Positions

Overview

  • Dr. Anupam Agarwal is currently Director, Division of Nephrology, and Executive Vice Dean, School of Medicine at the University of Alabama at Birmingham (UAB). He also serves as the Program Director of the NIH/NIDDK funded O’Brien Center for Acute Kidney Injury Research. He has graduate faculty status in the Departments of Biochemistry and Molecular Genetics, Pathology and Cell, Developmental and Integrative Biology at UAB.

    Dr. Agarwal has an active role in clinical medicine, teaching, research and administration. He is intensively involved in the teaching of medical students, internal medicine house staff and nephrology fellows and has been a recipient of Outstanding Teaching Awards from the Department of Medicine at the University of Florida (2003) as well as at UAB (2005, 2007). Dr. Agarwal has been responsible for the training of 18 pre- and 19 post-doctoral fellows in his laboratory, several of whom have been successful in obtaining post-doctoral fellowships from the American Heart Association and the National Kidney Foundation and have continued to pursue active academic careers.

    Dr. Agarwal’s research program has provided critical insights regarding the protective nature and significance of heme oxygenase-1 (HO-1) in vascular and renal inflammation, and the molecular regulation of the human HO-1 gene. His bibliography includes >150 peer-reviewed papers and >35 invited reviews/book chapters, the former appearing in journals such as the Journal of Clinical Investigation, Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, Circulation, Circulation Research, Journal of the American Society of Nephrology, American Journal of Pathology as well as others. He has been recognized by the Max Cooper award for excellence in research, the Thomas Andreoli Professorship in Nephrology, election to membership in the American Society of Clinical Investigation (ASCI), American Clinical and Climatological Association (ACCA), Association of American Physicians (AAP) the Marie S. Ingalls Endowed Chair in Nephrology leadership, a Dean’s Excellence award for leadership and the 2013 Graduate Dean’s Excellence in Mentorship award at UAB. He is the recipient of the UAB National Alumni Society Honorary Alumnus award and a Laureate Recipient for the Alabama Chapter of the American College of Physicians (2014).

    Dr. Agarwal has been invited to present at national and international meetings including the Annual Gifford Symposium, American Society of Nephrology, International Society of Nephrology, International conferences on HO in Italy, Sweden and Krakow, International Biometals Congress in Germany, Dutch Society of Nephrology, National Eye Institute, a state-of-the-art lecture at the Southern Society for Clinical Investigation and several prestigious named lectureships. He has been recognized for his leadership by several awards including Young Investigator awards from the National Kidney Foundation, election to the Council of the Society for Free Radical Biology and Fellow of the American Heart Association’s Council on the Kidney in Cardiovascular Disease, his serving on national and international review panels and editorial boards of prestigious journals. Dr. Agarwal served as Chair, Organizing Committee for the 6th International Congress on Heme Oxygenases in 2009. He has served on the Program Committee of the American Society of Nephrology (ASN) and was the Chair of this committee for the 2013 Annual Meeting and is an elected member of the ASN Council. He currently serves as the President-elect of the ASN (2019) and will serve as the President starting January 1, 2020.

    Dr. Agarwal enjoys golf, gardening and SEC college football. He plays Indian classical violin and enjoys attending the Alabama Symphony Orchestra.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management: Proceedings of the 9th Annual UAB-UCSD O'Brien Center SymposiumNephron.  143:153. 2019
    2019 Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073))Cell Reports.  28:3286. 2019
    2019 Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney diseaseLaboratory Investigation.  99:1376-1388. 2019
    2019 Renal Inflammation and Fibrosis: A Double-edged SwordJournal of Histochemistry and Cytochemistry.  67:663-681. 2019
    2019 Potential role of H-Ferritin in mitigating valvular mineralizationArteriosclerosis, Thrombosis, and Vascular Biology.  39:413-431. 2019
    2019 Resident macrophages reprogram toward a developmental state after acute kidney injuryJCI insight.  4. 2019
    2019 Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve diseaseBritish Journal of Pharmacology2019
    2019 Renal control of disease tolerance to malariaProceedings of the National Academy of Sciences.  116:5681-5686. 2019
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human TuberculosisCell Reports.  25:1938-1952.e5. 2018
    2018 Divergent effects of AKI to CKD models on inflammation and fibrosisAJP - Renal Physiology.  315:F1107-F1118. 2018
    2018 Changing paradigms in acute kidney injury: From mechanisms to management: Proceedings of the 8th annual UAB-UCSD O'brien center symposiumNephron.  140:79-80. 2018
    2018 Overcoming translational barriers in acute kidney injury: A report from an NIDDK workshopClinical Journal of the American Society of Nephrology.  13:1113-1123. 2018
    2018 Cutaneous exposure to lewisite causes acute kidney injury by invoking dna damage and autophagic responseAJP - Renal Physiology.  314:F1166-F1176. 2018
    2018 Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: Insights from the DCCT/EDIC studyJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7. 2018
    2018 Ferritin H deficiency in myeloid compartments dysregulates host energy metabolism and increases susceptibility to Mycobacterium tuberculosis infectionFrontiers in Immunology.  9. 2018
    2018 Parabiosis reveals leukocyte dynamics in the kidneyLaboratory Investigation.  98:391-402. 2018
    2018 Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver TransplantationNephron.  138:1-12. 2018
    2018 Heme oxygenase-1 mitigates Ferroptosis in renal proximal tubule cellsAJP - Renal Physiology.  314:F702-F714. 2018
    2017 New ultrasound techniques promise further advances in AKI and CKDJournal of the American Society of Nephrology.  28:3452-3460. 2017
    2017 Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction HealingScientific Reports.  7. 2017
    2017 Changing Paradigms in Acute Kidney Injury: From Mechanisms to ManagementNephron.  137:251-252. 2017
    2017 Dietary potassium regulates vascular calcification and arterial stiffness.JCI insight.  2. 2017
    2017 Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney InjuryAmerican Journal of Kidney Diseases.  69:531-545. 2017
    2017 Mononuclear phagocyte subpopulations in the mouse kidneyAJP - Renal Physiology.  312:F640-F646. 2017
    2016 Changing Paradigms in Acute Kidney Injury: From Mechanisms to ManagementNephron.  134:131-132. 2016
    2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototypeScientific Reports.  6. 2016
    2016 Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDICJournal of Urology, The.  196:1129-1135. 2016
    2016 Heme oxygenases in cardiovascular health and diseasePhysiological Reviews.  96:1449-1508. 2016
    2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel AntidotesAmerican Journal of Pathology.  186:2637-2649. 2016
    2016 A Festschrift Honoring Dr. David G. WarnockNephron.  134:1-4. 2016
    2016 Heme oxygenase-1 in kidney health and diseaseAntioxidants and Redox Signaling.  25:165-183. 2016
    2016 Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot studyPLoS ONE.  11. 2016
    2016 Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imagingAJP - Renal Physiology.  310:F1136-F1147. 2016
    2016 Cellular and molecular mechanisms of AKIJournal of the American Society of Nephrology.  27:1288-1299. 2016
    2016 Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injuryAJP - Renal Physiology.  310:F385-F394. 2016
    2016 Hemodiafiltration and hemodialysis differently affect P wave duration and dispersion on the surface electrocardiogramInternational Urology and Nephrology.  48:271-277. 2016
    2016 Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cellsJournal of Cellular and Molecular Medicine.  20:217-230. 2016
    2016 Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung InjuryAntioxidants and Redox Signaling.  24:99-112. 2016
    2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infectionsAJP - Lung Cellular and Molecular Physiology.  311:L928-L940. 2016
    2016 Heme oxygenase-1 gene polymorphisms-toward precision medicine for AKIJournal of the American Society of Nephrology.  27:3229-3231. 2016
    2016 Heme oxygenase-1 regulates mitochondrial quality control in the heart.JCI insight.  1:e85817. 2016
    2016 Targeting Iron Homeostasis in Acute Kidney InjurySeminars in Nephrology.  36:62-70. 2016
    2015 Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney InjuryClinical Positron Imaging.  17:786-792. 2015
    2015 Quality control measures over 30 years in a multicenter clinical study: Results from the Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) studyPLoS ONE.  10. 2015
    2015 Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injuryHuman Molecular Genetics.  24:4078-4093. 2015
    2015 Macrophage and epithelial cell H-ferritin expression regulates renal inflammationKidney International.  88:95-108. 2015
    2015 Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across speciesPLoS ONE.  10. 2015
    2015 Heme oxygenase-1 regulates myeloid cell trafficking in AKIJournal of the American Society of Nephrology.  26:2139-2151. 2015
    2015 Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated miceAJP - Lung Cellular and Molecular Physiology.  309:L280-L292. 2015
    2014 Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysisClinical and Experimental Nephrology.  18:952-959. 2014
    2014 The mononuclear phagocyte system in homeostasis and disease: A role for heme oxygenase-1Antioxidants and Redox Signaling.  20:1770-1788. 2014
    2014 A small molecule β2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathyFrontiers in Medicine.  1. 2014
    2014 Bilirubin: A potential biomarker and therapeutic target for diabetic nephropathyDiabetes.  63:2613-2616. 2014
    2014 Changing paradigms in acute kidney injury: From mechanisms to management - Proceedings of the 5th annual UAB-UCSD O'Brien center symposium (San Diego, Calif., USA, March 4, 2014)Nephron.  127:117-118. 2014
    2014 Erratum to: Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis [Clinical and Experimental Nephrology, DOI 10.1007/s10157-014-0950-9]Clinical and Experimental Nephrology.  18:960. 2014
    2014 Nitric oxide and carbon monoxide antagonize TGF-β through ligandindependent internalization of TβR1/ALK5AJP - Renal Physiology.  307:F727-F735. 2014
    2013 Proximal tubule h-ferritin mediates iron trafficking in acute kidney injuryJournal of Clinical Investigation.  123:4423-4434. 2013
    2013 Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinaseLaboratory Investigation.  93:868-879. 2013
    2013 Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cellsAJP - Renal Physiology.  305. 2013
    2013 Hemodialysis and hemodiafiltration differently modulate left ventricular diastolic functionBMC Nephrology.  14. 2013
    2013 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injuryAmerican Journal of Pathology.  182:1239-1247. 2013
    2013 Adaptive responses to tissue injury: role of heme oxygenase-1.Transactions- American Clinical and Climatological Association.  124:111-122. 2013
    2012 Superoxide in AVF dysfunction: A new target for interventionAJP - Renal Physiology.  303. 2012
    2012 A reproducible mouse model of chronic allograft nephropathy with vasculopathyKidney International.  82:1231-1235. 2012
    2012 Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in miceArthritis and Rheumatism.  64:4114-4124. 2012
    2012 Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteriaLaboratory Investigation.  92:1541-1552. 2012
    2012 In vivo regulation of the heme oxygenase-1 gene in humanized transgenic miceKidney International.  82:278-291. 2012
    2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant functionKidney International.  82:304-313. 2012
    2012 Heme Oxygenase-1 as a Target for TGF-β in Kidney DiseaseSeminars in Nephrology.  32:277-286. 2012
    2012 Enabling Innovative Translational Research in Acute Kidney InjuryClinical and Translational Science.  5:93-101. 2012
    2012 Orthotopic aortic transplantation in mice for the study of vascular disease.Journal of Visualized Experiments2012
    2011 Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cellsKidney International.  80:731-739. 2011
    2011 Identification of a microRNA signature in renal fibrosis: Role of miR-21AJP - Renal Physiology.  301. 2011
    2011 Sepsis and acute kidney injuryJournal of the American Society of Nephrology.  22:999-1006. 2011
    2011 Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1AJP - Renal Physiology.  300:1180-1192. 2011
    2011 Urine albumin as a biomarker in acute kidney injuryAJP - Renal Physiology.  300. 2011
    2011 ATP as a death factor: Purinergic signaling in renal epithelial-fibroblast cross talkAJP - Renal Physiology.  300. 2011
    2011 Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathyAmerican Journal of Pathology.  178:2573-2586. 2011
    2011 Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1AJP - Renal Physiology.  300. 2011
    2010 Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy MitoQBiochemical Journal.  432:9-19. 2010
    2010 Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cellsJournal of Biological Chemistry.  285:16476-16486. 2010
    2010 Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ12,14- prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanismsBiochemical Journal.  426:31-41. 2010
    2010 Heme oxygenase-1 expression in murine dendritic cell subpopulations: Effect on CD8+ dendritic cell differentiation in vivoAmerican Journal of Pathology.  176:2831-2839. 2010
    2010 Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injuryJournal of the American Society of Nephrology.  21:1702-1712. 2010
    2010 Hydrogen: Another gas with therapeutic potentialKidney International.  77:85-87. 2010
    2009 Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injuryCirculation Research.  105:965-972. 2009
    2009 Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactionsBiochemical Journal.  422:353-361. 2009
    2009 Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cellsJournal of the American Society of Nephrology.  20:1254-1263. 2009
    2009 The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cellsBiochemical Journal.  419:427-436. 2009
    2009 Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathwayFree Radical Biology and Medicine.  46:866-875. 2009
    2009 Heme oxygenase and renal diseaseCurrent Hypertension Reports.  11:56-62. 2009
    2009 Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanismAJP - Renal Physiology.  296. 2009
    2009 Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantationAmerican Journal of Pathology.  175:422-429. 2009
    2009 Neutrophils in acute kidney injury: Not neutral any moreKidney International.  75:674-676. 2009
    2008 Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trialArchives of Ophthalmology -New Series-.  126:1707-1715. 2008
    2008 Heme oxygenase-1 and the vascular bed: From molecular mechanisms to therapeutic opportunitiesAntioxidants and Redox Signaling.  10:1767-1812. 2008
    2008 Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: Evidence for blunted responsiveness in diabetesDiabetes.  57:2488-2494. 2008
    2008 Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosisJournal of the American Society of Nephrology.  19:1681-1691. 2008
    2008 Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation techniqueAJP - Renal Physiology.  295. 2008
    2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulonJournal of Biological Chemistry.  283:18032-18039. 2008
    2008 Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesisCirculation.  117:231-241. 2008
    2008 Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cellsAmerican Journal of Pathology.  173:154-160. 2008
    2007 Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injuryAJP - Renal Physiology.  293. 2007
    2007 Growth factors and heme oxygenase-1: Perspectives in physiology and pathophysiologyAntioxidants and Redox Signaling.  9:2197-2207. 2007
    2007 Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: Role of hydronephrosisAJP - Heart and Circulatory Physiology.  293. 2007
    2007 Subclinical kidney injury incites endotoxin hyperresponsivenessAJP - Renal Physiology.  293. 2007
    2007 Haem oxygenase-1 - A culprit in vascular and renal damage?Nephrology Dialysis Transplantation.  22:1495-1499. 2007
    2007 Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosisCirculation Research.  100:1703-1711. 2007
    2007 Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation modelAmerican Journal of Transplantation.  7:1112-1120. 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanismJournal of Experimental Medicine.  204:605-618. 2007
    2007 JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cellsJournal of Biological Chemistry.  282:6875-6886. 2007
    2007 Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivoAJP - Renal Physiology.  292. 2007
    2007 HOpe for contrast-induced acute kidney injuryKidney International.  72:907-909. 2007
    2007 Rhabdomyolysis and acute renal failure after fire ant bitesJournal of General Internal Medicine.  22:145-147. 2007
    2006 Nitrated fatty acids: Endogenous anti-inflammatory signaling mediatorsJournal of Biological Chemistry.  281:35686-35698. 2006
    2006 Epithelial cell polarity and hypoxia influence heme oxygenase-1 expression by heme in renal epithelial cellsAJP - Renal Physiology.  291. 2006
    2006 Mechanism of action of sulforaphane: Inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cellsCancer Research.  66:8804-8813. 2006
    2006 Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cellsJournal of Biological Chemistry.  281:24423-24430. 2006
    2006 Freeze-thaw increases adeno-associated virus transduction of cellsAmerican Journal of Physiology - Cell Physiology.  291. 2006
    2006 Response to p-Cresol for better or worse: But what are we measuring? [5]Kidney International.  70:232-233. 2006
    2006 Carbon monoxide: From silent killer to potential remedyAJP - Renal Physiology.  290. 2006
    2006 Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidneyAJP - Renal Physiology.  290. 2006
    2006 Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cellsFree Radical Biology and Medicine.  40:952-959. 2006
    2006 Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expressionProceedings of the National Academy of Sciences.  103:4299-4304. 2006
    2006 Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertensionLaboratory Investigation.  86:62-71. 2006
    2006 Hemodialysis reduces inhibitory effect of plasma ultrafiltrate on LDL oxidation and subsequent endothelial reactionsKidney International.  69:144-151. 2006
    2005 Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strainsBMC Nephrology.  6. 2005
    2005 IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal diseaseJournal of the American Society of Nephrology.  16:3651-3660. 2005
    2005 Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cellsCellular and Molecular Biology.  51:357-362. 2005
    2005 Adeno-associated virus vector-mediated gene delivery to the vasculature and kidneyActa Biochimica Polonica.  52:293-299. 2005
    2005 Heme oxygenase-1 expression in disease statesActa Biochimica Polonica.  52:273-284. 2005
    2005 A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemiaGene Therapy.  12:1163-1170. 2005
    2005 Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBPAJP - Renal Physiology.  289. 2005
    2005 Measuring Δψm in isolated tubulesAJP - Renal Physiology.  288. 2005
    2005 The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signalingCancer Research.  65:4789-4798. 2005
    2005 Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathwayProceedings of the National Academy of Sciences.  102:7251-7256. 2005
    2005 An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cellsJournal of Immunology.  174:5181-5186. 2005
    2005 Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidneyAJP - Renal Physiology.  288. 2005
    2005 Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectorsHuman Gene Therapy.  16:235-247. 2005
    2005 Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: Effect of HO-1 knockoutBiochemical and Biophysical Research Communications.  326:670-676. 2005
    2004 Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcriptionBiochemical Journal.  383:209-218. 2004
    2004 "Lumen digestion" technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout miceBioTechniques.  37:84-89. 2004
    2004 Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase: Evolutionary conservation of product inhibitionJournal of Biological Chemistry.  279:12769-12776. 2004
    2004 The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injuryAJP - Renal Physiology.  286. 2004
    2004 Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunityGene Therapy.  11:233-240. 2004
    2004 Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1-deficient mouseAmerican Journal of Pathology.  165:1045-1053. 2004
    2004 Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cellsKidney International.  65:139-147. 2004
    2003 An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1AJP - Renal Physiology.  285. 2003
    2003 An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1.AJP - Renal Physiology.  285:F515-F523. 2003
    2003 Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liverGene Therapy.  10:1551-1558. 2003
    2003 Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitisTransplantation.  76:650-656. 2003
    2003 A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cellsArteriosclerosis, Thrombosis, and Vascular Biology.  23:1416-1422. 2003
    2003 Intimal exuberance: Veins in jeopardyAmerican Journal of Pathology.  162:1759-1761. 2003
    2003 Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chainBiochemical Journal.  371:877-885. 2003
    2003 Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectorsJournal of the American Society of Nephrology.  14:947-958. 2003
    2003 Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD miceDiabetes.  52:708-716. 2003
    2003 Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: Implications in the antiproliferative response to rapamycinCirculation.  107:911-916. 2003
    2002 Development of hammerhead ribozymes to modulate endogenous gene expression for functional studiesMethods.  28:276-285. 2002
    2002 Heme oxygenase and the kidneyDNA (Mary Ann Liebert, Inc.).  21:307-321. 2002
    2002 Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein responseJournal of Biological Chemistry.  277:1933-1940. 2002
    2002 Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vectorMolecular Therapy.  5:154-160. 2002
    2001 Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cellsAJP - Renal Physiology.  281. 2001
    2001 Manganese superoxide dismutase attenuates cisplatin-induced renal injury: Importance of superoxideJournal of the American Society of Nephrology.  12:2683-2690. 2001
    2001 Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells.AJP - Renal Physiology.  281:F851-F859. 2001
    2001 Geneticin induces endogenous heme oxygenase-1 expression: Implication in transfection studiesAnalytical Biochemistry.  289:303-305. 2001
    2001 Beneficial effects of intensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT)Journal of Pediatrics.  139:804-812. 2001
    2001 Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectorsDiabetes.  50:515-520. 2001
    2000 Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-β in human renal epithelial cellsJournal of Biological Chemistry.  275:40904-40909. 2000
    2000 Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosisAJP - Renal Physiology.  278. 2000
    2000 Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.AJP - Renal Physiology.  278:F726-F736. 2000
    2000 Renal response to tissue injury: Lessons from heme oxygenase-1 gene ablation and expressionJournal of the American Society of Nephrology.  11:965-973. 2000
    1999 Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cellsAmerican Journal of Respiratory Cell and Molecular Biology.  20:797-804. 1999
    1998 Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cellsJournal of the American Society of Nephrology.  9:1990-1997. 1998
    1997 Temporal Induction of Clusterin in Cisplatin NephrotoxicityJournal of the American Society of Nephrology.  8:302-305. 1997
    1997 Glomerular and vascular tissues do not down-regulate nitric oxide synthesis during protracted endotoxemiaKidney International.  52:460-467. 1997
    1996 Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDLAJP - Renal Physiology.  271. 1996
    1996 Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL.American Journal of Physiology.  271:F814-F823. 1996
    1996 Gas-generating systems in acute renal allograft rejection in the rat: Co-induction of heme oxygenase and nitric oxide synthaseTransplantation.  61:93-98. 1996
    1995 Recurrent hemolytic uremic syndrome in an adult renal allograft recipient: Current concepts and managementJournal of the American Society of Nephrology.  6:1160-1169. 1995
    1995 Effect of quinidine on kidney biochemistry and function in male sprague-dawley ratsFood and Chemical Toxicology.  33:203-207. 1995
    1995 Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the ratKidney International.  48:1298-1307. 1995
    1994 Comparative in vitro renal damage due to stereoisomeric cinchona alkaloidsResearch communications in chemical pathology and pharmacology.  83:103-112. 1994
    1994 Pharmacologic Management of Shock-Induced Renal DysfunctionAdvances in Pharmacology.  30:129-198. 1994
    1994 Protection of carbon tetrachloride hepatotoxicity by cinchona alkaloidsResearch communications in chemical pathology and pharmacology.  84:223-232. 1994
    1994 Susceptibility of ageing kidney to quinidinePharmacological Research.  29:145-154. 1994
    1993 Effect of proteinuria on renal interstitium: Effect of products of nitrogen metabolismAmerican Journal of Nephrology.  13:376-384. 1993
    1993 In vitro and in vivo effects of quinidine on the kidneys in Fischer-344 ratsResearch communications in chemical pathology and pharmacology.  82:143-150. 1993

    Book

    Year Title Altmetric
    2005 Gene therapy for kidney diseases.  Ed. 31.  2005

    Chapter

    Year Title Altmetric
    2012 Ferritin/ferroxidase activity: A potent inhibitor of vascular calcification, osteoblastic transdifferentiation of vascular smooth muscle cells and osteoblast activity.  83-100. 2012

    Research Overview

  • Acute kidney injury, critical care nephrology, progression of kidney disease
  • Principal Investigator On

  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Acute Kidney Injury Associated with Immune Checkpoint Inhibitors  awarded by PARTNERS HEALTHCARE 2019 - 2022
  • Myeloid Expression of Heme Oxygenase-1 in the AKI to CKD Transition  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Private Grant  awarded by Sanofi US Services Inc 2019 - 2021
  • Private Grant  awarded by Sanofi US Services Inc 2019 - 2020
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2020
  • Private Grant  awarded by ASTRAZENECA AB 2019
  • Private Grant  awarded by Genzyme Corporation 2018 - 2019
  • Private Grant  awarded by HORIZON PHARMA USA, INC. 2019
  • Evaluation of the Efficacy of Novel Heme Oxygenase-1 Inducers on the Innate Protective Response Against Viral Infections  awarded by Food & Drug Administration 2017 - 2019
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core A (UCSD)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • Private Grant  awarded by Sanofi US Services Inc 2017 - 2018
  • Private Grant  awarded by OTSUKA AMERICA PHARMACEUTICAL, INC. 2018
  • Myeloid HO-1 Expression in the AKI to CKD Transition  awarded by American Heart Association 2017
  • Private Grant  awarded by Genzyme Corporation 2016 - 2017
  • ASN Ben J. Lipps Research Fellowship Award  awarded by American Society of Nephrology 2015 - 2017
  • Private Grant  awarded by AMAG PHARMACEUTICALS, INC. 2017
  • Private Grant  awarded by Sanofi US Services Inc 2015 - 2016
  • Private Grant  awarded by AMICUS THERAPEUTICS, INC 2015
  • Private Grant  awarded by GlaxoSmithKline 2013 - 2015
  • Private Grant  awarded by Sanofi US Services Inc 2015
  • Private Grant  awarded by AMAG PHARMACEUTICALS, INC. 2015
  • Private Grant  awarded by Genzyme Corporation 2014 - 2015
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core A (UCSD)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Pilot Project 4  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Private Grant  awarded by Sanofi US Services Inc 2013 - 2014
  • Private Grant  awarded by COMPLEXA, INC. 2012 - 2014
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2014
  • Private Grant  awarded by Baxter Healthcare Corporation 2013
  • Private Grant  awarded by Sanofi US Services Inc 2012 - 2013
  • Private Grant  awarded by Genzyme Corporation 2012 - 2013
  • Private Grant  awarded by AMGEN, INC. 2013
  • Private Grant  awarded by Genzyme Corporation 2011 - 2012
  • Private Grant  awarded by AMGEN, INC. 2012
  • Private Grant  awarded by AMGEN, INC. 2012
  • Private Grant  awarded by Genzyme Corporation 2012
  • Private Grant  awarded by Genzyme Corporation 2012
  • Private Grant  awarded by AMGEN, INC. 2011 - 2012
  • Private Grant  awarded by ASTELLAS PHARMA US, INC. 2011
  • Private Grant  awarded by Genzyme Corporation 2010 - 2011
  • Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2006 - 2011
  • Private Grant  awarded by AMGEN, INC. 2011
  • Private Grant  awarded by AMGEN, INC. 2010 - 2011
  • Private Grant  awarded by AMGEN, INC. 2010
  • Private Grant  awarded by AMGEN, INC. 2010
  • Investigator On

  • Mononuclear Phagocytes in the Pathogenesis of Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2023
  • UAB Research Center of Excellence in Arsenicals  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Pilot Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Targeting Ferritin in Vascular Calcification Associated With CKD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2021
  • Protective Effects of Thioredoxin Reductase Inhibtion in the Lung: Regulation and Contribution of Heme-Oxygenase-1  awarded by American Heart Association 2019 - 2020
  • C-Reactive Protein Mediated Signals in Renal Injury and Repair  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2020
  • Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease.  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Heme Oxygenase–1 and the Bioenergetic Threshold of Latent TB and HIV Co-Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2020
  • Laboratory Automation: Enhancing Biochemical Genetic Clinical and Research Services  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2019
  • Ferritin Mediates Epithelial Cell-Macrophage Cross Talk in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary Dysplasia  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • C-Reactive Protein in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • Mononuclear Phagocytes in Acute Kidney Injury  awarded by American Heart Association 2016 - 2018
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Central Role of Heme Oxygenase in Reversing Bromine Morbidity and Mortality  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2014 - 2016
  • The Role of Heme Oxygenase-1 in the Immune Response  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Role of Heme Oxygenase-1 in Doxorubicin-Induced Cardiac Toxicity  awarded by American Heart Association 2013 - 2015
  • Role of C-Reactive Protein in Acute Kidney Injury  awarded by American Heart Association 2013 - 2014
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Teaching Activities

    Education And Training

  • Bachelor of Medicine & Surgery (MBBS), 1985
  • Government Wenlock & Lady Goschen Hospit, Internship 1986
  • Postgraduate Institute of Medical Education/Resear, Residency 1989
  • University of Florida/Shands Hospital, Postdoctoral Fellowship 1996
  • ALABAMA MEDICAL LICENSURE COMMISSION, Postdoctoral Fellowship 1995
  • Postgraduate Institute of Medical Education/Resear, Postdoctoral Fellowship 1992
  • Full Name

  • Anupam Agarwal