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Alecia Gross Gutierrez
Associate Professor
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E-mail
agross@uab.edu
agross@uab.edu
Phone
205-975-8396
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Alecia Gross Gutierrez
Associate Professor
Positions
Associate Professor (S)
,
Ophthalmology
,
School of Medicine
Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
Investigator (C)
,
Evelyn F. McKnight Brain Institute
,
Neurology
Associate Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
Associate Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
Scientist (C)
,
Vision Science Research Center (Retired Org)
,
Vision Sciences (Retired Org)
Associate Scientist (C)
,
Center for Glial Biology in Medicine
,
Academic Joint Departments
Associate Professor (P)
,
Neurobiology
,
Academic Joint Departments
Associate Professor (S)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma
.
International Journal of Molecular Sciences
. 23.
2022
2021
Proinflammatory pathways are activated in the human q344x rhodopsin knock-in mouse model of retinitis pigmentosa
.
Biomolecules
. 11.
2021
2020
BBSome component BBS5 is required for cone photoreceptor protein trafficking and outer segment maintenance
2020
2020
Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy
.
Cells
. 9.
2020
2019
NudC regulates photoreceptor disk morphogenesis and rhodopsin localization
2019
2019
Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zone
2019
2018
Autosomal dominant retinitis pigmentosa rhodopsin mutant Q344X drives specific alterations in chromatin complex gene transcription
.
Molecular Vision
. 24:153-164.
2018
2016
Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodeling
.
Experimental Eye Research
. 150:71-80.
2016
2016
Novel hypomorphic alleles of the mouse tyrosinase gene induced by CRISPR-Cas9 nucleases cause non-albino pigmentation phenotypes
.
PLoS One
. 11.
2016
2014
Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin
2014
2014
Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice
.
PLoS One
. 9.
2014
2014
An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina
.
Cell Death and Disease
. 5.
2014
2013
Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transport
.
Vision Research
. 93:43-48.
2013
2013
The age-regulating protein klotho is vital to sustain retinal function
2013
2013
The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death
.
Journal of Biological Chemistry
. 288:29047-29055.
2013
2012
Defective trafficking of rhodopsin and its role in retinal degenerations
.
International review of cell and molecular biology
. 293:1-44.
2012
2012
In vitro biochemical assays to monitor rhodopsin function
.
Methods in Molecular Biology
. 884:167-181.
2012
2012
In vitro biochemical assays to monitor rhodopsin function
.
Methods in Molecular Biology
. 884:167-181.
2012
2010
1 rhodopsin mutations in congenital night blindness
.
Advances in Experimental Medicine and Biology
. 664:263-272.
2010
2010
Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice
.
Journal of Biological Chemistry
. 285:14521-14533.
2010
2008
Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB
2008
2006
Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration
.
Vision Research
. 46:4510-4518.
2006
2005
Rhodopsin-EGFP knock-ins for imaging quantal gene alterations
.
Vision Research
. 45:3445-3453.
2005
2004
Evolution guided mutagenesis of rhodopsin
2004
2004
Functional Studies of a human rhodopsin-EGFP fusion in knock-in mice.
2004
2004
Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions
.
Journal of Biological Chemistry
. 279:8126-8132.
2004
2003
An opsin mutant with increased thermal stability
.
Biochemistry
. 42:1995-2001.
2003
2003
Characterization of rhodopsin congenital night blindness mutant T94I
.
Biochemistry
. 42:2009-2015.
2003
2003
Slow binding of retinal to rhodopsin mutants G90D and T94D
.
Biochemistry
. 42:2002-2008.
2003
Research
Principal Investigator On
Evaluation of a Repurposed FDA-approved Compound in Slowing the Progression of Autosomal Dominant Retinitis Pigmentosa (adRP) in Mice
awarded by
Fight for Sight, Inc.
Photoreceptor Disk Formation and Retinal Degenerations
awarded by
National Eye Institute/NIH/DHHS
Photoreceptor Disk Formation and Retinal Degenerations
awarded by
National Eye Institute/NIH/DHHS
Rhodopsin Trafficking and Retinal Degenerations
awarded by
National Eye Institute/NIH/DHHS
Rhodopsin Trafficking in Transgenic Tadpoles
awarded by
E. MATILDA ZIEGLER FOUNDATION FOR THE BLIND, INC.
Investigator On
A MIR-486/Dock3 Signaling Axis Modulates Dystrophin-Deficient Pathology
awarded by
National Institute of Child Health and Human Development/NIH/DHHS
Cryo-EM of ABCA4 and Correction in Macular Degeneration Defects
awarded by
BRIGHT FOCUS FOUNDATION
Ocular Organ Culture Model
awarded by
ADVANCING SIGHT NETWORK
Predoctoral Training in Cell and Molecular Biology
awarded by
National Institute of General Medical Sciences/NIH/DHHS
Predoctoral Training in Cellular and Molecular Biology
awarded by
National Institute of General Medical Sciences/NIH/DHHS
Training Program in Cell, Molecular, and Developmental Biology
awarded by
National Institute of General Medical Sciences/NIH/DHHS
Training Program in the Neurobiology of Cognition and Cognitive Disorders
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Teaching
Teaching Activities
GBS709 - Basic Bio Organization (Fall Term 2022)
GBS792 - CMDB Seminar (Fall Term 2016)
GBS792 - CMDB Seminar (Fall Term 2017)
GBS792 - CMDB Seminar (Fall Term 2018)
GBS792 - CMDB Seminar (Fall Term 2019)
GBS792 - CMDB Seminar (Fall Term 2020)
GBS792 - CMDB Seminar (Fall Term 2021)
GBS792 - CMDB Seminar (Spring Term 2017)
GBS792 - CMDB Seminar (Spring Term 2018)
GBS792 - CMDB Seminar (Spring Term 2019)
GBS792 - CMDB Seminar (Spring Term 2020)
GBS792 - CMDB Seminar (Spring Term 2021)
GBS792 - CMDB Seminar (Spring Term 2022)
GBSC742 - Student Theme Meeting Course (Fall Term 2018)
GBSC742 - Student Theme Meeting Course (Spring Term 2019)
OPVS111 - Basic Science/Clinical Opt I (Fall Term 2009)
STH299 - Interdisciplinary Seminar (Fall Term 2009)
STH299 - Interdisciplinary Seminar (Fall Term 2010)
VIS700 - Vision Science Lit Review (Fall Term 2019)
VIS700 - Vision Science Lit Review (Fall Term 2020)
VIS700 - Vision Science Lit Review (Spring Term 2020)
VIS700 - Vision-Related Lit Review (Fall Term 2009)
VIS700 - Vision-Related Lit Review (Fall Term 2010)
VIS700 - Vision-Related Lit Review (Fall Term 2011)
VIS700 - Vision-Related Lit Review (Fall Term 2012)
VIS700 - Vision-Related Lit Review (Fall Term 2013)
VIS700 - Vision-Related Lit Review (Fall Term 2014)
VIS700 - Vision-Related Lit Review (Fall Term 2015)
VIS700 - Vision-Related Lit Review (Fall Term 2016)
VIS700 - Vision-Related Lit Review (Fall Term 2017)
VIS700 - Vision-Related Lit Review (Fall Term 2018)
VIS700 - Vision-Related Lit Review (Spring Term 2010)
VIS700 - Vision-Related Lit Review (Spring Term 2011)
VIS700 - Vision-Related Lit Review (Spring Term 2012)
VIS700 - Vision-Related Lit Review (Spring Term 2013)
VIS700 - Vision-Related Lit Review (Spring Term 2014)
VIS700 - Vision-Related Lit Review (Spring Term 2015)
VIS700 - Vision-Related Lit Review (Spring Term 2016)
VIS700 - Vision-Related Lit Review (Spring Term 2017)
VIS700 - Vision-Related Lit Review (Spring Term 2018)
VIS700 - Vision-Related Lit Review (Spring Term 2019)
VIS700 - Vision-Related Lit Review (Summer Term 2009)
VIS700 - Vision-Related Lit Review (Summer Term 2010)
VIS700 - Vision-Related Lit Review (Summer Term 2011)
VS113 - Biochemistry of the Eye (Fall Term 2012)
VS113 - Biochemistry of the Eye (Fall Term 2013)
VS113 - Biochemistry of the Eye (Fall Term 2014)
VS113 - Biochemistry of the Eye (Fall Term 2015)
VS113 - Biochemistry of the Eye (Fall Term 2016)
VS113 - Biochemistry of the Eye (Fall Term 2017)
VS113 - Biochemistry of the Eye (Fall Term 2018)
VS113 - Biochemistry of the Eye (Fall Term 2019)
VS113 - Biochemistry of the Eye (Fall Term 2020)
VS121 - Biochemistry of the Eye (Fall Term 2010)
VS121 - Biochemistry of the Eye (Fall Term 2011)
Background
Education And Training
Doctor of Philosophy in Biochemistry,
Brandeis University
2002
Contact
Full Name
Alecia
Gross Gutierrez