Positions

Overview

  • Dr. Bradley K. Yoder, Professor , completed his undergraduate studies in biochemistry and molecular biology at the University of Maryland Baltimore County (B.S. 1988), and received a Ph.D. in molecular and cellular biology from the University of Maryland in 1993. His postdoctoral studies were performed at Oak Ridge National Laboratory under the guidance of Dr. Rick Woychik where Dr. Yoder was an Alexander Hollaender Distinguished Postdoctoral Fellow. His research over the past two decades has focused on the cellular and molecular mechanisms regulating assembly, maintenance, and function of the primary cilium utilizing complementary approaches in mice, C. elegans, and in cell culture models. Work from his laboratory has utilized genetic screens in C. elegans to identify proteins required for ciliogenesis and cilia mediated signaling activities and how these genes function in pathways (e.g. Daf-2 Insulin/IGF-like pathway) that regulate life span and energy homeostasis. His group has analyzed in mammalian systems how the cilium regulates important developmental pathways and how loss of the cilium causes abnormalities in left-right body axis specification, limb and tooth patterning, skin and hair follicle morphogenesis, and impairs endochondrial bone formation. His group is also providing important fundamental insights into the connection between ciliary dysfunction and cystic kidney disorders, and novel roles for neuronal cilia in the regulation of satiation responses, disruption of which causes obesity and type II diabetes.
  • Research Overview

  • Cilia come in both motile and immotile forms. While motile cilia were known to have important roles in the lung and respiratory system, primary cilia were largely considered vestigial structures. A major paradigm shift in the field occurred with the generation of mouse mutants (such as the orpk mouse) that disrupt cilia formation. These new mouse mutants revealed important and novel roles for motile and immotile cilia and demonstrated that they are essential for mammalian development and tissue function. Defects in cilia have been implicated as the cause of a large and rapidly expanding group of human syndromes (Ciliopathies) with a wide range of developmental and disease phenotypes.

    The objectives of my research program are to uncover mechanisms regulating assembly, maintenance, and functions of both motile and primary forms of cilia and to determine how defects in these processes contribute to developmental abnormalities and disease pathogenesis. To accomplish these goals, my group utilizes complementary cell, genetic, and biochemical approaches in mice, C. elegans, and cell culture to identify new proteins involved in ciliogenesis and cilia mediated signaling. Work from my group has identified novel components of the ciliary transition zone, an important domain controlling what protein enter or are retained in the cilium. We have provided seminal insights into how the cilium regulates developmental pathways, such as hedgehog, and how alterations in cilia-mediated regulation of this pathway cause polydactyly, defects in endochondral bone formation, and abnormal skin and hair follicle morphogenesis. My group made fundamental contributions that connected ciliary dysfunction to the formation of cysts in the kidney, liver, and pancreas, and uncovered a new role for cilia on hypothalamic neurons in regulating satiation responses. We have shown that disruption of cilia on these neurons cause obesity and type II diabetes. We also identified genes important in regulating ciliary motility and waveform and determined that their loss in mice leads to hydrocephalus, bronchiectasis, and randomization of the left-right body axis. Importantly, as part of this work we determined that a mutation of one of these genes we identified in our mouse model is responsible for a form of primary ciliary dyskinesia (PCD) in humans. As in the mouse model, these human PCD patients frequently have left-right body situs defects.

    In summary, the research conducted by my group is providing important and innovative insights into how cilia are constructed and how they establish themselves as a unique signaling and sensory organelle with a distinct protein composition the rest of the cell membrane. We have uncovered many diverse and unexpected roles for cilia during development and in maintaining mammalian health.
  • Principal Investigator On

  • Training Program in Cell, Molecular, and Developmental Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2018 - 2023
  • Injury Response Mediated Pathogenesis in Renal Ciliopathies  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Understanding Ciliary Functions in Mammalian Development  awarded by University of California, San Francisco 2016 - 2021
  • The Primary Cilium as A Novel Regulator of The Immune Response in The Kidney  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2021
  • Acquiring A Recirculating Aquaria System With Automated-Feed For Zebrafish  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Hepato/Renal Fibrocystic Kidney Disease Core Center - Summer Research Internship  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Pilot and Feasibility Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Cellular Physiology Resource - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Engineered Models Resource - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Translational Resource - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Epigenetic Regulation of Kir4.1 and GLT1 in Pathophysiology  awarded by VIRGINIA TECH UNIVERSITY 2017 - 2019
  • Cilia and Cystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2019
  • Predoctoral Training in Cell and Molecular Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2013 - 2018
  • Ciliogenesis in Epithelial Injury  awarded by MASSACHUSETTS GENERAL HOSPITAL 2014 - 2018
  • Injury Response Mediated Pathogenesis in Ciliopathies  awarded by Polycystic Kidney Disease Foundation 2016 - 2018
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core C MUSC  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Summer Research Internship  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by OTSUKA AMERICA PHARMACEUTICAL, INC. 2016
  • Private Grant  awarded by RELYPSA - NEW 2016
  • In Vivo Analysis of Cilia Mechanosensation in the Kidney  awarded by PKD Foundation for Research in Polycystic Kidney Disease 2014 - 2016
  • Intraflagellar Transport Mediated Regulation of Hedgehog Signaling  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2008 - 2014
  • Role of Cilia/IFT in Skin and Hair  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Predoctoral Training in Cellular and Molecular Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2013
  • Private Grant  awarded by Genentech 2012 - 2013
  • Cilia and Cystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Cilial Dysfunction and Pathogenesis of Obesity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2006 - 2012
  • The Role of Primary Neuronal Cilia in Appetite and Satiation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2012
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2011
  • UAB Recessive PKD Research and Translational Core Center - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2005 - 2010
  • Rheumatic Diseases Core Center: Pilot Project - P & F 1  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2010
  • Investigator On

  • Interdisciplinary Training In Kidney Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • Mononuclear Phagocytes in the Pathogenesis of Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2023
  • The Role of Lhx1 in Pancreatic Beta Cell Development and Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Therapeutic and Screening Resource - Core D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Genetic Regulation of Unconventional Prostaglandin Metobolism  awarded by National Institute of General Medical Sciences/NIH/DHHS 2018 - 2020
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Mechanisms of C3 Effects in ARPKD Pathogenesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB Obesity Training Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2017
  • Light-Induced Genetic Alterations Within Single Cell of a Live Vertebrate Animal  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2011
  • UAB Recessive PKD Research and Translational Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2005 - 2010
  • Teaching Activities

  • GBS712 - Cell & Mol Aspects Dev Bio (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC733 - Art of Reproducible Science (Spring Term 2019) 2019
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2017) 2017
  • GBS746 - Special Topics (Fall Term 2016) 2016
  • GBS792 - CMDB Seminar (Spring Term 2016) 2016
  • GBS792 - CMDB Seminar (Fall Term 2015) 2015
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2015) 2015
  • GBS792 - CMDB Seminar (Spring Term 2015) 2015
  • GBS792 - CMDB Seminar (Fall Term 2014) 2014
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2014) 2014
  • GBS787 - Special Topics (Spring Term 2014) 2014
  • GBS792 - CMDB Seminar (Spring Term 2014) 2014
  • GBS792 - CMDB Seminar (Fall Term 2013) 2013
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2013) 2013
  • GBS792 - CMDB Seminar (Spring Term 2013) 2013
  • GBS792 - CMDB Seminar (Fall Term 2012) 2012
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2012) 2012
  • GBS792 - CMDB Seminar (Spring Term 2012) 2012
  • GBS712 - CELL AND MOLECULAR ASPECTS OF DEVELOPMENTAL BIOLOGY (Spring Term 2012) 2012
  • GBS792 - CMDB Seminar (Fall Term 2011) 2011
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2011) 2011
  • CB747 - Cell Biology Seminar (Spring Term 2010) 2010
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2010) 2010
  • CB747 - Cell Biology Seminar (Fall Term 2009) 2009
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2009) 2009
  • CB747 - Cell Biology Seminar (Fall Term 2008) 2008
  • CB747 - Cell Biology Seminar (Spring Term 2008) 2008
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2008) 2008
  • CB747 - Cell Biology Seminar (Fall Term 2007) 2007
  • Full Name

  • Bradley Yoder