Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 PMS2 variant results in loss of ATPase activity without compromising mismatch repairMolecular Genetics and Genomic Medicine.  10. 2022
2022 The Glycoprotein 340’s Scavenger Receptor Cysteine-Rich Domain Promotes Adhesion of Staphylococcus aureus and Pseudomonas aeruginosa to Contact Lens PolymersInfection and Immunity.  90. 2022
2021 Structure-function characterization of Streptococcus intermedius surface antigen pasJournal of Bacteriology.  203. 2021
2021 Structural and functional analysis of the C-terminal region of Streptococcus gordonii SspBActa Crystallographica. Section d, Structural Biology.  77:1206-1215. 2021
2021 PG1659 functions as anti-sigma factor to extracytoplasmic function sigma factor RpoE in Porphyromonas gingivalis W83 2021
2021 ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4 2021
2019 Cloning, expression, purification, and preliminary characterization of single-crystal X-ray diffraction of glucosyltransferase B of streptococcus mutans 2019
2018 Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteinsScientific Reports.  8. 2018
2018 Antigen I/II mediates interactions between Streptococcus mutans and Candida albicans 2018
2018 Glucan binding protein C of Streptococcus mutans mediates both sucrose-independent and sucrose-dependent adherenceInfection and Immunity.  86. 2018
2018 Glycoprotein 340 in mucosal immunity and ocular surface 2018
2015 Interaction of βa3-crystallin with deamidated mutants of αa-and bcrystallinsPLoS ONE.  10. 2015
2015 Variants of osteoprotegerin lacking trail binding for therapeutic bone remodeling in osteolytic malignancies 2015
2014 The calcium-induced conformation and glycosylation of scavenger-rich cysteine repeat (SRCR) domains of glycoprotein 340 influence the high affinity interaction with antigen I/II homologsJournal of Biological Chemistry.  289:21877-21887. 2014
2013 Structural and functional characterization of the mumps virus phosphoproteinJournal of Virology.  87:7558-7568. 2013
2013 Cloning, expression and purification of the SRCR domains of glycoprotein 340Protein Expression and Purification.  90:67-73. 2013
2012 Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptidesJournal of Lipid Research.  53:849-858. 2012
2011 Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactionsJournal of Biological Chemistry.  286:25963-25972. 2011
2011 Crystal structure of the C-terminal region of Streptococcus mutans antigen I/II and characterization of salivary agglutinin adherence domainsJournal of Biological Chemistry.  286:21657-21666. 2011
2010 Bacteriophage hyaluronidase effectively inhibits growth, migration and invasion by disrupting hyaluronan-mediated Erk1/2 activation and RhoA expression in human breast carcinoma cellsCancer Letters.  298:238-249. 2010
2010 Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of α- and PPII-helices 2010
2010 The changing faces of Streptococcus antigen I/II polypeptide family adhesins: MicroReview 2010
2008 TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensisJournal of Leukocyte Biology.  84:1434-1446. 2008
2007 Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracisActa Crystallographica Section D: Biological Crystallography.  63:891-905. 2007
2007 Protein crystallization.Methods in Molecular Biology.  383:337-349. 2007
2003 Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): Naturally selected mutations in IN augment DNA synthesisJournal of Virology.  77:11050-11059. 2003
2003 A structural model for the inhibition of calpain by calpastatin: Crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitorJournal of Molecular Biology.  328:131-146. 2003
2002 A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: Crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A 2002
2002 Crystallization and preliminary X-ray crystallographic analysis of Ace: A collagen-binding MSCRAMM from Enterococcus faecalis 2002
2001 Structural Organization of the Fibrinogen-binding Region of the Clumping Factor B MSCRAMM of Staphylococcus aureusJournal of Biological Chemistry.  276:44721-44728. 2001
2000 Structure of FKBP12.6 in complex with rapamycinActa Crystallographica Section D: Biological Crystallography.  56:266-271. 2000
2000 Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface proteinStructure.  8:67-78. 2000
1999 Erratum: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, α1β1 integrin and Staphylococcus aureus Cna MSCRAMM (Journal of Biological Chemistry (1999) 274 (24906-24913))Journal of Biological Chemistry.  274:28836. 1999
1999 Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus Cna MSCRAMM. (vol 274, pg 24906, 1999)Journal of Biological Chemistry.  274:28836-28836. 1999
1999 Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, α1β1 integrin and Staphylococcus aureus Cna MSCRAMMJournal of Biological Chemistry.  274:24906-24913. 1999
1999 Crystallization and preliminary X-ray analysis of B-domain fragments of a Staphylococcus aureus collagen-binding proteinActa Crystallographica Section D: Biological Crystallography.  55:525-527. 1999
1999 Crystallization of ClfA and ClfB fragments: The fibrinogen-binding surface proteins of Staphylococcus aureusActa Crystallographica Section D: Biological Crystallography.  55:554-556. 1999
1998 Domain structure of the Staphylococcus aureus collagen adhesinBiochemistry.  37:15423-15433. 1998

Investigator On

  • A Comprehensive Evaluation of Microgravity Protein Crystallization  awarded by NASA - National Aeronautics & Space Administration
  • Active - Structural Biology SF X-Ray Crystallography - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Bacterial Second Messenger Mediated Virulence Regulation in Streptococcus Mutans  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Structural Biology Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Defining the Impact of Frataxin Point Mutations on Friedreich's Ataxia pathogenesis  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Glycosylation and Biogenesis of Streptococcal Adhesins  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Insights into the Lid Margin: Characterization of Membrane Associated Mucins in Ocular Surface Disease  awarded by National Eye Institute/NIH/DHHS
  • Mechanism of Cell Surface Assembly Catalyzed by Sortases  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Small Molecule Inhibitors of Carciogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy Level Degree in Molecular Biology, 1995
  • Full Name

  • Champion Deivanayagam