Selected Publications

Academic Article

Year Title Altmetric
2022 Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest developmentDevelopmental Biology.  492:14-24. 2022
2022 Assays for Apical Constriction Using the Xenopus ModelMethods in Molecular Biology.  2438:415-437. 2022
2021 Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in XenopusDevelopmental Dynamics.  250:1113-1124. 2021
2021 The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomouslyDevelopmental Biology.  470:10-20. 2021
2021 Imaging of dynamic actin remodeling reveals distinct behaviors of head and trunk mesoderm in gastrulating Xenopus laevis.microPublication Biology.  2021. 2021
2020 STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cellsNature Communications.  11. 2020
2020 The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signalingDevelopmental Biology.  463:169-181. 2020
2019 A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathwayFrontiers in Physiology.  10. 2019
2018 The RhoGEF protein plekhg5 regulates apical constriction of bottle cells during gastrulation 2018
2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid HomeostasisStem Cells.  36:1368-1379. 2018
2018 Glioma-associated oncogene homolog inhibitors have the potential of suppressing cancer stem cells of breast cancerInternational Journal of Molecular Sciences.  19. 2018
2018 MicroRNA-31 is required for astrocyte specificationGlia.  66:987-998. 2018
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencingDevelopmental Biology.  426:429-441. 2017
2017 Bimodal regulation of Dishevelled function by Vangl2 during morphogenesisHuman Molecular Genetics.  26:2053-2061. 2017
2016 Agonists and antagonists of TGF-β family ligandsCold Spring Harbor perspectives in biology.  8. 2016
2016 Molecular model for force production and transmission during vertebrate gastrulation 2016
2016 Animal cap assay for TGF-β SignalingMethods in Molecular Biology.  1344:261-274. 2016
2015 Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C familyChemico-Biological Interactions.  234:135-143. 2015
2015 Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development 2015
2014 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cellsBlood.  124:2025-2033. 2014
2012 Regulation of early xenopus embryogenesis by smad ubiquitination regulatory factor 2Developmental Dynamics.  241:1260-1273. 2012
2012 The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organizationDevelopmental Biology.  364:42-55. 2012
2012 Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic developmentJournal of Biological Chemistry.  287:9061-9071. 2012
2011 Regulation of early Xenopus development by the PIAS genesDevelopmental Dynamics.  240:2120-2126. 2011
2011 Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46Journal of Biological Chemistry.  286:7190-7201. 2011
2009 Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β SignalingDevelopmental Cell.  16:345-357. 2009
2009 Samba, a Xenopus hnRNP expressed in neural and neural crest tissuesDevelopmental Dynamics.  238:204-209. 2009
2008 Parathyroid hormone signaling through low-density lipoprotein-related protein 6Genes and Development.  22:2968-2979. 2008
2007 Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation 2007
2007 Regulation of cell cycle progression and gene expression by H2A deubiquitinationNature.  449:1068-1072. 2007
2007 Erbin inhibits transforming growth factor β signaling through a novel Smad-interacting domainMolecular and Cellular Biology.  27:6183-6194. 2007
2007 PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulationMechanisms of Development.  124:657-667. 2007
2007 Endofin acts as a Smad anchor for a receptor activation in BMP signalingJournal of Cell Science.  120:1216-1224. 2007
2007 Regulation of Xenopus gastrulation by ErbB signalingDevelopmental Biology.  303:93-107. 2007
2006 Function of the two xenopus Smad4s in early frog developmentJournal of Biological Chemistry.  281:30794-30803. 2006
2006 Smads oppose Hox transcriptional activitiesExperimental Cell Research.  312:854-864. 2006
2006 Regulation of early xenopus development by ErbB signalingDevelopmental Dynamics.  235:301-314. 2006
2005 Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1Journal of Biological Chemistry.  280:24227-24237. 2005
2003 TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003 Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor CriptoGenes and Development.  17:2624-2629. 2003
2003 Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis 2003
2003 Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signalingJournal of Biological Chemistry.  278:27853-27863. 2003
2003 Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanismsDevelopmental Biology.  255:1-11. 2003
2002 The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signalingDevelopmental Biology.  248:118-127. 2002
2001 The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate developmentGenes and Development.  15:2010-2022. 2001
2001 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase 2001
2000 A post-mid-blastula transition requirement for TGFβ signaling in early endodermal specificationMechanisms of Development.  90:227-235. 2000
1999 Xenopus GDF6, a new antagonist of noggin and a partner of BMPs 1999
1998 Cell fate determination in embryonic ectodermDevelopmental Neurobiology.  36:128-151. 1998
1998 Neural crest induction by Xwnt7B in XenopusDevelopmental Biology.  194:129-134. 1998
1997 Smad5 induces ventral fates in Xenopus embryoDevelopmental Biology.  184:402-405. 1997
1994 A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16Molecular and Cellular Biology.  14:5175-5181. 1994
1993 Properties of initiator-associated transcription mediated by GAL4-VP16Molecular and Cellular Biology.  13:7469-7475. 1993


Year Title Altmetric
2022 Preface.  Ed. 2438.  2022

Research Overview

  • I am interested in understanding how growth factor signals and transcription factors regulate early vertebrate development. Our current research focuses on the following aspects: 1) control of cell movements by receptor tyrosine kinases and their cytoplasmic effectors during gastrulation; 2) regulation of bottle cell formation by RhoGEF; and 3) regulation of early neural and neural crest development by nuclear transcription factors and epigenetic modulators.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, California State University System : Los Angeles 1994
  • Master of Life Sciences, California State University System : Los Angeles 1990
  • Full Name

  • Chenbei Chang