Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnoverJournal of Biological Chemistry.  295:14153-14163. 2020
2019 Sustained delivery of the angiogenic QK peptide through the use of polyglutamate domains to control peptide release from bone graft materialsJournal of Biomedical Materials Research Part A.  107:2764-2773. 2019
2019 3D printed mesh reinforcements enhance the mechanical properties of electrospun scaffoldsBiomaterials Research.  23. 2019
2019 Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cellsJournal of Ovarian Research.  12. 2019
2019 Addition of an oligoglutamate domain to bone morphogenic protein 2 confers binding to hydroxyapatite materials and induces osteoblastic signalingPLoS ONE.  14. 2019
2019 Transfer of Functional Cargo in ExomeresCell Reports.  27:940-954.e6. 2019
2019 The addition of a polyglutamate domain to the angiogenic QK peptide improves peptide coupling to bone graft materials leading to enhanced endothelial cell activationPLoS ONE.  14. 2019
2018 Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammationJournal of Experimental Medicine.  215:1803-1812. 2018
2018 The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1 signalingJournal of Biological Chemistry.  293:5659-5667. 2018
2018 Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell deathJournal of Ovarian Research.  11. 2018
2018 ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptorJournal of Biological Chemistry.  293:1610-1622. 2018
2018 ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damageJournal of Biological Chemistry.  293:984-994. 2018
2017 Enhanced skin regeneration using a novel amniotic-derived tissue graft 2017
2017 The glycosyltransferase ST6Gal-I protects tumor cells against serum growth factor withdrawal by enhancing survival signaling and proliferative potentialJournal of Biological Chemistry.  292:4663-4673. 2017
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCancer Research.  76:3978-3988. 2016
2016 Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds 2016
2016 Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccinesBiomaterials.  77:307-319. 2016
2015 Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials 2015
2015 Using inositol as a biocompatible ligand for efficient transgene expressionInternational Journal of Nanomedicine.  10:2871-2884. 2015
2015 Microporous dermal-mimetic electrospun scaffolds pre-seeded with fibroblasts promote tissue regeneration in full-thickness skin woundsPLoS ONE.  10. 2015
2014 Comparing variable-length polyglutamate domains to anchor an osteoinductive collagen-mimetic peptide to diverse bone grafting materialsInternational Journal of Oral and Maxillofacial Implants.  29:1437-1445. 2014
2014 Microporous dermal-like electrospun scaffolds promote accelerated skin regeneration 2014
2014 Tunable delivery of bioactive peptides from hydroxyapatite biomaterials and allograft bone using variable-length polyglutamate domainsJournal of Biomedical Materials Research Part A.  102:1008-1016. 2014
2013 Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastomaClinical Cancer Research.  19:6484-6494. 2013
2013 ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cellsJournal of Ovarian Research.  6. 2013
2013 ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell linesCancer Research.  73:2368-2378. 2013
2013 Engineering nanocages with polyglutamate domains for coupling to hydroxyapatite biomaterials and allograft boneBiomaterials.  34:2455-2462. 2013
2013 Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft boneBiomaterials.  34:1506-1513. 2013
2012 Regulation of the metastatic cell phenotype by sialylated glycansCancer and Metastasis Reviews.  31:501-518. 2012
2012 Delivery of platelet-derived growth factor as a chemotactic factor for mesenchymal stem cells by bone-mimetic electrospun scaffoldsPLoS ONE.  7. 2012
2012 Increasing the pore sizes of bone-mimetic electrospun scaffolds comprised of polycaprolactone, collagen I and hydroxyapatite to enhance cell infiltrationBiomaterials.  33:524-534. 2012
2011 Nanocomposite scaffolds based on electrospun polycaprolactone/modified CNF/nanohydroxyapatite by electrophoretic depositionJournal of biomaterials and tissue engineering.  1:177-184. 2011
2011 ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptorJournal of Biological Chemistry.  286:39654-39662. 2011
2011 Sialylation of the Fas death receptor by St6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cellsJournal of Biological Chemistry.  286:22982-22990. 2011
2011 Advantages of RGD peptides for directing cell association with biomaterialsBiomaterials.  32:4205-4210. 2011
2011 Engineering an antiplatelet adhesion layer on an electrospun scaffold using porcine endothelial progenitor cellsJournal of Biomedical Materials Research Part A.  97 A:145-151. 2011
2011 Emerging role of α2,6-sialic acid as a negative regulator of galectin binding and functionJournal of Biological Chemistry.  286:5935-5941. 2011
2011 Mesenchymal stem cell responses to bone-mimetic electrospun matrices composed of polycaprolactone, collagen I and nanoparticulate hydroxyapatitePLoS ONE.  6. 2011
2010 Enhancement of peptide coupling to hydroxyapatite and implant osseointegration through collagen mimetic peptide modified with a polyglutamate domainBiomaterials.  31:9586-9594. 2010
2010 An in vitro regenerated functional human endothelium on a nanofibrous electrospun scaffoldBiomaterials.  31:4376-4381. 2010
2010 Aligned bioactive multi-component nanofibrous nanocomposite scaffolds for bone tissue engineeringMacromolecular Bioscience.  10:433-444. 2010
2009 Osteogenic differentiation of human mesenchymal stem cells directed by extracellular matrix-mimicking ligands in a biomimetic self-assembled peptide amphiphile nanomatrixBiomacromolecules.  10:2935-2944. 2009
2009 The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfacesBiomaterials.  30:1898-1909. 2009
2008 Comparison of mesenchymal stem cell and osteosarcoma cell adhesion to hydroxyapatiteJournal of Materials Science: Materials in Medicine.  19:3567-3574. 2008
2008 Effect of altered glycosylation on the structure of the I-like domain of β1 integrin: A molecular dynamics study 2008
2008 Working group report: The roles of glycans in hemostasis, inflammation and vascular biologyGlycobiology.  18:747-749. 2008
2008 ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function.Journal of Ovarian Research.  1:3. 2008
2008 Tumor cell migration and invasion are regulated by expression of variant integrin glycoformsExperimental Cell Research.  314:2941-2950. 2008
2008 Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of α4β1 integrinsJournal of Biological Chemistry.  283:26364-26373. 2008
2008 Sialylation of β1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosisJournal of Biological Chemistry.  283:22177-22185. 2008
2008 Mesenchymal stem cell interaction with ultra-smooth nanostructured diamond for wear-resistant orthopaedic implantsBiomaterials.  29:3461-3468. 2008
2008 The effect of RGD peptides on osseointegration of hydroxyapatite biomaterialsBiomaterials.  29:3075-3083. 2008
2008 Low temperature induces the delivery of mature and immature CFTR to the plasma membraneBiochemical and Biophysical Research Communications.  366:1025-1029. 2008
2007 Identification of a HoxA10 activation domain necessary for transcription of the gene encoding β3 integrin during myeloid differentiationJournal of Biological Chemistry.  282:16846-16859. 2007
2007 The effect of adsorbed serum proteins, RGD and proteoglycan-binding peptides on the adhesion of mesenchymal stem cells to hydroxyapatiteBiomaterials.  28:383-392. 2007
2006 Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxideBiomaterials.  27:2201-2212. 2006
2006 Mesenchymal stem cell adhesion and spreading on microwave plasma-nitrided titanium alloy 2006
2005 The effect of the addition of a polyglutamate motif to RGD on peptide tethering to hydroxyapatite and the promotion of mesenchymal stem cell adhesionBiomaterials.  26:7046-7056. 2005
2005 A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering β1 integrin sialylationJournal of Biological Chemistry.  280:37610-37615. 2005
2005 Hypersialylation of β 1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motilityCancer Research.  65:4645-4652. 2005
2005 Erratum: Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite (Journal of Biomedical Materials Research - Part A (2004) 68A, 2 (273-285) DOI: 10.1002/jbm.a.20043) 2005
2005 Regulation of mesenchymal stem cell attachment and spreading on hydroxyapatite by RGD peptides and adsorbed serum proteinsBiomaterials.  26:1467-1475. 2005
2004 Mesenchymal stem cell adhesion and spreading on nanostructured biomaterialsJournal of Nanoscience and Nanotechnology.  4:986-989. 2004
2004 Variant glycosylation: An underappreciated regulatory mechanism for β1 integrins 2004
2004 Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite 2004
2003 Ras oncogene directs expression of a differentially sialylated, functionally altered β1 integrinOncogene.  22:7137-7145. 2003
2002 Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptorsJournal of Biological Chemistry.  277:32830-32836. 2002
2001 TGF-β1 up-regulates paxillin protein expression in malignant astrocytoma cells: Requirement for a fibronectin substrateOncogene.  20:7976-7986. 2001
2001 Hydroxylapatite binds more serum proteins, purified integrins, and osteoblast precursor cells than titanium or steel 2001
1999 Steps in integrin beta1-chain glycosylation mediated by TGFbeta1 signaling through Ras.Journal of Cellular Physiology.  181:33-44. 1999
1999 Steps in integrin β1-chain glycosylation mediated by TGFβ1 signaling through rasJournal of Cellular Physiology.  181:33-44. 1999
1997 Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillinBiochemical Journal.  325:375-381. 1997
1995 Affinity purification of hydra glutathione bindings proteins. [FEBS Letters 354 (1994) 320-324] (PII:0014-5793(94)01154-0)FEBS Letters.  362:98. 1995
1995 Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinaseJournal of Biological Chemistry.  270:17437-17441. 1995
1994 Signal transduction for taurocholic acid in the olfactory system of atlantic salmonChemical Senses.  19:371-380. 1994
1994 Affinity purification of Hydra glutathione binding proteinsFEBS Letters.  354:320-324. 1994
1992 Chemoreception in hydra: specific binding of glutathione to a membrane fraction 1992
1992 Partial Characterization and Detergent Solubilization of the Putative Glutathione Chemoreceptor from HydraBiochemistry.  31:9838-9843. 1992
1991 Chemoreception in Hydra vulgaris (attenuata): initial characterization of two distinct binding sites for l-glutamic acid 1991

Principal Investigator On

  • Glycosylation-dependent Mechanisms Regulating Ovarian Tumor cell Phenotype  awarded by National Cancer Institute/NIH/DHHS 2019 - 2024
  • Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • Research Collaboration with University of Copenhagen  awarded by University of Copenhagen 2019 - 2022
  • Tunable Co-Delivery of VEGF and BMP2 Mimetic Peptides to Enhance Bone Regeneration  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2020
  • Coupling Osteoinductive Factors to Graft Materials to Promote Osteoregeneration  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2014 - 2019
  • Novel Mechanism of TNFR1 Regulation in Macrophage Apoptosis and Atherogenesis  awarded by American Heart Association 2017 - 2018
  • Glycosylation-Dependent Mechanisms Regulating Ovarian Tumor Cell Survival  awarded by National Institute of General Medical Sciences/NIH/DHHS 2014 - 2018
  • Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • Glycosylation-Dependent Control of TNFR1 Signaling in Macrophage Survival  awarded by American Heart Association (Southeast Affiliate) 2014 - 2016
  • UAB Skin Disease Research Center - P&F 20  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2014
  • Private Grant  awarded by NUTECH MEDICAL, INC 2014
  • TNFR1 Death Receptor Glycosylation in Macrophage Apoptosis  awarded by American Heart Association (Southeast Affiliate) 2011 - 2014
  • Role of Receptor Sialylation in the Ovarian Tumor Cell Phenotype  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2011 - 2014
  • Targeted Delivery of Osteoinductive Molecules to Biologic HA in Bone Grafts  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2014
  • Novel Method for Anchoring Osteoinductive Factors to Bone Graft Materials to Enhance Osseointegration  awarded by OSSEOINTEGRATION FOUNDATION 2012 - 2013
  • Regulation of Beta1 Integrin Glycosylation by Ras  awarded by National Cancer Institute/NIH/DHHS 2007 - 2013
  • Enhanced Coupling of Bone Regenerative Peptides to Hydroxyapatite-Containing Biomaterials  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2011 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 5  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Role of Fas Glycoforms in Macrophage Apoptosis  awarded by American Heart Association 2010 - 2012
  • Functionalizing Hydroxyapatite with Proadhesive Peptides  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2005 - 2011
  • Role of Sialylation in Macrophage Apoptosis  awarded by American Heart Association (Southeast Affiliate) 2009 - 2011
  • Cell and Molecular Analysis of Biomaterials Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2007 - 2011
  • Investigator On

  • CD4 T Cell Stemness and Inflammatory Bowel Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2020 - 2024
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Intra-Tumor Heterogeneity in Colorectal Cancer Progression and Treatment Response  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Sialylation Dependent Control of CD8 T cell Stemness during Chronic Viral Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2020
  • Role of Gastric Microbiota in Protecting Children from Precancerous Inflammation in H. Pylori Infection  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2019
  • Private Grant  awarded by BIOMET, INC. 2014 - 2018
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Nanotechnology in Biosensors and Bioengineering  awarded by National Institute of Biomedical Imaging and Bioengineering/NIH/DHHS 2007 - 2013
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Teaching Activities

  • GBSC743 - Glycobiology (Spring Term 2020) 2020
  • BME799 - Dissertation Research (Fall Term 2019) 2019
  • BME799 - Dissertation Research (Summer Term 2019) 2019
  • BME799 - Dissertation Research (Spring Term 2019) 2019
  • BME799 - Dissertation Research (Fall Term 2018) 2018
  • BME799 - Dissertation Research (Summer Term 2018) 2018
  • BME799 - Dissertation Research (Spring Term 2018) 2018
  • BME798 - Non-Dissertation Research (Fall Term 2017) 2017
  • BME798 - Non-Dissertation Research (Summer Term 2017) 2017
  • BME798 - Non-Dissertation Research (Spring Term 2017) 2017
  • BME798 - Non-Dissertation Research (Summer Term 2016) 2016
  • BME798 - Non-Dissertation Research (Spring Term 2016) 2016
  • BME798 - Non-Dissertation Research (Fall Term 2015) 2015
  • BME798 - Non-Dissertation Research (Summer Term 2015) 2015
  • BME798 - Non-Dissertation Research (Spring Term 2015) 2015
  • BME798 - Non-Dissertation Research (Fall Term 2014) 2014
  • BME799 - Dissertation Research (Spring Term 2013) 2013
  • BME799 - Dissertation Research (Fall Term 2012) 2012
  • BME799 - Dissertation Research (Summer Term 2012) 2012
  • BME799 - Dissertation Research (Spring Term 2012) 2012
  • BME798 - Non-Dissertation Research (Fall Term 2011) 2011
  • BME798 - Non-Dissertation Research (Summer Term 2011) 2011
  • BME798 - Non-Dissertation Research (Spring Term 2011) 2011
  • BME798 - Non-Dissertation Research (Fall Term 2010) 2010
  • BME699 - Masters Thesis Research (Summer Term 2010) 2010
  • BME699 - Masters Thesis Research (Spring Term 2010) 2010
  • BME698 - Non-Thesis Research (Fall Term 2009) 2009
  • BME698 - Non-Thesis Research (Summer Term 2009) 2009
  • BME698 - Non-Thesis Research (Spring Term 2009) 2009
  • BME698 - Non-Thesis Research (Fall Term 2008) 2008
  • BME799 - Dissertation Research (Fall Term 2008) 2008
  • PHY790 - Selected Topics Physiology I (Fall Term 2008) 2008
  • BME799 - Dissertation Research (Summer Term 2008) 2008
  • BME799 - Dissertation Research (Spring Term 2008) 2008
  • BME799 - Dissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biology / Biological Sciences, University of Rhode Island 1993
  • Full Name

  • Susan Bellis