Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Neuroimaging as a Window Into the Pathophysiological Mechanisms of SchizophreniaFrontiers in Psychiatry.  12. 2021
2021 White Matter Neurometabolic Signatures Support the Deficit and Nondeficit Distinction in Antipsychotic-Naïve First-Episode Psychosis Patients.Schizophrenia Bulletin2021
2021 Neural Signatures of Memory Encoding in Schizophrenia Are Modulated by Antipsychotic Treatment 2021
2020 A multimodal magnetoencephalography 7 T fMRI and 7 T proton MR spectroscopy study in first episode psychosisnpj Schizophrenia.  6. 2020
2020 Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated psychosisTranslational Psychiatry.  10. 2020
2020 Neurometabolic correlates of 6 and 16 weeks of treatment with risperidone in medication-naive first-episode psychosis patientsTranslational Psychiatry.  10. 2020
2020 Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteersNeuropsychopharmacology.  45:1842-1850. 2020
2020 White matter and neurite morphology differ in psychogenic nonepileptic seizuresAnnals of Clinical and Translational Neurology.  7:1973-1984. 2020
2020 Aberrant static and dynamic functional patterns of frontoparietal control network in antipsychotic-naïve first-episode psychosis subjectsHuman Brain Mapping.  41:2999-3008. 2020
2020 A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia 2020
2020 Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode PsychosisBiological Psychiatry: Cognitive Neuroscience and Neuroimaging.  5:231-238. 2020
2020 Baseline Functional Connectivity Predicts Connectivity Changes Due to a Small Dose of Midazolam in Older AdultsAnesthesia and Analgesia.  130:224-232. 2020
2020 Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in SchizophreniaBiological Psychiatry: Cognitive Neuroscience and Neuroimaging2020
2020 The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders – A systematic review of magnetic resonance spectroscopy studiesSchizophrenia Research2020
2020 Ultrastructural evidence for glutamatergic dysregulation in schizophreniaSchizophrenia Research2020
2020 White matter integrity, duration of untreated psychosis, and antipsychotic treatment response in medication-naïve first-episode psychosis patientsMolecular Psychiatry2020
2019 A longitudinal neurite and free water imaging study in patients with a schizophrenia spectrum disorderNeuropsychopharmacology.  44:1932-1939. 2019
2019 Ketamine induced changes in regional cerebral blood flow, interregional connectivity patterns, and glutamate metabolismJournal of Psychiatric Research.  117:108-115. 2019
2019 A longitudinal magnetic resonance spectroscopy study investigating effects of risperidone in the anterior cingulate cortex and hippocampus in schizophreniaSchizophrenia Research.  210:239-244. 2019
2019 A pilot study of combined endurance and resistance exercise rehabilitation for verbal memory and functional connectivity improvement in epilepsyEpilepsy and Behavior.  96:44-56. 2019
2019 Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic TreatmentBiological Psychiatry: Cognitive Neuroscience and Neuroimaging.  4:462-471. 2019
2019 Cognitive control network dysconnectivity and response to antipsychotic treatment in schizophreniaSchizophrenia Research.  204:262-270. 2019
2019 Relationship Between Cortical Excitation and Inhibition and Task-Induced Activation and Deactivation: A Combined Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study at 7T in First-Episode PsychosisBiological Psychiatry: Cognitive Neuroscience and Neuroimaging.  4:121-130. 2019
2019 7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode SchizophreniaSchizophrenia Bulletin.  45:180-189. 2019
2019 Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEGNeuroImage: Clinical.  24. 2019
2018 Digital trajectories to care in first-episode psychosisPsychiatric Services.  69:1259-1263. 2018
2018 Evaluation of fronto-striatal networks during cognitive control in unmedicated patients with schizophrenia and the effect of antipsychotic medicationnpj Schizophrenia.  4. 2018
2018 Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patientsPsychiatry Research: Neuroimaging.  281:101-106. 2018
2018 Four-way multimodal fusion of 7 T imaging data using an mCCA+jICA model in first-episode schizophreniaHuman Brain Mapping.  39:1475-1488. 2018
2018 Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to N-Methyl-D-Aspartate Receptor HypofunctionBiological Psychiatry: Cognitive Neuroscience and Neuroimaging.  3:231-238. 2018
2018 A Longitudinal Multimodal Neuroimaging Study to Examine Relationships Between Resting State Glutamate and Task Related BOLD Response in Schizophrenia.Frontiers in Psychiatry.  9:632. 2018
2018 Gyrification Connectomes in Unmedicated Patients With Schizophrenia and Following a Short Course of Antipsychotic Drug Treatment.Frontiers in Psychiatry.  9:699. 2018
2018 Paving the way for targeted drug development in schizophreniaJAMA Psychiatry.  75:19-20. 2018
2017 Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder- A systematic review of the magnetic resonance neuroimaging literaturenpj Schizophrenia.  3. 2017
2017 Glutamate/glutamine concentrations in the dorsal anterior cingulate vary with Post-Traumatic Stress Disorder symptomsJournal of Psychiatric Research.  91:169-176. 2017
2017 Ketamine modulates hippocampal neurochemistry and functional connectivity: A combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteersMolecular Psychiatry.  22:562-569. 2017
2017 The effect of saccadic eye movements on the sensor-level magnetoencephalogram 2017
2017 Risperidone effects on brain dynamic connectivity-A prospective resting-state fMRI study in SchizophreniaFrontiers in Psychiatry.  8. 2017
2017 Predictors of medication adherence and smoking cessation among smokers under community corrections supervisionAddictive Behaviors.  65:111-117. 2017
2016 Aberrant hippocampal connectivity in unmedicated patients with schizophrenia and effects of antipsychotic medication: A longitudinal resting state functional mri studySchizophrenia Bulletin.  42:1046-1055. 2016
2016 Biochemistry of the cingulate cortex in autism: An MR spectroscopy study 2016
2016 Change in brain network topology as a function of treatment response in schizophrenia: A longitudinal resting-state fMRI study using graph theorynpj Schizophrenia.  2. 2016
2016 A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophreniaSchizophrenia Research.  170:341-350. 2016
2016 Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidoneNeuroImage: Clinical.  10:146-158. 2016
2016 Making progress toward individualized medicine in the treatment of psychosisAmerican Journal of Psychiatry.  173:5-7. 2016
2016 Rapid clozapine titration in an acutely agitated patient with schizoaffective disorder a case reportJournal of Clinical Psychopharmacology.  36:276-277. 2016
2015 Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophreniaSchizophrenia Research.  168:543-553. 2015
2015 Cognitive risk profiles for anxiety disorders in a high-risk populationPsychiatry Research.  229:572-576. 2015
2015 Multimodal neuroimaging based classification of autism spectrum disorder using anatomical, neurochemical, and white matter correlatesCortex.  66:46-59. 2015
2015 Effective connectivity during episodic memory retrieval in schizophrenia participants before and after antipsychotic medicationHuman Brain Mapping.  36:1442-1457. 2015
2015 A Full-Brain, Bootstrapped Analysis of Diffusion Tensor Imaging Robustly Differentiates Parkinson Disease from Healthy ControlsNeuroinformatics.  13:7-18. 2015
2015 Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: A combined magnetic resonance spectroscopy/functional imaging studynpj Schizophrenia.  1. 2015
2015 Race and Medication Adherence Moderate Cessation Outcomes in Criminal Justice SmokersAmerican Journal of Preventive Medicine.  49:335-344. 2015
2015 SLC7A1 expression is associated with seizures, predicts poor survival in patients with malignant gliomaScience Translational Medicine.  7. 2015
2014 Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophreniaNeuropsychopharmacology.  39:1020-1030. 2014
2014 Delay discounting and task performance consistency in patients with schizophreniaPsychiatry Research.  215:286-293. 2014
2014 Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medicationPsychiatry Research: Neuroimaging.  221:6-12. 2014
2014 Expectancies for the effectiveness of different tobacco interventions account for racial and gender differences in motivation to quit and abstinence self-efficacyNicotine and Tobacco Research.  16. 2014
2014 Hippocampal-parietal dysconnectivity and glutamate abnormalities in unmedicated patients with schizophrenia 2014
2014 How low should you go? Determining the optimal cutoff for exhaled carbon monoxide to confirm smoking abstinence when using cotinine as referenceNicotine and Tobacco Research.  16:1348-1355. 2014
2014 In replyJAMA Psychiatry.  71:339-340. 2014
2014 Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: Preliminary findingsFrontiers in Pharmacology.  5 JUL. 2014
2014 Synaptic proteins in the postmortem anterior cingulate cortex in schizophrenia: Relationship to treatment and treatment responseNeuropsychopharmacology.  39:2095-2103. 2014
2014 Vergence eye movements in patients with schizophreniaVision Research.  102:64-70. 2014
2013 Memory deficits in Schizophrenia: A selective review of functional magnetic resonance imaging (fMRI) studiesBehavioral Sciences.  3:330-347. 2013
2013 XSpatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical networkCell.  154. 2013
2013 An fMRI investigation of delay discounting in patients with schizophreniaBrain and Behavior.  3:384-401. 2013
2013 Proton magnetic resonance spectroscopy of the substantia nigra in schizophreniaSchizophrenia Research.  147:348-354. 2013
2013 Magnetic transfer contrast accurately localizes substantia nigra confirmed by histologyBiological Psychiatry.  73:289-294. 2013
2013 Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophreniaJAMA Psychiatry.  70:1294-1302. 2013
2012 Ocular convergence deficits in schizophreniaFrontiers in Psychiatry.  3. 2012
2012 Antipsychotic drugs alter functional connectivity between the medial frontal cortex, hippocampus, and nucleus accumbens as measured by H215O PETFrontiers in Psychiatry.  3. 2012
2012 Regional decoupling of n-acetyl-aspartate and glutamate in schizophreniaNeuropsychopharmacology.  37:2635-2642. 2012
2012 Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imagingSchizophrenia Research.  140:136-142. 2012
2012 Heritability of functioning in families with schizophrenia in relation to neurocognitionSchizophrenia Research.  139:105-109. 2012
2012 Neurometabolites in schizophrenia and bipolar disorder - A systematic review and meta-analysisPsychiatry Research: Neuroimaging.  203:111-125. 2012
2011 Aberrant visual circuitry associated with normal spatial match-to-sample accuracy in schizophreniaPsychiatry Research: Neuroimaging.  193:138-143. 2011
2011 Is there evidence for neurotoxicity in the prodromal and early stages of schizophreniaNeuropsychopharmacology.  36:1779-1780. 2011
2011 Mitochondria in the striatum of subjects with schizophrenia: Relationship to treatment response 2011
2010 Assessments of function and biochemistry of the anterior cingulate cortex in schizophreniaBiological Psychiatry.  68:625-633. 2010
2010 Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamineNeuropsychopharmacology.  35:632-640. 2010
2009 Modulation of limbic circuitry predicts treatment response to antipsychotic medication: A functional imaging study in schizophreniaNeuropsychopharmacology.  34:2675-2690. 2009
2009 Dopaminergic synapses in the caudate of subjects with schizophrenia: Relationship to treatment response 2009
2006 Negative signs and symptoms secondary to antipsychotics: A double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteersAmerican Journal of Psychiatry.  163:488-493. 2006
2006 Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophreniaNeuropsychopharmacology.  31:221-230. 2006
2005 Effects of noncompetitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophreniaNeuropsychopharmacology.  30:2275-2282. 2005
2005 The effects of a subanesthetic dose of ketamine on verbal memory in normal volunteersPsychopharmacology.  183:265-274. 2005
2005 Subtle effects of ketamine on memory when administered following stimulus presentationPsychopharmacology.  180:385-390. 2005
2005 Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophreniaPsychiatry Research: Neuroimaging.  139:19-30. 2005
2004 Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminationsPsychiatry Research.  127:207-216. 2004
2004 Clozapine but not Haloperidol Re-establishes Normal Task-Activated rCBF Patterns in Schizophrenia within the Anterior Cingulate CortexNeuropsychopharmacology.  29:171-178. 2004
2003 Schizophrenia, VIIIAmerican Journal of Psychiatry.  160:2091. 2003
2003 Functional effects of antipsychotic drugs: Comparing clozapine with haloperidolBiological Psychiatry.  53:601-608. 2003
2002 Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophreniaAmerican Journal of Psychiatry.  159:1490-1496. 2002
2001 Probing the human hippocampus using rCBF: Contrasts in schizophrenia 2001
2001 Perceptual skill and brain physiology in subgroups of persons with schizophrenia.Dialogues in Clinical Neuroscience.  3:294-295. 2001
2001 Treatments for chronic psychosis.Dialogues in Clinical Neuroscience.  3:281-292. 2001
2001 Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition taskAmerican Journal of Psychiatry.  158:1797-1808. 2001
2001 Effects of ketamine in normal and schizophrenic volunteersNeuropsychopharmacology.  25:455-467. 2001
2001 Sequential regional cerebral blood flow brain scans using PET with H215O demonstrate ketamine actions in CNS dynamicallyNeuropsychopharmacology.  25:165-172. 2001
2001 Long-term outcome of patients who receive ketamine during researchBiological Psychiatry.  49:869-875. 2001
2000 Ketamine effects on eye movementsNeuropsychopharmacology.  23:645-653. 2000
2000 The limbic cortex in schizophrenia: Focus on the anterior cingulateBrain Research Reviews.  31:364-370. 2000
2000 Brain activation patterns in schizophrenic and comparison volunteers during a matched-performance auditory recognition taskAmerican Journal of Psychiatry.  157:1634-1645. 2000
2000 Decisional capacity for informed consent in schizophrenia researchArchives of General Psychiatry.  57:533-538. 2000
1999 Nmda-sensitive glutamate antagonism: A human model for psychosisNeuropsychopharmacology.  21:S158-S169. 1999
1999 Treatment of schizophrenia 1999Journal of Clinical Psychiatry.  60:3-80. 1999
1998 Effects of the D3 and autoreceptor-preferring dopamine antagonist (+)-UH232 in schizophreniaJournal of Neural Transmission.  105:719-734. 1998
1998 Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteersCerebral Cortex.  8:534-542. 1998
1998 Smooth pursuit eye movements to extraretinal motion signals: Deficits in relatives of patients with schizophreniaArchives of General Psychiatry.  55:830-836. 1998
1998 The relationship between smooth pursuit eye movements and tardive dyskinesia in schizophreniaSchizophrenia Research.  31:141-150. 1998
1998 Antipsychotic properties of the partial dopamine agonist (-)-3-(3- hydroxyphenyl)-N-n-propylpiperidine (preclamol) in schizophreniaBiological Psychiatry.  43:2-11. 1998
1998 Association between eye tracking disorder in schizophrenia and poor sensory integrationAmerican Journal of Psychiatry.  155:1352-1357. 1998
1998 Specific measures account for most of the variance in qualitative ratings of smooth pursuit eye movements in schizophrenia.Archives of General Psychiatry.  55:184-186. 1998
1998 Time course of rCBF changes after acute haloperidol in patients with schizophreniaNeuroImage.  7. 1998
1997 Eye tracking disorder in schizophrenia is characterized by specific ocular motor defects and is associated with the deficit syndromeBiological Psychiatry.  42:781-796. 1997
1997 Clinical genetics, V: Association of genetic and personality characteristicsAmerican Journal of Psychiatry.  154:1496. 1997
1996 Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism?Psychiatry Research.  59:221-237. 1996
1996 Absence of ketamine effects on memory and other cognitive functions in schizophrenic patientsJournal of Psychiatric Research.  30:321-330. 1996
1996 Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patientsAmerican Journal of Psychiatry.  153:1158-1165. 1996
1995 Glutamate pharmacology and the treatment of schizophrenia: Current status and future directionsInternational Clinical Psychopharmacology.  10:29-37. 1995
1995 Ketamine activates psychosis and alters limbic blood flow in schizophreniaNeuroReport.  6:869-872. 1995
1995 Recent developments in the neuropharmacology of schizophreniaAmerican Journal of Health-System Pharmacy.  52. 1995
1995 Subanesthetic doses of ketamine stimulate psychosis in schizophreniaNeuropsychopharmacology.  13:9-19. 1995
1993 Psychiatric illnesses in families of subjects with schizophrenia-spectrum personality disorders: High morbidity risks for unspecified functional psychoses and schizophreniaAmerican Journal of Psychiatry.  150:66-71. 1993
1991 Tobacco smoking increases square-wave jerks during pursuit eye movementsBiological Psychiatry.  29:82-88. 1991
1990 Psychiatric Morbidity in Research VolunteersArchives of General Psychiatry.  47:980. 1990

Education And Training

  • Doctor of Medicine, University of Liege 1978
  • University of Michigan Hospitals & Health Centers, Internship 1990
  • University of Michigan Hospitals & Health Centers, Residency 1992
  • University of Liege, Residency 1983
  • University of Maryland Medical System, Postdoctoral Fellowship 1989
  • Full Name

  • Adrienne Lahti