Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Immune exhaustion: Past lessons and new insights from lymphocytic choriomeningitis virus 2019
2019 Inscribing the core memories of killers 2019
2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection 2017
2017 Late arising T follicular helper cells cultivate the B cell crop during chronic infections 2017
2016 IL-10 regulates memory T Cell development and the balance between Th1 and follicular Th cell responses during an Acute Viral Infection 2016
2016 IL-21 and T Cell Differentiation: Consider the Context 2016
2016 A context-dependent role for IL-21 in modulating the differentiation, distribution, and abundance of effector and memory CD8 T cell subsets 2016
2016 Editorial overview: Viral immunology 2016
2015 A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control 2015
2015 T cell exhaustion during persistent viral infections 2015
2014 A stay of execution: Type I Interferons Pardon T cells from death by natural killers 2014
2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients 2014
2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice 2014
2014 Tissue-resident T cells lose their S1P 1 exit visas 2014
2014 Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors 2014
2013 Temporal requirements for B cells in the establishment of CD4 T cell memory 2013
2013 IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis 2013
2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells 2013
2013 ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection 2013
2013 Anti-viral CD8 T cells and the cytokines that they love 2013
2011 IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response 2011
2011 Exhausted cd8 t cells downregulate the il-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections 2011
2011 Cytokines and the inception of CD8 T cell responses 2011
2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers 2011
2010 Interleukin-21: A multifunctional regulator of immunity to infections 2010
2010 IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection 2010
2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels 2010
2010 Shaping successful and unsuccessful CD8 T cell responses following infection 2010
2010 T-cell exhaustion: Characteristics, causes and conversion 2010
2009 A vital role for Interleukin-21 in the control of a chronic viral infection 2009
2008 Memory CD4 T cells emerge from effector T-cell progenitors 2008
2007 HIV-189.6 Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in mice 2007
2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatment 2007
2006 CD127 and virus infection 2006
2006 Bim mediates apoptosis of CD127lo effector T cells and limits T cell memory 2006
2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforin 2006
2005 Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses 2005
2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
2005 Cutting edge: Emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help 2005
2004 Maintenance, Loss, and Resurgence of T Cell Responses during Acute, Protracted, and Chronic Viral Infections 2004
2004 CD4 T Cell-Dependent CD8 T Cell Maturation 2004
2003 Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: In vitro expression and immune responses in DNA-vaccinated mice 2003
2003 Ablation of CD8 and CD4 T cell responses by high viral loads 2003
2003 Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice 2003
2002 T cell responses to viral infections: Lessons from lymphocytic choriomeningitis virus 2002
2002 Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome 2002
2002 Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8+ T cells 2002
2001 In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb 2001
2000 Cutting edge: Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells 2000
1999 Impaired anti-viral T cell responses due to expression of the LY49A inhibitory receptor 1999
1998 Viral immune evasion due to persistence of activated T cells without effector function 1998
1998 Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection 1998
1998 Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection 1998
1998 Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cells 1998
1997 Virus-specific, CD8+major histocompatibility complex class I- restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus- infected β2-microglobulin-deficient mice 1997
1996 Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection 1996
1995 Natural killer cell activity in lymphocytic choriomeningitis virus-infected β2-microglobulin-deficient mice 1995
1995 Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1 1995
1995 The Cell‐Mediated Immune Response Against Lymphocytic Choriomeningitis Virus in β2‐microglobulin Deficient Mice 1995
1994 In vitro characterization of an internal ribosomal entry site (IRES) present within the 5′ nontranslated region of hepatitis A virus RNA: Comparison with the IRES of encephalomyocarditis virus 1994
1993 Transfer of lymphocytic choriomeningitis disease in β2-microglobulin-deficient mice by CD4+ T cells 1993
1992 Assignment of mutant tsN19 (complementation group E) of respiratory syncytial virus to the P protein gene 1992
1991 Parameters influencing the attachment of hepatitis A virus to a variety of continuous cell lines 1991

Chapter

Year Title Altmetric
2014 Immune Response to Viruses: Cell-Mediated Immunity 2014
2006 CD8 T-cell Immunodominance, Repertoire, and Memory.  109-145. 2006

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of North Carolina System : Chapel Hill 1996
  • Bachelor of Science or Mathematics in Microbiological Sciences and Immunology, University of Warwick 1991

    • Full Name

  • Allan Zajac