Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.  Science Translational Medicine.  12. 2020
2020 Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.  Mucosal Immunology.  2020
2019 Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.  Cell Metabolism.  30:1141-1151.e5. 2019
2019 Dolutegravir plus lamivudine for initial treatment of HIV-1-infected participants with HIV-1 RNA <500 000 copies/mL: Week 48 outcomes from ACTG 5353.  Journal of Antimicrobial Chemotherapy.  74:1376-1380. 2019
2019 Endoplasmic reticulum stress signaling pathways: Activation and diseases.  Current Protein and Peptide Science.  20:935-943. 2019
2018 The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization.  Journal of Biological Chemistry.  293:4110-4121. 2018
2017 Preliminary X-Ray Crystallographic Studies of the N-Terminal Domains of Hsp104 from Yeast Candida albicans and Saccharomyces cerevisiae 2017
2017 Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.  Acta Crystallographica. Section d, Structural Biology.  73:365-372. 2017
2016 The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.  Acta Crystallographica. Section d, Structural Biology.  72:1290-1297. 2016
2015 The structure of Tim50(164-361) suggests the mechanism by which Tim50 receives mitochondrial presequences.  Acta Crystallographica Section F: Structural Biology Communications.  71:1146-1151. 2015
2011 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.  Biochemical Journal.  438:447-455. 2011
2011 Structural basis for the function of Tim50 in the mitochondrial presequence translocase.  Journal of Molecular Biology.  411:513-519. 2011
2011 ACK2-dependent mechanism for activation of the JAK-STAT signaling pathway.  Blood.  118:156-166. 2011
2011 Membrane binding mechanism of yeast mitochondrial peripheral membrane protzein TIM44 2011
2011 The structure of the PERK kinase domain suggests the mechanism for its activation.  Acta Crystallographica Section D: Biological Crystallography.  67:423-428. 2011
2011 Structural insight into the protective role of P58(IPK) during unfolded protein response.  Methods in Enzymology.  490:259-270. 2011
2010 The structural plasticity of Tom71 for mitochondrial precursor translocations 2010
2010 Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation.  Journal of Biological Chemistry.  285:9322-9326. 2010
2010 Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR.  Journal of Molecular Biology.  397:1307-1315. 2010
2009 The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion.  PLoS ONE.  4. 2009
2009 Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.  Journal of Biological Chemistry.  284:23852-23859. 2009
2009 Preliminary X-ray crystallographic studies of yeast Get3 2009
2009 Heat shock protein 40: Structural studies and their functional implications 2009
2008 Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment 2008
2008 The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1.  BMC Structural Biology.  8. 2008
2008 SAD phasing by OASIS at different resolutions down to 0.30 nm and below 2008
2006 Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex.  Biochemical Journal.  398:353-360. 2006
2006 Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p 2006
2006 Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70p 2006
2006 Crystal Structure of Yeast Mitochondrial Peripheral Membrane Protein Tim44p C-terminal Domain.  Journal of Molecular Biology.  359:798-804. 2006
2006 Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p 2006
2005 Structure-based mutagenesis studies of the peptide substrate binding fragment of type I heat-shock protein 40.  Biochemical Journal.  386:453-460. 2005
2005 The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40.  Journal of Molecular Biology.  346:1005-1011. 2005
2004 Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library.  Biological Procedures Online.  6:204-208. 2004
2003 Preliminary X-ray crystallographic studies of yeast Hsp40 Ydj1 complexed with its peptide substrate.  Acta Crystallographica Section D: Biological Crystallography.  59:1317-1319. 2003
2003 Crystal structure of the E. coli Hsp100 ClpB N-terminal domain.  Structure.  11:323-328. 2003
2003 The Crystal Structure of the Yeast Hsp40 Ydj1 Complexed with Its Peptide Substrate.  Structure.  11:1475-1483. 2003
2002 Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.  Journal of Biological Chemistry.  277:48596-48601. 2002
2002 Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 nucleotide-binding domain 2 (NBD2).  Acta Crystallographica Section D: Biological Crystallography.  58:1030-1031. 2002
2002 Crystal structure of E. coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1) and mechanistic studies on ClpB ATPase activity..  Journal of Molecular Biology.  318:1127-1137. 2002
2002 Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: Yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1.  Biochemical Journal.  361:27-34. 2002
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 ClpB N-terminal domain.  Acta Crystallographica Section D: Biological Crystallography.  57:1933-1935. 2001
2001 The crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein: Interfaces can rotate in the oligomeric structures of M1.  Virology.  289:34-44. 2001
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of escherichia coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1).  Acta Crystallographica Section D: Biological Crystallography.  57:909-911. 2001
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of yeast Hsp40 Sis1 complexed with Hsp70 Ssa1 C-terminal lid domain.  Acta Crystallographica Section D: Biological Crystallography.  57:748-750. 2001
2000 The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1.  Structure.  8:799-807. 2000
1999 PI transfer protein: The specific recognition of phospholipids and its functions 1999
1999 Purification, crystallization and preliminary X-ray crystallographic studies of S. cerevisiae Hsp40 Sis1.  Acta Crystallographica Section D: Biological Crystallography.  55:1234-1236. 1999
1999 Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: An evolutionary link between negative-stranded RNA viruses and retroviruses.  Journal of General Virology.  80:863-869. 1999
1999 Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.  Molecular Cell.  4:187-197. 1999
1998 Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer protein.  Nature.  391:506-510. 1998
1997 Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1 1997
1997 Crystallization and preliminary X-ray crystallographic studies of type A influenza virus matrix protein M1.  Acta Crystallographica Section D: Biological Crystallography.  53:458-460. 1997
1997 Crystallization and preliminary X-ray diffraction studies of the Saccharomyces cerevisiae phospholipid-transfer protein Sec14p.  Acta Crystallographica Section D: Biological Crystallography.  53:784-786. 1997
1994 EDIM93: a program for electron diffraction intensity measurement from photographic data.  Journal of Applied Crystallography.  27:430-432. 1994
1994 Direct methods for incommensurate intergrowth compounds. II. Determination of the modulation using only main reflections 1994
1993 Correction for the dynamical electron diffraction effect in crystal structure analysis 1993
1992 Structural features of the incommensurate modulation in the Pb-doped Bi-2223 high-Tc phase revealed by direct-method electron diffraction analysis.  Superconductor Science and Technology.  5:69-72. 1992
1992 Incommensurate modulation of the bi-2223 superconducting phase observed by direct-method electron diffraction analysis 1992
1991 Prevalence of measles antibodies in asymptomatic human immunodeficiency virus-infected adults.  Journal of Infectious Diseases.  164:973-975. 1991

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1994

    • Full Name

  • Bingdong Sha