Selected Publications

Academic Article

Year Title Altmetric
2019 Chronic rhino-sinusitis treatment in children with cystic fibrosis: A cross-sectional survey of pediatric pulmonologists and otolaryngologists 2019
2019 A Primary Clival Defect: Endoscopic Binostril Approach With Nasal Septal Flap Closure and Preservation of Septal Integrity 2019
2019 Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis 2019
2019 Editorial by Dr. Woodworth 2019
2019 In-vitro evaluation of a ciprofloxacin- and ivacaftor-coated sinus stent against Pseudomonas aeruginosa biofilms 2019
2019 Predictors of Nasoseptal Flap Use After Endoscopic Transsphenoidal Pituitary Mass Resection 2019
2019 Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa 2019
2019 Management of spontaneous cerebrospinal fluid leaks 2019
2019 Lateral nasal wall extension of the nasoseptal flap for skull-base and medial orbital wall defects 2019
2019 Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease 2019
2018 Porcine small intestine submucosal grafts improve remucosalization and progenitor cell recruitment to sites of upper airway tissue remodeling 2018
2018 Acquired cystic fibrosis transmembrane conductance regulator dysfunction. 2018
2018 Osteoplastic Flap Without Obliteration: How I Do It 2018
2018 In response to in reference to intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks 2018
2018 l-Methionine anti-biofilm activity against Pseudomonas aeruginosa is enhanced by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor 2018
2018 Preclinical therapeutic efficacy of the ciprofloxacin-eluting sinus stent for Pseudomonas aeruginosa sinusitis 2018
2018 Submucosal gland mucus strand velocity is decreased in chronic rhinosinusitis 2018
2018 Medical interventions for chronic rhinosinusitis in cystic fibrosis 2018
2018 Sinus microanatomy and microbiota in a rabbit model of rhinosinusitis 2018
2017 Survival outcomes for stage-matched endoscopic and open resection of olfactory neuroblastoma 2017
2017 Characterization of primary rat nasal epithelial cultures in CFTR knockout rats as a model for CF sinus disease 2017
2017 Response to: Letter to the Editor regarding “Changing the surgical dogma in frontal sinus trauma: transnasal endoscopic repair” 2017
2017 Activity of bacteriophages in removing biofilms of pseudomonas aeruginosa isolates from chronic rhinosinusitis patients 2017
2017 Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography 2017
2017 Intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks 2017
2017 Sinus hypoplasia in the cystic fibrosis rat resolves in the absence of chronic infection 2017
2017 Changing the surgical dogma in frontal sinus trauma: transnasal endoscopic repair 2017
2017 Enlargement of Meckel's cave in patients with spontaneous cerebrospinal fluid leaks 2017
2017 Tolerance and pharmacokinetics of a ciprofloxacin-coated sinus stent in a preclinical model 2017
2017 Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis. 2017
2017 Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B. 2017
2017 Successful repair of intraoperative cerebrospinal fluid leaks improves outcomes in endoscopic skull base surgery 2017
2016 Factors impacting cerebrospinal fluid leak rates in endoscopic sellar surgery 2016
2016 In reference to what is the optimal perioperative management of antiplatelet therapy? 2016
2016 Management of Frontal Sinus Cerebrospinal Fluid Leaks and Encephaloceles 2016
2016 Management Strategies for Skull Base Inverted Papilloma 2016
2016 Draf III mucosal graft technique: Long-term results 2016
2016 Cystic fibrosis transmembrane conductance regulator activation by the solvent ethanol: Implications for topical drug delivery 2016
2016 International Consensus Statement on Allergy and Rhinology: Rhinosinusitis 2016
2016 Olfactory neuroblastoma 2016
2016 Acquired Cystic Fibrosis Transmembrane Conductance Regulator Deficiency 2016
2016 Comments on "Endoscopic Transpterygoid Approach and Skull Base Repair After Sphenoid Meningoencephalocele Resection" 2016
2016 Gynecomastia and hyperprolactinemia secondary to advanced allergic fungal rhinosinusitis in a pediatric patient 2016
2016 Management of cerebrospinal fluid rhinorrhea: An evidence-based review with recommendations 2016
2015 Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection 2015
2015 Inaccurate Assessments of Anterior Cranial Base Malignancy Following Nasoseptal Flap Reconstruction 2015
2015 Letter to the Editor: In Response to "minimally Invasive Technique for Repairing CSF Leaks Due to Defects of Posterior Table of Frontal Sinus" 2015
2015 Inverted papilloma of the sphenoid sinus: Risk factors for disease recurrence 2015
2015 Chlorogenic Acid Activates CFTR-Mediated Cl- Secretion in Mice and Humans: Therapeutic Implications for Chronic Rhinosinusitis 2015
2015 Endoscopic resection of anterolateral maxillary sinus inverted papillomas 2015
2015 Objective assessment of olfaction after transsphenoidal pituitary surgery 2015
2015 Outcomes of Pressure-Induced Cranial Neuropathies from Allergic Fungal Rhinosinusitis 2015
2015 Resveratrol ameliorates abnormalities of fluid and electrolyte secretion in a hypoxia-Induced model of acquired CFTR deficiency 2015
2015 The use of image-guidance during transsphenoidal pituitary surgery in the United States 2015
2014 Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance 2014
2014 Management of lateral frontal sinus pathology in the endoscopic era 2014
2014 Smell sparing unilateral intracranial dermoid resection. 2014
2014 Frontal sinus cholesterol granuloma: Case report. 2014
2014 Erratum: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability (PLoS ONE (2014) 9:1 (DOI:10.1371/annotation/d852ff1d-2824- 4f4d-80f2-9be7a42a5f25)) 2014
2014 In response to simultaneous pericranial and nasoseptal flap reconstruction of anterior skull base defects following endoscopic-assisted craniofacial resection 2014
2014 Increased intracranial pressure in spontaneous CSF leak patients is not associated with papilledema 2014
2014 Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice 2014
2014 Management of the upper airway in cystic fibrosis 2014
2014 Marked repression of CFTR mRNA in the transgenic Cftrtm1kth mouse model 2014
2014 Pathology quiz case: Plasmacytoid dendritic cell neoplasm. 2014
2014 Porcine nasal epithelial cultures for studies of cystic fibrosis sinusitis 2014
2014 Porcine small intestine submucosal grafts for post-tumor resection orbital reconstruction 2014
2014 Resolution of diminished olfactory sensation after treatment of bilateral ophthalmic segment aneurysms with flow diversion: Case report 2014
2014 Spontaneous cerebrospinal fluid leak repair: A five-year prospective evaluation 2014
2014 Spontaneous sphenoid lateral recess cerebrospinal fluid leaks arise from intracranial hypertension, not Sternberg's canal 2014
2014 Topical triamcinolone acetonide/carboxymethylcellulose foam for acute exacerbations of chronic rhinosinusitis/nasal polyposis 2014
2014 Transnasal endoscopic resection of a calcifying cystic odontogenic tumor 2014
2013 Spontaneous cerebrospinal fluid otorrhea and rhinorrhea in idiopathic intracranial hypertension patients. 2013
2013 Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability 2013
2013 Epidemiology and differential diagnosis of nasal polyps 2013
2013 Porcine small intestine submucosal graft for endoscopic skull base reconstruction 2013
2013 Simultaneous pericranial and nasoseptal flap reconstruction of anterior skull base defects following endoscopic-assisted craniofacial resection 2013
2013 Surgical approaches to central skull base and postsurgical imaging 2013
2013 Acetazolamide for high intracranial pressure cerebrospinal fluid leaks 2013
2013 Cystic fibrosis chronic rhinosinusitis: A comprehensive review 2013
2013 IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary Exacerbations 2013
2013 Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR modulators genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures 2013
2013 Complications of skull base reconstruction 2013
2013 Invasive mucormycosis in an immunocompetent patient with allergic fungal rhinosinusitis 2013
2013 Spontaneous cerebrospinal fluid otorrhea and rhinorrhea in idiopathic intracranial hypertension patients 2013
2012 Transnasal endoscopic repair of posterior table fractures 2012
2012 Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein 2012
2012 Cerebrospinal fluid volume replacement following large endoscopic anterior cranial base resection 2012
2012 Changing paradigms in frontal sinus cerebrospinal fluid leak repair 2012
2012 Treatment strategies for lateral sphenoid sinus recess cerebrospinal fluid leaks 2012
2012 The draf III mucosal grafting technique: A prospective study 2012
2012 Extensive surgical and comprehensive postoperative medical management for cystic fibrosis chronic rhinosinusitis 2012
2011 Coblation for epistaxis management in patients with hereditary haemorrhagic telangiectasia: A multicentre case series 2011
2011 Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: Therapeutic implications for chronic rhinosinusitis 2011
2011 Transepithelial ion transport is suppressed in hypoxic sinonasal epithelium 2011
2011 Frontal sinus skull base defect repair using the pedicled nasoseptal flap 2011
2011 Juvenile Nasopharyngeal Angiofibroma 2011
2011 Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epithelium 2011
2011 Endoscopic Removal of a Bullet Penetrating the Middle Cranial Fossa 2011
2011 Endoscopic resection of intracranial dermoid cysts 2011
2011 Nasal Sinus Leiomyosarcoma in a Patient with History of Non-Hereditary Unilateral Treated Retinoblastoma 2011
2010 Endoscopic Coblator™-assisted management of encephaloceles 2010
2010 Hesperidin stimulates cystic fibrosis transmembrane conductance regulatormediated chloride secretion and ciliary beat frequency in sinonasal epithelium 2010
2010 ΔF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers 2010
2010 Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures 2010
2010 Intranasal eosinophilic angiocentric fibrosis: A case report and review 2010
2010 Evolving Materials and Techniques for Endoscopic Sinus Surgery 2010
2010 Randomized controlled trial of hyaluronic acid/carboxymethylcellulose dressing after endoscopic sinus surgery 2010
2010 Temporal bone pneumatization and its relationship to paranasal sinus development in cystic fibrosis 2010
2010 Radiofrequency coblation decreases blood loss during endoscopic sinonasal and skull base tumor removal 2010
2010 The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo 2010
2010 Zinc increases ciliary beat frequency in a calcium-dependent manner 2010
2009 Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency 2009
2009 Comparison of vectorial ion transport in primary murine airway and human sinonasal air-liquid interface cultures, models for studies of cystic fibrosis, and other airway diseases 2009
2009 Sternberg's canal: Fact or fiction? 2009
2009 Frontal recess cells: A rare cause of frontal sinus pneumocoele 2009
2009 Endoscopic closure of CSF rhinorrhea: 193 cases over 21 years 2009
2009 Endoscopic repair of supraorbital ethmoid cerebrospinal fluid leaks 2009
2009 Spontaneous cerebrospinal fluid leaks 2009
2009 A gelatin-thrombin matrix for hemostasis after endoscopic sinus surgery 2009
2008 Physiologic alterations in the murine model after nasal fungal antigenic exposure 2008
2008 Endoscopic management of frontal sinus mucoeceles with anterior table erosion 2008
2008 Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery 2008
2008 Spontaneous CSF leaks: A paradigm for definitive repair and management of intracranial hypertension 2008
2008 An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers 2008
2008 Real-time computed tomography image update for endoscopic skull base surgery 2008
2008 Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient 2008
2008 Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: A 15-year experience (American Journal of Rhinology (2007) (595)) 2008
2008 Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis 2008
2007 Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: A 15-year experience 2007
2007 Innate and adaptive mediators in cystic fibrosis and allergic fungal rhinosinusitis 2007
2007 Murine tracheal and nasal septal epithelium for air-liquid interface cultures: A comparative study 2007
2007 Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: A preliminary report 2007
2007 Surfactant protein B detection and gene expression in chronic rhinosinusitis 2007
2007 Immunolocalization of dendritic cells and pattern recognition receptors in chronic rhinosinusitis 2007
2007 Murine nasal septa for respiratory epithelial air-liquid interface cultures 2007
2007 The delta F508 mutation in cystic fibrosis and impact on sinus development 2007
2006 Surfactant protein A and D in human sinus mucosa: A preliminary report 2006
2006 Muscle-sparing abdominal free flaps in head and neck reconstruction 2006
2006 Immunolocalization of surfactant protein A and D in sinonasal mucosa 2006
2006 Nasal cerebrospinal fluid leaks and encephaloceles 2006
2006 Modified endoscopic medial maxillectomy for chronic maxillary sinusitis 2006
2006 Endoscopic resection of sinonasal hemangiomas and hemangiopericytomas 2006
2006 Sphenoid sinus cerebrospinal fluid leaks 2006
2006 Chronic rhinosinusitis in congenital craniofacial malformations 2006
2006 Spontaneous cerebrospinal fluid leaks: A variant of benign intracranial hypertension 2006
2005 Presence of surfactant lamellar bodies in normal and diseased sinus mucosa 2005
2005 Comparison of laser versus surface-touch registration for image-guided sinus surgery 2005
2005 Endoscopic repair of frontal sinus cerebrospinal fluid leaks 2005
2005 Endoscopic repair of a congenital intranasal encephalocele in a 23 months old infant 2005
2005 Management of paranasal sinus malignancy 2005
2004 Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps 2004
2004 Evolutions in the management of congenital intranasal skull base defects 2004
2004 The canalith repositioning procedure for benign positional vertigo: A meta-analysis 2004
2001 Merkel cell carcinoma: an overview and case report. 2001
2000 PH-20: A novel tumor marker for laryngeal cancer 2000
2000 Meniere's disease. 2000


Year Title Altmetric
2018 CBCT-based image guidance for sinus and skull base surgery.  1057-1070. 2018
2018 Managing Complications of Endoscopic Sinus Surgery 2018
2018 Modified Medial Maxillectomy for Recalcitrant Maxillary Sinusitis 2018
2016 Frontal sinus cerebrospinal fluid leaks.  469-483. 2016
2015 Closure of skull base defects and encephaloceles 2015
2010 Biofilms.  75-81. 2010
2009 Biofilms.  241-246. 2009
2008 Recurrent mucoceles.  185-192. 2008
2007 Repair of anterior skull base defects and CSF leaks.  139-147. 2007
2005 Frontal sinus cerebrospinal fluid leaks.  143-152. 2005

Research Overview

  • First, I am pursuing a novel pathophysiologic mechanism (Acquired CFTR deficiency) that I believe is responsible for disrupted mucociliary function in chronic sinus disease. My second area of emphasis involves therapeutic interventions that enhance mucociliary clearance in both cystic fibrosis (where chronic sinusitis is virtually universal) and non-CF chronic sinusitis. Finally, I investigate clinical outcomes in rhinologic and endoscopic skull base surgical procedures.
  • Education And Training

  • University of Pennsylvania, Postdoctoral Research 2007
  • Doctor of Medicine, Tulane University 2001
  • Medical University of South Carolina Medical Center, Internship 2002
  • Medical University of South Carolina Medical Center, Residency 2006
  • University of Pennsylvania Hospital, Postdoctoral Fellowship 2007
  • Full Name

  • Bradford Woodworth