Positions

Overview

  • Dr. Bradley's research focuses on the interactions among biological and psychosocial factors associated with abnormal pain sensitivity in persons with osteoarthritis (OA) of the knee, and other chronic painful disorders. Several studies are ongoing with support of an R01 grant and complementary grant funds: (1) In collaboration with investigators from the University of Florida, the goal of the R01 project is to characterize ethnic differences in experimental pain sensitivity, endogenous pain inhibition, clinical pain, and pain-related disability in older African-Americans and non-Hispanic whites with and without knee OA; (2) determine whether these measures of pain sensitivity/pain inhibition along with biological, psychological, and socio-cultural variables mediate ethnic group differences in clinical pain and pain-related disability; (3) examine the extent to which differences in pain responses between African-American and white patients with knee OA are mediated by group differences in biomarkers such as sleep disturbance or lipid mediators; and (4) examine the relationship between polysomnography measures of sleep and experimental as well as clinical pain to better understand the biological, psychological, and socio-cultural variables that mediate ethnic group differences in both sleep and pain.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Movement-evoked pain, physical function, and perceived stress: An observational study of ethnic/racial differences in aging non-Hispanic Blacks and non-Hispanic Whites with knee osteoarthritis 2019
    2019 Resilience factors may buffer cellular aging in individuals with and without chronic knee pain 2019
    2019 At the Intersection of Ethnicity/Race and Poverty: Knee Pain and Physical Function 2019
    2018 Optimism and Psychological Resilience are Beneficially Associated with Measures of Clinical and Experimental Pain in Adults with or at Risk for Knee Osteoarthritis 2018
    2018 Omega-6:Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain 2018
    2017 Physical performance and movement-evoked pain profiles in community-dwelling individuals at risk for knee osteoarthritis 2017
    2017 Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sites 2017
    2017 Ethnicity, cortisol, and experimental pain responses among persons with symptomatic knee osteoarthritis 2017
    2017 Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee Osteoarthritis 2017
    2016 Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis 2016
    2016 Minority aging and endogenous pain facilitatory processes 2016
    2016 (165) Sleep disturbance mediates the association between social discrimination and pain severity in knee osteoarthritis. 2016
    2016 Enhanced Pain Sensitivity among Individuals with Symptomatic Knee Osteoarthritis: Potential Sex Differences in Central Sensitization 2016
    2016 Association of Joint Inflammation with Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study 2016
    2015 A cross-sectional examination of Vitamin D, obesity, and measures of pain and function in middle-aged and older adults with knee osteoarthritis 2015
    2015 Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis 2015
    2014 Pain hypervigilance is associated with greater clinical pain severity and enhanced experimental pain sensitivity among adults with symptomatic knee osteoarthritis 2014
    2014 Age and race effects on pain sensitivity and modulation among middle-aged and older adults 2014
    2014 Benzodiazepine (BZD) Use in Community-Dwelling Older Adults: Longitudinal Associations with Mobility, Functioning, and Pain 2014
    2014 Examining sex differences in knee pain: The multicenter osteoarthritis study 2014
    2014 Predictors of adherence to a brief behavioral insomnia intervention: Daily process analysis 2014
    2014 Racial and ethnic differences in older adults with knee osteoarthritis 2014
    2014 Temporal summation of pain as a prospective predictor of clinical pain severity in adults aged 45 years and older with knee osteoarthritis: Ethnic differences 2014
    2013 Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: Trait or state? 2013
    2013 Association of pain with HbA1c in a predominantly black population of community-dwelling adults with diabetes: A cross-sectional analysis 2013
    2013 The association of parity with osteoarthritis and knee replacement in the Multicenter Osteoarthritis Study 2013
    2013 Corrigendum to "Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis" [Osteoarthritis and Cartilage 2013;21:1243-1252] 2013
    2013 Perceived racial discrimination, but not mistrust of medical researchers, predicts the heat pain tolerance of african americans with symptomatic knee osteoarthritis 2013
    2013 Psychological profiles and pain characteristics of older adults with knee osteoarthritis 2013
    2013 Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis 2013
    2013 Measuring the value of better diabetes management. 2013
    2013 The association of greater dispositional optimism with less endogenous pain facilitation is indirectly transmitted through lower levels of pain catastrophizing 2013
    2012 Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis 2012
    2012 Chronic pain, perceived stress, and cellular aging: An exploratory study 2012
    2011 Consistency of knee pain and risk of knee replacement: The multicenter osteoarthritis study 2011
    2011 Estimation of minimum clinically important difference for pain in fibromyalgia 2011
    2011 Effects of coping skills training and sertraline in patients with non-cardiac chest pain: A randomized controlled study 2011
    2011 Recognizing and Assessing Key Symptom Domains in Chronic Widespread Pain: Focus on Fibromyalgia 2011
    2011 Comparative pain and mood effects in patients with comorbid fibromyalgia and major depressive disorder: Secondary analyses of four pooled randomized controlled trials of duloxetine 2011
    2010 Effect of duloxetine in patients with fibromyalgia: Tiredness subgroups 2010
    2010 Pain response profile of patients with fibromyalgia treated with duloxetine 2010
    2009 Pathophysiology of Fibromyalgia 2009
    2009 What makes patients with fibromyalgia feel better? Correlations between patient global impression of improvement and changes in clinical symptoms and function: A pooled analysis of 4 randomized placebo-controlled trials of duloxetine 2009
    2009 Assessing single joints in arthritis clinical trials 2009
    2009 Association between radiographic features of knee osteoarthritis and pain: Results from two cohort studies 2009
    2008 Family and genetic influences on fibromyalgia syndrome 2008
    2008 A six-month double-blind, placebo-controlled, randomized clinical trial of duloxetine for the treatment of fibromyalgia. 2008
    2008 Pathophysiologic mechanisms of fibromyalgia and its related disorders 2008
    2008 Evaluating and diagnosing fibromyalgia and comorbid psychiatric disorders. 2008
    2008 Multidisciplinary care and stepwise treatment for fibromyalgia. 2008
    2006 Psychosocial Aspects of the Functional Gastrointestinal Disorders 2006
    2005 Pain-related beliefs and affective pain responses: Implications for ethnic disparities in preferences for joint arthroplasty 2005
    2005 Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study 2005
    2005 Psychiatric comorbidity in fibromyalgia 2005
    2004 Lessons from fibromyalgia: Abnormal pain sensitivity in knee osteoarthritis 2004
    2004 Recent Approaches to Understanding Osteoarthritis Pain 2004
    2004 Increased DNA fragmentation and ultrastructural changes in fibromyalgic muscle fibres 2004
    2003 Cognitive-behavioral therapy interventions for pain associated with chronic illnesses 2003
    2002 Systemic lupus erythematosus in three ethnic groups. X. Measuring cognitive impairment with the cognitive symptoms inventory 2002
    2002 Central nervous system mechanisms of pain in fibromyalgia and other musculoskeletal disorders: Behavioral and psychologic treatment approaches 2002
    2002 Is fibromyalgia a neurologic disease? 2002
    2002 Oral corticosteroids increase esophageal acid contact times in patients with stable asthma 2002
    2001 Psychosocial and health status variables independently predict health care seeking in fibromyalgia 2001
    2001 Chest pain in the absence of coronary artery disease: A biopsychosocial perspective 2001
    2001 Theoretical perspectives on the relation between catastrophizing and pain 2001
    2000 Detection of activation by phasic mechanical pain stimulation using Tc-99m HMPAO brain SPECT imaging 2000
    2000 Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis 2000
    2000 Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome. 2000
    2000 Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia. 2000
    1999 Is Chiari malformation associated with increased levels of substance P and clinical symptoms in persons with fibromyalgia? [1] 1999
    1999 Fibromyalgia and physical and emotional trauma: How are they related? Comment on the article by Aaron et al [5] (multiple letters) 1999
    1999 Preface 1999
    1999 Psychological and behavioral approaches to pain management for patients with rheumatic disease 1999
    1998 Fibromyalgia: A model for chronic pain 1998
    1998 Clinical Features of ANA Positive and ANA-Negative Patients with Fibromyalgia. 1998
    1998 Intravenous methotrexate in the treatment of resistant chronic polyarthritis. 1998
    1998 Immunohistochemical and molecular studies of serotonin, substance P, galanin, pituitary adenylyl cyclase-activating polypeptide, and secretoneurin in fibromyalgic muscle tissue 1998
    1998 Abnormal functional activity of the central nervous system in fibromyalgia syndrome 1998
    1998 Advances in the treatment of fibromyalgia: Current status and future directions 1998
    1998 Clinical features of ANA-positive and ANA-negative patients with fibromyalgia 1998
    1998 Clinical features of ANA-positive and ANA-negative patients with fibromyalgia [3] (multiple letters) 1998
    1998 Current concepts in the pathophysiology of abnormal pain perception in fibromyalgia 1998
    1998 Detecting sincerity of effort: A summary of methods and approaches 1998
    1998 Introduction: Fibromyalgia symposium 1998
    1998 Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage 1998
    1998 Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage 1998
    1997 Abnormal pain perception in patients with fibromyalgia: comment on the article by Bendtsen et al. 1997
    1997 Perceived physical and emotional trauma as precipitating events in fibromyalgia: Associations with health care seeking and disability status but not pain severity 1997
    1997 Structure/bioactivity of adrenocorticotropic hormone in fibromyalgia 1997
    1996 Gastroesophageal reflux-induced bronchoconstriction. Is microaspiration a factor? 1996
    1996 Coping strategies predict disability in patients with primary fibromyalgia 1996
    1996 Integration of behavioral and relaxation approaches into the treatment of chronic pain and insomnia 1996
    1996 Drug treatment of functional dyspepsia: A systematic analysis of trial methodology with recommendations for design of future trials 1996
    1996 Workshop on chronic pain, pain control, and patient outcomes in rheumatoid arthritis and osteoarthritis 1996
    1996 Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness 1996
    1996 Asthma and gastroesophageal reflux: Acid suppressive therapy improves asthma outcome 1996
    1996 Omprazole to treat asthma? 1996
    1995 Decreases in health care resource utilization in patients with rheumatoid arthritis following a cognitive behavioral intervention 1995
    1995 Development of an observation method for assessing pain behaviors in children with juvenile rheumatoid arthritis 1995
    1995 Fibromyalgia in women 1995
    1995 Gastroesophageal reflux-induced bronchoconstriction is microaspiration a factor? 1995
    1995 Personality assessment and the Minnesota Multiphasic Personality Inventory: 50 Years on: Do we still need our security blanket? 1995
    1995 Sexual abuse and gastrointestinal disease 1995
    1994 Altered pain perception and psychosocial features among women with gastrointestinal disorders and history of abuse: A preliminary model 1994
    1994 Behavioral interventions for managing chronic pain 1994
    1994 Gastroesophageal reflux-induced bronchoconstriction: An intraesophageal acid infusion study using state-of-the-art technology 1994
    1994 HIP Osteonecrosis Secondary to the Administration of Corticosteroids for Feigned Bronchial Asthma 1994
    1994 Health care seeking behavior in fibromyalgia: Associations with pain thresholds, symptom severity, and psychiatric morbidity 1994
    1994 Pain behavior of rheumatoid arthritis patients enrolled in experimental drug trials 1994
    1994 Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease 1994
    1993 The symptom index - Differential usefulness in suspected acid-related complaints of heartburn and chest pain 1993
    1993 Biopsychosocial contributions to the management of arthritis disability 1993
    1993 Determinants of oesophageal 'alkaline' pH environment in controls and patients with gastro-oesophageal reflux disease 1993
    1993 Introduction 1993
    1993 Pain measurement in arthritis 1993
    1993 Pain measurement in arthritis 1993
    1993 The Relationship between Stress and Symptoms of Gastroesophageal Reflux: The Influence of Psychological Factors 1993
    1993 Use of self ‐ administered joint counts in the evaluation of rheumatoid arthritis patients 1993
    1992 Psychosocial and psychophysical assessments of patients with unexplained chest pain 1992
    1992 Normal 24-Hr ambulatory esophageal pH values - Influence of study center, pH electrode, age, and gender 1992
    1992 Psychosocial and psychophysical assessments of patients with unexplained chest pain 1992
    1992 A multi-center evaluation of the McGill Pain Questionnaire: results from more than 1700 chronic pain patients 1992
    1992 An 18-month follow-up of a secondary prevention program for back pain: Help and hindrance factors related to outcome maintenance 1992
    1992 Challenges facing psychologists in arthritis research. Reflections on a tenth anniversary 1992
    1992 Observation of pain behavior in rheumatoid arthritis patients during physical examination. Relationship to disease activity and psychological variables 1992
    1991 A comparison of the full and short versions of the arthritis impact measurement scales 1991
    1991 A comparison of the full and short versions of the arthritis impact measurement scales 1991
    1991 Arthritis care and research. A quality/needs assessment 1991
    1991 Disease and psychosocial factors related to physical functioning in rheumatoid arthritis 1991
    1991 Pain threshold levels and coping strategies among patients who have chest pain and normal coronary arteries 1991
    1990 Chest pain with normal coronary arteries - Another perspective 1990
    1990 Behavioral assessment of low back pain: identification of pain behavior subgroups 1990
    1989 Cognitive-behavioral therapy for primary fibromyalgia 1989
    1989 Adherence with treatment regimens among adult rheumatoid arthritis patients: Current status and future directions 1989
    1989 Adherence with treatment regimens among adult rheumatoid arthritis patients: Current status and future directions 1989
    1989 Arthritis treatment, adherence, and behavioral medicine 1989
    1989 Arthritis treatment, adherence, and behavioral medicine 1989
    1989 Esophageal chest pain: Current controversies in pathogenesis, diagnosis, and therapy 1989
    1989 Hypertensive lower esophageal sphincter: What does it mean? 1989
    1989 Psychosocial factors and disease outcomes in rheumatoid arthritis: Old problems, new solutions, and a future agenda 1989
    1989 Stress induces alteration of esophageal pressures in healthy volunteers and non-cardiac chest pain patients 1989
    1989 The secondary prevention of low back pain: a controlled study with follow-up 1989
    1989 Validation of an observation method of pain assessment in non-chronic back pain 1989
    1988 Prediction of pain behavior and functional status of rheumatoid arthritis patients using medical status and psychological variables 1988
    1987 The assessment of pain in rheumatoid arthritis: Disease differentiation and temporal stability of a behavioral observation method 1987
    1987 Effects of psychological therapy on pain behavior of rheumatoid arthritis patients. treatment outcome and six‐month followup 1987
    1987 Oral nifedipine in the treatment of noncardiac chest pain in patients with the nutcracker esophagus 1987
    1987 The Effects of Psychological and Environmental Stressors on Peristaltic Esophageal Contractions in Healthy Volunteers 1987
    1987 The assessment of pain in rheumatoid arthritis 1987
    1986 Psychological comparison of patients with nutcracker esophagus and irritable bowel syndrome 1986
    1986 Development of an observation method for assessing pain behavior in rheumatoid arthritis patients 1986
    1986 Elevated MMPI scores for hypochondriasis, depression, and hysteria in patients with rheumatoid arthritis reflect disease rather than psychological status 1986
    1986 Illness behavior as a predictor of pain and overt behavior patterns in chronic low back pain patients 1986
    1986 Use of external examinations to involve faculty in curriculum content evaluation 1986
    1985 Psychological aspects of arthritis. 1985
    1985 Rheumatoid Arthritis. Review of Psychological Factors Related to Etiology, Effects, and Treatment 1985
    1985 Effects of cognitive-behavioral therapy on pain behavior of rheumatoid arthritis (RA) patients: Preliminary outcomes 1985
    1984 Behavioral and psychological approaches to the assessment and treatment of chronic pain 1984
    1984 Pain-related correlates of MMPI profile subgroups among back pain patients. 1984
    1984 Psychological approaches to the management of arthritis pain 1984
    1982 Cross-validation of the factor structure of the McGill Pain Questionnaire 1982
    1982 Effects of Diagnostician Prestige and Sex Upon Subjects' Acceptance of Genuine Personality Feedback 1982
    1980 Effects of “Favorability” and Type of Assessment Device Upon Acceptance of General Personality Interpretations 1980
    1980 Multivariate Analysis of the MMPI Profiles of Patients with Multiple Pain Comptaints 1980
    1980 The language of low back pain: Factor structure of the McGill pain questionnaire 1980
    1978 Multivariate analyses of the MMPI profiles of low back pain patients 1978
    1978 Comment on “Personality Organization as an Aspect of Back Pain in a Medical Setting” 1978
    1977 Experimenter Prestige and Feedback Related to Acceptance of Genuine Personality Interpretations and Self-Attitude 1977
    1975 Effects of prognostic information on global ratings of psychotherapy outcome 1975
    1975 Effects of impression management efforts on FIRO-B profiles 1975
    1974 Situational Determinants of Personal Validation of General Personality Interpretations 1974

    Principal Investigator On

    Investigator On

    Full Name

  • Laurence Bradley