Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Cyclic Pattern of Intraocular Pressure (IOP) and Transient IOP Fluctuations in Nonhuman Primates Measured with Continuous Wireless Telemetry.  Southern Online Journal of Nursing Research (SOJNR).  44:1244-1252. 2019
2019 The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model.  Investigative Ophthalmology & Visual Science.  60:4141-4150. 2019
2019 Effect of Anesthesia on Intraocular Pressure Measured With Continuous Wireless Telemetry in Nonhuman Primates.  Investigative Ophthalmology & Visual Science.  60:3830-3834. 2019
2019 Transient intraocular pressure fluctuations: Source, magnitude, frequency, and associated mechanical energy.  Investigative Ophthalmology & Visual Science.  60:2572-2582. 2019
2019 Bayesian Semiparametric Functional Mixed Models for Serially Correlated Functional Data, With Application to Glaucoma Data.  Journal of the American Statistical Association.  114:495-513. 2019
2019 The Magnitude of Intraocular Pressure Elevation Associated with Eye Rubbing.  Ophthalmology: Journal of The American Academy of Ophthalmology.  126:171-172. 2019
2018 A novel tree shrew (Tupaia belangeri) model of glaucoma.  Investigative Ophthalmology & Visual Science.  59:3136-3143. 2018
2017 The magnitude and time course of IOP change in response to body position change in nonhuman primates measured using continuous IOP telemetry.  Investigative Ophthalmology & Visual Science.  58:6232-6240. 2017
2017 Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: Lamina cribrosa and peripapillary scleral thickness and position.  Investigative Ophthalmology & Visual Science.  58:3759-3769. 2017
2017 The Magnitude of Hypotony and Time Course of Intraocular Pressure Recovery Following Anterior Chamber Cannulation in Nonhuman Primates.  Investigative Ophthalmology & Visual Science.  58:3225-3230. 2017
2017 Lamina cribrosa in glaucoma.  Bioprocessing Journal.  28:113-119. 2017
2016 Image-based quantification of fiber alignment within electrospun tissue engineering scaffolds is related to mechanical anisotropy.  Journal of Biomedical Materials Research Part A.  104:1680-1686. 2016
2016 Nanofiber alignment regulates NIH3T3 cell orientation and cytoskeletal gene expression on electrospun PCL+gelatin nanofibers.  PLoS ONE.  11. 2016
2015 High-magnitude and/or high-frequency mechanical strain promotes peripapillary scleral myofibroblast differentiation.  Investigative Ophthalmology & Visual Science.  56:7821-7830. 2015
2015 Physical factors affecting outflow facility measurements in mice.  Investigative Ophthalmology & Visual Science.  56:8331-8339. 2015
2015 IOP telemetry in the nonhuman primate.  Experimental Eye Research.  141:91-98. 2015
2015 Optic nerve head biomechanics in aging and disease.  Experimental Eye Research.  133:19-29. 2015
2015 Peripapillary choroidal thickness variation with age and race in normal eyes.  Investigative Ophthalmology & Visual Science.  56:1872-1879. 2015
2015 Lamina cribrosa microarchitecture in normal monkey eyes part 1: Methods and initial results.  Investigative Ophthalmology & Visual Science.  56:1618-1637. 2015
2015 Schiotz tonometry accurately measures intraocular pressure in Boston type 1 keratoprosthesis eyes.  Current Womens Health Reports.  34:682-685. 2015
2015 The Thrombospondin1-TGF-β Pathway and Glaucoma.  Journal of Ocular Pharmacology and Therapeutics.  31:371-375. 2015
2014 The promise of prediction: Biomechanical analyses in neuro-ophthalmology.  Journal of Neuro-Ophthalmology.  34:321-323. 2014
2014 Variation of laminar depth in normal eyes with age and race.  Investigative Ophthalmology & Visual Science.  55:8123-8133. 2014
2014 Human scleral structural stiffness increases more rapidly with age in donors of African descent compared to donors of European descent.  Investigative Ophthalmology & Visual Science.  55:7189-7198. 2014
2014 Age-and race-related differences in human scleral material properties.  Investigative Ophthalmology & Visual Science.  55:8163-8172. 2014
2014 The role of matricellular proteins in glaucoma.  Synapse.  37:174-182. 2014
2014 Age-related changes in human peripapillary scleral strain.  Journal of Clinical Psychopharmacology.  13:551-563. 2014
2014 Age-related differences in longitudinal structural change by spectral-domain optical coherence tomography in early experimental glaucoma.  Investigative Ophthalmology & Visual Science.  55:6409-6420. 2014
2014 Material properties of the posterior human sclera.  Journal of the Mechanical Behavior of Biomedical Materials.  29:602-617. 2014
2013 A forward incremental prestressing method with application to inverse parameter estimations and eye-specific simulations of posterior scleral shells.  Revista Chilena de Infectología.  16:768-780. 2013
2012 Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma.  Experimental Eye Research.  103:1-8. 2012
2012 Regional variations in mechanical strain in the posterior human sclera.  Investigative Ophthalmology & Visual Science.  53:5326-5333. 2012
2012 Compensation method for obtaining accurate, sub-micrometer displacement measurements of immersed specimens using electronic speckle interferometry.  Journal of Investigative Medicine.  3:407-417. 2012
2012 Lamina cribrosa thickening in early glaucoma predicted by a microstructure motivated growth and remodeling approach.  Mechanics of Materials.  44:99-109. 2012
2012 Perspectives on biomechanical growth and remodeling mechanisms in glaucoma.  Mechanics Research Communications.  42:92-106. 2012
2011 IOP-induced lamina cribrosa deformation and scleral canal expansion: Independent or related?.  Investigative Ophthalmology & Visual Science.  52:9023-9032. 2011
2011 24-hour IOP telemetry in the nonhuman primate: implant system performance and initial characterization of IOP at multiple timescales..  Investigative Ophthalmology & Visual Science.  52:7365-7375. 2011
2011 Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma..  Investigative Ophthalmology & Visual Science.  52:7109-7121. 2011
2011 Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism.  Experimental Eye Research.  93:133-140. 2011
2011 Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations..  Investigative Ophthalmology & Visual Science.  52:5656-5669. 2011
2011 IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models..  Investigative Ophthalmology & Visual Science.  52:1896-1907. 2011
2011 Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions.  Investigative Ophthalmology & Visual Science.  52:345-363. 2011
2010 Changes in the biomechanical response of the optic nerve head in early experimental glaucoma..  Investigative Ophthalmology & Visual Science.  51:5675-5684. 2010
2010 Morphing methods to parameterize specimen-specific finite element model geometries.  Journal of Biomechanics.  43:254-262. 2010
2010 Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes.  Investigative Ophthalmology & Visual Science.  51:295-307. 2010
2009 Comparison of clinical and three-dimensional histomorphometric optic disc margin anatomy.  Investigative Ophthalmology & Visual Science.  50:2165-2174. 2009
2009 Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions.  Investigative Ophthalmology & Visual Science.  50:5785-5799. 2009
2009 Impact of systemic blood pressure on the relationship between intraocular pressure and blood flow in the optic nerve head of nonhuman primates.  Investigative Ophthalmology & Visual Science.  50:2154-2160. 2009
2009 The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness, and retardance.  Investigative Ophthalmology & Visual Science.  50:4719-4726. 2009
2009 Scleral biomechanics in the aging monkey eye.  Investigative Ophthalmology & Visual Science.  50:5226-5237. 2009
2009 Peripapillary and posterior scleral mechanics - Part I: Development of an anisotropic hyperelastic constitutive model.  Journal of Biomechanical Engineering.  131. 2009
2009 Peripapillary and posterior scleral mechanics - Part II: Experimental and inverse finite element characterization.  Journal of Biomechanical Engineering.  131. 2009
2009 Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma.  Investigative Ophthalmology & Visual Science.  50:681-690. 2009
2009 Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data sets.  Investigative Ophthalmology & Visual Science.  50:214-223. 2009
2009 Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye..  実践哲学研究.  4277-4280. 2009
2009 Physiologic intereye differences in monkey optic nerve head architecture and their relation to changes in early experimental glaucoma.  Investigative Ophthalmology & Visual Science.  50:224-234. 2009
2008 Experimental surface strain mapping of porcine peripapillary sclera due to elevations of intraocular pressure.  Journal of Biomechanical Engineering.  130. 2008
2008 Experimental surface strain mapping of porcine peripapillary sclera due to elevations of intraocular pressure.  Journal of Biomechanical Engineering.  130. 2008
2008 Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head.  Journal of Glaucoma.  17:318-328. 2008
2008 Mechanical Environment of the Optic Nerve Head in Glaucoma.  Optometry and Vision Science.  85:E425-E435. 2008
2007 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Prelaminar neural tissues and cupping.  Investigative Ophthalmology & Visual Science.  48:5068-5084. 2007
2007 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Lamina cribrosa and peripapillary scleral position and thickness.  Investigative Ophthalmology & Visual Science.  48:4597-4607. 2007
2007 Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: Neural canal and subarachnoid space architecture.  Investigative Ophthalmology & Visual Science.  48:3195-3208. 2007
2007 Effects of storage time on the mechanical properties of rabbit peripapillary sclera after enucleation.  Southern Online Journal of Nursing Research (SOJNR).  32:465-470. 2007
2006 A cellular solid model of the lamina cribrosa: Mechanical dependence on morphology.  Journal of Biomechanical Engineering.  128:879-889. 2006
2006 Segmentation of trabeculated structures using an anisotropic markov random field: Application to the study of the optic nerve head in glaucoma.  IEEE Transactions on Medical Imaging.  25:245-255. 2006
2005 Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes.  Investigative Ophthalmology & Visual Science.  46:540-546. 2005
2005 The optic nerve head as a biomechanical structure: A new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage.  Progress in Retinal and Eye Research.  24:39-73. 2005
2004 Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissues.  Investigative Ophthalmology & Visual Science.  45:4388-4399. 2004
2004 Tethered protein/peptide-surface-modified hydrogels.  Journal of Biomaterials Science, Polymer Edition.  15:905-916. 2004
2004 Time Scale for Periosteal Readhesion after Brow Lift.  Laryngoscope.  114:50-55. 2004
2003 Anterior scleral canal geometry in pressurised (IOP 10) and non-pressurised (IOP 0) normal monkey eyes.  Nature Reviews Neurology.  87:1284-1290. 2003
2003 Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma.  Investigative Ophthalmology & Visual Science.  44:623-637. 2003
2003 Viscoelastic characterization of peripapillary sclera: Material properties by quadrant in rabbit and monkey eyes.  Journal of Biomechanical Engineering.  125:124-131. 2003
2002 Peripapillary scleral thickness in perfusion-fixed normal monkey eyes.  Investigative Ophthalmology & Visual Science.  43:2229-2235. 2002
2002 Periosteal readhesion after brow-lift in New Zealand white rabbits..  Journal of Cardiac Failure.  4:248-251. 2002
2001 Posterior scierai thickness in perfusion-fixed normal and early-glaucoma monkey eyes.  Investigative Ophthalmology & Visual Science.  42:3202-3208. 2001

Chapter

Year Title Altmetric
2016 Glaucoma and structure-based mechanics of the lamina cribrosa at multiple scales.  93-122. 2016
2015 Mechanical Strain and Restructuring of the Optic Nerve Head.  67-87. 2015
2010 Biomechanical changes of the optic disc.  153-164. 2010
2010 Clinical cupping: Laminar and prelaminar components.  185-194. 2010

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Tulane University 2002

    • Full Name

  • J. Crawford Downs