Beatriz Leon-Ruiz Ph.D.

Beatriz Leon-Ruiz Ph.D.
Associate Professor

Scientist (C), UAB Immunology Institute , School of Medicine
Scientist (C), UWIRC Microbiome Center , School of Medicine
Associate Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Associate Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Scientist (C), Center for AIDS Research , School of Medicine
Associate Scientist, Inflammation, Immunology and Immunotherapeutics , O'Neal Comprehensive Cancer Center
Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Associate Professor (P), Microbiology , Academic Joint Departments
Co-Director, Microbiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Fooling TLR4 to promote fungal virulence.. Immunity. 55:1591-1593. 2022
2021	GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation. Cell Reports. 37. 2021
2021	Lung dendritic cells migrate to the spleen to prime long-lived TCF1hi memory CD8+ T cell precursors after influenza infection. Science Immunology. 6. 2021
2021	Modulating Th2 Cell Immunity for the Treatment of Asthma. Frontiers in Immunology. 12. 2021
2020	GM-CSF Availability Determines LPS-Mediated Functions in Allergic Inflammation 2020
2019	Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation. Mammalian Genome. 30:245-259. 2019
2019	Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells. Science Immunology. 4. 2019
2019	Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisions. Immunological Reviews. 289:84-100. 2019
2019	Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants. Immunity. 50:225-240.e4. 2019
2017	Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nature Immunology. 18:1249-1260. 2017
2017	CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs. Immunity. 47:251-267.e7. 2017
2017	T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway.. Current Allergy and Asthma Reports. 17:43. 2017
2016	T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite. Immunity. 44:259-273. 2016
2014	Dendritic cells and B cells: Unexpected partners in Th2 development. Journal of Immunology. 193:1531-1537. 2014
2014	Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8⁺ T Cells. Immunity. 41:127-140. 2014
2014	FoxP3⁺ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability. Nature Communications. 5. 2014
2014	Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells. Journal of Experimental Medicine. 211:1637-1655. 2014
2013	CD4⁺ T helper cells use CD154-CD40 interactions to counteract T reg cell- mediated suppression of CD8⁺ T cell responses to influenza. Journal of Experimental Medicine. 210:1591-1601. 2013
2013	IL-17-producing B cells combat parasites. Nature Immunology. 14:419-421. 2013
2012	Regulation of T H2 development by CXCR5 ⁺ dendritic cells and lymphotoxin-expressing B cells. Nature Immunology. 13:681-690. 2012
2012	Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation. Immunity. 36:847-856. 2012
2012	Unraveling effector functions of B cells during infection: The hidden world beyond antibody production. Infectious Disorders: Drug Targets. 12:213-221. 2012
2010	Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8⁺T cell responses to influenza. Nature Immunology. 11:216-224. 2010
2008	Statins induce regulatory T cell recruitment via a CCL1 dependent pathway.. Journal of Immunology. 181:3524-3534. 2008
2008	Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1.. Blood. 111:3126-3130. 2008
2008	Monocyte-derived dendritic cells in innate and adaptive immunity.. Immunology and Cell Biology. 86:320-324. 2008
2007	Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania.. Immunity. 26:519-531. 2007
2005	Monocyte-derived dendritic cells.. Seminars in Immunology. 17:313-318. 2005
2004	Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells.. Blood. 103:2668-2676. 2004