Positions

Overview

  • Dr. Barnes is an Assistant Professor of Medicine at the University of Alabama at Birmingham (UAB). Following his training in Glycobiology at the Complex Carbohydrate Research Center at the University of Georgia, he was recruited to the Cleveland Clinic Lerner College of Medicine, where he combined his basic research experiences with more translational approaches in the Department of Pathobiology within the Lerner Research Institute. During his stint at the Cleveland Clinic, Dr. Barnes became a Research Associate, the Director of the Pulmonary Vascular Disease Center of Excellence Biorepository, and received support from multiple sources, including grants from the National Institutes of Health.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 The Glycobiology of Pulmonary Arterial Hypertension.  Metabolites.  12. 2022
    2022 Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice.  Theranostics.  12:530-541. 2022
    2021 ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.  Frontiers in Immunology.  12. 2021
    2020 Targeting aging pathways in chronic obstructive pulmonary disease.  International Journal of Molecular Sciences.  21:1-17. 2020
    2020 Specific O-GlcNAc modification at Ser-615 modulates eNOS function.  Redox Biology.  36. 2020
    2020 Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?.  Frontiers in Medicine.  7. 2020
    2020 Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion.  Redox Biology.  34. 2020
    2020 Upregulation of sortilin, a lysosomal sorting receptor, corresponds with reduced bioavailability of latent TGFβ in mucolipidosis II cells.  Biomolecules.  10. 2020
    2020 The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance.  Frontiers in Medicine.  6. 2020
    2020 Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction.  PLoS ONE.  15. 2020
    2019 O-GlcNAc transferase regulates angiogenesis in idiopathic pulmonary arterial hypertension.  International Journal of Molecular Sciences.  20. 2019
    2019 High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium 2019
    2019 Fibroblast growth factor 23 is associated with a frequent exacerbator phenotype in COPD: A cross-sectional pilot study.  International Journal of Molecular Sciences.  20. 2019
    2019 How to detect tobacco-related vasculopathy: Are we there yet?.  Annals of the American Thoracic Society.  16:674-675. 2019
    2019 Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis 2019
    2018 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells.  Frontiers in Endocrinology.  9. 2018
    2018 Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases.  International Journal of Molecular Sciences.  19. 2018
    2018 Things we “kNOw” and do not “kNOw” about pulmonary hypertension.  American Journal of Respiratory and Critical Care Medicine.  198:151-152. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammation.  European Respiratory Journal.  52. 2018
    2017 Pulmonary hypertension and precision medicine through the "omics" looking glass.  American Journal of Respiratory and Critical Care Medicine.  195:1558-1560. 2017
    2017 Abnormal glucose metabolism and high-energy expenditure in idiopathic pulmonary arterial hypertension.  Annals of the American Thoracic Society.  14:190-199. 2017
    2017 Corrigendum to Abstract 389 "Identification of Educational Gaps Amongst Physicians Who Manage Patients with Chronic Heart Failure": Journal of Cardiac Failure, Vol. 22, No. 8S, August 2016, p. S135..  Journal of Cardiac Failure.  23:93. 2017
    2016 Novel methods in pulmonary hypertension phenotyping in the age of precision medicine (2015 grover conference series).  Pulmonary Circulation.  6:439-447. 2016
    2016 Bone morphogenic protein type 2 receptor mutation-independent mechanisms of disrupted bone morphogenetic protein signaling in idiopathic pulmonary arterial hypertension.  American Journal of Respiratory Cell and Molecular Biology.  55:564-575. 2016
    2016 Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis.  MethodsX.  3:251-260. 2016
    2015 Shot-noise Limited Faraday Rotation Spectroscopy for Detection of Nitric Oxide Isotopes in Breath, Urine, and Blood.  Scientific Reports.  5. 2015
    2015 O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension.  Circulation.  131:1260-1268. 2015
    2014 Is pulmonary hypertension a metabolic disease?.  American Journal of Respiratory and Critical Care Medicine.  190:973-975. 2014
    2014 Impact of weight loss on ankle-brachial index and interartery blood pressures 2014
    2014 Breath analysis in pulmonary arterial hypertension..  Chest.  145:551-558. 2014
    2014 A novel intermediate mucolipidosis II/IIIβ caused by GNPTAB mutation in the cytosolic N-terminal domain.  European Journal of Human Genetics.  22:594-601. 2014
    2014 The multiple mechanistic faces of a pure volume overload: Implications for therapy.  American Journal of the Medical Sciences.  348:337-346. 2014
    2014 Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy.  Therapeutic Advances in Cardiovascular Disease.  8:97-118. 2014
    2012 Latency-associated peptide of transforming growth factor-β1 is not subject to physiological mannose phosphorylation.  Journal of Biological Chemistry.  287:7526-7534. 2012
    2011 Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms.  Journal of Biological Chemistry.  286:24855-24864. 2011

    Research Overview

  • Dr. Barnes’ research has focused on dysregulated glucose metabolism and its role in aberrant glycosylation in pulmonary vascular disease. Specifically, his work has demonstrated that glucose dysregulation impacts glycosylation and glycosyl transferases that drive cell proliferation in idiopathic pulmonary arterial hypertension (IPAH). His research will continue to explore the molecular mechanisms that regulate metabolism and glycosylation in IPAH as well as other pulmonary diseases.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Cleveland Clinic Department of Pathobiology, Postdoctoral Research
  • Doctor of Philosophy in Biochemistry and Molecular Biology, University of Georgia 2011
  • Master of Science in Biochemistry and Molecular Biology, University of Georgia 2004
  • Bachelor of Science or Mathematics in Biochemistry and Molecular Biology, University of Georgia 2001

    • Awards And Honors

    Full Name

  • Jarrod Barnes