Chenbei Chang Ph.D.

Chenbei Chang Ph.D.
Professor

Senior Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Senior Scientist (C), Integrative Center for Aging Research , School of Medicine
Senior Scientist, Cancer Cell Biology , O'Neal Comprehensive Cancer Center
Senior Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Senior Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments
Associate Scientist (C), Biomatrix Eng Regen Med (BERM) Center , Biomedical Engineering

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus. Developmental Dynamics. 250:1113-1124. 2021
2021	The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously. Developmental Biology. 470:10-20. 2021
2020	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nature Communications. 11. 2020
2020	The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling. Developmental Biology. 463:169-181. 2020
2019	A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway. Frontiers in Physiology. 10. 2019
2018	The RhoGEF protein plekhg5 regulates apical constriction of bottle cells during gastrulation 2018
2018	Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis. STEM CELLS. 36:1368-1379. 2018
2018	Glioma-associated oncogene homolog inhibitors have the potential of suppressing cancer stem cells of breast cancer. International Journal of Molecular Sciences. 19. 2018
2018	MicroRNA-31 is required for astrocyte specification. Glia. 66:987-998. 2018
2017	Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017	Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing. Developmental Biology. 426:429-441. 2017
2017	Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis. Human Molecular Genetics. 26:2053-2061. 2017
2016	Agonists and antagonists of TGF-β family ligands. Cold Spring Harbor perspectives in biology. 8. 2016
2016	Molecular model for force production and transmission during vertebrate gastrulation 2016
2016	Animal cap assay for TGF-β Signaling. Methods in Molecular Biology. 1344:261-274. 2016
2015	Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family. Chemico-Biological Interactions. 234:135-143. 2015
2015	Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development 2015
2014	The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 124:2025-2033. 2014
2012	Regulation of early xenopus embryogenesis by smad ubiquitination regulatory factor 2. Developmental Dynamics. 241:1260-1273. 2012
2012	The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization. Developmental Biology. 364:42-55. 2012
2012	Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development. Journal of Biological Chemistry. 287:9061-9071. 2012
2011	Regulation of early Xenopus development by the PIAS genes. Developmental Dynamics. 240:2120-2126. 2011
2011	Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46. Journal of Biological Chemistry. 286:7190-7201. 2011
2009	Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β Signaling. Developmental Cell. 16:345-357. 2009
2009	Samba, a Xenopus hnRNP expressed in neural and neural crest tissues. Developmental Dynamics. 238:204-209. 2009
2008	Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes and Development. 22:2968-2979. 2008
2007	Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation 2007
2007	Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 449:1068-1072. 2007
2007	Erbin inhibits transforming growth factor β signaling through a novel Smad-interacting domain. Molecular and Cellular Biology. 27:6183-6194. 2007
2007	PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation. Mechanisms of Development. 124:657-667. 2007
2007	Endofin acts as a Smad anchor for a receptor activation in BMP signaling. Journal of Cell Science. 120:1216-1224. 2007
2007	Regulation of Xenopus gastrulation by ErbB signaling. Developmental Biology. 303:93-107. 2007
2006	Function of the two xenopus Smad4s in early frog development. Journal of Biological Chemistry. 281:30794-30803. 2006
2006	Smads oppose Hox transcriptional activities. Experimental Cell Research. 312:854-864. 2006
2006	Regulation of early xenopus development by ErbB signaling. Developmental Dynamics. 235:301-314. 2006
2005	Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. Journal of Biological Chemistry. 280:24227-24237. 2005
2003	TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003	Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. Genes and Development. 17:2624-2629. 2003
2003	Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis 2003
2003	Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling. Journal of Biological Chemistry. 278:27853-27863. 2003
2003	Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms. Developmental Biology. 255:1-11. 2003
2002	The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Developmental Biology. 248:118-127. 2002
2001	The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes and Development. 15:2010-2022. 2001
2001	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase 2001
2000	A post-mid-blastula transition requirement for TGFβ signaling in early endodermal specification. Mechanisms of Development. 90:227-235. 2000
1999	Xenopus GDF6, a new antagonist of noggin and a partner of BMPs 1999
1998	Cell fate determination in embryonic ectoderm 1998
1998	Neural crest induction by Xwnt7B in Xenopus. Developmental Biology. 194:129-134. 1998
1997	Smad5 induces ventral fates in Xenopus embryo. Developmental Biology. 184:402-405. 1997
1994	A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16. Molecular and Cellular Biology. 14:5175-5181. 1994
1993	Properties of initiator-associated transcription mediated by GAL4-VP16. Molecular and Cellular Biology. 13:7469-7475. 1993

Research Overview

I am interested in understanding how growth factor signals and transcription factors regulate early vertebrate development. Our current research focuses on the following aspects: 1) control of cell movements by receptor tyrosine kinases and their cytoplasmic effectors during gastrulation; 2) regulation of bottle cell formation by RhoGEF; and 3) regulation of early neural and neural crest development by nuclear transcription factors and epigenetic modulators.