Selected Publications

Academic Article

Year Title Altmetric
2020 12/15-lipoxygenase deficiency impairs neutrophil granulopoiesis and lung proinflammatory responses to Aspergillus fumigatus 2020
2020 CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion 2020
2019 Host defense mechanisms against Aspergillus fumigatus lung colonization and invasion 2019
2019 IL-1RA regulates immunopathogenesis during fungal-Associated allergic airway inflammation 2019
2019 Development of a Non-invasive Device for Swallow Screening in Patients at Risk of Oropharyngeal Dysphagia: Results from a Prospective Exploratory Study 2019
2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics 2018
2018 Role of common γ-Chain cytokines in lung interleukin-22 regulation after acute exposure to aspergillus fumigatus 2018
2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells 2018
2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21 2018
2018 The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma 2018
2018 An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness 2018
2018 Acidic mammalian chitinase negatively affects immune responses during acute and chronic Aspergillus fumigatus exposure 2018
2018 Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma 2018
2017 Increased Inflammation in Pericardial Fluid Persists 48 Hours after Cardiac Surgery 2017
2017 IL-33 signaling regulates innate IL-17A and IL-22 production via suppression of prostaglandin E2 during lung fungal infection 2017
2017 Innate Lung Defense during Invasive Aspergillosis: New Mechanisms 2017
2017 LDB1 regulates energy homeostasis during diet-induced obesity 2017
2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanism 2016
2016 T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signaling 2016
2015 Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesothelioma 2015
2015 Eosinophils contribute to early clearance of pneumocystis murina infection 2015
2015 Erratum: CD4+ T cell'independent DNA vaccination against opportunistic infections (Journal of Clinical Investigation (2005) 115: 12 (3536-3544) DOI: 10.1172/JCI26306) 2015
2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients 2015
2015 Respiratory syncytial virus infection increases chlorine-induced airway hyperresponsiveness 2015
2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity 2015
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt 2014
2014 Eosinophil deficiency compromises lung defense against Aspergillus fumigatus 2014
2014 CREB-Induced inflammation is important for malignant mesothelioma growth 2014
2014 Innate receptors and cellular defense against pulmonary infections 2014
2014 Mesenchymal stromal cells mediate aspergillus hyphal extract-induced allergic airway inflammation by inhibition of the th17 signaling pathway 2014
2014 Nitrite therapy improves survival postexposure to chlorine gas 2014
2013 Dectin immunoadhesins and Pneumocystis pneumonia 2013
2013 The interdependent, overlapping, and differential roles of type i and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis 2013
2013 IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary Exacerbations 2013
2013 Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells 2013
2013 STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina 2013
2013 Chlorine gas exposure increases susceptibility to invasive lung fungal infection 2013
2013 VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice 2013
2013 CD36, but not G2A, modulates efferocytosis, infl ammation, and fibrosis following bleomycin-induced lung injury 2013
2013 Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice 2013
2013 Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD 2013
2012 Serum (1→3)-β-D-glucan levels in HIV-infected individuals are associated with immunosuppression, inflammation, and cardiopulmonary function 2012
2012 Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modality 2012
2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22 2012
2012 Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production 2012
2012 NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy 2012
2012 Immunology of fungal infections: Lessons learned from animal models 2012
2012 Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice 2012
2012 Characterisation of innate fungal recognition in the lung 2012
2012 Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era 2012
2012 Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1) 2012
2012 Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells 2012
2012 Asthma diagnosis and airway bronchodilator response in HIV-infected patients 2012
2012 Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus 2012
2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infection 2011
2011 Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection 2011
2011 Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice 2011
2011 IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina 2011
2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis 2011
2011 Aspergillus terreus accessory conidia are multinucleated, hyperpolarizing structures that display differential dectin staining and can induce heightened inflammatory responses in a pulmonary model of aspergillosis. 2011
2011 Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis 2011
2011 γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10 2011
2010 NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity 2010
2010 Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis 2010
2010 Inflammation and asbestos-associated diseases 2010
2010 Immune Tolerance to Aspergillus fumigatus versus Allergic Bronchopulmonary Aspergillosis: roles of TSLP, OX40L, and Vitamin D 2010
2010 CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis 2010
2010 Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivo 2010
2010 Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model 2010
2010 Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1) 2010
2009 Airway obstruction is increased in Pneumocystis-colonized human immunodeficiency virus-infected outpatients 2009
2009 Complement C3 plays an essential role in the control of opportunistic fungal infections 2009
2009 Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis 2009
2009 Complement C3 plays an essential role in the control of opportunistic fungal infections 2009
2009 Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity 2009
2009 Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production 2009
2009 Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure 2009
2009 The absence of Hck, Fgr, and lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina 2009
2009 Requisite role for the dectin-1 β-glucan receptor in pulmonary defense against aspergillus fumigatus 2009
2009 Gamma Delta T Cells Attenuate Pulmonary Fibrosis through the Production of IP-10 2009
2009 STAT4-Dependent, T-Bet Independent Lung Immune Responses to Pneumocystis 2009
2009 The Absence of Hck, Fgr and Lyn Tyrosine Kinases Augments Lung Innate Immune Responses to Pneumocystis 2009
2008 Dysregulated expression of T-helper cell responses and susceptibility to infections in high-risk liver transplant recipients 2008
2008 CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients 2008
2008 Inhaled asbestos exacerbates atherosclerosis in apolipoprotein E-deficient mice via CD4+ T cells 2008
2008 Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica 2008
2008 Aspergillus fumigatus primes dendritic cells to stimulate IL-17 production from CD4+T cells 2008
2008 Dectin-1 Fc targeting of Aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis 2008
2008 Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant 2008
2007 De novo-derived cationic antimicrobial peptide activity in a murine model of Pseudomonas aeruginosa bacteraemia 2007
2007 Erratum: Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion protein (Journal of Immunology (2007) 178, (3702-3712)) 2007
2007 Enhanced defense against Pneumocystis carinii mediated by a novel dectin-1 receptor Fc fusion protein 2007
2007 Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain 2007
2007 Airway epithelial NF-κB activation modulates asbestos-induced inflammation and mucin production in vivo 2007
2007 Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-δ knockout mice 2007
2007 Dectin-1 is required for β-glucan recognition and control of fungal infection 2007
2006 Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of Pneumocystis pneumonia 2006
2006 CXCR3 and IFN protein-10 in Pneumocystis pneumonia 2006
2006 Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infection 2006
2006 Metformin prevents endotoxin-induced liver injury after partial hepatectomy 2006
2006 Pneumocystis: Immune recognition and evasion 2006
2005 CD4+ T cell-independent DNA vaccination against opportunistic infections. 2005
2005 The beta-glucan receptor dectin-1 recognizes specific morphologies of aspergillus fumigatus 2005
2005 In vitro effector activity of Pneumocystis murina-specific T-cytotoxic-1 CD8+ T cells: Role of granulocyte-macrophage colony-stimulating factor 2005
2005 Erratum: T cytotoxic-1 CD8+ T cells are effector cells against pneumocystis in mice (Journal of Immunology (2004) 172 (1132-1138)) 2005
2005 Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-α and granulocyte colony-stimulating factor in bronchial epithelium: Implications for airway inflammation in cystic fibrosis 2005
2005 Immunity against the opportunistic fungal pathogen Pneumocystis 2005
2005 CD4+ T cell-independent DNA vaccination against opportunistic infections 2005
2005 Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by gram-negative bacteria 2005
2005 Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis 2005
2005 Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells 2005
2004 Tc1CD8+T-cells are effector cells against Pneumocystis in mice 2004
2004 Molecular recognition receptors and alveolar macrophage host defense against Pneutnocystis carinii 2004
2004 T Cytotoxic-1 CD8+ T Cells Are Effector Cells against Pneumocystis in Mice 2004
2003 Alveolar Macrophage-mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor 2003
2003 Induction of CD4+ T cell-independent B cell responses in vivo by CD40 ligand DNA vaccination: Implications for vaccine development 2003
2003 Quantitative molecular analysis of macrophage-mediated killing of Pneumocystis carinii 2003
2003 Macroprage-mediated killing mechanisms against pneumocystis carinii 2003
2003 Product of anti-OVA sera adjuvant by CD40L in CD4 depleted mice. 2003
2002 Vaginal and oral epithelial cell anti-Candida activity 2002
2002 Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis 2002
2002 Increased host resistance against Pneumocystis carinii pneumonia in γδ T-cell-deficient mice: Protective role of gamma interferon and CD8+ T cells 2002
2002 Modulation of T cell recruitment by gamma delta T cells in Pneumocystis carinii pneumonia 2002
2002 Vaccination against Pneumocystis carinii in CD4-Depleted mice 2002
2002 Cytokine and chemokine production by human oral and vaginal epithelial cells in response to Candida albicans 2002
2002 Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed candida albicans and the mucosal adjuvant LT(R192G) 2002
2001 Growth inhibition of Candida albicans by human vaginal epithelial cells 2001
2001 Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cells 2001
2001 Resistance of T-cell receptor δ-chain-deficient mice to experimental Candida albicans vaginitis 2001
2000 Cytokine and chemokine production by vaginal epithelial cells in response to Candida albicans. 2000
2000 Effects of reproductive hormones on experimental vaginal candidiasis 2000
2000 Growth inhibition of Candida by human oral epithelia cells 2000
1999 Differential susceptibility of two species of macaques to experimental vaginal candidiasis 1999
1999 Growth inhibition of Candida albicans by vaginal cells from naive mice 1999
1999 Analysis of vaginal cell populations during experimental vaginal candidiasis 1999
1998 Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: A pilot study in HIV-positive individuals with oropharyngeal candidiasis 1998


Year Title Altmetric
2007 Pneumocystis.  311-330. 2007

Principal Investigator On

  • Biology of Innate IL-22 During Lung Fungal Infection  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Immunopathogenesis in Fungal Asthma  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • The CXCL 10/CXCR3 Axis in CF-Related Fungal Exposure  awarded by Cystic Fibrosis Foundation 2016 - 2018
  • Adaptive Immunity Against Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2013 - 2018
  • UAB Predoctoral Training Program in Lung Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017
  • Eosinophils and Lung Immunity to Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Pulmonary Defense Against Aspergillus Fumigatus  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2015
  • STAT4 Mediated Immunity to Pneumocystis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2014
  • Dectin-1 and Invasive Pulmonary Aspergillosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2012
  • Host Factors Regulating Allergic Responses to Aspergillus  awarded by University of Pittsburgh 2009 - 2011
  • Immune Tolerance & Inflammation in ABPA in Patients with Cystic Fibrosis  awarded by University of Pittsburgh 2009 - 2011
  • Pneumocystis in Pathogenesis of HIV-Associated Emphysema.  awarded by University of Pittsburgh 2007 - 2011
  • Dectin-1 and Immunity Against Pneumocystis Carinii  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2007 - 2011
  • Full Name

  • Claude Steele