Selected Publications

Academic Article

Year Title Altmetric
2021 The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation 2021
2020 Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma studyThorax.  75:808-811. 2020
2020 CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion 2020
2020 12/15-lipoxygenase deficiency impairs neutrophil granulopoiesis and lung proinflammatory responses to Aspergillus fumigatusJournal of Immunology.  204:1849-1858. 2020
2019 Host defense mechanisms against Aspergillus fumigatus lung colonization and invasionCurrent Opinion in Microbiology.  52:14-19. 2019
2019 IL-1RA regulates immunopathogenesis during fungal-Associated allergic airway inflammationJCI insight.  4. 2019
2019 Development of a Non-invasive Device for Swallow Screening in Patients at Risk of Oropharyngeal Dysphagia: Results from a Prospective Exploratory StudyDysphagia.  34:698-707. 2019
2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of AsthmaticsScientific Reports.  8. 2018
2018 Role of common γ-Chain cytokines in lung interleukin-22 regulation after acute exposure to aspergillus fumigatusInfection and Immunity.  86. 2018
2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cellsRedox Biology.  18:54-64. 2018
2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
2018 The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthmaMucosal Immunology.  11:1352-1362. 2018
2018 An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsivenessScience Translational Medicine.  10. 2018
2018 Acidic mammalian chitinase negatively affects immune responses during acute and chronic Aspergillus fumigatus exposureInfection and Immunity.  86. 2018
2018 Complex association patterns for inflammatory mediators in induced sputum from subjects with asthmaClinical and Experimental Allergy.  48:787-797. 2018
2017 Increased Inflammation in Pericardial Fluid Persists 48 Hours after Cardiac SurgeryCirculation.  136:2284-2286. 2017
2017 IL-33 signaling regulates innate IL-17A and IL-22 production via suppression of prostaglandin E2 during lung fungal infectionJournal of Immunology.  199:2140-2148. 2017
2017 Innate Lung Defense during Invasive Aspergillosis: New MechanismsJournal of Innate Immunity.  9:271-280. 2017
2017 LDB1 regulates energy homeostasis during diet-induced obesityEndocrinology.  158:1289-1297. 2017
2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanismPLoS ONE.  11. 2016
2016 T cell cytokine signatures: Biomarkers in pediatric multiple sclerosisJournal of Neuroimmunology.  297:1-8. 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signalingFrontiers in Bioscience.  21:397-409. 2016
2015 Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesotheliomaCancer Gene Therapy.  22:44-54. 2015
2015 Eosinophils contribute to early clearance of pneumocystis murina infectionJournal of Immunology.  195:185-193. 2015
2015 Erratum: CD4+ T cell'independent DNA vaccination against opportunistic infections (Journal of Clinical Investigation (2005) 115: 12 (3536-3544) DOI: 10.1172/JCI26306)Journal of Clinical Investigation.  125:1364. 2015
2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
2015 Respiratory syncytial virus infection increases chlorine-induced airway hyperresponsiveness 2015
2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivityInternational Journal of Oncology.  46:1079-1088. 2015
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγtNature Communications.  5. 2014
2014 Eosinophil deficiency compromises lung defense against Aspergillus fumigatusInfection and Immunity.  82:1315-1325. 2014
2014 CREB-Induced inflammation is important for malignant mesothelioma growthAmerican Journal of Pathology.  184:2816-2827. 2014
2014 Innate receptors and cellular defense against pulmonary infectionsJournal of Immunology.  193:3842-3850. 2014
2014 Mesenchymal stromal cells mediate aspergillus hyphal extract-induced allergic airway inflammation by inhibition of the th17 signaling pathwayStem Cells Translational Medicine.  3:194-205. 2014
2014 Nitrite therapy improves survival postexposure to chlorine gas 2014
2013 Dectin immunoadhesins and Pneumocystis pneumoniaInfection and Immunity.  81:3451-3462. 2013
2013 The interdependent, overlapping, and differential roles of type i and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitisJournal of Immunology.  191:2967-2977. 2013
2013 IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary ExacerbationsPLoS ONE.  8. 2013
2013 Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cellsParticle and Fibre Toxicology.  10:1-14. 2013
2013 STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murinaJournal of Immunology.  190:6287-6294. 2013
2013 Chlorine gas exposure increases susceptibility to invasive lung fungal infection 2013
2013 VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice 2013
2013 CD36, but not G2A, modulates efferocytosis, infl ammation, and fibrosis following bleomycin-induced lung injuryJournal of Lipid Research.  54:1114-1123. 2013
2013 Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice 2013
2013 Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPDChest.  144:498-506. 2013
2012 Serum (1→3)-β-D-glucan levels in HIV-infected individuals are associated with immunosuppression, inflammation, and cardiopulmonary function 2012
2012 Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modalityFree Radical Biology and Medicine.  53:1431-1439. 2012
2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22Journal of Immunology.  189:3653-3660. 2012
2012 Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production 2012
2012 NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophyAmerican Journal of Respiratory Cell and Molecular Biology.  47:288-297. 2012
2012 Immunology of fungal infections: Lessons learned from animal modelsCurrent Opinion in Microbiology.  15:413-419. 2012
2012 Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic miceFree Radical Biology and Medicine.  52:2047-2056. 2012
2012 Characterisation of innate fungal recognition in the lungPLoS ONE.  7. 2012
2012 Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy eraAIDS.  26:731-740. 2012
2012 Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1)Life Sciences.  90:440-445. 2012
2012 Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cellsParticle and Fibre Toxicology.  9. 2012
2012 Asthma diagnosis and airway bronchodilator response in HIV-infected patientsJournal of Allergy and Clinical Immunology.  129. 2012
2012 Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatusInfection and Immunity.  80:410-417. 2012
2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infectionInfection and Immunity.  79:3966-3977. 2011
2011 Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infectionJournal of Immunology.  187:382-390. 2011
2011 Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in miceSTEM CELLS.  29:1137-1148. 2011
2011 IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murinaJournal of Immunology.  186:2372-2381. 2011
2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosisVirulence.  2. 2011
2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis.Virulence.  2:200-207. 2011
2011 Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosisAmerican Journal of Pathology.  178:1975-1985. 2011
2011 γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10American Journal of Pathology.  178:1167-1176. 2011
2010 NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunityJournal of Immunology.  185:5247-5258. 2010
2010 Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosisJournal of Clinical Investigation.  120:3242-3254. 2010
2010 Inflammation and asbestos-associated diseasesACS National Meeting Book of Abstracts.  240. 2010
2010 Immune Tolerance to Aspergillus fumigatus versus Allergic Bronchopulmonary Aspergillosis: roles of TSLP, OX40L, and Vitamin DJournal of Allergy and Clinical Immunology.  125:AB107-AB107. 2010
2010 CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosisPLoS ONE.  5. 2010
2010 Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivoInflammation Research.  59:571-578. 2010
2010 Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft modelAnnals of the New York Academy of Sciences.  1203:7-14. 2010
2010 Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1) 2010
2009 Airway obstruction is increased in Pneumocystis-colonized human immunodeficiency virus-infected outpatientsJournal of Clinical Microbiology.  47:3773-3776. 2009
2009 Complement C3 plays an essential role in the control of opportunistic fungal infectionsCytokine.  48:42-42. 2009
2009 Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosisPLoS ONE.  4. 2009
2009 Complement C3 plays an essential role in the control of opportunistic fungal infectionsInfection and Immunity.  77:3679-3685. 2009
2009 Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicityAmerican Journal of Respiratory Cell and Molecular Biology.  41:114-123. 2009
2009 Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine productionJournal of Immunology.  182:7990-7996. 2009
2009 Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposureAmerican Journal of Respiratory Cell and Molecular Biology.  40:710-716. 2009
2009 The absence of Hck, Fgr, and lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murinaInfection and Immunity.  77:1790-1797. 2009
2009 Requisite role for the dectin-1 β-glucan receptor in pulmonary defense against aspergillus fumigatusJournal of Immunology.  182:4938-4946. 2009
2009 Gamma Delta T Cells Attenuate Pulmonary Fibrosis through the Production of IP-10American Journal of Respiratory and Critical Care Medicine.  179. 2009
2009 STAT4-Dependent, T-Bet Independent Lung Immune Responses to PneumocystisAmerican Journal of Respiratory and Critical Care Medicine.  179. 2009
2009 The Absence of Hck, Fgr and Lyn Tyrosine Kinases Augments Lung Innate Immune Responses to PneumocystisAmerican Journal of Respiratory and Critical Care Medicine.  179. 2009
2008 Dysregulated expression of T-helper cell responses and susceptibility to infections in high-risk liver transplant recipientsTransplant Immunology.  20:68-72. 2008
2008 CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipientsAmerican Journal of Respiratory and Critical Care Medicine.  178:765-773. 2008
2008 Inhaled asbestos exacerbates atherosclerosis in apolipoprotein E-deficient mice via CD4+ T cellsEnvironmental Health Perspectives.  116:1218-1225. 2008
2008 Innate immune activation through Nalp3 inflammasome sensing of asbestos and silicaScience.  320:674-677. 2008
2008 Aspergillus fumigatus primes dendritic cells to stimulate IL-17 production from CD4+T cellsThe FASEB Journal.  22. 2008
2008 Dectin-1 Fc targeting of Aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosisAntimicrobial Agents and Chemotherapy.  52:1171-1172. 2008
2008 Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplantAmerican Journal of Respiratory Cell and Molecular Biology.  38:16-25. 2008
2007 De novo-derived cationic antimicrobial peptide activity in a murine model of Pseudomonas aeruginosa bacteraemiaJournal of Antimicrobial Chemotherapy.  60:669-672. 2007
2007 Erratum: Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion protein (Journal of Immunology (2007) 178, (3702-3712))Journal of Immunology.  178:6653. 2007
2007 Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion proteinJournal of Immunology.  178:3702-3712. 2007
2007 Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strainInfection and Immunity.  75:1453-1462. 2007
2007 Airway epithelial NF-κB activation modulates asbestos-induced inflammation and mucin production in vivoJournal of Immunology.  178:1800-1808. 2007
2007 Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-δ knockout miceAmerican Journal of Pathology.  170:140-151. 2007
2007 Dectin-1 is required for β-glucan recognition and control of fungal infectionNature Immunology.  8:31-38. 2007
2006 Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of Pneumocystis pneumoniaJournal of Immunology.  177:6215-6226. 2006
2006 CXCR3 and IFN protein-10 in Pneumocystis pneumoniaJournal of Immunology.  177:1846-1854. 2006
2006 Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infectionTransplant Immunology.  16:69-72. 2006
2006 Metformin prevents endotoxin-induced liver injury after partial hepatectomyJournal of Pharmacology and Experimental Therapeutics.  316:1053-1061. 2006
2006 Pneumocystis: Immune recognition and evasion 2006
2005 CD4+ T cell-independent DNA vaccination against opportunistic infections.Journal of Clinical Investigation.  115:3536-3544. 2005
2005 The beta-glucan receptor dectin-1 recognizes specific morphologies of aspergillus fumigatusPLoS Pathogens.  1:0323-0334. 2005
2005 In vitro effector activity of Pneumocystis murina-specific T-cytotoxic-1 CD8+ T cells: Role of granulocyte-macrophage colony-stimulating factorInfection and Immunity.  73:7450-7457. 2005
2005 Erratum: T cytotoxic-1 CD8+ T cells are effector cells against pneumocystis in mice (Journal of Immunology (2004) 172 (1132-1138))Journal of Immunology.  175:3447. 2005
2005 Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-α and granulocyte colony-stimulating factor in bronchial epithelium: Implications for airway inflammation in cystic fibrosisJournal of Immunology.  175:404-412. 2005
2005 Immunity against the opportunistic fungal pathogen PneumocystisMedical Mycology.  43:1-19. 2005
2005 CD4+ T cell-independent DNA vaccination against opportunistic infectionsJournal of Clinical Investigation.  115:3536-3544. 2005
2005 Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by gram-negative bacteriaInfection and Immunity.  73:532-545. 2005
2005 Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesisAmerican Journal of Pathology.  167:1243-1256. 2005
2005 Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells 2005
2004 Tc1CD8+T-cells are effector cells against Pneumocystis in miceThe FASEB Journal.  18:A801-A801. 2004
2004 Molecular recognition receptors and alveolar macrophage host defense against Pneutnocystis cariniiThe FASEB Journal.  18:A419-A419. 2004
2004 T Cytotoxic-1 CD8+ T Cells Are Effector Cells against Pneumocystis in MiceJournal of Immunology.  172:1132-1138. 2004
2003 Alveolar Macrophage-mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan ReceptorJournal of Experimental Medicine.  198:1677-1688. 2003
2003 Induction of CD4+ T cell-independent B cell responses in vivo by CD40 ligand DNA vaccination: Implications for vaccine developmentMolecular Therapy.  7:S312-S312. 2003
2003 Quantitative molecular analysis of macrophage-mediated killing of Pneumocystis cariniiThe FASEB Journal.  17:C57-C57. 2003
2003 Macroprage-mediated killing mechanisms against pneumocystis cariniiJournal of Investigative Medicine.  51:S293-S293. 2003
2003 Product of anti-OVA sera adjuvant by CD40L in CD4 depleted mice.Journal of Investigative Medicine.  51:S266-S266. 2003
2002 Vaginal and oral epithelial cell anti-Candida activityInfection and Immunity.  70:7081-7088. 2002
2002 Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis 2002
2002 Increased host resistance against Pneumocystis carinii pneumonia in γδ T-cell-deficient mice: Protective role of gamma interferon and CD8+ T cellsInfection and Immunity.  70:5208-5215. 2002
2002 Modulation of T cell recruitment by gamma delta T cells in Pneumocystis carinii pneumoniaThe FASEB Journal.  16:A1067-A1067. 2002
2002 Vaccination against Pneumocystis carinii in CD4-Depleted miceThe FASEB Journal.  16:A1067-A1067. 2002
2002 Cytokine and chemokine production by human oral and vaginal epithelial cells in response to Candida albicansInfection and Immunity.  70:577-583. 2002
2002 Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed candida albicans and the mucosal adjuvant LT(R192G)Medical Mycology.  40:291-299. 2002
2001 Growth inhibition of Candida albicans by human vaginal epithelial cellsJournal of Infectious Diseases.  184:1489-1493. 2001
2001 Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cellsInfection and Immunity.  69:7091-7099. 2001
2001 Resistance of T-cell receptor δ-chain-deficient mice to experimental Candida albicans vaginitisInfection and Immunity.  69:7162-7164. 2001
2000 Cytokine and chemokine production by vaginal epithelial cells in response to Candida albicans.The FASEB Journal.  14:A972-A972. 2000
2000 Effects of reproductive hormones on experimental vaginal candidiasisInfection and Immunity.  68:651-657. 2000
2000 Growth inhibition of Candida by human oral epithelia cellsJournal of Infectious Diseases.  182:1479-1485. 2000
1999 Differential susceptibility of two species of macaques to experimental vaginal candidiasisJournal of Infectious Diseases.  180:802-810. 1999
1999 Growth inhibition of Candida albicans by vaginal cells from naive miceMedical Mycology.  37:251-259. 1999
1999 Analysis of vaginal cell populations during experimental vaginal candidiasisInfection and Immunity.  67:3135-3140. 1999
1998 Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: A pilot study in HIV-positive individuals with oropharyngeal candidiasis 1998


Year Title Altmetric
2007 Pneumocystis.  311-330. 2007

Principal Investigator On

  • Biology of Innate IL-22 During Lung Fungal Infection  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Immunopathogenesis in Fungal Asthma  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • The CXCL 10/CXCR3 Axis in CF-Related Fungal Exposure  awarded by Cystic Fibrosis Foundation ^ 2016 - 2018
  • Adaptive Immunity Against Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • UAB Predoctoral Training Program in Lung Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017
  • Eosinophils and Lung Immunity to Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Pulmonary Defense Against Aspergillus Fumigatus  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2015
  • STAT4 Mediated Immunity to Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2014
  • Dectin-1 and Invasive Pulmonary Aspergillosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2012
  • Host Factors Regulating Allergic Responses to Aspergillus  awarded by University of Pittsburgh The 2009 - 2011
  • Immune Tolerance & Inflammation in ABPA in Patients with Cystic Fibrosis  awarded by University of Pittsburgh The 2009 - 2011
  • Pneumocystis in Pathogenesis of HIV-Associated Emphysema.  awarded by University of Pittsburgh The 2007 - 2011
  • Dectin-1 and Immunity Against Pneumocystis Carinii  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2007 - 2011
  • Full Name

  • Claude Steele