Positions

Overview

  • J. Edwin Blalock, Ph.D., joined the Department of Medicine as a Professor in the Division of Pulmonary, Allergy, and Critical Care Medicine and became the Scientific Director of the Lung Health Center in 2009. Dr. Blalock is a Distinguished Alumnus of the University of Florida where he received both a B.S. and Ph.D. degree. He was previously a Professor in the UAB Department of Physiology and Biophysics, having been recruited to UAB in 1986 from the University of Texas Medical Branch, where he was a Professor of Microbiology. Dr. Blalock is internationally recognized for his research in neuroimmunology, rational drug design, as well as the role of inflammation in chronic lung diseases. He has published over 350 journal articles and book chapters and enjoyed uninterrupted funding for the past 38 years. Dr. Blalock has served on two NIH study sections, as well as study sections for the American Heart Association and the National Multiple Sclerosis Society.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 An Ancient CFTR Ortholog Informs Molecular Evolution in ABC TransportersDevelopmental Cell.  51:421-430.e3. 2019
    2019 The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICSRespiratory Research.  20:254. 2019
    2019 Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibitionBiochemical and Biophysical Research Communications.  517:691-696. 2019
    2019 Vaporized e-cigarette liquids induce ion transport dysfunction in airway epitheliaAmerican Journal of Respiratory Cell and Molecular Biology.  61:162-173. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the LungCell.  176:113-126.e15. 2019
    2019 Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosisJournal of Cystic Fibrosis2019
    2019 Proline-glycine-proline peptides are critical in the development of smoke-induced emphysemaAmerican Journal of Respiratory Cell and Molecular Biology.  61:560-566. 2019
    2019 Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness"Science Translational Medicine.  11. 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasiaAJP - Lung Cellular and Molecular Physiology.  315:L810-L815. 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndromeAJP - Lung Cellular and Molecular Physiology.  315:L653-L661. 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.AJP - Lung Cellular and Molecular Physiology.  315:L653-L661. 2018
    2018 An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsivenessScience Translational Medicine.  10. 2018
    2018 Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infantsJCI insight.  3. 2018
    2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac RejectionScientific Reports.  7. 2017
    2017 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosisJCI insight.  2. 2017
    2017 Doxycycline improves clinical outcomes during cystic fibrosis exacerbationsEuropean Respiratory Journal.  49. 2017
    2017 The development of novel LTA4 H modulators to selectively target LTB4 generationScientific Reports.  7. 2017
    2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanismPLoS ONE.  11. 2016
    2016 A ferret model of COPD-related chronic bronchitisJCI insight.  1:e87536. 2016
    2016 Disease phenotyping in chronic obstructive pulmonary disease: The neutrophilic endotypeCurrent Opinion in Pulmonary Medicine.  22:91-99. 2016
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomesAmerican Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Genetic regulation of expression of leukotriene A4 hydrolaseErs Monograph.  2. 2016
    2015 The soot of all evileLife.  4. 2015
    2015 Addendum: Kong, M.Y.; Whitley, R.J.; Peng, N.; Oster, R.; Schoeb, T.R.; Sullender, W.; Ambalavanan, N.; Clancy, J.P.; Gaggar, A.; Blalock J.E. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses 2015, 30, 7, 4230–4253.Viruses.  7:5609. 2015
    2015 Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infectionNature Communications.  6. 2015
    2015 Matrix metalloproteinase-9 mediates RSV infection in vitro and in vivoViruses.  7:4230-4253. 2015
    2015 A Potential Role for Acrolein in Neutrophil-Mediated Chronic InflammationInflammation.  38:2279-2287. 2015
    2015 The matrikine PGP as a potential biomarker in COPDAJP - Lung Cellular and Molecular Physiology.  308:L1095-L1101. 2015
    2015 MMP generated matrikinesCollagen and related research.  44-46:122-129. 2015
    2015 The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeabilityScience Advances.  1. 2015
    2015 A randomized, placebo-controlled trial of roflumilast effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  192:934-942. 2015
    2014 Innate immune cell-produced IL-17 sustains inflammation in bullous pemphigoidJournal of Investigative Dermatology.  134:2908-2917. 2014
    2014 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  190:51-61. 2014
    2014 Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammationPLoS ONE.  9. 2014
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virusEuropean Respiratory Journal.  43:1086-1096. 2014
    2014 Collagen degradation and neutrophilic infiltration: A vicious circle in inflammatory bowel diseaseGut.  63:578-587. 2014
    2013 Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator functionAmerican Journal of Respiratory and Critical Care Medicine.  188:1321-1330. 2013
    2013 Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function.American Journal of Respiratory and Critical Care Medicine.  188:1321-1330. 2013
    2013 Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbationsBMJ Open.  3. 2013
    2013 Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?PLoS ONE.  8. 2013
    2012 Proline-glycine-proline as a potential biomarker in chronic obstructive pulmonary disease and cystic fibrosisTanaffos : Journal of Respiratory Disease, Thoracic Surgery, Intensive Care and Tuberculosis.  11:12-15. 2012
    2012 Cigarette smoke enhances chemotaxis via acetylation of proline-glycine- prolineFrontiers in bioscience (Elite edition).  4 E:2402-2409. 2012
    2012 Molecular recognition theory and sense-antisense interaction: Therapeutic applications in autoimmunityFrontiers in bioscience (Elite edition).  4 E:1864-1870. 2012
    2011 Stress-sensitization and cytokinesCurrent trends in immunology.  12:14-19. 2011
    2011 A CXCL8 receptor antagonist based on the structure of N-acetyl-proline- glycine-prolineEuropean Journal of Pharmacology.  668:435-442. 2011
    2011 A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammationPLoS ONE.  6. 2011
    2011 Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdownAJP - Lung Cellular and Molecular Physiology.  300. 2011
    2011 CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritisAmerican Journal of Pathology.  178:724-734. 2011
    2010 A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammationScience.  330:90-94. 2010
    2010 Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: Implications to cystic fibrosis proteolytic dysfunctionMolecular Medicine.  16:159-166. 2010
    2010 Proline-Glycine-Proline (PGP) and high mobility group box protein-1 (HMGB1): Potential mediators of cystic fibrosis airway inflammationOpen Respiratory Medicine Journal.  4:32-38. 2010
    2009 Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagenJournal of Neuroimmunology.  217:51-54. 2009
    2009 Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegenerationPLoS ONE.  4. 2009
    2009 N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPDRespiratory Research.  10. 2009
    2009 The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantationJournal of Immunology.  182:4423-4431. 2009
    2008 Potential role of high-mobility group box 1 in cystic fibrosis airway diseaseAmerican Journal of Respiratory and Critical Care Medicine.  178:822-831. 2008
    2008 Induction of lung emphysema is prevented by L-arginine-threonine-arginineFederation proceedings.  22:3403-3408. 2008
    2008 Interfering with extracellular matrix degradation to blunt inflammationCurrent Opinion in Pharmacology.  8:242-248. 2008
    2008 A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in Chronic neutrophilic inflammationJournal of Immunology.  180:5662-5669. 2008
    2008 Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide pro-gly-proAmerican Journal of Pathology.  173:144-153. 2008
    2007 Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patientsAJP - Lung Cellular and Molecular Physiology.  293. 2007
    2007 Estrogen modulates TNF-α-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activationAJP - Heart and Circulatory Physiology.  292. 2007
    2007 Possible therapeutic vaccines for canine myasthenia gravis: Implications for the human disease and associated fatigueBrain, Behavior, and Immunity.  21:323-331. 2007
    2007 Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensisJournal of Immunology.  178:1013-1020. 2007
    2007 Conceptual development of the immune system as a sixth senseBrain, Behavior, and Immunity.  21:23-33. 2007
    2006 Weathington et al. reply [2]Nature Medicine.  12:604. 2006
    2006 A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammationNature Medicine.  12:317-323. 2006
    2005 A store-operated nonselective cation channel in human lymphocytesCellular and Molecular Neurobiology.  25:625-647. 2005
    2005 The immune system as the sixth senseJournal of Internal Medicine.  257:126-138. 2005
    2004 Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophagesLaboratory Investigation.  84:29-40. 2004
    2004 Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteriesCirculation.  110:1664-1669. 2004
    2004 Calcium sensors as new therapeutic targets for asthma and chronic obstructive pulmonary diseaseClinical and Experimental Allergy.  34:170-176. 2004
    2004 Ca2+ Modulation of Ca2+ Release-Activated Ca 2+ Channels Is Responsible for the Inactivation of Its Monovalent Cation CurrentBiophysical Journal.  86:805-814. 2004
    2003 The requirement of ammonium or other cations linked with p-cresol sulfate for cross-reactivity with a peptide of myelin basic proteinArchives of Biochemistry and Biophysics.  418:119-124. 2003
    2003 Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.European Journal of Pharmacology.  476:151-157. 2003
    2003 Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthmaEuropean Journal of Pharmacology.  476:151-157. 2003
    2003 Rational design of peptide vaccines for autoimmune disease: Harnessing molecular recognition to fix a broken networkExpert Review of Vaccines.  2:61-73. 2003
    2003 Regulation of Ca2+ release-activated Ca2+ channels by INAD and Ca2+ influx factorAmerican Journal of Physiology - Cell Physiology.  284. 2003
    2002 Harnessing a neural-immune circuit to control inflammation and shockJournal of Experimental Medicine.  195. 2002
    2002 Growth hormone and the immune system during health and diseaseCurrent Opinion in European Medicine.  3:40-67. 2002
    2001 Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit corneaInvestigative Ophthalmology & Visual Science.  42:2769-2775. 2001
    2001 Changes in rat adipocyte and liver glucose metabolism following repeated restraint stressProceedings of the Society for Experimental Biology and Medicine.  226:312-319. 2001
    2001 A store-operated nonselective cation channel in lymphocytes is activated directly by CA2+ influx factor and diacylglycerolAmerican Journal of Physiology - Cell Physiology.  280. 2001
    2001 The role of adjuvants in the efficacy of a peptide vaccine for myasthenia gravis.Proceedings of the Society for Experimental Biology and Medicine.  226:307-311. 2001
    2001 Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cellsCellular Immunology.  208:107-114. 2001
    2001 Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells.Cellular Immunology.  208:107-114. 2001
    2001 An IgM anti-MBP Ab in a case of Waldenstrom's macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAEJournal of Neuroimmunology.  113:163-169. 2001
    2001 Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-handsJournal of Immunology.  166:861-867. 2001
    2001 Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma.Federation proceedings.  15:1831-1833. 2001
    2000 Cellular uptake and in situ binding of a peptide agonist for calmodulinBiochemical and Biophysical Research Communications.  277:462-469. 2000
    2000 A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosisFederation proceedings.  14:1297-1306. 2000
    2000 A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis.Federation proceedings.  14:1297-1306. 2000
    2000 Synthetic complementary peptides inhibit a neutrophil chemoattractant found in the alkali-injured corneaCornea.  19:384-389. 2000
    2000 De novo design of peptides targeted to the EF hands of calmodulinJournal of Biological Chemistry.  275:2676-2685. 2000
    2000 A peptide vaccine that prevents experimental autoimmune myasthenia gravis by specifically blocking T cell helpFederation proceedings.  14:185-196. 2000
    2000 Characterization of the promoter-directing expression of growth hormone in a monocyte cell lineNeuroimmunomodulation.  7:126-134. 2000
    1999 Highly related immunoglobulin light chain sequences in different multiple sclerosis patientsJournal of Neuroimmunology.  100:98-101. 1999
    1999 CFTR chloride channel regulation by an interdomain interactionScience.  286:544-548. 1999
    1999 An analysis of the binding of repressor protein ModE to modABCD (molybdate transport) operator/promoter DNA of Escherichia coliJournal of Biological Chemistry.  274:24308-24315. 1999
    1999 On the evolution of ligands: Did peptides functionally precede metals and small organic molecules?Cellular and Molecular Life Sciences.  55:513-518. 1999
    1999 Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium storesProceedings of the National Academy of Sciences.  96:121-126. 1999
    1999 Proopiomelanocortin and the immune-neuroendocrine connectionAnnals of the New York Academy of Sciences.  885:161-172. 1999
    1998 Molecular mimicry of carcinoembryonic antigen by peptides derived from the structure of an anti-idiotype antibodyCancer Research.  58:1217-1224. 1998
    1998 Molecular cloning, sequence analysis, expression, and tissue distribution of suppressin, a novel suppressor of cell cycle entryJournal of Biological Chemistry.  273:361-368. 1998
    1998 A cross-reactive anti-myelin basic protein idiotope in cerebrospinal fluid cells in multiple sclerosisNeurology.  50:411-417. 1998
    1998 Beta-endorphin in immune cells.Immunology Today.  19:191-192. 1998
    1998 Current concepts in the pathophysiology of abnormal pain perception in fibromyalgiaAmerican Journal of the Medical Sciences.  315:405-412. 1998
    1997 Production of peptide hormones and neurotransmitters by the immune systemProgress in allergy.  69:1-30. 1997
    1997 Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytesJournal of Neuroimmunology.  78:47-56. 1997
    1997 Natural painkillers [1]Nature Medicine.  3:1302. 1997
    1996 Monoclonal antibody (MAB) to a complementary peptide for torpedo acetylcholjne receptor (ACHR) residues 100-116 recognizes t-cell receptors (TCR) SPECIFIC to achr 100-116 in experimental autoimmune myasthenia gravis (EAMG)Federation proceedings.  10. 1996
    1996 Prevention of experimental autoimmune myasthenia gravis by a monoclonal antibody to a complementary peptide for the main immunogenic region of the acetylcholine receptorJournal of Immunology.  157:386-392. 1996
    1996 Murine Vλx and Vλx-containing antibodies bind human myelin basic proteinJournal of Clinical Investigation.  97:486-492. 1996
    1996 Preferential association of Vλx light chains with γ2a heavy chains in naturally occurring human myelin basic protein reactive antibodiesJournal of Neuroimmunology.  70:15-20. 1996
    1995 The kinetics of ACTH expression in rat leukocyte subpopulationsJournal of Neuroimmunology.  63:103-112. 1995
    1995 Associations between the neuroendocrine and immune systemsJournal of Leukocyte Biology.  58:137-150. 1995
    1995 Cloning and sequencing immunoglobulin and T-cell receptor variable regions involved in neuroimmune disordersMethods in Neurosciences.  24:321-334. 1995
    1995 Genetic origins of protein shape and interaction rulesNature Medicine.  1:876-878. 1995
    1995 Reply to “…but not to protein folding?”Nature Medicine.  1:1223. 1995
    1995 The molecular recognition theory applied to bispecific antibodies...but not to protein folding? [1]Nature Medicine.  1:1222-1223. 1995
    1994 Protein configurations [6]Science.  265:1511. 1994
    1994 Adrenocorticotropic hormone stimulates a transient calcium uptake in rat lymphocytes.Endocrinology.  135:1780-1786. 1994
    1994 The syntax of immune-neuroendocrine communicationImmunology Today.  15:504-511. 1994
    1994 EditorialImmunoMethods.  5:89-90. 1994
    1994 Identification of Interactive Determinants on Idiotypic-Anti-idiotypic Antibodies through Comparison of Their Hydropathic ProfilesImmunoMethods.  5:107-113. 1994
    1994 Peptide Design Using a Genetically Patterned Binary Code: Growth Hormone-Releasing Hormone as a ModelImmunoMethods.  5:91-97. 1994
    1994 Use of Complementary Peptides and Their Antibodies in B-Cell-Mediated Autoimmune Disease: Prevention of Experimental Autoimmune Myasthenia Gravis with a Peptide VaccineImmunoMethods.  5:130-135. 1994
    1994 A cross-reactive idiotope on T cells from PL/J mice and Lewis rats that recognizes different myelin basic protein encephalitogenic epitopes but is restricted by TCR Vβ8.2Journal of Immunology.  153:2340-2351. 1994
    1994 A V lambda x-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptors.Journal of Immunology.  153:1132-1140. 1994
    1994 A Vλx-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptorsJournal of Immunology.  153:1132-1140. 1994
    1994 EditorialImmunoMethods.  5:1-2. 1994
    1994 PCR-Based Cloning, Sequencing, and Exon Mapping of Lymphocyte-Derived Neuroendocrine PeptidesImmunoMethods.  5:3-7. 1994
    1994 Characterization and localization of mosquito-gut receptors for trypsin modulating oostatic factor using a complementary peptide and immunocytochemistryFederation proceedings.  8:350-355. 1994
    1994 Induction of pituitary sensitivity to interleukin-1: A new function for corticotropin-releasing hormoneBiochemical and Biophysical Research Communications.  198:480-484. 1994
    1994 Adrenocorticotropic hormone stimulates a transient calcium uptake in rat lymphocytesEndocrinology.  135:1780-1786. 1994
    1994 Effect of the administration of growth-hormone-producing lymphocytes on weight gain and immune function in dwarf miceNeuroimmunomodulation.  1:50-58. 1994
    1994 Erratum: Prevention of experimental autoimmune myasthenia gravis by manipulation of the immune network with a complementary peptide for the acetylcholine receptor (Proc. Natl. Acad. Sci. (September 15, 1993) 90:18 (8747-8751))Proceedings of the National Academy of Sciences.  91:1598. 1994
    1994 Pituitary control of immune cells [1]Immunology Today.  15:39. 1994
    1994 Protein configurations [4]Science.  265:1510. 1994
    1994 Shared ligands and receptors as a molecular mechanism for communication between the immune and neuroendocrine systemsAnnals of the New York Academy of Sciences.  741:292-298. 1994
    1994 The syntax of immune-neuroendocrine communicationImmunology Today.  15:504-511. 1994
    1993 Identification of suppressin-producing cells in the rat pituitary.Endocrinology.  133:241-247. 1993
    1993 Solution structure of trypsin modulating oostatic factor is a left-handed helixBiochemical and Biophysical Research Communications.  193:688-693. 1993
    1993 Identification of suppressin-producing cells in the rat pituitaryEndocrinology.  133:241-247. 1993
    1993 Mitogen-stimulated lymphocytes release biologically active corticotropinEndocrinology.  132:983-988. 1993
    1993 Prevention of experimental autoimmune myasthenia gravis by manipulation of the immune network with a complementary peptide for the acetylcholine receptorProceedings of the National Academy of Sciences.  90:8747-8751. 1993
    1993 The structure of a myelin basic protein-associated idiotopeJournal of Neuroimmunology.  46:235-243. 1993
    1992 Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNACellular and Molecular Neurobiology.  12:447-454. 1992
    1992 Opioid Modulation of Immunoglobulin Production by Lymphocytes Isolated from Peyer's Patches and SpleenAnnals of the New York Academy of Sciences.  650:125-127. 1992
    1992 Phentolamine but not propranolol blocks the immunopotentiating effect of cold stress on antigen-specific IgM production in mice orally immunized with sheep red blood cellsBrain, Behavior, and Immunity.  6:50-63. 1992
    1992 Phosphatidylserine Suppresses Antigen-Specific IgM Production by Mice Orally Administered Sheep Red Blood CellsProceedings of the Society for Experimental Biology and Medicine.  200:548-554. 1992
    1992 Production of peptide hormones and neurotransmitters by the immune systemProgress in allergy.  52:1-24. 1992
    1992 The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytesBrain, Behavior, and Immunity.  6:365-376. 1992
    1991 Cloning and direct sequencing from lambda cDNA libraries using the polymerase chain reaction: suppressin and the vasopressin receptor as models.Netherlands Journal of Medicine.  39:295-305. 1991
    1991 Cloning and direct sequencing from λ cDNA libraries using the polymerase chain reaction: suppressin and the vasopressin receptor as modelsNetherlands Journal of Medicine.  39:295-305. 1991
    1991 A peptide mimetic of calciumProceedings of the National Academy of Sciences.  88:9726-9729. 1991
    1991 An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferationEndocrinology.  128:2053-2057. 1991
    1991 Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cellsProceedings of the National Academy of Sciences.  88:7759-7762. 1991
    1991 Characterization of immunoreactive insulin-like growth factor-i from leukocytes and its regulation by growth hormoneEndocrinology.  129:1727-1734. 1991
    1991 Corticotropin-releasing factor upregulates expression of two truncated pro-opiomelanocortin transcripts in murine lymphocytesJournal of Neuroimmunology.  31:51-58. 1991
    1991 Detection of Growth Hormone and Growth Hormone-Releasing Hormone-Related Messenger RNA in Rat Leukocytes by the Polymerase Chain ReactionProceedings of the Society for Experimental Biology and Medicine.  198:643-648. 1991
    1991 Enantioselective kappa opioid binding sites on the macrophage cell line, P388d1Life Sciences.  49:45-51. 1991
    1991 Expression of immunoreactive growth hormone in leukocytes in vivoJournal of Neuroimmunology.  33:43-54. 1991
    1991 Functional assessment and partial characterization of [3H](+)-pentazocine binding sites on cells of the immune systemJournal of Neuroimmunology.  35:153-166. 1991
    1991 Growth hormone releasing hormone receptors on thymocytes and splenocytes from ratsCellular Immunology.  136:291-302. 1991
    1991 Naloxone administration in vivo stereoselectively alters antigen-dependent and antigen-independent immune responsesPsychoneuroendocrinology.  16:407-415. 1991
    1991 Purification and Characterization of Immunoregulatory Peptides from Neuroendocrine Tissues: Suppressin as a ModelMethods in Neurosciences.  6:297-306. 1991
    1991 Role of leukocyte-derived pro-opiomelanocortin peptides in endotoxic shockCirculatory shock.  35:181-191. 1991
    1991 The production of growth hormone by subpopulations of rat mononuclear leukocytesCellular Immunology.  135:55-65. 1991
    1990 Steroidogenic activity of a peptide specified by the reversed sequence of corticotropin mRNAProceedings of the National Academy of Sciences.  87:9708-9711. 1990
    1990 Structural and functional similarities of opiate receptors of neural and immune originNIDA Research Monograph Series.  122-130. 1990
    1990 More about complementary hydropathy (I: Reply)Trends in Biotechnology.  8:282. 1990
    1990 Complementarity of peptides specified by 'sense' and 'antisense' strands of DNA.Trends in Biotechnology.  8:140-144. 1990
    1990 Isolation, purification, and partial characterization of suppressin, a novel inhibitor of cell proliferationJournal of Biological Chemistry.  265:158-165. 1990
    1990 An antibody directed against a peptide encoded by RNA complementary to mRNA for vasopressin recognizes putative vasopressin receptorsNeuroendocrinology.  51:487-492. 1990
    1990 Anti-opioid receptor antibody recognition of a binding site on brain and leukocyte opioid receptorsNeuroendocrinology.  51:552-560. 1990
    1990 Bidirectional Communication between the Neuroendocrine and Immune Systems Common Hormones and Hormone ReceptorsAnnals of the New York Academy of Sciences.  579:17-27. 1990
    1990 Biochemical and Cellular Characteristics of Suppressin. A Novel Pituitary‐derived Inhibitor of Neuroendocrine and Immune Cell ProliferationAnnals of the New York Academy of Sciences.  594:393-395. 1990
    1990 Characteristics of Lymphocyte‐derived Proopiomelanocortin‐related mRNAAnnals of the New York Academy of Sciences.  594:382-384. 1990
    1990 Complementarity of peptides specified by 'sense' and 'antisense' strands of DNATrends in Biotechnology.  8:140-144. 1990
    1990 Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathwayJournal of Neuroimmunology.  28:53-61. 1990
    1990 Corticotropin‐releasing Hormone Enhances Murine Natural Killer Cell Activity through an Opioid‐Mediated PathwayAnnals of the New York Academy of Sciences.  594:371-373. 1990
    1990 Differential effect of opioids on immunoglobulin production by lymphocytes isolated from Peyer's patches and SpleenLife Sciences.  47:1059-1069. 1990
    1990 Growth Hormone Production and Growth Hormone Releasing Hormone Receptors in the Rat Immune SystemAnnals of the New York Academy of Sciences.  594:432-434. 1990
    1990 Immunomodulatory characteristics of a novel antiproliferative protein, suppressinJournal of Neuroimmunology.  30:179-187. 1990
    1990 Immunoreactive growth hormone-releasing hormone in rat leukocytesJournal of Neuroimmunology.  29:1-13. 1990
    1990 Molecular mechanisms of bidirectional communication between the immune and neuroendocrine systemsInternational Journal of Neuroscience.  51:363-364. 1990
    1990 Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: Endotoxin induction of a truncated peptideProceedings of the National Academy of Sciences.  87:1057-1060. 1990
    1990 Possible alternate splicing or initiation of the proopiomelanocortin gene in lymphocytesInternational Journal of Neuroscience.  51:171-172. 1990
    1990 Reply from BlalockTrends in Biotechnology.  8:282. 1990
    1989 Neuroendocrine characteristics of the immune systemEos -Roma-.  9:195-199. 1989
    1989 Cloning and sequencing of imniunoglobulin variable-region genes using degenerate oligodeoxy-ribonucleotides and polymerase chain reactionGene.  82:371-377. 1989
    1989 A molecular basis for bidirectional communication between the immune and neuroendocrine systemsPhysiol Rev.  69:1-32. 1989
    1989 A molecular basis for bidirectional communication between the immune and neuroendocrine systemsPhysiological Reviews.  69:1-32. 1989
    1989 A molecular basis for intersystem communication between the immune and neuroendocrine systemsInternational Reviews of Immunology.  4:213-228. 1989
    1989 Antipeptide antibodies that recognize a lymphocyte substance P receptorJournal of Immunology.  143:3697-3702. 1989
    1989 Complementary peptides as interactive sites for protein bindingViral Immunology.  2:229-238. 1989
    1989 Expression of growth hormone by lymphocytesInternational Reviews of Immunology.  4:193-211. 1989
    1989 From the neuroendocrinology of lymphocytes toward a molecular basis of the network theoryHormone Research.  31:76-80. 1989
    1989 Hormones common to the neuroendocrine and immune systemsDrug design and delivery.  4:187-195. 1989
    1989 Immune Neuroendocrine Interactions: Implications for Reproductive PhysiologyAnnals of the New York Academy of Sciences.  564:261-266. 1989
    1989 Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cellsJournal of Neuroimmunology.  21:249-254. 1989
    1989 Monoclonal antibody against a peptide specified by [Met]- enkephalin complementary RNA recognizes the delta-class opioid receptorImmunology Letters.  20:181-186. 1989
    1989 Opioid receptors on cells of the immune system: Evidence for δ- and κ-classesJournal of Endocrinology.  122:161-168. 1989
    1989 Preparation and use of complementary peptidesMethods in Enzymology.  168:16-28. 1989
    1989 Production of anti‐idiotypic antibodies by immunization with a pair of complementary peptidesJournal of Molecular Recognition.  1:179-183. 1989
    1989 Protection of mice from Semliki Forest virus infection by lymphocytes treated with low levels of interferon.Molecular biotherapy.  1:305-310. 1989
    1989 Structural and functional relationships between the immune and neuroendocrine systemsBulletin de l'Institut Pasteur.  87:61-92. 1989
    1989 Thyrotropin: An endogenous regulator of the in vitro immune responseJournal of Immunology.  142:744-747. 1989
    1989 Use of peptides encoded by complementary RNA for generating anti-idiotypic antibodies of predefined specificityMethods in Enzymology.  178:63-74. 1989
    1988 ACTH receptor-mediated induction of leukocyte cyclic AMPBiochemical and Biophysical Research Communications.  157:1205-1211. 1988
    1988 Individuals infected with HIV possess antibodies against IL-2Immunology.  65:611-615. 1988
    1988 Ligand receptor characteristics of peptides encoded by complementary nucleic acids: implications for a molecular recognition code.Recent Progress in Hormone Research.  44:199-222. 1988
    1988 Evidence for a δ-class opioid receptor on cells of the immune systemCellular Immunology.  116:44-51. 1988
    1988 "Classical" neuroendocrine peptide hormones produced by cells of the immune systemBrain, Behavior, and Immunity.  2:328-334. 1988
    1988 A molecular basis for interactions between the immune and neuroendocrine systemsInternational Journal of Neuroscience.  38:455-464. 1988
    1988 Immunologically-mediated pituitary-adrenal activation.Advances in Experimental Medicine and Biology.  245:217-223. 1988
    1988 Inhibition of self-binding antibodies (autobodies) by a V H-derived peptideScience.  240:1034-1036. 1988
    1988 Neuroendocrine properties of the immune system.Advances in biochemical psychopharmacology.  44:15-20. 1988
    1988 Opioid Receptors on Murine Splenocytes: Possible Coupling to K+ ChannelsAnnals of the New York Academy of Sciences.  540:694-697. 1988
    1988 Opioid receptors on murine splenocytes. Possible coupling to K+ channels.Annals of the New York Academy of Sciences.  540:694-697. 1988
    1988 Production of immunoreactive growth hormone by mononuclear leukocytesFederation proceedings.  2:2812-2818. 1988
    1988 Productions of neuroendocrine peptide hormones by the immune systemProgress in allergy.  43:1-13. 1988
    1988 Purification of an angiotensin II binding protein by using antibodies to a peptide encoded by angiotensin II complementary RNAProceedings of the National Academy of Sciences.  85:2518-2522. 1988
    1988 The production of antibodies which recognize opiate receptors on murine leukocytesLife Sciences.  42:2615-2624. 1988
    1988 The use of complementary peptides in the purification of an angiotensin II binding proteinJournal of Hypertension -Supplement-.  6:S404-S407. 1988
    1987 Response: virus-induced increases in plasma corticosterone.Science.  238:1424-1425. 1987
    1987 Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cellsJournal of Immunology.  139:3181-3183. 1987
    1987 Immunoaffinity-purified opiate receptor specifically binds the δ-class opiate receptor ligand, cis-(+)-3-methylfentanylisothiocyanate, SUPERFITFEBS Letters.  224:272-276. 1987
    1987 An ACTH Receptor on Human Mononuclear LeukocytesNew England Journal of Medicine.  317:1266-1269. 1987
    1987 Generation of idiotypic and anti-idiotypic antibodies by immunization with peptides encoded by complementary RNA: A possible molecular basis for the network theoryJournal of Immunology.  138:7-9. 1987
    1987 In vivo immunoreactive adrenocorticotropin (ACTH) production by human mononuclear leukocytes from normal and ACTH-Deficient individualsJournal of Clinical Endocrinology and Metabolism.  64:98-105. 1987
    1987 Interactions between the Neuroendocrine and Immune Systems: Common Hormones and ReceptorsImmunological Reviews.  100:79-108. 1987
    1987 Leukocyte Production of EndorphinsAnnals of the New York Academy of Sciences.  496:192-195. 1987
    1987 Novel processing pathway for proopiomelanocortin in lymphocytes: Endotoxin induction of a new prohormone‐Cleaving enzymeJournal of Neuroscience Research.  18:95-101. 1987
    1987 Presence of ACTH and its receptor on a B lymphocytic cell line: a possible autocrine function for a neuroendocrine hormone.Journal of Biological Regulators and Homeostatic Agents.  1:23-27. 1987
    1987 Splenic lymphocyte production of an endorphin during endotoxic shockBrain, Behavior, and Immunity.  1:123-133. 1987
    1987 Virus-induced increases in plasma corticosterone [9]Science.  238:1424-1425. 1987
    1986 Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphinsNature.  321:881-882. 1986
    1986 The HTLV-III envelope protein contains a hexapeptide homologous to a region of interleukin-2 that binds to the interleukin-2 receptorBiochemical and Biophysical Research Communications.  139:367-374. 1986
    1986 Induction of interferon by transformed cells: Inhibition by retinoic acidBiochemical and Biophysical Research Communications.  138:47-53. 1986
    1986 An antibody to a peptide specified by an RNA that is complementary to γ-endorphin mRNA recognizes an opiate receptorJournal of Neuroimmunology.  12:329-337. 1986
    1986 Antibodies to the binding site of the receptor for luteinizing hormone-releasing hormone (LHRH): Generation with a synthetic decapeptide encoded by an RNA complementary to LHRH mRNAProceedings of the National Academy of Sciences.  83:9714-9718. 1986
    1986 Binding of peptides that are specified by complementary RNAsBiochemical Journal.  234:679-683. 1986
    1986 Cellular requirements for thyrotropin enhancement of in vitro antibody productionJournal of Immunology.  137:197-200. 1986
    1986 Interferon Inducing Transformed Cell Surface Glycoproteins: Purification by Ia Antigen Affinity ChromatographyProceedings of the Society for Experimental Biology and Medicine.  182:564-567. 1986
    1986 Molecular characterization of a corticotropin (ACTH) receptorMolecular and Cellular Endocrinology.  44:1-9. 1986
    1986 Production of immunoreactive chorionic gonadotropin during mixed lymphocyte reactions: A possible selective mechanism for genetic diversityProceedings of the National Academy of Sciences.  83:6834-6838. 1986
    1986 Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2Proceedings of the National Academy of Sciences.  83:9188-9192. 1986
    1985 Lymphocyte production of endorphins and endorphin-mediated immunoregulatory activityJournal of Immunology.  135. 1985
    1985 Opiate receptor mediated effects of IFN-alpha and lymphocyte derived endorphin-like peptides.Progress in clinical and biological research.  192:259-264. 1985
    1985 Peptide hormones shared by the neuroendocrine and immunologic systemsJournal of Immunology.  135. 1985
    1985 Lymphocyte production of endorphins and endorphin-mediated immunoregulatory activity.Journal of Immunology.  135:779s-782s. 1985
    1985 Peptide hormones shared by the neuroendocrine and immunologic systems.Journal of Immunology.  135:858s-861s. 1985
    1985 Proopiomelanocortin-derived peptides in the immune system.Clinical Endocrinology.  22:823-827. 1985
    1985 Regions of complementarity between the messenger RNAs for epidermal growth factor, transferrin, interleukin-2 and their respective receptorsBiochemical and Biophysical Research Communications.  128:1373-1380. 1985
    1985 Control of Polyomavirus T-Antigen and DNA Synthesis in Mouse Embryo Fibroblast Cells by Vitamin ACancer Research.  45:2098-2102. 1985
    1985 Interferon-induced transfer of natural cytotoxic activity between human leukocytes.Journal of biological response modifiers.  4:60-69. 1985
    1985 A complete regulatory loop between the immune and neuroendocrine systemsFederation proceedings.  44:108-111. 1985
    1985 A complete regulatory loop between the immune and neuroendocrine systems.Federation proceedings.  44:108-111. 1985
    1985 Bacterial lipopolysaccharide induction of leukocyte-derived corticotropin and endorphinsInfection and Immunity.  48:813-817. 1985
    1985 Bacterial lipopolysaccharide induction of lymphocyte derived pro-opiomelanocortin related peptidesFederation proceedings.  44. 1985
    1985 Cellular requirements for thyrotropin enhancement of in vitro antibody productionFederation proceedings.  44. 1985
    1985 Characterization of ACTH receptors from murine adrenal cells and from human peripheral leukocytesFederation proceedings.  44. 1985
    1985 Corticotropin-releasing activity of monokinesScience.  230:1035-1037. 1985
    1985 Generation of a soluble IFN-γ inducer by oxidation of galactose residues on macrophagesCellular Immunology.  94:440-446. 1985
    1985 Inhibition of herpes simplex virus-1 replication by a proliferation-dependent cytotoxic peptideFederation proceedings.  44. 1985
    1985 Neuroendocrine peptide hormones and their receptors in the immune system. production, processing and actionJournal of Neuroimmunology.  10:31-40. 1985
    1985 PROOPIOMELANOCORTIN‐DERIVED PEPTIDES IN THE IMMUNE SYSTEMClinical Endocrinology.  22:823-827. 1985
    1985 Similarity between the corticotropin (ACTH) receptor and a peptide encoded by an RNA that is complementary to ACTH mRNAProceedings of the National Academy of Sciences.  82:1372-1375. 1985
    1985 The immune system: our mobile brain?Immunology Today.  6:115-117. 1985
    1985 The pituitary-adrenocortical axis and the immune systemClinics in endocrinology and metabolism.  14:1021-1038. 1985
    1984 Enhancement of the in vitro antibody response by thyrotropinBiochemical and Biophysical Research Communications.  125:30-34. 1984
    1984 Vitamin A inhibition of polyoma virus replicationBiochemical and Biophysical Research Communications.  122:851-858. 1984
    1984 Hydropathic anti-complementarity of amino acids based on the genetic codeBiochemical and Biophysical Research Communications.  121:203-207. 1984
    1984 The immune system as a sensory organ.Journal of Immunology.  132:1067-1070. 1984
    1984 Regulation of lymphokine (γ-interferon) production by corticotropinJournal of Immunology.  132:246-250. 1984
    1984 A cytotoxic peptide common to the immune and endocrine systemsFederation proceedings.  43. 1984
    1984 Control of polyoma virus DNA synthesis by vitamin AFederation proceedings.  43. 1984
    1984 Implications for a 'lymphoid adrenal axis'Immunology Today.  5:87. 1984
    1984 Interferon-induced transfer of viral resistance by human B and T lymphocytesCellular Immunology.  87:678-683. 1984
    1984 Synergism of Antiviral Activity in Cell Cultures Treated with Low Concentrations of Interferon and Interferon-Treated LymphocytesProceedings of the Society for Experimental Biology and Medicine.  177:257-261. 1984
    1983 Human lymphocyte production of immunoreactive thyrotropin.Proceedings of the National Academy of Sciences.  80:6010-6013. 1983
    1983 A corticotropin (ACTH) related peptide with cytotoxic activityBiochemical and Biophysical Research Communications.  115:339-345. 1983
    1983 Action of an opiate receptor blocker on ovine cardiopulmonary responses to endotoxinAJP - Heart and Circulatory Physiology.  14. 1983
    1983 Action of an opiate receptor blocker on ovine cardiopulmonary responses to endotoxinAJP - Heart and Circulatory Physiology.  14. 1983
    1983 Cell-to-cell transfer of interferon-induced antiproliferative activityScience.  221:953-955. 1983
    1983 Human lymphocyte production of immunoreactive thyrotropinProceedings of the National Academy of Sciences.  80:6010-6013. 1983
    1983 Ia antigen: A murine B lymphocyte receptor for transformed cell induction of interferon-α/βJournal of Immunology.  131:1895-1899. 1983
    1983 Nonsensitized murine B lymphocytes produce mouse interferon α/β in response to foreign cellsCellular Immunology.  78:375-378. 1983
    1983 Retinoic (vitamin A) acid inhibition of an L-cell glycoprotein that induces interferon α/β in non-sensitized mouse spleen cellsFederation proceedings.  42. 1983
    1983 Staphylococcus aureus protein A induces the production of interferon-α in human lymphocytes and interferon-α/β in mouse spleen cellsJournal of Immunology.  130:773-776. 1983
    1983 Transformed and normal cell surface glycoproteins that induce interferon production by nonsensitized lymphocytesInfection and Immunity.  39:220-224. 1983
    1982 Human natural killer‐like activity against mouse spleen cellsEuropean Journal of Immunology.  12:222-227. 1982
    1982 Involvement of endorphins in the lung lymph changes produced by endotoxinFederation proceedings.  41. 1982
    1982 Regulation of the in vitro antibody response by neuroendocrine hormonesProceedings of the National Academy of Sciences.  79:4171-4174. 1982
    1982 Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axisScience.  218:1311-1312. 1982
    1981 Human lymphocyte production of corticotropin and endorphin-like substances: Association with leukocyte interferonProceedings of the National Academy of Sciences.  78:7530-7534. 1981
    1981 Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.Proceedings of the National Academy of Sciences.  78:7530-7534. 1981
    1981 Human leukocyte interferon (HuIFN-α): Potent endorphin-like opioid activityBiochemical and Biophysical Research Communications.  101:472-478. 1981
    1981 Human B lymphocytes produce leukocyte interferon after interaction with foreign cellsInfection and Immunity.  32:508-512. 1981
    1981 Interferon and adrenocorticotropic hormone induction of steroidogenesis, melanogenesis and antiviral activityArchives of Virology.  67:45-49. 1981
    1981 Anticellular and Immunosuppressive Activities of Foodborne Phenolic Compounds (41185)Proceedings of the Society for Experimental Biology and Medicine.  167:391-393. 1981
    1981 Cell-produced viral inhibitor: Possible mechanism of action and chemical compositionInfection and Immunity.  32:454-457. 1981
    1981 Human lymphocyte production of neuroendocrine hormone-related substancesJournal of Clinical Hematology and Oncology.  11. 1981
    1981 Methods and Procedures for Experiments with Mixed Cell Populations: Transfer of the Antiviral State Induced by InterferonMethods in Enzymology.  79:353-359. 1981
    1981 Methods and procedures for experiments with mixed cell populations: transfer of the antiviral state induced by interferon.Methods in Enzymology.  79:353-359. 1981
    1981 Retinoic acid: Enhancement of a tumor and inhibition of interferon’s antitumor actionJNCI: Journal of the National Cancer Institute.  67:95-97. 1981
    1981 The hormonal nature of the interferon systemTexas reports on biology and medicine.  Vol. 41:350-358. 1981
    1981 Transmission of IFN-induced activities by cell to cell communicationTexas reports on biology and medicine.  Vol. 41:344-349. 1981
    1980 Interferon nomenclatureJournal of Immunology.  125:2353. 1980
    1980 Common pathways of interferon and hormonal action [27]Nature.  283:406-408. 1980
    1980 Human leukocyte interferon: Structural and biological relatedness to adrenocorticotropic hormone and endorphinsProceedings of the National Academy of Sciences.  77:5972-5974. 1980
    1980 Interferon nomenclatureEuropean Journal of Immunology.  10:660. 1980
    1980 Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.Proceedings of the National Academy of Sciences.  77:5972-5974. 1980
    1980 IMMUNE INTERFERON: SOME PROPERTIES AND FUNCTIONSAnnals of the New York Academy of Sciences.  350:130-144. 1980
    1980 Interferon immunosuppression: Mediation by a suppressor factorInfection and Immunity.  29:301-305. 1980
    1980 Interferon nomenclatureArchives of Virology.  66:167-168. 1980
    1980 Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferonCellular Immunology.  49:390-394. 1980
    1980 Transfer of interferon-induced viral resistance from human leukocytes to other cell typesInfection and Immunity.  29:356-360. 1980
    1979 Nonsensitized lymphocytes produce leukocyte interferon when cultured with foreign cellsCellular Immunology.  43:197-201. 1979
    1979 A Small Fraction of Cells Communicates the Maximal Interferon Sensitivity to a PopulationProceedings of the Society for Experimental Biology and Medicine.  162:80-84. 1979
    1979 A non-interferon, broadly active antiviral substances produced by most cellsJournal of Clinical Hematology and Oncology.  9. 1979
    1979 Cellular interactions determine the rate and degree of interferon actionInfection and Immunity.  23:496-501. 1979
    1979 Human lymphocyte transfer of viral resistanceJournal of Clinical Hematology and Oncology.  9. 1979
    1979 Immune-type interferon-induced transfer of viral resistanceJournal of Immunology.  122:1018-1021. 1979
    1979 Interferon induced transfer of viral resistance: Possible natural functions and implicationsJournal of Clinical Hematology and Oncology.  9. 1979
    1979 Interferon-induced suppressor cell activityFederation proceedings.  38. 1979
    1979 Interferon-induced suppressor factor: Possible mechanism of regulation of normal and tumor cellsJournal of Clinical Hematology and Oncology.  9. 1979
    1979 Mechanisms of interferon induced transfer of viral resistance between animal cellsJournal of General Virology.  42:363-372. 1979
    1978 Effect of serum on the antiviral and anticellular activities of mouse interferonArchives of Virology.  56:237-242. 1978
    1978 Various heterologous cells exhibit interferon induced transfer of viral resistanceArchives of Virology.  58:77-80. 1978
    1978 Efficient transfer of interferon-induced virus resistance between human cellsJournal of General Virology.  41:325-331. 1978
    1978 Retinoic acid and the restoration of anchorage dependent growth to transformed mammalian cellsExperimental Cell Research.  117:15-22. 1978
    1977 Interferon-induced transfer of viral resistance between animal cellsNature.  269:422-425. 1977
    1977 Vitamin A-induced density-dependent inhibition of L-cell proliferation.JNCI: Journal of the National Cancer Institute.  58:795-801. 1977
    1977 Brief communication: Vitamin a-induced density-dependent inhibition of l-cell proliferationJNCI: Journal of the National Cancer Institute.  58:795-801. 1977
    1977 Inhibition of interferon production by retinoic acid (vitamin A acid)Texas reports on biology and medicine.  Vol. 35:69-77. 1977
    1977 Retinoic acid (vitamin A acid) induced transcriptional control of interferon production.Proceedings of the National Academy of Sciences.  74:5382-5386. 1977
    1977 Separation of mitogen-induced suppressor and helper cell activities during inhibition of interferon production by cyclic AMPCellular Immunology.  33:170-179. 1977
    1977 The transfer of interferon-induced viral resistance between animal cellsTexas reports on biology and medicine.  Vol. 35:307-315. 1977
    1976 Comparison of the Suppression of Interferon Production and Inhibition of Its Action by Vitamin A and Related Compounds (39532)Proceedings of the Society for Experimental Biology and Medicine.  153:298-300. 1976
    1976 Suppression of interferon production by vitamin AJournal of General Virology.  32:143-147. 1976
    1975 Effect of Tween 80 and Aquasol A on virus plaque formationInfection and Immunity.  12:490-494. 1975
    1975 Inhibition of interferon action by vitamin AJournal of General Virology.  29:315-324. 1975
    1974 Effect of 'Aquasol A', vitamin A, and 'Tween 80' on vesicular stomatitis virus plaque formation and on interferon action. Brief reportARCH.GES.VIRUSFORSCH..  45:161-164. 1974
    1974 Effect of "Aquasol A", vitamin A, and "Tween 80" on vesicular stomatitis virus plaque formation and on interferon actionArchives of Virology.  45:161-164. 1974

    Book

    Year Title Altmetric
    2005 The Biology of CXC Chemokines and Their Receptors.  Ed. 55.  2005

    Chapter

    Year Title Altmetric
    2007 Bidirectional communication between the brain and the immune system.  3-25. 2007

    Research Overview

  • Unrelenting neutrophilic inflammation is a driving force in many human diseases. Research in the Blalock laboratory has focused on understanding the cause(s) of and potential treatments for this aberrant process. In what some consider a paradigm altering observation, the group has found that at inflammatory sites, neutrophil degradation of connective tissue proteins generates novel peptide fragments that can attract a new wave of neutrophils. In certain individuals, it is believed that this neutrophil-mediated process becomes uncontrolled, leading to self-propagating inflammation and chronic disease. In particular, a tripeptide (proline-glycine-proline, PGP) derived from collagen fragmentation, has been shown to attract and activate neutrophils via receptors previously thought to be only utilized by classical chemokines such as interleukin-8 (IL-8).

    Moreover, chronic administration of this peptide into the airways of experimental animals causes robust neutrophil influx and a disease similar to emphysema with alveolar enlargement and right ventricular hypertrophy. Consequently, the research has focused on airway disorders characterized by a chronic neutrophilic inflammation such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF) and lung transplantation organ rejection. In COPD and CF, these researchers have apparently identified a unique proteolytic pathway leading to collagen breakdown and PGP generation. This seems to involve matrix metalloproteases (MMPs) and a novel serine protease, prolyl endopeptidase (PE); these enzymes have been found to be elevated in these disorders. Collectively, these findings have far-reaching translational potential for human pulmonary disorders, in particular, and chronic inflammatory diseases, in general. This is rapidly being implemented in the diagnostic arena where PGP and certain isoforms appear to be biomarkers for COPD, CF, and chronic lung transplant rejection. Future studies will examine whether PGP and its isoforms are prognostic for disease progression and efficacy of certain therapeutic regimens. Rational drug design has led to the development of a variety of PGP antagonists and MMP/PE inhibitors that target this novel pathway of neutrophilic inflammation and, consequently, are prototypes for drugs to treat chronic inflammatory conditions.
  • Principal Investigator On

  • A Novel Exosomal Inflammatory Pathway  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • Innate Immune Aspects of Ocular Surface Disease  awarded by UNIVERSITY OF ILLINOIS (CHICAGO) 2015 - 2020
  • Genetics of Smoke-Altered LTA4H in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • PGP: A Possible Biomarker for COPD Exacerbations/ Progression  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2017
  • HL-A New Pathway for Neutrophil-Induced Airway Inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016
  • Acquired LTA4H Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2016
  • A New Pathway for Neutrophil-Induced Airway Inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2015
  • Private Grant  awarded by FOREST LABORATORIES, INC. 2012 - 2014
  • The Identification of a Novel, Retinoid Modulator of Leukotriene A4 Hydrolase that Augments its Aminopeptidase Activity and Blunts Neutrophilic Inflammation via Enhanced Proline-Glycine-Proline Degradation and/or Reduced Leukotriene B4 Generation  awarded by Howard Hughes Medical Institute 2012 - 2014
  • Private Grant  awarded by GlaxoSmithKline 2011 - 2012
  • MMP-9 Modulation as an Immunotherapeutic Intervention for Respiratory Infections  awarded by Albany Medical Center 2008 - 2012
  • Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2007 - 2012
  • Therapeutics for Chronic Lung Disease: New Antagonists of PGP, Chemokines and CXCR  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2009 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2011
  • Private Grant  awarded by GlaxoSmithKline 2009 - 2010
  • Full Name

  • James Blalock