Positions

Overview

  • Dr. Elmets major research interests focus on environmental influences on the skin and on the immune system. His research has investigated how ultraviolet light and other environmental agents interact with immunological function of the skin. Initial studies in mice showed that in vivo exposure of murine skin produced a local deficiency in the antigen presenting function of skin, thereby resulting in the preferential generation of antigen specific regulatory T-cells. Studies examining the mechanism by which ultraviolet radiation impaired the function of antigen presenting cells in in vitro systems showed that ultraviolet radiation inhibited expression of the adhesion molecule CD54 (ICAM-1), which was at least in part, responsible for deficient activation of T-cells. More recent studies have assessed the cutaneous and immunological effects of photodynamic therapy. Those studies were the first to show that photodynamic therapy has immunosuppressive effects which may reduce the overall efficacy of this form of cancer therapy.

    Another major research interest is the immunogenicity of topically applied chemical carcinogens. Using polyaromatic hydrocarbons as prototypic carcinogenic chemicals, he has shown that topical application of these compounds results in the development of allergic contact hypersensitivity. Metabolism of the compounds is required for the development of this response which only occurs in mice with certain MHC haplotypes and in Ah receptor positive strains of mice. Bases on these results, he has developed the hypothesis that the presence of allergic contact hypersensitivity to polyaromatic hydrocarbons serves to protect mice from the carcinogenic effects of these agents. In support of this hypothesis, he has shown the MHC congenic strains of mice that do not develop polyaromatic hyrdrocarbon contact hypersensitivity are at increased risk for development of skin cancers by those agents.

    A third area of research interest is in chemoprevention of skin cancer. In both animals and humans green tea polyphenols have a protective effect on UV-induced damage to the skin. He has shown in animals that this agent protects against UV induced immunosuppression and in humans it prevents the clinical and histological features of sunburn reaction and DNA damage. He is also investigating whether celecoxib exerts a chemopreventive effect against actinic keratoses in humans and whether topical application of DNA repair enzymes will prevent the development of non-melanoma skin cancers in renal transplant patients.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy 2019
    2019 Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities 2019
    2019 Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics 2019
    2019 Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome 2019
    2019 CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses 2019
    2018 Retraction: (–)-epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12–dependent DNA repair (Cancer Research (2006) 66 (5512–5520) DOI: 10.1158/0008-5472.CAN-06-0218) 2018
    2018 Retraction: Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors (Cancer Research (2007) 67 (3785–3793) DOI: 10.1158/0008-5472.CAN-06-3134) 2018
    2018 Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial 2018
    2018 The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis 2018
    2018 Addressing potential conflicts of interest in dermatology clinical practice guidelines 2018
    2018 On the role of classical and novel forms of vitamin D in melanoma progression and management 2018
    2018 Editorial 2018
    2018 Tea polyphenols for the prevention of UVB-induced skin cancer 2018
    2017 Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond 2017
    2017 Loss of INK4a/Arf gene enhances ultraviolet radiation-induced cutaneous tumor development 2017
    2017 Association of vitamin D receptor polymorphisms with the risk of nonmelanoma skin cancer in adults 2017
    2017 Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1+/−/SKH-1 Hairless Mice 2017
    2017 The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study 2017
    2017 Vitamin D signaling and melanoma: Role of Vitamin D and its receptors in melanoma progression and management 2017
    2017 IL-23 Inhibits Melanoma Development by Augmenting DNA repair and modulating T cell subpopulations 2017
    2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype 2016
    2016 Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions 2016
    2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes 2016
    2016 Phytochemicals for the management of melanoma 2016
    2016 To the Editor 2016
    2016 A murine model for the development of melanocytic nevi and their progression to melanoma 2016
    2016 Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermis 2016
    2016 Anti-IL-17 Medications Used in the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review 2016
    2016 Polypodium leucotomos - An overview of basic investigative findings 2016
    2016 Secukinumab (AIN-457) for the treatment of Psoriasis 2016
    2016 A Histological Snapshot of Hypothetical Multistep Progression from Nevus Sebaceus to Invasive Syringocystadenocarcinoma Papilliferum 2016
    2016 Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma 2016
    2016 Primary Cutaneous T-cell Lymphoma with Coexpression of T-Cell Receptors αβ and γδ 2016
    2015 Erratum: Vitamin D and skin cancer (Photochemistry and Photobiology 91:1 (204) 10.1111/php.12382) 2015
    2015 Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation 2015
    2015 Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice 2015
    2015 Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells 2015
    2015 Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutations 2015
    2015 In vivo suppression of heat shock protein (HSP)27 and HSP70 accelerates DMBA-induced skin carcinogenesis by inducing antigenic unresponsiveness to the initiating carcinogenic chemical 2015
    2015 Interleukin-17 mediated inflammatory responses are required for ultraviolet radiation-induced immune suppression 2015
    2015 Long-standing spicules in a patient with acute lymphoblastic Leukemia 2015
    2015 Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis 2015
    2015 Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome 2015
    2015 Tanning accelerators: Prevalence, predictors of use, and adverse effects 2015
    2015 Targeting drivers of melanoma with synthetic small molecules and phytochemicals 2015
    2015 Vitamin D and skin cancer 2015
    2014 Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch 2014
    2014 Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway 2014
    2014 Guidelines of care for the management of atopic dermatitis: Section 1. Diagnosis and assessment of atopic dermatitis Work Group 2014
    2014 Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways 2014
    2014 A randomized, double-blind, placebo-controlled phase II clinical trial of lovastatin for various endpoints of melanoma pathobiology 2014
    2014 Cyclooxygenases: Mediators of UV-induced skin cancer and potential targets for prevention 2014
    2014 Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies 2014
    2014 Guidelines of care for the management of atopic dermatitis: Section 3. Management and treatment with phototherapy and systemic agents 2014
    2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches Work Group 2014
    2014 Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in ptch+/- mice 2014
    2014 Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development 2014
    2014 Photoimmunology 2014
    2014 Research gaps in psoriasis: Opportunities for future studies 2014
    2014 The mechanistic basis of arsenicosis: Pathogenesis of skin cancer 2014
    2014 Toll-like receptor-4 deficiency enhances repair of UVR-induced cutaneous DNA damage by nucleotide excision repair mechanism 2014
    2013 Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by Targeting Akt-ERK axis 2013
    2013 Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption 2013
    2013 Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling Pathways 2013
    2013 Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein 2013
    2013 Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: Role of mitochondrial membrane potential disruption and consequent caspases activation 2013
    2013 Introduction to milestones in photobiology. 2013
    2013 Milestones in photocarcinogenesis. 2013
    2013 Atypical presentation of exophytic herpes simplex virus type 2 with concurrent cytomegalovirus infection: A significant pitfall in diagnosis 2013
    2013 Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis 2013
    2013 Silymarin inhibits ultraviolet radiation-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells 2013
    2013 Bioactive grape proanthocyanidins enhance immune reactivity in UV-irradiated skin through functional activation of dendritic cells in mice 2013
    2013 Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model 2013
    2013 Introduction to milestones in photobiology. 2013
    2013 Milestones in photocarcinogenesis. 2013
    2013 Palmoplantar pustulosis with fulminant dystrophic 20-nail psoriasis in a patient receiving adalimumab therapy 2013
    2013 To the editor 2013
    2012 Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway 2012
    2012 Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis 2012
    2012 Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs 2012
    2012 Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cells 2012
    2012 Skin cancer risk perceptions: A comparison across ethnicity, age, education, gender, and income 2012
    2012 IL-17 mediated inflammation promotes tumor growth and progression in the skin 2012
    2012 Dermatologic Health Disparities 2012
    2012 UVB immunosuppression: Vitamin D or not vitamin D? That is the question 2012
    2011 Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammation 2011
    2011 Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathway 2011
    2011 Liver Kinase B1 (LKB1) in the pathogenesis of epithelial cancers 2011
    2011 Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway 2011
    2011 Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma 2011
    2011 Pathogenesis of nonmelanoma skin cancers in organ transplant recipients 2011
    2011 Interest in cosmetic improvement as a marker for tanning behavior: A survey of 1602 respondents 2011
    2011 New Agents for Prevention of Ultraviolet-Induced Nonmelanoma Skin Cancer 2011
    2011 Proanthocyanidins inhibit UV-induced immunosuppression through IL-12-dependent stimulation of CD8 + effector T cells and inactivation of CD4 + T cells 2011
    2011 Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: Case-based presentations and evidence-based conclusions 2011
    2011 Pharmacological Activation of p53 in Cancer Cells 2011
    2011 Prospects for skin cancer treatment and prevention: The potential contribution of an engineered virus 2011
    2010 Chemoprevention of nonmelanoma skin cancer with celecoxib: A randomized, double-blind, placebo-controlled trial 2010
    2010 Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis 2010
    2010 The other end of the rainbow: Infrared and skin 2010
    2010 IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells 2010
    2010 Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy 2010
    2010 Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans 2010
    2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model 2010
    2009 IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation 2009
    2009 Tanning beds are human carcinogens: Report from the WHO International Agency for Research on Cancer 2009
    2009 Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents 2009
    2009 Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis 2009
    2009 IL-17 and IFN-γ mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses 2009
    2009 Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies 2009
    2009 Use of genetic tools to control tumor margins in melanoma 2009
    2009 Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity 2009
    2008 The safety and efficacy of high-dose alefacept compared with a loading dose of alefacept in patients with chronic plaque psoriasis 2008
    2008 Infliximab for the treatment of severe pustular psoriasis: 6 Years later 2008
    2008 A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis 2008
    2008 T4 endonuclease V: Review and application to dermatology 2008
    2008 Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis 2008
    2008 Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics 2008
    2008 Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 2. Psoriatic arthritis: Overview and guidelines of care for treatment with an emphasis on the biologics 2008
    2008 DNA damage, apoptosis and Langerhans cells - Activators of UV-induced immune tolerance 2008
    2008 Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis (Cancer Research (2008) 68, (615-622)) 2008
    2008 The immunosuppressive effects of phthalocyanine photodynamic therapy in mice are mediated by CD4+ and CD8+ T cells and can be adoptively transferred to naive recipients 2008
    2008 Utilization of narrow-band ultraviolet light B therapy and etanercept for the treatment of psoriasis (UNITE): Efficacy, safety, and patient-reported outcomes 2008
    2008 Safety and efficacy of subcutaneously administered efalizumab in adults with moderate-to-severe hand and foot psoriasis: An open-label study 2008
    2008 Protective role of toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis 2008
    2008 Osteopontin expression in normal skin and non-melanoma skin tumors 2008
    2008 Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma 2008
    2007 Quantitative proteomes and in vivo secretomes of progressive and regressive UV-induced fibrosarcoma tumor cells: Mimicking tumor microenvironment using a dermis-based cell-trapped system linked to tissue chamber 2007
    2007 Acquired and innate immunity to polyaromatic hydrocarbons 2007
    2007 Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair 2007
    2007 Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors 2007
    2007 New opportunities in preventative dermatology: How far should we go? 2007
    2007 Photoprotective effects of green tea polyphenols 2007
    2006 An animal model of psoriasis in mice deficient in epidermal Jun proteins 2006
    2006 CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. 2006
    2006 CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses 2006
    2006 A new method to test the effectiveness of sunscreen ingredients in a novel nano-surface skin cell mimic 2006
    2006 CD4 T cell-induced, bid-dependent apoptosis of cutaneous dendritic cells regulates T cell expansion and immune responses 2006
    2006 Fluorescence of sunscreens adsorbed to dielectric nanospheres: Parallels to optical behavior on HaCat cells and skin 2006
    2006 In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics 2006
    2006 Mass spectrometric proteomics profiles of in vivo tumor secretomes: Capillary ultrafiltration sampling of regressive tumor masses 2006
    2006 UVA1 phototherapy for cutaneous diseases: An experience of 92 cases in the United States 2006
    2006 Papilloma development is delayed in osteopontin-null mice: Implicating an antiapoptosis role for osteopontin 2006
    2006 Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice 2006
    2006 (-)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair 2006
    2006 High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals 2006
    2006 Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas 2006
    2006 In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomics 2006
    2006 Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics 2006
    2005 Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors 2005
    2005 Selective cyclooxygenase-2 inhibition produces heterogeneous erythema response to ultraviolet irradiation [3] 2005
    2005 Proteomic characterization of skin and epidermis in response to environmental agents 2005
    2005 Prospective highlights of functional skin proteomics 2005
    2005 Non-melanoma skin cancer in patients with atopic dermatitis treated with topical tacrolimus 2005
    2005 A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen 2005
    2005 Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans 2005
    2005 Grape seed proanthocyanidins induce apoptosis through p53, bax, and caspase 3 pathways 2005
    2004 Identification of Bacillus anthracis proteins associated with germination and early outgrowth by proteomic profiling of anthrax spores 2004
    2004 Topical application of dimethylbenz[a]anthracene results in the generation of multiple melanocytic nevi in C3H/HeN mice 2004
    2004 Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin 2004
    2004 Photodynamic Therapy of Multiple Nonmelanoma Skin Cancers with Verteporfin and Red Light-Emitting Diodes Two-Year Results Evaluating Tumor Response and Cosmetic Outcomes 2004
    2004 Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs. 2004
    2003 Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses 2003
    2003 Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation 2003
    2003 Comparative proteomic profiling of murine skin 2003
    2003 Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin 2003
    2003 CD11b+ Cells are the Major Source of Oxidative Stress in UV Radiation-irradiated Skin: Possible Role in Photoaging and Photocarcinogenesis 2003
    2001 Green tea polyphenols: DNA photodamage and photimmunology 2001
    2001 Host defense mechanisms in polyaromatic hydrocarbon carcinogenesis 2001
    2001 Protection against tetanus by needle-free inoculation of adenovirus-vectored nasal and epicutaneous vaccines 2001
    2001 The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node 2001
    2001 The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. 2001
    2001 AdEasy system made easier by selecting the viral backbone plasmid preceding homologous recombination 2001
    2001 A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma 2001
    2001 Cutaneous photoprotection from ultraviolet injury by green tea polyphenols 2001
    2001 Green tea polyphenolic antioxidants and skin photoprotection (Review). 2001
    2000 Drug-induced photosensitivity with antimycotics 2000
    2000 Sensitization versus elicitation in allergic contact dermatitis: Potential differences at cellular and molecular levels 2000
    1999 Polyphenolic Antioxidant (-)-Epigallocatechin-3-Gallate from Green Tea Reduces UVB-Induced Inflammatory Responses and Infiltration of Leukocytes in Human Skin 1999
    1999 Immunosuppressive effects of silicon phthalocyanine photodynamic therapy 1999
    1999 Phthalocyanine 4 (Pc 4) Photodynamic Therapy of Human OVCAR-3 Tumor Xenografts 1999
    1998 Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex 1998
    1998 A Comparative Analysis of Silicon Phthalocyanine Photosensitizers for in vivo Photodynamic Therapy of RIF-1 Tumors in C3H Mice 1998
    1997 Induction of Biologically Active IL-1β-Converting Enzyme and Mature IL-1β in Human Keratinocytes by Inflammatory and Immunologic Stimuli 1997
    1997 Genotypic differences in host immunoreactivity and their effect on the development of polycyclic hydrocarbon-induced tumors 1997
    1997 Analysis of tumor-infiltrating lymphocytes in cutaneous squamous cell carcinoma 1997
    1997 ICAM-1 mRNA levels and relative transcription rates are decreased by UV irradiation of monocytes 1997
    1997 Genetic variation in low-dose UV-induced suppression of contact hypersensitivity and in the skin photocarcinogenesis response 1997
    1997 High incidence of Kaposi's sarcoma-associated herpesvirus and Epstein- Barr virus in tumor lesions and peripheral blood mononuclear cells from patients with Kaposi's sarcoma in Uganda 1997
    1997 Phthalocyanine photodynamic therapy: Disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression 1997
    1996 Progress in the development of an in vitro assay for contact allergens: Results of the avon program project experience 1996
    1996 In situ changes in the relative abundance of human epidermal cytokine messenger RNA levels following exposure to the poison ivy/oak contact allergen urushiol 1996
    1996 Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells 1996
    1996 Photocarcinogenesis: Mechanisms, models and human health implications 1996
    1996 Sunscreens and photocarcinogenesis: An objective assessment 1996
    1995 Cutaneous photosensitivity diseases induced by exogenous agents 1995
    1995 Hyperfocal Cryotherapy of Multiple Molluscum contagiosum Lesions in Patients with the Acquired Immune Deficiency Syndrome 1995
    1995 Messenger RNAs for the multifunctional cytokines interleukin‐1α, interleukin‐1β and tumor necrosis factor‐α are present in adnexal tissues and in dermis of normal human skin 1995
    1995 Metabolic requirements for induction of contact hypersensitivity to immunotoxic polyaromatic hydrocarbons 1995
    1995 PROTECTION AGAINST ULTRAVIOLET‐B RADIATION‐INDUCED LOCAL and SYSTEMIC SUPPRESSION OF CONTACT HYPERSENSITIVITY and EDEMA RESPONSES IN C3H/HeN MICE BY GREEN TEA POLYPHENOLS 1995
    1995 Photocarcinogenesis 1995
    1995 Photoexacerbation of cutaneous lupus erythematosus due to ultraviolet a emissions from a photocopier 1995
    1995 Reduced growth factor requirements and accelerated cell-cycle kinetics in adult human melanocytes transformed with SV40 large T antigen 1995
    1994 Management of common superficial fungal infections in patients with AIDS. 1994
    1994 An inflammatory eruption associated with recombinant human IL‐6 1994
    1994 In situ detection of cytokine messenger RNAs in the eccrine sweat gland of normal human skin 1994
    1994 Management of common superficial fungal infections in patients with AIDS 1994
    1993 In Situ expression of a B7-like adhesion molecule on keratinocytes from human epidermis 1993
    1993 MODULATION OF INTERFERON‐GAMMA‐INDUCED HLA‐DR EXPRESSION ON THE HUMAN KERATINOCYTE CELL LINE SCC‐13 BY ULTRAVIOLET RADIATION 1993
    1992 Photoprotective effects of sunscreens in cosmetics on sunburn and Langerhans cell photodamage 1992
    1992 Ultraviolet B-irradiated antigen-presenting cells display altered accessory signaling for T-cell activation: relevance to immune responses initiated in skin. 1992
    1992 Immunogenetic Influences on the Initiation Stage of the Cutaneous Chemical Carcinogenesis Pathway 1992
    1992 PHOTODYNAMIC THERAPY OF CHEMICALLY‐ AND ULTRAVIOLET B RADIATION‐INDUCED MURINE SKIN PAPILLOMAS BY CHLOROALUMINUM PHTHALOCYANINE TETRASULFONATE 1992
    1992 Ultraviolet B - irradiated antigen-presenting cells display altered accessory signaling for T-cell activation: Relevance to immune responses initiated in skin 1992
    1992 Ultraviolet-irradiated monocytes efficiently inhibit the intracellular replication of mycobacterium avium intracellulare 1992
    1991 Photodynamic therapy of murine skin tumors using Photofrin®-II 1991
    1991 Eosinophilic pustular folliculitis. 1991
    1991 Eosinophilie pustular folliculitis 1991
    1991 Improvement in severe onchocercal skin disease after a single dose of ivermectin 1991
    1991 The accessory function of B lymphocytes is resistant to the adverse effects of UV radiation 1991
    1990 Cell membrane is a major locus for ultraviolet B-induced alterations in accessory cells 1990
    1990 UVB radiation and human monocyte accessory function: Differential effects on pre-mitotic events in T-cell activation 1990
    1989 Leukocytoclastic vasculitis in a patient infected with human immunodeficiency virus. 1989
    1989 Effects of occlusive and semiocclusive dressings on the return of barrier function to transepidermal water loss in standardized human wounds. 1989
    1989 A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway 1989
    1989 Effects of occlusive and semiocclusive dressings on the return of barrier function to transepidermal water loss in standardized human wounds 1989
    1989 Inhibition of the high affinity Fc receptor (Fc(γ)RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals 1989
    1989 Leukocytoclastic vasculitis in a patient infected with human immunodeficiency virus 1989
    1988 In situ evidence for the involvement of superoxide anions in cutaneous porphyrin photosensitization 1988
    1988 Impaired immunological surveillance by 7,12-dimethylbenz(a)anthracene augments its skin tumorigenicity in C3H mice 1988
    1988 Involvement of superoxide anions in cutaneous porphyrin photosensitization: An in vivo study 1988
    1988 Recent studies on mechanisms in photoimmunology. 1988
    1987 Deleterious effect of ultraviolet-B radiation on accessory function of human blood adherent mononuclear cells 1987
    1987 Induction of Contact Hypersensitivity to Dimethylbenz(a)anthracene and Benzo(a)pyrene in C3N/HeN Mice1 1987
    1987 Inhibition of postbinding target cell lysis and of lymphokine-induced enhancement of human natural killer cell activity by in vitro exposure to ultraviolet B radiation 1987
    1987 Molluscum contagiosum and the acquired immunodeficiency syndrome: clinical and immunological details of two cases 1987
    1986 Immunological suppression in mice treated with hematoporphyrin derivative photoradiation. 1986
    1986 Relation between Complications of Type I Diabetes Mellitus and Collagen-Linked Fluorescence 1986
    1986 Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy 1986
    1986 Cutaneous porphyrin photosensitization: Murine ear swelling as a marker of the acute response 1986
    1986 Drug-induced photoallergy 1986
    1986 Glycation of skin collagen in type I diabetes mellitus. Correlation with long-term complications 1986
    1986 Immunohistologic identification of antigen-presenting cells in cutaneous sarcoidosis 1986
    1985 Molluscum contagiosum and the acquired immunodeficiency syndrome. 1985
    1985 ACTION SPECTRUM STUDIES FOR INDUCTION OF IMMUNOLOGIC UNRESPONSIVENESS TO DINITROFLUOROBENZENE FOLLOWING IN VIVO LOW DOSE ULTRAVIOLET RADIATION 1985
    1985 Low dose ultraviolet B (UVB) radiation inhibits in vitro correlates of dinitrofluorobenzene (DNFB) contact hypersensitivity 1985
    1983 Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation 1983
    1983 Phenotypic characterization of cutaneous infiltrates. 1983
    1982 Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity 1982
    1982 Differential distribution of Langerhans cells organ culture of human skin 1982
    1982 ULTRAVIOLET RADIATION EFFECTS ON IMMUNE PROCESSES 1982
    1980 Amelanotic melanoma present as a pyogenic granuloma 1980
    1979 Complications with heparin-lock needles 1979
    1979 Complications With Heparin-Lock Needles 1979
    1979 Brain tuberculoma. Diagnosis and treatment. 1979

    Book

    Year Title Altmetric
    2009 Dermatological phototherapy and photodiagnostic methods 2009

    Chapter

    Year Title Altmetric
    2017 UV and skin: Photocarcinogenesis.  67-103. 2017
    2012 Host defenses in the skin.  228-238. 2012
    2011 Systemic and topical use of green tea polyphenols for healthy skin.  71-83. 2011
    2009 Green Tea and Skin Cancer: Immunological Modulation and DNA Repair.  471-499. 2009
    2009 Mechanisms of photo(chemo)therapy.  63-77. 2009
    2009 Photodynamic therapy in dermatology.  241-280. 2009
    2005 Photoprotection by green tea polyphenols.  639-656. 2005

    Research Overview

  • Keywords - psoriasis, contact dermatitis, photosensitivity diseases, phototherapy
  • Principal Investigator On

  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Core 1: Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Program Integration and Management  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Project 1: Evaluation if UAB30 on Skin Cancer Biomarkers in Human Renal Transplant Recipients  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by IDERA PHARMACEUTICALS, INC. 2016 - 2021
  • Topical Chemoprevention of Skin Cancer Biomarkers  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Private Grant  awarded by SOLIGENIX, INC 2015 - 2020
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2017 - 2020
  • Private Grant  awarded by ELORAC, INC. 2017 - 2020
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Dietary Prevention of Photodamage in Skin with Grapes: A Human Clinical Study  awarded by California Table Grape Commission 2014 - 2018
  • Private Grant  awarded by KYOWA PHARMACEUTICAL, INC. 2014 - 2018
  • Cancer Prevention Agent Development Program: Early Phase Clinical Research  awarded by University of Wisconsin-Madison 2012 - 2018
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • UAB Skin Disease Research Center - Administrative Core - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • The Effect of Polypodium Leucotomos on UV-Induced Photodamage in Skin  awarded by HENRY FORD HOSPITAL 2014 - 2015
  • Private Grant  awarded by ABBOTT LABORATORIES 2008 - 2014
  • Private Grant  awarded by AMGEN, INC. 2012 - 2014
  • Private Grant  awarded by AMGEN, INC. 2011 - 2013
  • Private Grant  awarded by ABBVIE INC 2008 - 2013
  • A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of Lovastatin for Various Endpoints of Melanoma Pathobiology  awarded by University of California, Irvine 2009 - 2012
  • Private Grant  awarded by ALLERGAN, INC. 2009 - 2012
  • Private Grant  awarded by BASILEA PHARMACEUTICA LTD 2009 - 2012
  • Training in Investigative Dermatology  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • A Phase IIB Randomized, Placebo-Controlled Trial of Pioglitazone for Oral Pre-Malignant Lesions: An Inter-Consortium Collaborative Study  awarded by University of Wisconsin-Madison 2010 - 2011
  • Private Grant  awarded by BIOGEN, INC. 2006 - 2011
  • Private Grant  awarded by Genentech 2008 - 2011
  • Investigator On

  • Private Grant  awarded by MIRAGEN THERAPEUTICS INC. 2019 - 2024
  • Mechanism of Ultraviolet Radiation Induced Immune Tolerance  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • Mechanism of Action and Function of Novel Secosteroid 20(OH)D3 in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2023
  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Significance of Metabolic Activation of Lumisterol in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Chemoprevention of Environmental UVB-Induced Skin Cancer in Immunosuppressed Mice  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Blocking Arsenicals-Induced Cutaneous Injury  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2020
  • Pharmacological Management of Ultraviolet Radiation Induced Skin Cancer  awarded by DOD - Department of Defense 2018 - 2020
  • Mechanisms of Ultraviolet Radiation Induced Immune Suppression  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2015 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Private Grant  awarded by JANSSEN RESEARCH & DEVELOPMENT, LLC 2017 - 2018
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer  awarded by National Cancer Institute/NIH/DHHS 2011 - 2017
  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by ABBVIE INC 2012 - 2016
  • Private Grant  awarded by Solvay Pharmaceuticals, Inc. 2010 - 2014
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2009 - 2013
  • Bid Regulation of Cutaneous Photodamage Responses  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2013
  • Teaching Activities

  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2018) 2018
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2018) 2018
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2018) 2018
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-502 - DERMATOLOGY RESEARCH (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-502 - DERMATOLOGY RESEARCH (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-502 - DERMATOLOGY RESEARCH (Spring Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2016) 2016
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2016) 2016
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Fall Term 2015) 2015
  • 16-509 - VISITING ELECTIVE IN CANCER DERMATOLOGY (Spring Term 2012) 2012
  • 10-999D - SCHOLARS' WEEK EXPERIENCE IN DERMATOLOGY (Fall Term 2009) 2009
  • Full Name

  • Craig Elmets