Chenbei Chang Ph.D.

Chenbei Chang Ph.D.
Professor

Senior Scientist, Cancer Cell Biology , O'Neal Comprehensive Cancer Center
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments 2006 -
Associate Scientist (C), Biomatrix Eng Regen Med (BERM) Center , Biomedical Engineering 2006 -
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments 2012 -
Senior Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine 2015 -
Senior Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry 2017 -
Senior Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center 2019 -
Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine 2019 -
Senior Scientist (C), Integrative Center for Aging Research , School of Medicine 2020 -

Selected Publications

Academic Article

Year	Title	Altmetric
2021	The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously. Developmental Biology. 470:10-20. 2021
2021	Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus. Developmental Dynamics. 2021
2020	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nature Communications. 11. 2020
2020	The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling. Developmental Biology. 463:169-181. 2020
2019	A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway. Frontiers in Physiology. 10. 2019
2018	The RhoGEF protein plekhg5 regulates apical constriction of bottle cells during gastrulation 2018
2018	Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis. STEM CELLS. 36:1368-1379. 2018
2018	Glioma-associated oncogene homolog inhibitors have the potential of suppressing cancer stem cells of breast cancer. International Journal of Molecular Sciences. 19. 2018
2018	MicroRNA-31 is required for astrocyte specification. Glia. 66:987-998. 2018
2017	Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017	Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing. Developmental Biology. 426:429-441. 2017
2017	Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis. Human Molecular Genetics. 26:2053-2061. 2017
2016	Agonists and antagonists of TGF-β family ligands. Cold Spring Harbor perspectives in biology. 8. 2016
2016	Molecular model for force production and transmission during vertebrate gastrulation 2016
2016	Animal cap assay for TGF-β Signaling. Methods in Molecular Biology. 1344:261-274. 2016
2015	Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family. Chemico-Biological Interactions. 234:135-143. 2015
2015	Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development 2015
2014	The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 124:2025-2033. 2014
2012	Regulation of early xenopus embryogenesis by smad ubiquitination regulatory factor 2. Developmental Dynamics. 241:1260-1273. 2012
2012	The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization. Developmental Biology. 364:42-55. 2012
2012	Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development. Journal of Biological Chemistry. 287:9061-9071. 2012
2011	Regulation of early Xenopus development by the PIAS genes. Developmental Dynamics. 240:2120-2126. 2011
2011	Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46. Journal of Biological Chemistry. 286:7190-7201. 2011
2009	Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β Signaling. Developmental Cell. 16:345-357. 2009
2009	Samba, a Xenopus hnRNP expressed in neural and neural crest tissues. Developmental Dynamics. 238:204-209. 2009
2008	Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes and Development. 22:2968-2979. 2008
2007	Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation 2007
2007	Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature. 449:1068-1072. 2007
2007	Erbin inhibits transforming growth factor β signaling through a novel Smad-interacting domain. Molecular and Cellular Biology. 27:6183-6194. 2007
2007	PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation. Mechanisms of Development. 124:657-667. 2007
2007	Endofin acts as a Smad anchor for a receptor activation in BMP signaling. Journal of Cell Science. 120:1216-1224. 2007
2007	Regulation of Xenopus gastrulation by ErbB signaling. Developmental Biology. 303:93-107. 2007
2006	Function of the two xenopus Smad4s in early frog development. Journal of Biological Chemistry. 281:30794-30803. 2006
2006	Smads oppose Hox transcriptional activities. Experimental Cell Research. 312:854-864. 2006
2006	Regulation of early xenopus development by ErbB signaling. Developmental Dynamics. 235:301-314. 2006
2005	Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. Journal of Biological Chemistry. 280:24227-24237. 2005
2003	TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003	Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. Genes and Development. 17:2624-2629. 2003
2003	Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis 2003
2003	Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling. Journal of Biological Chemistry. 278:27853-27863. 2003
2003	Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms. Developmental Biology. 255:1-11. 2003
2002	The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Developmental Biology. 248:118-127. 2002
2001	The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes and Development. 15:2010-2022. 2001
2001	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase 2001
2000	A post-mid-blastula transition requirement for TGFβ signaling in early endodermal specification. Mechanisms of Development. 90:227-235. 2000
1999	Xenopus GDF6, a new antagonist of noggin and a partner of BMPs 1999
1998	Cell fate determination in embryonic ectoderm 1998
1998	Neural crest induction by Xwnt7B in Xenopus. Developmental Biology. 194:129-134. 1998
1997	Smad5 induces ventral fates in Xenopus embryo. Developmental Biology. 184:402-405. 1997
1994	A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16. Molecular and Cellular Biology. 14:5175-5181. 1994
1993	Properties of initiator-associated transcription mediated by GAL4-VP16. Molecular and Cellular Biology. 13:7469-7475. 1993

Research Overview

I am interested in understanding how growth factor signals and transcription factors regulate early vertebrate development. Our current research focuses on the following aspects: 1) control of cell movements by receptor tyrosine kinases and their cytoplasmic effectors during gastrulation; 2) regulation of bottle cell formation by RhoGEF; and 3) regulation of early neural and neural crest development by nuclear transcription factors and epigenetic modulators.