Selected Publications

Academic Article

Year Title Altmetric
2021 Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in XenopusDevelopmental Dynamics.  250:1113-1124. 2021
2021 The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomouslyDevelopmental Biology.  470:10-20. 2021
2020 STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cellsNature Communications.  11. 2020
2020 The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signalingDevelopmental Biology.  463:169-181. 2020
2019 A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathwayFrontiers in Physiology.  10. 2019
2018 The RhoGEF protein plekhg5 regulates apical constriction of bottle cells during gastrulation 2018
2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid HomeostasisSTEM CELLS.  36:1368-1379. 2018
2018 Glioma-associated oncogene homolog inhibitors have the potential of suppressing cancer stem cells of breast cancerInternational Journal of Molecular Sciences.  19. 2018
2018 MicroRNA-31 is required for astrocyte specificationGlia.  66:987-998. 2018
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencingDevelopmental Biology.  426:429-441. 2017
2017 Bimodal regulation of Dishevelled function by Vangl2 during morphogenesisHuman Molecular Genetics.  26:2053-2061. 2017
2016 Agonists and antagonists of TGF-β family ligandsCold Spring Harbor perspectives in biology.  8. 2016
2016 Molecular model for force production and transmission during vertebrate gastrulation 2016
2016 Animal cap assay for TGF-β SignalingMethods in Molecular Biology.  1344:261-274. 2016
2015 Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C familyChemico-Biological Interactions.  234:135-143. 2015
2015 Snail2/slug cooperates with polycomb repressive complex 2 (Prc2) to regulate neural crest development 2015
2014 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cellsBlood.  124:2025-2033. 2014
2012 Regulation of early xenopus embryogenesis by smad ubiquitination regulatory factor 2Developmental Dynamics.  241:1260-1273. 2012
2012 The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organizationDevelopmental Biology.  364:42-55. 2012
2012 Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic developmentJournal of Biological Chemistry.  287:9061-9071. 2012
2011 Regulation of early Xenopus development by the PIAS genesDevelopmental Dynamics.  240:2120-2126. 2011
2011 Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46Journal of Biological Chemistry.  286:7190-7201. 2011
2009 Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β SignalingDevelopmental Cell.  16:345-357. 2009
2009 Samba, a Xenopus hnRNP expressed in neural and neural crest tissuesDevelopmental Dynamics.  238:204-209. 2009
2008 Parathyroid hormone signaling through low-density lipoprotein-related protein 6Genes and Development.  22:2968-2979. 2008
2007 Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation 2007
2007 Regulation of cell cycle progression and gene expression by H2A deubiquitinationNature.  449:1068-1072. 2007
2007 Erbin inhibits transforming growth factor β signaling through a novel Smad-interacting domainMolecular and Cellular Biology.  27:6183-6194. 2007
2007 PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulationMechanisms of Development.  124:657-667. 2007
2007 Endofin acts as a Smad anchor for a receptor activation in BMP signalingJournal of Cell Science.  120:1216-1224. 2007
2007 Regulation of Xenopus gastrulation by ErbB signalingDevelopmental Biology.  303:93-107. 2007
2006 Function of the two xenopus Smad4s in early frog developmentJournal of Biological Chemistry.  281:30794-30803. 2006
2006 Smads oppose Hox transcriptional activitiesExperimental Cell Research.  312:854-864. 2006
2006 Regulation of early xenopus development by ErbB signalingDevelopmental Dynamics.  235:301-314. 2006
2005 Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1Journal of Biological Chemistry.  280:24227-24237. 2005
2003 TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003 Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor CriptoGenes and Development.  17:2624-2629. 2003
2003 Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis 2003
2003 Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signalingJournal of Biological Chemistry.  278:27853-27863. 2003
2003 Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanismsDevelopmental Biology.  255:1-11. 2003
2002 The latent-TGFβ-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signalingDevelopmental Biology.  248:118-127. 2002
2001 The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate developmentGenes and Development.  15:2010-2022. 2001
2001 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase 2001
2000 A post-mid-blastula transition requirement for TGFβ signaling in early endodermal specificationMechanisms of Development.  90:227-235. 2000
1999 Xenopus GDF6, a new antagonist of noggin and a partner of BMPs 1999
1998 Cell fate determination in embryonic ectoderm 1998
1998 Neural crest induction by Xwnt7B in XenopusDevelopmental Biology.  194:129-134. 1998
1997 Smad5 induces ventral fates in Xenopus embryoDevelopmental Biology.  184:402-405. 1997
1994 A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16Molecular and Cellular Biology.  14:5175-5181. 1994
1993 Properties of initiator-associated transcription mediated by GAL4-VP16Molecular and Cellular Biology.  13:7469-7475. 1993

Research Overview

  • I am interested in understanding how growth factor signals and transcription factors regulate early vertebrate development. Our current research focuses on the following aspects: 1) control of cell movements by receptor tyrosine kinases and their cytoplasmic effectors during gastrulation; 2) regulation of bottle cell formation by RhoGEF; and 3) regulation of early neural and neural crest development by nuclear transcription factors and epigenetic modulators.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, California State University System : Los Angeles 1994
  • Master of Life Sciences, California State University System : Los Angeles 1990
  • Full Name

  • Chenbei Chang