Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Human neuromuscular aging: Sex differences revealed at the myocellular levelExperimental Gerontology.  106:116-124. 2018
2017 Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophyExperimental Gerontology.  99:98-109. 2017
2015 Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon MetabolismCell Metabolism.  22:861-873. 2015
2013 Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans 2013
2013 Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscapeGenome Biology.  14. 2013
2013 Increased expression of atrogenes and TWEAK family members after severe burn injury in nonburned human skeletal muscle 2013
2013 Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophyPhysiological Genomics.  45:499-507. 2013
2012 Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubesFree Radical Biology and Medicine.  52:198-207. 2012
2010 Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loadingPhysiological Genomics.  40:141-149. 2010
2009 Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis 2009

Chapter

Year Title Altmetric
2012 Insulin-like growth factor system in different ethnic groups and relationship with growth and health.  1471-1490. 2012

Research Overview

  • The overarching objective of my lab is to identify and understand nutrient and metabolic determinants of skeletal muscle (SkM) regeneration and atrophy. This objective is achieved by 1) examining nutrient requirements and the metabolic signature of SkM stem/ progenitor cell expansion; 2) characterizing novel metabolic and molecular regulators of cell expansion, differentiation, and myotube formation; and 3) developing optimal nutrition and anti-inflammatory therapies to improve SkM health. To address these objectives my research program utilizes human and mouse, primary skeletal muscle cell cultures and muscle tissue coupled with state-of-the-art imaging and –omics techniques and technologies. We developed a cell culture system that allows us rapidly quantify markers of regenerative capacity, gene and protein expression, mitochondrial biogenesis, and metabolism in human and mouse primary satellite cells. Our approach to research is truly translational—spanning from cells and molecules to clinical trials.
  • Full Name

  • Anna Thalacker-Mercer