Selected Publications

Academic Article

Year Title Altmetric
2021 Methylation of dual-specificity phosphatase 4 controls cell differentiationCell Reports.  36. 2021
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1Blood Advances.  2:2829-2836. 2018
2017 The assembly competence domain is essential for inv(16)-associated acute myeloid leukemiaLeukemia.  31:2267-2271. 2017
2017 Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic ProgenyStem Cells.  35:473-484. 2017
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCancer Research.  76:3978-3988. 2016
2016 Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancerProteomics.  16:516-531. 2016
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell functionProceedings of the National Academy of Sciences of USA.  113:E51-E60. 2016
2012 Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and humanProteomics.  12:3393-3402. 2012
2012 GM-CSFRα: The sex-chromosome link to t(8;21)+ AML?Blood.  119:2976-2977. 2012
2012 Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemiaBlood.  119:1522-1531. 2012
2011 Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responsesPLoS One.  6. 2011
2009 Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineageProceedings of the National Academy of Sciences of USA.  106:552-557. 2009
2008 Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancerJournal of Gastrointestinal Surgery.  12:1683-1690. 2008
2008 Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemiaLeukemia Research.  32:1101-1111. 2008
2008 Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation techniqueAmerican Journal of Physiology: Renal Physiology.  295. 2008
2008 FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemiaBlood.  111:1567-1574. 2008
2007 Inactivation of Smad4 accelerates KrasG12D-mediated pancreatic neoplasiaCancer Research.  67:8121-8130. 2007
2007 Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in miceBlood.  109:2190-2197. 2007
2006 TGFβ/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding abilityThe EMBO Journal.  25:1469-1480. 2006
2005 The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemiaJournal of Biological Chemistry.  280:40097-40103. 2005
2004 The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cellsBlood.  104:3894-3900. 2004
2004 Mutation of CpGs in the Murine Stem Cell Virus Retroviral Vector Long Terminal Repeat Represses Silencing in Embryonic Stem CellsJournal of Biological Chemistry.  279:34-41. 2004
2003 Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B CellsMolecular and Cellular Biology.  23:8637-8650. 2003
2003 Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptorThe EMBO Journal.  22:5511-5521. 2003
2003 Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineageThe EMBO Journal.  22:4759-4769. 2003
2003 Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cellsJournal of Immunology.  171:2783-2788. 2003
2003 Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage developmentBlood.  101:4342-4346. 2003
2003 The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivoBlood Cells, Molecules and Diseases.  30:201-206. 2003
2002 Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocationMolecular and Cellular Biology.  22:5506-5517. 2002
2002 Mechanisms that regulate silencing of gene expression from retroviral vectorsStem Cells and Development.  11:449-456. 2002
2002 Differential gene expression profiling of adult murine hematopoietic stem cellsBlood.  99:488-498. 2002
2002 Retroviral Transduction of FACS-Purified Hematopoietic Stem Cells.Methods in Molecular Medicine.  63:243-252. 2002
2001 Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cellsJournal of Biological Chemistry.  276:915-923. 2001
2000 Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progenyBlood.  96:894-901. 2000
1999 Mechanisms of transcriptional regulation in lymphocyte progenitors: Insight from an analysis of the terminal transferase promoterCold Spring Harbor Laboratory: Symposia on Quantitative Biology.  64:87-97. 1999
1998 Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796))Genes and Development.  12:1240. 1998
1998 Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatinGenes and Development.  12:782-796. 1998
1998 Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytesProceedings of the National Academy of Sciences of USA.  95:657-662. 1998
1994 Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administrationProceedings of the National Academy of Sciences of USA.  91:11393-11397. 1994
1994 The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytesGenes and Development.  8:678-687. 1994
1993 Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activationThe EMBO Journal.  12:2763-2772. 1993
1992 BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1Molecular and Cellular Biology.  12:1126-1133. 1992

Education And Training

  • Doctor of Philosophy in Molecular Genetics, University of Chicago 1993
  • Full Name

  • Christopher Klug