Alecia Gross Gutierrez

Alecia Gross Gutierrez
Associate Professor

Associate Professor (S), Ophthalmology , School of Medicine
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Investigator (C), Evelyn F. McKnight Brain Institute , Neurology
Associate Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry
Scientist (C), Vision Science Research Center (Retired Org) , Vision Sciences (Retired Org)
Associate Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments
Associate Professor (P), Neurobiology , Academic Joint Departments
Associate Professor (S), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Proinflammatory pathways are activated in the human q344x rhodopsin knock-in mouse model of retinitis pigmentosa. Biomolecules. 11. 2021
2020	BBSome component BBS5 is required for cone photoreceptor protein trafficking and outer segment maintenance. Investigative Ophthalmology and Visual Science. 61. 2020
2020	Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy. Cells. 9. 2020
2019	NudC regulates photoreceptor disk morphogenesis and rhodopsin localization. The FASEB Journal. 33:8799-8808. 2019
2019	Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zone. The FASEB Journal. 33:1440-1455. 2019
2018	Autosomal dominant retinitis pigmentosa rhodopsin mutant Q344X drives specific alterations in chromatin complex gene transcription. Molecular Vision. 24:153-164. 2018
2016	Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodeling. Experimental Eye Research. 150:71-80. 2016
2016	Novel hypomorphic alleles of the mouse tyrosinase gene induced by CRISPR-Cas9 nucleases cause non-albino pigmentation phenotypes. PLoS ONE. 11. 2016
2014	Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin 2014
2014	Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS ONE. 9. 2014
2014	An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina. Cell Death and Disease. 5. 2014
2013	Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transport. Vision Research. 93:43-48. 2013
2013	The age-regulating protein klotho is vital to sustain retinal function. Investigative Ophthalmology and Visual Science. 54:6675-6685. 2013
2013	The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death. Journal of Biological Chemistry. 288:29047-29055. 2013
2012	Defective trafficking of rhodopsin and its role in retinal degenerations. International Review of Cell and Molecular Biology. 293:1-44. 2012
2012	In vitro biochemical assays to monitor rhodopsin function. Methods in Molecular Biology. 884:167-181. 2012
2012	In vitro biochemical assays to monitor rhodopsin function. Methods in Molecular Biology. 884:167-181. 2012
2010	Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. Journal of Biological Chemistry. 285:14521-14533. 2010
2008	Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB. Investigative Ophthalmology and Visual Science. 49:4105-4114. 2008
2006	Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration. Vision Research. 46:4510-4518. 2006
2005	Rhodopsin-EGFP knock-ins for imaging quantal gene alterations. Vision Research. 45:3445-3453. 2005
2004	Evolution guided mutagenesis of rhodopsin. Investigative Ophthalmology and Visual Science. 45:U183-U183. 2004
2004	Functional Studies of a human rhodopsin-EGFP fusion in knock-in mice.. Investigative Ophthalmology and Visual Science. 45:U183-U183. 2004
2004	Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions. Journal of Biological Chemistry. 279:8126-8132. 2004
2003	An opsin mutant with increased thermal stability. Biochemistry. 42:1995-2001. 2003
2003	Characterization of rhodopsin congenital night blindness mutant T94I. Biochemistry. 42:2009-2015. 2003
2003	Slow binding of retinal to rhodopsin mutants G90D and T94D. Biochemistry. 42:2002-2008. 2003