Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Role of O-Linked N-Acetylglucosamine Protein Modification in Cellular (Patho)PhysiologyPhysiological Reviews.  101:427-493. 2021
2021 The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemiaExperimental Cell Research.  400. 2021
2020 Maintaining myocardial glucose utilization in diabetic cardiomyopathy accelerates mitochondrial dysfunctionDiabetes.  69:2094-2111. 2020
2020 Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization 2020
2020 Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem CellsFrontiers in Genetics.  11. 2020
2020 Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodelingJCI insight.  5. 2020
2020 The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory FormationBiological Psychiatry.  87:577-587. 2020
2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
2019 Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1Frontiers in Endocrinology.  10. 2019
2019 Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism 2019
2019 Epigenetics in the development of diabetic cardiomyopathyEpigenomics.  11:469-472. 2019
2019 Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failureLaboratory Investigation.  99:371-386. 2019
2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
2019 The Growing Case for Use of SGLT2i in Heart Failure: Additional Benefits of Empagliflozin in a HFpEF Rodent ModelJACC: Basic to Translational Science.  4:38-40. 2019
2019 Resident macrophages reprogram toward a developmental state after acute kidney injuryJCI insight.  4. 2019
2019 DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure 2019
2019 Prolactin receptor signaling regulates a pregnancy-specific transcriptional program in mouse isletsEndocrinology.  160:1150-1163. 2019
2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intoleranceMolecular Metabolism.  12:48-61. 2018
2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
2018 Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial FissionCirculation Research.  122:58-73. 2018
2018 Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humansBasic Research in Cardiology.  113. 2018
2017 Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 Diabetes-related cardiac dysfunctionEndocrinology and Metabolism.  32:171-179. 2017
2017 Metabolic Origins of Heart FailureJACC: Basic to Translational Science.  2:297-310. 2017
2017 O-GlcNAcylation and cardiovascular diseaseBiochemical Society Transactions.  45:545-553. 2017
2017 My sweetheart is broken: Role of glucose in diabetic cardiomyopathyDiabetes and Metabolism Journal.  41:1-9. 2017
2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
2016 Post-translational modifications of the cardiac proteome in diabetes and heart failure 2016
2015 Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptationsJournal of Molecular and Cellular Cardiology.  89:297-305. 2015
2015 Unsticking the broken diabetic heart: O-GlcNAcylation and calcium sensitivityDiabetes.  64:3339-3341. 2015
2015 Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1Basic Research in Cardiology.  110. 2015
2015 Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genesMolecular and Cellular Biology.  35:831-846. 2015
2014 Intramuscular fat and inflammation differ in older adults: The impact of frailty and inactivityJournal of Nutrition, Health and Aging.  18:532-538. 2014
2014 The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization 2014
2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heartJournal of Biological Rhythms.  29:257-276. 2014
2014 GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failureJournal of Molecular and Cellular Cardiology.  72:95-103. 2014
2014 Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise trainingMolecular and Cellular Biology.  34:3450-3460. 2014
2014 Intramuscular fat and inflammation differ in older adults: The impact of frailty and inactivityJournal of Nutrition, Health and Aging.  18:532-538. 2014
2014 Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial functionThe FASEB Journal.  28:3691-3702. 2014
2013 Insulin receptor substrate signaling suppresses neonatal autophagy in the heartJournal of Clinical Investigation.  123:5319-5333. 2013
2013 APpEaLINg therapeutic target for obesity cardiomyopathy?Journal of Molecular and Cellular Cardiology.  63:165-168. 2013
2013 Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α 2013
2013 Metabolic Determinants of Electrical Failure in Ex-Vivo Canine Model of Cardiac Arrest: Evidence for the Protective Role of Inorganic PyrophosphatePLoS ONE.  8. 2013
2013 Regionalmuscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetesJournal of Endocrinological Investigation.  36:111-117. 2013
2013 Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation 2013
2013 Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxiaExperimental Physiology.  98:746-757. 2013
2013 Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction 2013
2012 Mechanisms of lipotoxicity in the cardiovascular systemCurrent Hypertension Reports.  14:517-531. 2012
2012 Genetic loss of insulin receptors worsens cardiac efficiency in diabetesJournal of Molecular and Cellular Cardiology.  52:1019-1026. 2012
2012 Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice 2012
2011 The maximal downstroke of epicardial potentials as an index of electrical activity in mouse heartsIEEE Transactions on Biomedical Engineering.  58:3175-3183. 2011
2011 PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophyCirculation Research.  109:783-793. 2011
2011 Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemiaJournal of Molecular and Cellular Cardiology.  51:236-243. 2011
2011 Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload 2011
2010 Aberrant water homeostasis detected by stable isotope analysisPLoS ONE.  5. 2010
2010 Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita miceEndocrinology.  151:3536-3542. 2010
2010 Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARαCirculation Research.  107:233-241. 2010
2010 Lipotoxicity in the heart 2010
2008 Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy 2008
2007 A role for the transcriptional coactivator PGC-1α in muscle refuelingJournal of Biological Chemistry.  282:36642-36651. 2007
2007 Cardiac hypertrophy caused by peroxisome proliferator-activated receptor-γ agonist treatment occurs independently of changes in myocardial insulin signalingEndocrinology.  148:6047-6053. 2007
2007 A Conserved Role for Phosphatidylinositol 3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac HypertrophyCell Metabolism.  6:294-306. 2007
2006 Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)-deficient miceJournal of Biological Chemistry.  281:19000-19008. 2006
2005 PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: A mechanism for transcriptional control of muscle glucose metabolismMolecular and Cellular Biology.  25:10684-10694. 2005
2005 PGC-1α deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosisPLoS Biology.  3:0672-0687. 2005
2004 Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscleJournal of Biological Chemistry.  279:39593-39603. 2004
2002 Adaptations of skeletal muscle to exercise: Rapid increase in the transcriptional coactivator PGC-1The FASEB Journal.  16:1879-1886. 2002
Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets

Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Washington University/St. Louis 2006
  • Full Name

  • Adam Wende