• Dr. Barnes is an Assistant Professor of Medicine at the University of Alabama at Birmingham (UAB). Following his training in Glycobiology at the Complex Carbohydrate Research Center at the University of Georgia, he was recruited to the Cleveland Clinic Lerner College of Medicine, where he combined his basic research experiences with more translational approaches in the Department of Pathobiology within the Lerner Research Institute. During his stint at the Cleveland Clinic, Dr. Barnes became a Research Associate, the Director of the Pulmonary Vascular Disease Center of Excellence Biorepository, and received support from multiple sources, including grants from the National Institutes of Health.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Upregulation of sortilin, a lysosomal sorting receptor, corresponds with reduced bioavailability of latent TGFβ in mucolipidosis II cells 2020
    2020 The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance 2020
    2020 Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction 2020
    2020 Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion 2020
    2019 O-GlcNAc transferase regulates angiogenesis in idiopathic pulmonary arterial hypertension 2019
    2019 High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium 2019
    2019 Fibroblast growth factor 23 is associated with a frequent exacerbator phenotype in COPD: A cross-sectional pilot study 2019
    2019 How to detect tobacco-related vasculopathy: Are we there yet? 2019
    2019 Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis 2019
    2018 Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases 2018
    2018 Things we “kNOw” and do not “kNOw” about pulmonary hypertension 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammation 2018
    2018 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells. 2018
    2017 Pulmonary hypertension and precision medicine through the "omics" looking glass 2017
    2017 Abnormal glucose metabolism and high-energy expenditure in idiopathic pulmonary arterial hypertension 2017
    2017 Corrigendum to Abstract 389 "Identification of Educational Gaps Amongst Physicians Who Manage Patients with Chronic Heart Failure": Journal of Cardiac Failure, Vol. 22, No. 8S, August 2016, p. S135. 2017
    2016 Novel methods in pulmonary hypertension phenotyping in the age of precision medicine (2015 grover conference series) 2016
    2016 Bone morphogenic protein type 2 receptor mutation-independent mechanisms of disrupted bone morphogenetic protein signaling in idiopathic pulmonary arterial hypertension 2016
    2016 Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis 2016
    2015 Shot-noise Limited Faraday Rotation Spectroscopy for Detection of Nitric Oxide Isotopes in Breath, Urine, and Blood 2015
    2015 O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension 2015
    2014 Is pulmonary hypertension a metabolic disease? 2014
    2014 Impact of weight loss on ankle-brachial index and interartery blood pressures 2014
    2014 Breath analysis in pulmonary arterial hypertension. 2014
    2014 The multiple mechanistic faces of a pure volume overload: Implications for therapy 2014
    2014 Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy 2014

    Research Overview

  • Dr. Barnes’ research has focused on dysregulated glucose metabolism and its role in aberrant glycosylation in pulmonary vascular disease. Specifically, his work has demonstrated that glucose dysregulation impacts glycosylation and glycosyl transferases that drive cell proliferation in idiopathic pulmonary arterial hypertension (IPAH). His research will continue to explore the molecular mechanisms that regulate metabolism and glycosylation in IPAH as well as other pulmonary diseases.
  • Education And Training

  • Cleveland Clinic Department of Pathobiology, Postdoctoral Research
  • Doctor of Philosophy in Biochemistry and Molecular Biology, University of Georgia 2011
  • Master of Science in Biochemistry and Molecular Biology, University of Georgia 2004
  • Bachelor of Science or Mathematics in Biochemistry and Molecular Biology, University of Georgia 2001
  • Full Name

  • Jarrod Barnes