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Christopher Klug Ph.D.
Professor
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E-mail
chrisk@uab.edu
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Christopher Klug Ph.D.
Professor
Positions
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
Senior Scientist
,
Experimental Therapeutics
,
O'Neal Comprehensive Cancer Center
Senior Scientist (C)
,
Nephrology Research & Training Center
,
General Clinical Research Center
Assistant Professor (S)
,
Medicine - Developmental & Clinical Immunology
,
Department of Medicine
Associate Scientist (C)
,
Gene Therapy Center
,
Medicine - Division of Human Gene Therapy
Senior Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
Assistant Professor (S)
,
Biochemistry & Molecular Genetics
,
Academic Joint Departments
Professor (P)
,
Microbiology
,
Academic Joint Departments
Administrator
,
Microbiology
,
Academic Joint Departments
Assistant Professor (S)
,
Pathology
,
Academic Joint Departments
Assistant Professor (S)
,
Genetics
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2021
Methylation of dual-specificity phosphatase 4 controls cell differentiation
.
Cell Reports
. 36.
2021
2018
Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1
.
Blood Advances
. 2:2829-2836.
2018
2017
The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia
.
Leukemia
. 31:2267-2271.
2017
2017
Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic Progeny
.
STEM CELLS
. 35:473-484.
2017
2016
The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype
.
Cancer Research
. 76:3978-3988.
2016
2016
Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer
.
Proteomics
. 16:516-531.
2016
2016
The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function
2016
2012
Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human
.
Proteomics
. 12:3393-3402.
2012
2012
GM-CSFRα: The sex-chromosome link to t(8;21)+ AML?
.
Blood
. 119:2976-2977.
2012
2012
Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia
.
Blood
. 119:1522-1531.
2012
2011
Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses
.
PLoS ONE
. 6.
2011
2009
Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage
2009
2008
Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer
.
Journal of Gastrointestinal Surgery
. 12:1683-1690.
2008
2008
Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation technique
2008
2008
Roles of p15
Ink4b
and p16
Ink4a
in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia
.
Leukemia Research
. 32:1101-1111.
2008
2008
FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia
.
Blood
. 111:1567-1574.
2008
2007
Inactivation of Smad4 accelerates Kras
G12D
-mediated pancreatic neoplasia
.
Cancer Research
. 67:8121-8130.
2007
2007
Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice
.
Blood
. 109:2190-2197.
2007
2006
TGFβ/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability
2006
2005
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia
.
Journal of Biological Chemistry
. 280:40097-40103.
2005
2004
The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells
.
Blood
. 104:3894-3900.
2004
2004
Mutation of CpGs in the Murine Stem Cell Virus Retroviral Vector Long Terminal Repeat Represses Silencing in Embryonic Stem Cells
.
Journal of Biological Chemistry
. 279:34-41.
2004
2003
Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells
.
Molecular and Cellular Biology
. 23:8637-8650.
2003
2003
Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor
2003
2003
Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage
2003
2003
Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells
.
Journal of Immunology
. 171:2783-2788.
2003
2003
Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development
.
Blood
. 101:4342-4346.
2003
2003
The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo
.
Blood Cells, Molecules and Diseases
. 30:201-206.
2003
2002
Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
.
Molecular and Cellular Biology
. 22:5506-5517.
2002
2002
Mechanisms that regulate silencing of gene expression from retroviral vectors
2002
2002
Differential gene expression profiling of adult murine hematopoietic stem cells
.
Blood
. 99:488-498.
2002
2002
Retroviral Transduction of FACS-Purified Hematopoietic Stem Cells.
.
Methods in Molecular Medicine
. 63:243-252.
2002
2001
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells
.
Journal of Biological Chemistry
. 276:915-923.
2001
2000
Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny
.
Blood
. 96:894-901.
2000
1999
Mechanisms of transcriptional regulation in lymphocyte progenitors: Insight from an analysis of the terminal transferase promoter
1999
1998
Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796))
.
Genes and Development
. 12:1240.
1998
1998
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
.
Genes and Development
. 12:782-796.
1998
1998
Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
1998
1994
Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration
1994
1994
The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes
.
Genes and Development
. 8:678-687.
1994
1993
Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation
1993
1992
BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1
.
Molecular and Cellular Biology
. 12:1126-1133.
1992
Research
Principal Investigator On
Defining Pathways Promoting HSC Self-Renewal by Mesenchymal Stem/Stromal Cells
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Regulation of Hematopoietic Stem Cell Self-Renewal by NUP98-HOXA9
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Role of NF-kB in Hematopoietic Stem Cells and Leukemia-Initiating Cell Formation
awarded by
National Cancer Institute/NIH/DHHS
UAB / UMN SPORE in Pancreatic Cancer - Project 1
awarded by
National Cancer Institute/NIH/DHHS
Investigator On
Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant
awarded by
National Cancer Institute/NIH/DHHS
Cell Therapies for Cooley's Anemia
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Comprehensive Cancer Center Core Support Grant
awarded by
National Cancer Institute/NIH/DHHS
Comprehensive Cancer Center Core Support Grant
awarded by
National Cancer Institute/NIH/DHHS
Comprehensive Cancer Center Core Support Grant
awarded by
National Cancer Institute/NIH/DHHS
Comprehensive Cancer Center Core Support Grant - Experimental Therapeutics Program
awarded by
National Cancer Institute/NIH/DHHS
Comprehensive Cancer Center Core Support Grant - Experimental Therapeutics Program
awarded by
National Cancer Institute/NIH/DHHS
Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer
awarded by
National Cancer Institute/NIH/DHHS
PRMT1-Mediated Metabolic Reprogramming in Leukemia Progression
awarded by
National Cancer Institute/NIH/DHHS
Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression
awarded by
National Cancer Institute/NIH/DHHS
UAB / UMN SPORE in Pancreatic Cancer
awarded by
National Cancer Institute/NIH/DHHS
Teaching
Teaching Activities
CMB712 - Methods and Logic (Fall Term 2007)
CMB712 - Methods and Logic (Fall Term 2008)
CMB712 - Methods and Logic (Fall Term 2009)
GBSC742 - Student Theme Meeting Course (Fall Term 2018)
GBSC742 - Student Theme Meeting Course (Fall Term 2019)
GBSC742 - Student Theme Meeting Course (Fall Term 2020)
GBSC742 - Student Theme Meeting Course (Fall Term 2021)
GBSC742 - Student Theme Meeting Course (Spring Term 2019)
GBSC742 - Student Theme Meeting Course (Spring Term 2020)
GBSC742 - Student Theme Meeting Course (Spring Term 2021)
GBSC742 - Student Theme Meeting Course (Spring Term 2022)
Background
Education And Training
Doctor of Philosophy in Molecular Genetics,
University of Chicago
1993
Contact
Full Name
Christopher
Klug