Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Regulation of bacterial gene expression by transcription attenuationMicrobiology and Molecular Biology Reviews.  83. 2019
2017 Activities of gyrase and topoisomerase IV on positively supercoiled DNANucleic Acids Research.  45:9611-9624. 2017
2017 Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug ResistanceBiochemistry.  56:4191-4200. 2017
2017 X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathwayProceedings of the National Academy of Sciences.  114:8211-8216. 2017
2015 Activity of quinolone CP-115,955 against bacterial and human type ii topoisomerases is mediated by different interactionsBiochemistry.  54:1278-1286. 2015
2014 Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeAntimicrobial Agents and Chemotherapy.  58:7182-7187. 2014
2014 Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis sporesAntimicrobial Agents and Chemotherapy.  58:1813-1815. 2014
2014 Cryo-EM analysis of the organization of BclA and BxpB in the Bacillus anthracis exosporiumJournal of ultrastructure research.  186:181-187. 2014
2014 Transcription start site sequence and spacing between the -10 region and the start site affect reiterative transcription-mediated regulation of gene expression in Escherichia coliJournal of Bacteriology.  196:2912-2920. 2014
2013 Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactionsACS Chemical Biology.  8:2660-2668. 2013
2013 Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: Mechanistic basis of quinolone resistanceNucleic Acids Research.  41:4628-4639. 2013
2012 Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis sporesStructure.  20:479-486. 2012
2012 Drug interactions with bacillus anthracis topoisomerase IV: Biochemical basis for quinolone action and resistanceBiochemistry.  51:370-381. 2012
2011 An unusual mechanism of isopeptide bond formation attaches the collagenlike glycoprotein BcIA to the exosporium of bacillus anthracismBio.  2. 2011
2011 Regulation of gene expression by reiterative transcriptionCurrent Opinion in Microbiology.  14:142-147. 2011
2010 Characterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracisJournal of Bacteriology.  192:5053-5062. 2010
2010 Sequence motifs and proteolytic cleavage of the collagen-like glycoprotein BclA required for its attachment to the exosporium of Bacillus anthracis.Journal of Bacteriology.  192:1259-1268. 2010
2010 ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracisMicrobiological sciences.  76:1527-1538. 2010
2009 Identification of the UDP-N-acetylglucosamine 4-epimerase involved in exosporium protein glycosylation in Bacillus anthracisJournal of Bacteriology.  191:7094-7101. 2009
2009 CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophagesProceedings of the National Academy of Sciences.  106:13957-13962. 2009
2009 The spore-specific alanine racemase of Bacillus anthracis and its role in suppressing germination during spore development.Journal of Bacteriology.  191:1303-1310. 2009
2008 Regulation of bacterial gene expression by the NTP substrates of transcription initiation.Microbiological sciences.  69:10-14. 2008
2008 Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.Microbiology and Molecular Biology Reviews.  72:266-300. 2008
2008 Anthrose biosynthetic operon of Bacillus anthracisJournal of Bacteriology.  190:2350-2359. 2008
2008 Antibody responses of variable lymphocyte receptors in the lampreyNature Immunology.  9:319-327. 2008
2008 Structure and specificity of lamprey monoclonal antibodiesProceedings of the National Academy of Sciences.  105:2040-2045. 2008
2008 The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytesProceedings of the National Academy of Sciences.  105:1261-1266. 2008
2007 Systematic mutagenesis of the thymidine tract of the pyrBI attenuator and its effects on intrinsic transcription termination in Escherichia coli.Microbiological sciences.  66:127-138. 2007
2007 Non-uniform assembly of the Bacillus anthracis exosporium and a bottle cap model for spore germination and outgrowthMicrobiological sciences.  64:359-367. 2007
2006 The ExsY protein is required for complete formation of the exosporium of Bacillus anthracisJournal of Bacteriology.  188:7440-7448. 2006
2006 The phage meeting: Classical venue, new momentum.Journal of Bacteriology.  188:4597-4600. 2006
2006 Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowthJournal of Immunology.  176:6076-6084. 2006
2005 Characterization of the exosporium basal layer protein BxpB of Bacillus anthracisJournal of Bacteriology.  187:5868-5876. 2005
2005 Orientation within the exosporium and structural stability of the collagen-like glycoprotein BclA of Bacillus anthracis.Journal of Bacteriology.  187:5310-5317. 2005
2004 Diagnostic probes for Bacillus anthracis spores selected from a landscape phage libraryClinical Chemistry.  50:1899-1906. 2004
2004 Attenuation control of pyrG expression in Bacillus subtilis is mediated by CTP-sensitive reiterative transcription.Proceedings of the National Academy of Sciences.  101:10943-10948. 2004
2004 Novel oligosaccharide side chains of the collagen-like region of BclA, the major glycoprotein of the Bacillus anthracis exosporiumJournal of Biological Chemistry.  279:30945-30953. 2004
2004 Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation.Microbiological sciences.  51:1471-1481. 2004
2004 Interaction of modified liposomes with Bacillus sporesChemical Communications.  4:430-431. 2004
2004 Surface Layer Protein EA1 Is Not a Component of Bacillus anthracis Spores but Is a Persistent Contaminant in Spore PreparationsJournal of Bacteriology.  186:566-569. 2004
2003 Peptide Ligands that Bind Selectively to Spores of Bacillus subtilis and Closely Related SpeciesApplied and Environmental Microbiology.  69:6841-6847. 2003
2003 Species-Specific Peptide Ligands for the Detection of Bacillus anthracis SporesApplied and Environmental Microbiology.  69:6288-6293. 2003
2003 Discovery of phage display peptide ligands for species-specific detection of Bacillus spores.Journal of Microbiological Methods.  53:263-271. 2003
2003 Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporiumJournal of Bacteriology.  185:1903-1910. 2003
2001 A long T ยท A tract in the upp initially transcribed region is required for regulation of upp expression by UTP-dependent reiterative transcription in Escherichia coliJournal of Bacteriology.  183:221-228. 2001
1999 Multiple mechanisms are used for growth rate and stringent control of leuV transcriptional initiation in Escherichia coli.Journal of Bacteriology.  181:5771-5782. 1999
1998 Regulation of carAB expression in Escherichia coli occurs in part through UTP-sensitive reiterative transcriptionJournal of Bacteriology.  180:705-713. 1998
1998 Erratum: Regulation of upp expression in escherichia coli by UTP- psensitive selection of transcriptional start sites coupled with UTP- dependent reiterative transcription (Journal of Bacteriology 17921 (6665- 6673))Journal of Bacteriology.  180:4991. 1998
1997 Transcription regulation by initiating NTP concentration: rRNA synthesis in bacteriaScience.  278:2092-2097. 1997
1997 Regulation of upp expression in Escherichia coli by UTP-sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription.Journal of Bacteriology.  179:6665-6673. 1997
1997 Erratum: Regulation of upp expression in Escherichia coli by UTP- sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription (Journal of Bacteriology 179:21 (6665-6673))Journal of Bacteriology.  179:7887. 1997
1996 In vitro assay for reiterative transcription during transcriptional initiation by Escherichia coli RNA polymerase.Methods in Enzymology.  273:71-85. 1996
1995 Regulation of codBA operon expression in Escherichia coli by UTP-dependent reiterative transcription and UTP-sensitive transcriptional start site switching.Journal of Molecular Biology.  254:552-565. 1995
1995 Rapid confirmation of single copy lambda prophage integration by PCRNucleic Acids Research.  23:1278. 1995
1994 Rapid confirmation of single copy lambda prophage integration by PCRNucleic Acids Research.  22:5765-5766. 1994
1994 Regulation of pyrBI operon expression in Escherichia coli by UTP-sensitive reiterative RNA synthesis during transcriptional initiation.Genes and Development.  8:2904-2912. 1994
1994 Nucleotide-specific transcriptional pausing in the pyrBI leader region of Escherichia coli K-12.Journal of Biological Chemistry.  269:18185-18191. 1994
1994 Effects of transcriptional start site sequence and position on nucleotide-sensitive selection of alternative start sites at the pyrC promoter in Escherichia coli.Journal of Bacteriology.  176:2938-2945. 1994
1994 Identification of the Shine-Dalgarno sequence required for expression and translational control of the pyrC gene in Escherichia coli K-12.Journal of Bacteriology.  176:2513-2516. 1994
1994 An escherichia coli RNA polymerase defective in transcription due to its overproduction of abortive initiation productsJournal of Molecular Biology.  236:72-80. 1994
1993 Genetic evidence that promoter P2 is the physiologically significant promoter for the pyrBI operon of Escherichia coli K-12.Journal of Bacteriology.  175:2363-2369. 1993
1992 Translational control of pyrC expression mediated by nucleotide-sensitive selection of transcriptional start sites in Escherichia coliJournal of Bacteriology.  174:514-524. 1992
1990 Characterization of transcriptional initiation from promoters P1 and P2 of the pyrBI operon of Escherichia coli K12.Journal of Biological Chemistry.  265:19091-19099. 1990
1990 Role of the purine repressor in the regulation of pyrimidine gene expression in Escherichia coli K-12.Journal of Bacteriology.  172:3208-3213. 1990
1989 Multiple control mechanisms for pyrimidine-mediated regulation of pyrBI operon expression in Escherichia coli K-12.Journal of Bacteriology.  171:3337-3342. 1989
1988 Role of the ribosome in suppressing transcriptional termination at the pyrBI attenuator of Escherichia coli K-12.Proceedings of the National Academy of Sciences.  85:7149-7153. 1988
1987 Nucleotide sequence and characterization of the pyrF operon of Escherichia coli K12.Journal of Biological Chemistry.  262:10239-10245. 1987
1987 Nucleotide sequence and expression of the pyrC gene of Escherichia coli K-12.Journal of Bacteriology.  169:3051-3058. 1987
1986 Genetic mapping of novel virulence determinants of Salmonella typhimurium to the region between trpD and supDMicrobial Pathogenesis.  1:115-124. 1986
1986 Salmonella typhimurium virulence genes necessary to exploit the Ity(s/s) genotype of the mouseInfection and Immunity.  51:872-878. 1986
1985 The ability of Salmonella typhimurium to produce the siderophore enterobactin is not a virulence factor in mouse typhoidInfection and Immunity.  50:392-397. 1985
1985 Role of translation and attenuation in the control of pyrBI operon expression in Escherichia coli K-12.Journal of Bacteriology.  163:991-999. 1985
1985 Toxicity of the pyrimidine biosynthetic pathway intermediate carbamyl aspartate in Salmonella typhimurium.Journal of Bacteriology.  163:500-505. 1985
1983 Regulation of Escherichia coli aspartate transcarbamylase synthesis by guanosine tetraphosphate and pyrimidine ribonucleoside triphosphates.Journal of Bacteriology.  153:998-1007. 1983
1983 Attenuation control of pyrBI operon expression in Escherichia coli K-12.Proceedings of the National Academy of Sciences.  80:368-372. 1983
1981 Infection of Salmonella typhimurium with coliphage Mu d1 (Apr lac): construction of pyr::lac gene fusions.Journal of Bacteriology.  145:299-305. 1981
1981 Purification and Properties of Glutamine Phosphoribosylpyrophosphate Amidotransferase from Bacillus subtilisBiochemistry.  20:5669-5674. 1981
1979 Pseudouridylation of tRNAs and its role in regulation in Salmonella typhimurium.Journal of Biological Chemistry.  254:5111-5119. 1979
1975 Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in stationary-phase cultures of Bacillus subtilis.Journal of Bacteriology.  121:108-114. 1975
1975 Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in vitro inactivation.Journal of Bacteriology.  121:115-120. 1975

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Illinois System : Urbana-Champaign 1975
  • Master of Sciences or Mathematics in Chemistry, University of Illinois System : Urbana-Champaign 1970
  • Full Name

  • Charles Turnbough