Positions

Overview

  • Medicinal Chemist; Manager, CNS Discovery/Computational Chemistry; Southern Research Institute
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models 2019
    2018 Interactions between cocaine and the putative allosteric dopamine transporter ligand SRI-31142 2018
    2018 The role of human dopamine transporter in NeuroAIDS 2018
    2017 Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter 2017
    2017 Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain 2017
    2017 Hu antigen R (HuR) multimerization contributes to glioma disease progression 2017
    2016 Discovery of a novel inhibitor of kinesin-like protein KIFC1 2016
    2016 The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference 2016
    2016 Identification of quinazoline compounds as novel potent inhibitors of wnt/β-catenin signaling in colorectal cancer cells 2016
    2016 Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats 2016
    2015 The selective dopamine D3 receptor antagonist, SR 21502, reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats 2015
    2015 Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency 2015
    2015 Advancing biological understanding and therapeutics discovery with small-molecule probes 2015
    2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocket 2014
    2014 Lifting the mask: Identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis 2014
    2014 The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats 2014
    2014 The effects of the novel da D3 receptor antagonist SR 21502 on cocaine reward, cocaine seeking and cocaine-induced locomotor activity in rats 2014
    2014 Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: Insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity 2014
    2013 A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus 2013
    2012 Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors 2012
    2012 (S)- N -(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2- carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection 2012
    2012 14-Alkoxy-and 14-acyloxypyridomorphinans: μ Agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects 2012
    2012 Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors 2012
    2012 Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors 2012
    2012 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors 2012
    2012 The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking 2012
    2012 High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity 2012
    2012 Novel substituted pyrimidines as HCV replication (replicase) inhibitors 2012
    2012 High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv 2012
    2011 Recombinant human immunodeficiency virus-1 transactivator of transcription 1-86 allosterically modulates dopamine transporter activity 2011
    2011 Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen 2011
    2011 Identification of novel small molecule activators of nuclear factor-κb with neuroprotective action via high-throughput screening 2011
    2010 Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones 2010
    2010 A high-throughput screen for chemical inhibitors of exocytic transport in yeast 2010
    2010 HTS-driven discovery of new chemotypes with West Nile virus inhibitory activity 2010
    2009 Antituberculosis activity of the molecular libraries screening center network library 2009
    2009 High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv 2009
    2009 Synthesis of pyrimidines and condensed pyrimidines through reactions of nitriles with o-aminocarbonyl substrates under acidic conditions 2009
    2009 Studies of the biogenic amine transporters. 13. identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release 2009
    2009 Recent advances in structure-based virtual screening of G-Protein coupled receptors 2009
    2008 A Novel Delta Opioid Receptor Antagonist, SoRI-9409, Produces a Selective and Long-Lasting Decrease in Ethanol Consumption in Heavy-Drinking Rats 2008
    2008 Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function 2008
    2008 High-throughput screening of a 100,000-compound library for inhibitors of influenza a virus (H3N2) 2008
    2008 Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release 2008
    2007 Programs to facilitate tuberculosis drug discovery: The tuberculosis antimicrobial acquisition and coordinating facility 2007
    2007 Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library 2007
    2006 Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics 2006
    2005 Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids 2005
    2004 Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter 2004
    2004 Erratum: Identification of Opioid Ligands Possessing Mixed μ Agonist/δ Antagonist Activity among Pyridomorphinans Derived from Naloxone, Oxymorphone, and Hydromorphone (Journal of Medicinal Chemistry (2004) 47 (1400)) 2004
    2004 Identification of Opioid Ligands Possessing Mixed μ Agonist/δ Antagonist Activity among Pyridomorphinans Derived from Naloxone, Oxymorphone, and Hydropmorphone 2004
    2003 Docking and biological activity of pteridine analogs: Search for inhibitors of pteridine reductase enzymes from Trypanosoma cruzi 2003
    2003 Novel ligands for the opioid receptors: Synthesis and structure-activity relationships among 5′-aryl and 5′-heteroaryl 17-cyclopropylmethyl-4,5α-epoxypyrido[2′,3′:6,7]morphinans 2003
    2003 Synthesis, opioid receptor binding, and functional activity of 5′-substituted 17-cyclopropylmethylpyrido[2′,3′:6,7]morphinans 2003
    2002 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines 2002
    2002 Synthesis and antituberculous activity of N-Mannich bases of 3-[4-(4-chlorophenyl)-6-(4-methylphenyl) pyrimidin-2-yl] iminoisatin derivatives 2002
    2002 Studies of the biogenic amine transporters. VIII: Identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding 2002
    2001 SoRI 9409, a non-peptide opioid μ receptor agonist/δ receptor antagonist, fails to stimulate [35S]-GTP-γ-S binding at cloned opioid receptors 2001
    2001 Antituberculous activity of norfloxacin Mannich bases with isatin derivatives 2001
    2001 In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid μ-agonist/δ-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence 2001
    2000 Antitubercular activity of thioseniicarbazones and semicarbazones 2000
    1999 Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans 1999
    1999 Electrocatalytic glycol cleavage by periodate/iodate redox system under phase transfer conditions 1999
    1998 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety 1998
    1998 Opioid peptide receptor studies. 8. One of the mouse brain δ(NCX) binding sites is similar to the cloned mouse opioid δ receptor: Further evidence for heterogeneity of δ opioid receptors 1998
    1998 Novel non-peptidic opioid compounds with immunopotentiating effects 1998
    1995 Opioid peptide receptor studies. 1. Identification of a novel δ-opioid receptor binding site in rat brain membranes 1995
    1994 Additions and Corrections: Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group ((J. Med. Chem. (1993) 36(24) (3771–3783) (10.1021/jm00076a004)) 1994
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group 1993
    1993 Synthesis and Structure-Activity Relationships of 3,5-Disubstituted 4,5-Dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at Diazepam-Sensitive and Diazepam-Insensitive Benzodiazepine Receptors 1993
    1993 Synthetic and Computer-Assisted Analysis of the Structural Requirements for Selective, High-Affinity Ligand Binding to Diazepam-Insensitive Benzodiazepine Receptors 1993
    1990 Reaction of nitriles under acidic conditions. Part VI. Synthesis of condensed 4‐chloro‐ and 4‐aminopyrimidines from ortho‐aminonitriles 1990
    1989 Reaction of nitriles under acadic conditions: Part IV- Synthesis of some 2-substituted quinazolin-4-ones and thienopyrimidin-4-ones of biological interest and isolation of o-functionalized amidine intermediates 1989
    1989 Mono and Bis(bioreductive) Alkylating Agents: Synthesis and Antitumor Activities in a B16 Melanoma Model 1989
    1989 Synthesis of some 2,4-diamino-6-substituted amino-5-arylpyrimidines 1989
    1988 A facile synthesis of 3‐amino‐5‐substitutedaminoisothiazole‐4‐carboxylic acid derivatives 1988
    1988 Synthesis of 5H‐Triazolo[1,5‐d]‐ and 5H‐ Tetrazolo‐ [1,5‐d]thieno[3,2‐f]‐1,4‐diazepin‐6(7H)‐ones 1988
    1987 Studies on the synthesis and interconversion of isomeric triazolothienopyrimidines. Part III. Cyclization reactions of 2‐amino‐3‐(1H‐1,2,4‐triazol‐3‐yl)thiophenes 1987
    1986 Quinoline-2-aldoxime Methiodide 1986
    1986 Synthesis of indenes from phenylpropanones using alumina catalyst 1986
    1985 Studies on the synthesis and interconversion of isomeric triazolotheinopyrimidines. Part II. Effect of 5‐substituents on the dimroth rearrangement of 1,2,4‐triazolo[4,3‐c]thieno[3,2‐e]pyrimidines 1985
    1985 Studies on the synthesis of 2‐(2‐arylvinyl)thieno[2,3‐d]pyrimidines and 5‐(2‐arylvinyl)triazolothieno[3,2‐e]pyrimidines 1985
    1984 Heterocyclization of functionalized ketene acetals: Synthesis of pyrimidines via vinylamidine intermediates 1984
    1984 Reaction of benzaldehyde with other carbonyl compounds over thoria and mixed oxides of thoria: Development of an effective catalyst and a process for the conversion of benzaldehyde to phenyl alkyl ketones 1984
    1984 Reaction of nitriles under acidic conditions. Part III. A facile synthesis of thienopyrimidin‐4(3H)‐ones 1984
    1983 Reaction of nitriles under acidic conditions: a novel, direct formation of condensed 4-chloropyrimidines 1983
    1981 Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines 1981
    1980 Reaction of nitriles under acidic conditions. Part I. A general method of synthesis of condensed pyrimidines 1980

    Chapter

    Year Title Altmetric
    2008 Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics.  367-380. 2008

    Research Overview

  • Drug Design and Synthetic Medicinal Chemistry
  • Full Name

  • Subramaniam Ananthan