Selected Publications

Academic Article

Year Title Altmetric
2022 Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protectionScience Immunology.  7. 2022
2022 Editorial overview: Viral immunology before COVID-19Current Opinion in Virology.  52:217-219. 2022
2020 IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppressionScience Advances.  6. 2020
2019 IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of ColitisImmunoHorizons.  3:194-202. 2019
2019 Immune exhaustion: Past lessons and new insights from lymphocytic choriomeningitis virusViruses.  11. 2019
2019 Inscribing the core memories of killersCellular and Molecular Immunology.  16:104-105. 2019
2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infectionNature Immunology.  18:1249-1260. 2017
2017 Late arising T follicular helper cells cultivate the B cell crop during chronic infectionsScience Immunology.  2. 2017
2016 IL-10 regulates memory T Cell development and the balance between Th1 and follicular Th cell responses during an Acute Viral InfectionJournal of Immunology.  197:1308-1321. 2016
2016 IL-21 and T Cell Differentiation: Consider the ContextTrends in Immunology.  37:557-568. 2016
2016 A context-dependent role for IL-21 in modulating the differentiation, distribution, and abundance of effector and memory CD8 T cell subsetsJournal of Immunology.  196:2153-2166. 2016
2016 Editorial overview: Viral immunologyCurrent Opinion in Virology.  16:vii-ix. 2016
2015 A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral ControlCell Reports.  13:1118-1124. 2015
2015 T cell exhaustion during persistent viral infectionsVirology.  479-480:180-193. 2015
2014 A stay of execution: Type I Interferons Pardon T cells from death by natural killersImmunity.  40:861-862. 2014
2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patientsAIDS.  28:2627-2631. 2014
2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 miceArthritis and Rheumatology.  66:2601-2612. 2014
2014 Tissue-resident T cells lose their S1P 1 exit visasCellular and Molecular Immunology.  11:221-223. 2014
2014 Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factorsJournal of Leukocyte Biology.  95:705-713. 2014
2013 Temporal requirements for B cells in the establishment of CD4 T cell memoryJournal of Immunology.  191:6052-6059. 2013
2013 IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitisJournal of Neuroimmunology.  263:43-54. 2013
2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cellsJournal of Immunology.  191:1614-1624. 2013
2013 ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection 2013
2013 Anti-viral CD8 T cells and the cytokines that they loveVirology.  435:157-169. 2013
2011 IL-21 is an antitolerogenic cytokine of the late-phase alloimmune responseDiabetes.  60:3223-3234. 2011
2011 Exhausted cd8 t cells downregulate the il-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infectionsPLoS Pathogens.  7. 2011
2011 Cytokines and the inception of CD8 T cell responsesTrends in Immunology.  32:180-186. 2011
2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersJournal of Virology.  85:2316-2324. 2011
2010 Interleukin-21: A multifunctional regulator of immunity to infections 2010
2010 IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infectionJournal of Immunology.  185:4835-4845. 2010
2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levelsJournal of Immunology.  185:3643-3651. 2010
2010 Shaping successful and unsuccessful CD8 T cell responses following infectionBioMed Research International.  2010. 2010
2010 T-cell exhaustion: Characteristics, causes and conversionImmunology.  129:474-481. 2010
2009 A vital role for Interleukin-21 in the control of a chronic viral infectionScience.  324:1572-1576. 2009
2008 Memory CD4 T cells emerge from effector T-cell progenitorsNature.  452:356-360. 2008
2007 HIV-189.6 Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in miceVaccine.  25:6764-6773. 2007
2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatmentJournal of Infectious Diseases.  195:108-117. 2007
2006 CD127 and virus infectionModern Aspects of Immunobiology.  19:2. 2006
2006 Bim mediates apoptosis of CD127lo effector T cells and limits T cell memoryEuropean Journal of Immunology.  36:1694-1706. 2006
2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforinHuman gene therapy. Clinical development.  17:669-682. 2006
2005 Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responsesJournal of Virology.  79:12703-12713. 2005
2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
2005 Cutting edge: Emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell helpJournal of Immunology.  174:5926-5930. 2005
2004 Maintenance, Loss, and Resurgence of T Cell Responses during Acute, Protracted, and Chronic Viral InfectionsJournal of Immunology.  172:4204-4214. 2004
2004 CD4 T Cell-Dependent CD8 T Cell MaturationJournal of Immunology.  172:2834-2844. 2004
2003 Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: In vitro expression and immune responses in DNA-vaccinated miceAIDS Research and Human Retroviruses.  19:817-823. 2003
2003 Ablation of CD8 and CD4 T cell responses by high viral loadsJournal of Immunology.  170:477-486. 2003
2003 Control of lymphocytic choriomeningitis virus infection in granzyme B deficient miceVirology.  305:1-9. 2003
2002 T cell responses to viral infections: Lessons from lymphocytic choriomeningitis virusImmunologic Research.  26:309-321. 2002
2002 Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndromeJournal of Virology.  76:8347-8359. 2002
2002 Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8+ T cellsJournal of Immunology.  169:1444-1452. 2002
2001 In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2KbJournal of Virology.  75:5099-5107. 2001
2000 Cutting edge: Increased expression of Bcl-2 in antigen-specific memory CD8+ T cellsJournal of Immunology.  164:3950-3954. 2000
1999 Impaired anti-viral T cell responses due to expression of the LY49A inhibitory receptorJournal of Immunology.  163:5526-5534. 1999
1998 Viral immune evasion due to persistence of activated T cells without effector functionJournal of Experimental Medicine.  188:2205-2213. 1998
1998 Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infectionJournal of Experimental Medicine.  188:71-82. 1998
1998 Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infectionImmunity.  8:177-187. 1998
1998 Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cellsCurrent Opinion in Immunology.  10:444-449. 1998
1997 Virus-specific, CD8+ major histocompatibility complex class I- restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus- infected β2-microglobulin-deficient miceJournal of Virology.  71:8392-8396. 1997
1996 Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection 1996
1995 Natural killer cell activity in lymphocytic choriomeningitis virus-infected β2-microglobulin-deficient miceInternational Immunology.  7:1545-1556. 1995
1995 Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1Virology.  212:102-110. 1995
1995 The Cell‐Mediated Immune Response Against Lymphocytic Choriomeningitis Virus in β2‐microglobulin Deficient MiceImmunological Reviews.  148:151-168. 1995
1994 In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: Comparison with the IRES of encephalomyocarditis virusJournal of Virology.  68:1066-1074. 1994
1993 Transfer of lymphocytic choriomeningitis disease in β2-microglobulin-deficient mice by CD4+ T cellsInternational Immunology.  5:1193-1198. 1993
1992 Assignment of mutant tsN19 (complementation group E) of respiratory syncytial virus to the P protein geneJournal of General Virology.  73:865-873. 1992
1991 Parameters influencing the attachment of hepatitis A virus to a variety of continuous cell linesJournal of General Virology.  72:1667-1675. 1991


Year Title Altmetric
2014 Immune Response to Viruses: Cell-Mediated Immunity 2014
2008 Immune Response to Viruses: Cell-Mediated Immunity.  70-77. 2008
2006 CD8 T-cell Immunodominance, Repertoire, and Memory.  109-145. 2006

Investigator On

  • Adaptive Immunity and Persistent SARS-CoV-2 Replication  awarded by National Cancer Institute/NIH/DHHS
  • Mechanism of Alphavirus Packaging: Designing of Pseudoinfectious Viruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Mechanistic Role of ns2 Protein in Evasion of Innate Immune Response by Alphaviruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Modeling FCRL6 Regulation and Function in Transgenic Mice  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • New Generation of Efficient Vaccines Against Encephalitogenic Alphaviruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Sialylation Dependent Control of CD8 T cell Stemness during Chronic Viral Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - Administrative Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - Administrative Supplement  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Viral Adaptation to CD4 T Cell Responses and the Impact on HIV Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Virus-Induced Cell Fate Decisions in Anti-Viral Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of North Carolina System : Chapel Hill 1996
  • Bachelor of Science or Mathematics in Microbiological Sciences and Immunology, University of Warwick 1991
  • Full Name

  • Allan Zajac