, intellectual disability, cognitive dysfunction
  • Full Name

  • Craig Powell