Positions

Selected Publications

Academic Article

Year Title Altmetric
2016 Expression and purification of the alpha subunit of the epithelial sodium channel, ENaCProtein Expression and Purification.  117:67-75. 2016
2015 Physical and functional interactions between a glioma cation channel and Integrin-β1 require α-actininLife Science Alliance.  309:C308-C319. 2015
2014 I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: Sex matters" and "Do you know the sex of your cells?"Life Science Alliance.  306. 2014
2012 Time for TMEM?Journal of Physiology.  590:5931-5932. 2012
2012 Low temperature and chemical rescue affect molecular proximity of ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC)Journal of Biological Chemistry.  287:16781-16790. 2012
2012 ENaCs and ASICs as therapeutic targetsLife Science Alliance.  302. 2012
2012 Glioma-specific cation conductance regulates migration and cell cycle progressionJournal of Biological Chemistry.  287:4053-4065. 2012
2011 Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytesLife Science Alliance.  300. 2011
2010 Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptaseJournal of Biological Chemistry.  285:27130-27143. 2010
2010 Amiloride docking to acid-sensing ion channel-1Journal of Biological Chemistry.  285:9627-9635. 2010
2009 Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migrationJournal of Biological Chemistry.  284:24526-24541. 2009
2009 Psalmotoxin-1 docking to human acid-sensing ion channel-1Journal of Biological Chemistry.  284:17625-17633. 2009
2009 Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its functionLife Science Alliance.  296. 2009
2008 Putting the brakes on vascular smooth muscle cell migrationJournal of Mid-Life Health.  294. 2008
2008 Selecting your first postdoctoral position.Physiologist.  51:20-21. 2008
2007 Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transferJournal of Biological Chemistry.  282:36481-36488. 2007
2007 Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cellsJournal of Biological Chemistry.  282:34381-34391. 2007
2007 Amiloride-sensitive Na+ channels contribute to regulatory volume increases in human glioma cellsLife Science Alliance.  293. 2007
2007 Heteromeric assembly of acid-sensitive ion channel and epithelial sodium channel subunitsJournal of Biological Chemistry.  282:25548-25559. 2007
2006 Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cellsJournal of Biological Chemistry.  281:19220-19232. 2006
2005 Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytesLife Science Alliance.  289. 2005
2004 Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1Life Science Alliance.  287. 2004
2004 ENaC subunit-subunit interactions and inhibition by syntaxin 1AJournal of Youth and Adolescence.  286. 2004
2004 Mutations in the extracellular loop of α-rENaC alter sensitivity to amiloride and reactive speciesJournal of Youth and Adolescence.  286. 2004
2004 The Role of Pre-H2 Domains of α- and δ-Epithelial Na + Channels in Ion Permeation, Conductance, and Amiloride SensitivityJournal of Biological Chemistry.  279:8428-8440. 2004
2003 Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoterGene.  313:91-101. 2003
2003 Acid-sensing ion channels in malignant gliomasJournal of Biological Chemistry.  278:15023-15034. 2003
2003 Relationship between a HCO3--permeable conductance and a CLCA protein from rat pancreatic zymogen granulesJournal of Healthcare Leadership.  300:546-554. 2003
2002 Protein kinase C isoform antagonism controls BNaC2 (ASIC1) functionJournal of Biological Chemistry.  277:45734-45740. 2002
2002 Intrinsic gating mechanisms of epithelial sodium channelsLife Science Alliance.  283. 2002
2002 Up-regulation of acid-gated Na+ channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytesJournal of Biological Chemistry.  277:8395-8405. 2002
2002 The serine protease trypsin cleaves C termini of β- and γ-subunits of epithelial Na+ channelsJournal of Biological Chemistry.  277:4134-4140. 2002
2001 Chlorzoxazone or 1-EBIO increases Na+ absorption across cystic fibrosis airway epithelial cellsPeritoneal Dialysis International.  281. 2001
2001 Ca2+-activated Cl- channels: A newly emerging anion transport familyPflügers Archiv European Journal of Physiology.  443. 2001
2001 pH Alterations "Reset" Ca2+ Sensitivity of Brain Na+ Channel 2, a Degenerin/Epithelial Na+ Ion Channel, in Planar Lipid BilayersJournal of Biological Chemistry.  276:38755-38761. 2001
2001 Focus on "contrasting effects of cPLA2 on epithelial Na+ transport"Life Science Alliance.  281. 2001
2001 Point mutations in the post-M2 region of human α-ENaC regulate cation selectivityLife Science Alliance.  281. 2001
2001 Regions in the carboxy terminus of α-bENaC involved in gating and functional effects of actinLife Science Alliance.  281. 2001
2001 Differential gene expression profiling in human brain tumorsPhysiological Genomics.  2001:21-33. 2001
2001 Expression and Regulation of Normal and Polymorphic Epithelial Sodium Channel by Human LymphocytesJournal of Biological Chemistry.  276:8557-8566. 2001
2001 Identification of a new chloride channel: A sweet story?Gastroenterology.  120:299-303. 2001
2000 Electrophysiological characteristics of the Ca2+-activated Cl- channel family of anion transport proteinsNorth Dakota Journal of Speech and Theatre.  27:906-910. 2000
2000 The cytosolic termini of the β- and γ-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channelJournal of Biological Chemistry.  275:27947-27956. 2000
2000 Ca2+-activated Cl- channels: A newly emerging anion transport familyNews in Physiological Sciences.  15:165-171. 2000
2000 The CLCA gene family: a novel family of putative chloride channelsLaryngoscope Investigative Otolaryngology.  1:201-222. 2000
1999 Peptide inhibition of constitutively activated epithelial Na+ channels expressed in Xenopus oocytesJournal of Biological Chemistry.  274:37693-37704. 1999
1999 Regulation of epithelial Na+ channels by actin in planar lipid bilayers and in the Xenopus oocyte expression systemJournal of Biological Chemistry.  274:37845-37854. 1999
1999 Chapter 1 Mapping Structure/Function Relations in αbENaCMonographs in allergy.  47:3-24. 1999
1999 Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lungJournal of Biological Chemistry.  273:32096-32101. 1999
1999 Malignant human gliomas express an amiloride-sensitive Na+ conductanceLife Science Alliance.  276. 1999
1999 Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary glandLife Science Alliance.  276. 1999
1999 Peptide inhibition of ENaCBiomarker Insights.  38:354-363. 1999
1998 Functional expression of a truncated Ca2+-activated Cl-channel and activation by phorbol esterBMC Pharmacology.  274. 1998
1998 Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteinsGenomics.  54:200-214. 1998
1998 Osmotic pressure regulates -rENaC expressed in Xenopus oocytesBMC Pharmacology.  275. 1998
1998 α-adrenergic receptors regulate human lymphocyte amiloride-sensitive sodium channelsLife Science Alliance.  275. 1998
1998 Alpha-adrenergic receptors regulate human lymphocyte amiloride-sensitive sodium channels.BMC Pharmacology.  275:C702-C710. 1998
1998 Peroxynitrite inhibits amiloride-sensitive Na+ currents in Xenopus oocytes expressing alpha beta gamma-rENaC.BMC Pharmacology.  274:C1417-C1423. 1998
1998 Peroxynitrite inhibits amiloride-sensitive Na+ currents in Xenopus oocytes expressing αβγ-rENaCLife Science Alliance.  274. 1998
1998 Mechanosensitivity of αβγ rENaC expressed in Xenopus oocytesFederation proceedings.  12. 1998
1998 Phenol red blocks the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl channelFederation proceedings.  12. 1998
1998 Functional expression of a truncated Ca(2+)-activated Cl- channel and activation by phorbol ester.BMC Pharmacology.  274:C455-C464. 1998
1998 Functional expression of a truncated Ca2+-activated Cl- channel and activation by phorbol esterLife Science Alliance.  274. 1998
1998 Cystic fibrosis: A multiple exocrinopathy caused by dysfunctions in a multifunctional transport proteinElectronic Journal of Biotechnology.  104:576-590. 1998
1998 Ultrastructural localization of amiloride-sensitive sodium channels and Na+,K+-ATPase in the rat's olfactory epithelial surfaceJournal of the International Federation of Gynaecology and Obstetrics.  23:137-149. 1998
1997 Peroxynitrite (ONOO-) inhibits Na+ channel activity in xenopus oocytes expressing αβγ-rENaCFederation proceedings.  11. 1997
1997 Point mutations in αbENaC regulate channel gating, ion conductance, and sensitivity to amilorideFederation proceedings.  11. 1997
1997 Identification of an amiloride binding domain within the α-subunit of the epithelial Na+ channelJournal of Biological Chemistry.  272:21075-21083. 1997
1997 Role of actin in regulation of epithelial sodium channels by CFTRLife Science Alliance.  272. 1997
1997 Amiloride-sensitive Na+ channels: Insights and outlooksNews in Physiological Sciences.  12:55-61. 1997
1997 Role of actin in regulation of epithelial sodium channels by CFTR.BMC Pharmacology.  272:C1077-C1086. 1997
1997 Point mutations in αbENaC regulate channel gating, ion selectivity, and sensitivity to amilorideJournal of Human Lactation.  72:1622-1632. 1997
1996 Kinetic interconversion of rat and bovine homologs of the a-subunit of an amiloride-sensitive Na channel by carboxy terminal truncation of the bovine subunitFederation proceedings.  10. 1996
1996 Kinetic interconversion of rat and bovine homologs of the α subunit of an amiloride-sensitive Na+ channel by C-terminal truncation of the bovine subunitJournal of Biological Chemistry.  271:26602-26608. 1996
1996 A biologic function for an "orphan" messenger: D-myo-Inositol 3,4,5,6-tetrakisphosphate selectively blocks epithelial calcium-activated chloride channelsProceedings of the National Academy of Sciences.  93:10505-10509. 1996
1996 Regulation of epithelial sodium channels by short actin filamentsJournal of Biological Chemistry.  271:17704-17710. 1996
1996 Protein kinase regulation of a cloned epithelial Na+ channelJournal of General Physiology.  108:49-65. 1996
1996 Apical recruitment of CFTR in T-84 cells is dependent on cAMP and microtubules but not Ca2+ or microfilamentsJournal of Cell Science.  109:1325-1334. 1996
1996 Associated proteins and renal epithelial Na+ channel functionJournal of Membrane Biology.  149:123-132. 1996
1996 G-protein regulation of outwardly rectified epithelial chloride channels incorporated into planar bilayer membranesJournal of Biological Chemistry.  271:4776-4780. 1996
1996 Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulatorJournal of Biological Chemistry.  271:4725-4732. 1996
1996 Triple-barrel organization of ENaC, a cloned epithelial Na+ channelJournal of Biological Chemistry.  271:807-816. 1996
1996 Diversity and regulation of amiloride-sensitive Na+ channelsKidney International.  49:1632-1637. 1996
1996 Liddle's disease: Abnormal regulation of amiloride-sensitive Na+ channels by β-subunit mutationLife Science Alliance.  270. 1996
1996 Liddle's disease: abnormal regulation of amiloride-sensitive Na+ channels by beta-subunit mutation.BMC Pharmacology.  270:C208-C213. 1996
1996 Peptide block of constitutively activated Na + channels in Liddle's diseaseLife Science Alliance.  270. 1996
1996 Peptide block of constitutively activated Na+ channels in Liddle's disease.BMC Pharmacology.  270:C214-C223. 1996
1995 Cloning of an epithelial chloride channel from bovine tracheaJournal of Biological Chemistry.  270:31016-31026. 1995
1995 Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channelsJournal of Biological Chemistry.  270:29194-29200. 1995
1995 Cloning of a bovine renal epithelial Na+ channel subunitLife Science Alliance.  269. 1995
1995 Cloning of a bovine renal epithelial Na+ channel subunit.BMC Pharmacology.  269:C641-C654. 1995
1994 Phosphorylation and activation of a bovine tracheal anion channel by Ca2+/calmodulin-dependent protein kinase IIJournal of Biological Chemistry.  269:26642-26649. 1994
1994 Forskolin- but not ionomycin-evoked Cl - secretion in colonic epithelia depends on intact microtubulesBMC Pharmacology.  266. 1994
1994 Forskolin- but not ionomycin-evoked Cl- secretion in colonic epithelia depends on intact microtubulesBMC Pharmacology.  266. 1994
1994 Forskolin- but not ionomycin-evoked Cl- secretion in colonic epithelia depends on intact microtubules.BMC Pharmacology.  266:C661-C668. 1994
1992 Functional reconstitution of a chloride channel protein from bovine tracheaJournal of Biological Chemistry.  267:20630-20637. 1992
1992 CFTR!BMC Pharmacology.  263. 1992
1992 CFTR!BMC Pharmacology.  263:C267-C286. 1992
1992 Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptideBMC Pharmacology.  262. 1992
1992 Peroxynitrite inhibits sodium uptake in rat colonic membrane vesiclesInternational Journal of Genomics.  1104:87-94. 1992
1992 Antibodies against the cystic fibrosis transmembrane regulator.BMC Pharmacology.  262:C396-C404. 1992
1992 Antibodies against the cystic fibrosis transmembrane regulatorBMC Pharmacology.  262. 1992
1991 The physiology and biochemistry of sodium and chloride permeability pathways in epitheliaJournal of Nutritional Biochemistry.  2:348-362. 1991
1989 Secretagogue and second messenger-activated Cl- permeabilities in isolated pancreatic zymogen granulesPflügers Archiv European Journal of Physiology.  415:29-36. 1989
1989 Ionic and osmotic dependence of secretion from permeabilised acini of the rat pancreasPflügers Archiv European Journal of Physiology.  413:385-394. 1989
1987 Cholinergic receptors regulate a voltage-insensitive but Na+-dependent calcium influx pathway in salivary acinar cellsFEBS Letters.  211:195-199. 1987
1987 Cholinergic Receptor-regulation of Potassium Channels and Potassium Transport in Human Submandibular Acinar CellsJournal of Dental Research.  66:541-546. 1987
1985 Human pancreatic acinar cells: Studies of stimulus-secretion couplingGastroenterology.  89:109-117. 1985

Book

Year Title Altmetric
2002 Electrophysiology of the CLCA family.  Ed. 53.  2002

Research Overview

  • Ion channels and signaling in glioma (ASIC, ENaC), channel trafficking and regulation; polycystic kidney disease; epithelial transport.
  • Education And Training

  • Doctor of Philosophy Level Degree in Physiology, University of Liverpool 1986
  • Awards And Honors

  • Argus Award Best Educator in GI Module, Class of 2022, 2019
  • Argus Award, Best MS1 Organ Module, (GI), Class of 2022, 2019
  • Benos Award for Educational Excellence, 2018
  • Argus Award Best Educator in GI Module, Class of 2021, 2018
  • Argus Award, Best MS1 Organ Module, (GI), Class of 2021, 2018
  • Outstanding Reviewer Award, Med. Sci. Edu, 2018
  • Argus Award, Best MS1 Organ Module, (GI), Class of 2020, 2017
  • Argus Award, Best MS1 Organ Module, (GI), Class of 2019, 2016
  • Argus Award Best Educator in GI Module, Class of 2019, 2016
  • Argus Award Best Educator in GI Module, Class of 2018, 2015
  • Argus Award, Best MS1 Organ Module, (GI), Class of 2018, 2015
  • Argus Award, Best MS1 Organ Module, (GI) UASOM Class of 2017, 2014
  • Argus Award, Best MS1 Module Director, UASOM Class of 2017, 2014
  • Argus Award, Best Lecturer in GI Module UASOM Class of 2017, 2014
  • Argus Award, Best Lecturer, UASOM Class of 2016, 2013
  • Argus Award, Best Module, UASOM Class of 2016, 2013
  • President’s Award for Excellence in Teaching, 2013
  • Argus Award, Best Lecturer, UASOM Class of 2015, 2012
  • Argus Award, Best Module, UASOM Class of 2015, 2012
  • Argus Award, Best Module, UASOM Class of 2012, 2010
  • Argus Award, Best Module, UASOM Class of 2011, 2009
  • Argus Award, Small Group Teaching, UASOM Class of 2004, 2000
  • Excellence in Basic Science Teaching Award (President’s Award for Excellence in Teaching), 1997
  • Young Investigator Awardee, 1993
  • Medical Research Council Travel Award to attend I.U.P.S. (European Section) Meeting, 1984
  • Cheeseman Memorial Prize in Physiology, 1982
  • Full Name

  • Catherine Fuller