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Chenbei Chang Ph.D.
Professor
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E-mail
cchang@uab.edu
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Map of Science
Co-investigator Network
Chenbei Chang Ph.D.
Professor
Positions
Senior Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Associate Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
2006 -
Associate Scientist (C)
,
Biomatrix Eng Regen Med (BERM) Center
,
Biomedical Engineering
2006 -
Professor (P)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
2012 -
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
2015 -
Senior Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
2017 -
Senior Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
2019 -
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Senior Scientist (C)
,
Integrative Center for Aging Research
,
School of Medicine
2020 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2020
STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells
.
Nature Communications
. 11.
2020
2020
The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling
.
Developmental Biology
. 463:169-181.
2020
2019
A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway
.
Frontiers in Physiology
. 10.
2019
2018
The RhoGEF protein plekhg5 regulates apical constriction of bottle cells during gastrulation
2018
2018
Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis
.
STEM CELLS
. 36:1368-1379.
2018
2018
Glioma-associated oncogene homolog inhibitors have the potential of suppressing cancer stem cells of breast cancer
.
International Journal of Molecular Sciences
. 19.
2018
2018
MicroRNA-31 is required for astrocyte specification
.
Glia
. 66:987-998.
2018
2017
Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing
2017
2017
Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing
.
Developmental Biology
. 426:429-441.
2017
2017
Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis
.
Human Molecular Genetics
. 26:2053-2061.
2017
2016
Agonists and antagonists of TGF-β family ligands
.
Cold Spring Harbor perspectives in biology
. 8.
2016
2016
Molecular model for force production and transmission during vertebrate gastrulation.
2016
2016
Animal Cap Assay for TGF-β Signaling.
.
Methods in Molecular Biology
. 1344:261-274.
2016
2015
Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family
.
Chemico-Biological Interactions
. 234:135-143.
2015
2015
Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development
2015
2014
The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells
.
Blood
. 124:2025-2033.
2014
2012
Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2.
.
Developmental Dynamics
. 241:1260-1273.
2012
2012
The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization
.
Developmental Biology
. 364:42-55.
2012
2012
Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development
.
Journal of Biological Chemistry
. 287:9061-9071.
2012
2011
Regulation of early Xenopus development by the PIAS genes
.
Developmental Dynamics
. 240:2120-2126.
2011
2011
Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46
.
Journal of Biological Chemistry
. 286:7190-7201.
2011
2009
Samba, a Xenopus hnRNP expressed in neural and neural crest tissues
.
Developmental Dynamics
. 238:204-209.
2009
2008
Parathyroid hormone signaling through low-density lipoprotein-related protein 6
.
Genes and Development
. 22:2968-2979.
2008
2007
Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation
2007
2007
Regulation of cell cycle progression and gene expression by H2A deubiquitination
.
Nature
. 449:1068-1072.
2007
2007
PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation
.
Mechanisms of Development
. 124:657-667.
2007
2007
Endofin acts as a Smad anchor for a receptor activation in BMP signaling
.
Journal of Cell Science
. 120:1216-1224.
2007
2007
Regulation of Xenopus gastrulation by ErbB signaling
.
Developmental Biology
. 303:93-107.
2007
2006
Function of the two xenopus Smad4s in early frog development
.
Journal of Biological Chemistry
. 281:30794-30803.
2006
2006
Smads oppose Hox transcriptional activities
.
Experimental Cell Research
. 312:854-864.
2006
2006
Regulation of early xenopus development by ErbB signaling
.
Developmental Dynamics
. 235:301-314.
2006
2005
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
.
Journal of Biological Chemistry
. 280:24227-24237.
2005
2003
TGF-β Signaling in Human Skeletal and Patterning Disorders
2003
2003
Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto.
.
Genes and Development
. 17:2624-2629.
2003
2003
Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms
.
Developmental Biology
. 255:1-11.
2003
Research
Principal Investigator On
Functional and Mechanistic Characterization of YWHAZ Variants Associated with Human Diseases
awarded by
National Institute of Child Health and Human Development/NIH/DHHS
2020 - 2024
Regulation of Apical Constriction of Bottle Cells by the RhoGEF Protein Plekhg5 During Gastrulation Morphogenesis
awarded by
National Institute of General Medical Sciences/NIH/DHHS
2019 - 2023
Epigenetic Regulation of Early Development of Vertebrate Nervous System
awarded by
NSF - National Science Foundation
2016 - 2019
Connecting Signaling with Cytoskeleton: Abl and Arg In Vertebrate Gastrulation
awarded by
National Institute of General Medical Sciences/NIH/DHHS
2012 - 2017
ErbB Signaling in Vertebrate Morphogenesis
awarded by
National Institute of General Medical Sciences/NIH/DHHS
2009 - 2012
ErbB Signaling in Vertebrate Heart Development
awarded by
American Heart Association (Southeast Affiliate)
2008 - 2010
Investigator On
UAB Pilot Center for Precision Animal Modeling (C-PAM)
awarded by
NIH - OFFICE OF THE DIRECTOR
2020 - 2025
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Disease Modeling Unit
awarded by
NIH - OFFICE OF THE DIRECTOR
2020 - 2025
Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination-Mediated Gene Silencing
awarded by
National Institute of General Medical Sciences/NIH/DHHS
2019 - 2021
The Role of Planar Cell Polarity Signaling in Outflow Tract Malformation in 22q11.2 Deletion Syndrome
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2017 - 2021
Mechanism of Vangl2-Mediated Planar Cell Polarity Signaling in Heart Development
awarded by
American Heart Association (Southeast Affiliate)
2014 - 2017
Teaching
Teaching Activities
GBS710 - Cell Signaling (Spring Term 2020)
2020
GBS710 - Cell Signaling (Spring Term 2019)
2019
BHS502 - Molecules and Cells (Summer Term 2018)
2018
BHS502 - Molecules and Cells (Summer Term 2017)
2017
BHS502 - Molecules and Cells (Summer Term 2016)
2016
BHS502 - Molecules and Cells (Summer Term 2015)
2015
GBS789 - Evol Developmental Biology (Spring Term 2013)
2013
GBS789 - Evol Developmental Biology (Spring Term 2012)
2012
Background
Education And Training
Doctor of Philosophy in Biochemistry,
California State University System : Los Angeles
1994
Master of Life Sciences,
California State University System : Los Angeles
1990
Awards And Honors
HHMI Institutional Career Development Award
,
2001
C. H. Li Memorial Fellowship for Postdoctoral Fellows
,
1994
Contact
Full Name
Chenbei
Chang