Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.  Mucosal Immunology.  13:788-798. 2020
2020 β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.  Science Translational Medicine.  12. 2020
2019 Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.  Cell Metabolism.  30:1141-1151.e5. 2019
2019 Dolutegravir plus lamivudine for initial treatment of HIV-1-infected participants with HIV-1 RNA <500 000 copies/mL: Week 48 outcomes from ACTG 5353.  Journal of Antimicrobial Chemotherapy.  74:1376-1380. 2019
2019 Endoplasmic reticulum stress signaling pathways: Activation and diseases.  Current Protein and Peptide Science.  20:935-943. 2019
2018 The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization.  Journal of Biological Chemistry.  293:4110-4121. 2018
2017 Preliminary X-Ray Crystallographic Studies of the N-Terminal Domains of Hsp104 from Yeast Candida albicans and Saccharomyces cerevisiae 2017
2011 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.  Biochemical Journal.  438:447-455. 2011
2011 Structural basis for the function of Tim50 in the mitochondrial presequence translocase.  Journal of Molecular Biology.  411:513-519. 2011
2011 ACK2-dependent mechanism for activation of the JAK-STAT signaling pathway.  Blood.  118:156-166. 2011
2011 Membrane binding mechanism of yeast mitochondrial peripheral membrane protzein TIM44 2011
2011 Structural insight into the protective role of P58(IPK) during unfolded protein response.  Methods in Enzymology.  490:259-270. 2011
2010 Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation.  Journal of Biological Chemistry.  285:9322-9326. 2010
2010 Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR.  Journal of Molecular Biology.  397:1307-1315. 2010
2009 The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion.  PLoS ONE.  4. 2009
2009 Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.  Journal of Biological Chemistry.  284:23852-23859. 2009
2009 Heat shock protein 40: Structural studies and their functional implications 2009
2008 The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1.  BMC Structural Biology.  8. 2008
2006 Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex.  Biochemical Journal.  398:353-360. 2006
2006 Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p 2006
2006 Crystal Structure of Yeast Mitochondrial Peripheral Membrane Protein Tim44p C-terminal Domain.  Journal of Molecular Biology.  359:798-804. 2006
2005 Structure-based mutagenesis studies of the peptide substrate binding fragment of type I heat-shock protein 40.  Biochemical Journal.  386:453-460. 2005
2005 The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40.  Journal of Molecular Biology.  346:1005-1011. 2005
2004 Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library.  Biological Procedures Online.  6:204-208. 2004
2003 Crystal structure of the E. coli Hsp100 ClpB N-terminal domain.  Structure.  11:323-328. 2003
2003 The Crystal Structure of the Yeast Hsp40 Ydj1 Complexed with Its Peptide Substrate.  Structure.  11:1475-1483. 2003
2002 Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.  Journal of Biological Chemistry.  277:48596-48601. 2002
2002 Crystal structure of E. coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1) and mechanistic studies on ClpB ATPase activity..  Journal of Molecular Biology.  318:1127-1137. 2002
2002 Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: Yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1.  Biochemical Journal.  361:27-34. 2002
2001 The crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein: Interfaces can rotate in the oligomeric structures of M1.  Virology.  289:34-44. 2001
2000 The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1.  Structure.  8:799-807. 2000
1999 PI transfer protein: The specific recognition of phospholipids and its functions 1999
1999 Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: An evolutionary link between negative-stranded RNA viruses and retroviruses.  Journal of General Virology.  80:863-869. 1999
1999 Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.  Molecular Cell.  4:187-197. 1999
1998 Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer protein.  Nature.  391:506-510. 1998
1997 Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1 1997
1994 EDIM93: a program for electron diffraction intensity measurement from photographic data.  Journal of Applied Crystallography.  27:430-432. 1994
1992 Structural features of the incommensurate modulation in the Pb-doped Bi-2223 high-Tc phase revealed by direct-method electron diffraction analysis.  Superconductor Science and Technology.  5:69-72. 1992
1992 Incommensurate modulation of the bi-2223 superconducting phase observed by direct-method electron diffraction analysis 1992
1991 Prevalence of measles antibodies in asymptomatic human immunodeficiency virus-infected adults.  Journal of Infectious Diseases.  164:973-975. 1991

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1994

    • Full Name

  • Bingdong Sha