Positions

Overview

  • Dr. Anupam Agarwal is currently Director, Division of Nephrology, and Executive Vice Dean, School of Medicine at the University of Alabama at Birmingham (UAB). He also serves as the Program Director of the NIH/NIDDK funded O’Brien Center for Acute Kidney Injury Research. He has graduate faculty status in the Departments of Biochemistry and Molecular Genetics, Pathology and Cell, Developmental and Integrative Biology at UAB.

    Dr. Agarwal has an active role in clinical medicine, teaching, research and administration. He is intensively involved in the teaching of medical students, internal medicine house staff and nephrology fellows and has been a recipient of Outstanding Teaching Awards from the Department of Medicine at the University of Florida (2003) as well as at UAB (2005, 2007). Dr. Agarwal has been responsible for the training of 18 pre- and 19 post-doctoral fellows in his laboratory, several of whom have been successful in obtaining post-doctoral fellowships from the American Heart Association and the National Kidney Foundation and have continued to pursue active academic careers.

    Dr. Agarwal’s research program has provided critical insights regarding the protective nature and significance of heme oxygenase-1 (HO-1) in vascular and renal inflammation, and the molecular regulation of the human HO-1 gene. His bibliography includes >150 peer-reviewed papers and >35 invited reviews/book chapters, the former appearing in journals such as the Journal of Clinical Investigation, Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, Circulation, Circulation Research, Journal of the American Society of Nephrology, American Journal of Pathology as well as others. He has been recognized by the Max Cooper award for excellence in research, the Thomas Andreoli Professorship in Nephrology, election to membership in the American Society of Clinical Investigation (ASCI), American Clinical and Climatological Association (ACCA), Association of American Physicians (AAP) the Marie S. Ingalls Endowed Chair in Nephrology leadership, a Dean’s Excellence award for leadership and the 2013 Graduate Dean’s Excellence in Mentorship award at UAB. He is the recipient of the UAB National Alumni Society Honorary Alumnus award and a Laureate Recipient for the Alabama Chapter of the American College of Physicians (2014).

    Dr. Agarwal has been invited to present at national and international meetings including the Annual Gifford Symposium, American Society of Nephrology, International Society of Nephrology, International conferences on HO in Italy, Sweden and Krakow, International Biometals Congress in Germany, Dutch Society of Nephrology, National Eye Institute, a state-of-the-art lecture at the Southern Society for Clinical Investigation and several prestigious named lectureships. He has been recognized for his leadership by several awards including Young Investigator awards from the National Kidney Foundation, election to the Council of the Society for Free Radical Biology and Fellow of the American Heart Association’s Council on the Kidney in Cardiovascular Disease, his serving on national and international review panels and editorial boards of prestigious journals. Dr. Agarwal served as Chair, Organizing Committee for the 6th International Congress on Heme Oxygenases in 2009. He has served on the Program Committee of the American Society of Nephrology (ASN) and was the Chair of this committee for the 2013 Annual Meeting and is an elected member of the ASN Council. He currently serves as Past President of the ASN (2021).

    Dr. Agarwal enjoys golf, gardening and SEC college football. He plays Indian classical violin and enjoys attending the Alabama Symphony Orchestra.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Returning to Growth: One Academic Medical Center's Successful Five-Step Approach to Change Management..  Academic Medicine.  96:1401-1407. 2021
    2021 Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury.  Laboratory Investigation.  101:1186-1196. 2021
    2021 Recovery after Critical Illness and Acute Kidney Injury..  Clinical Journal of the American Society of Nephrology.  2021
    2021 Reply to Bankir: The ever-expanding role of lactate in the kidney 2021
    2021 Association of cystic fibrosis transmembrane conductance regulator with epithelial sodium channel subunits carrying Liddle’s syndrome mutations 2021
    2021 Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes 2021
    2021 Nephrology—taking the lead.  Clinical Journal of the American Society of Nephrology.  16:1113-1116. 2021
    2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1..  European Respiratory Journal.  2021
    2021 NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns.  JCI insight.  6. 2021
    2021 Expression of lactate dehydrogenase A and B isoforms in the mouse kidney 2021
    2021 UAB-UCSD o'brien center for acute kidney injury research 2021
    2021 Heme oxygenase-1 as a pharmacological target for host-directed therapy to limit tuberculosis associated immunopathology.  Antioxidants.  10:1-18. 2021
    2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.  Autophagy.  17:1-382. 2021
    2020 Aki!now initiative: Recommendations for awareness, recognition, and management of aki.  Clinical Journal of the American Society of Nephrology.  15:1838-1847. 2020
    2020 Stepping into the void remunerating, valuing, and understanding nephrologists.  Clinical Journal of the American Society of Nephrology.  15:1832-1834. 2020
    2020 New insights into the role of heme oxygenase-1 in acute kidney injury 2020
    2020 Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals.  Annals of the New York Academy of Sciences.  1480:155-169. 2020
    2020 Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier.  Acta Neuropathologica.  140:549-567. 2020
    2020 Cutaneous lewisite exposure causes acute lung injury.  Annals of the New York Academy of Sciences.  1479:210-222. 2020
    2020 Current State and Future of Research in Nephrology.  Advances in Renal Replacement Therapy.  27:305-311.e1. 2020
    2020 Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.  British Journal of Pharmacology.  177:793-809. 2020
    2020 Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate.  Frontiers in Physiology.  10. 2020
    2020 Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice.  Oxidative Medicine and Cellular Longevity.  2020. 2020
    2020 Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.  Oxidative Medicine and Cellular Longevity.  2020. 2020
    2019 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management: Proceedings of the 9th Annual UAB-UCSD O'Brien Center Symposium 2019
    2019 Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073)).  Cell Reports.  28:3286. 2019
    2019 Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney disease.  Laboratory Investigation.  99:1376-1388. 2019
    2019 Renal Inflammation and Fibrosis: A Double-edged Sword 2019
    2019 Potential role of H-Ferritin in mitigating valvular mineralization 2019
    2019 Resident macrophages reprogram toward a developmental state after acute kidney injury.  JCI insight.  4. 2019
    2019 Renal control of disease tolerance to malaria 2019
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.  Cell Reports.  25:1938-1952.e5. 2018
    2018 Divergent effects of AKI to CKD models on inflammation and fibrosis 2018
    2018 Changing paradigms in acute kidney injury: From mechanisms to management: Proceedings of the 8th annual UAB-UCSD O'brien center symposium 2018
    2018 Overcoming translational barriers in acute kidney injury: A report from an NIDDK workshop.  Clinical Journal of the American Society of Nephrology.  13:1113-1123. 2018
    2018 Cutaneous exposure to lewisite causes acute kidney injury by invoking dna damage and autophagic response 2018
    2018 Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: Insights from the DCCT/EDIC study 2018
    2018 Ferritin H deficiency in myeloid compartments dysregulates host energy metabolism and increases susceptibility to Mycobacterium tuberculosis infection.  Frontiers in Immunology.  9. 2018
    2018 Parabiosis reveals leukocyte dynamics in the kidney.  Laboratory Investigation.  98:391-402. 2018
    2018 Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation 2018
    2018 Heme oxygenase-1 mitigates Ferroptosis in renal proximal tubule cells 2018
    2017 New ultrasound techniques promise further advances in AKI and CKD.  Journal of the American Society of Nephrology.  28:3452-3460. 2017
    2017 Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing.  Scientific Reports.  7. 2017
    2017 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management 2017
    2017 Dietary potassium regulates vascular calcification and arterial stiffness..  JCI insight.  2. 2017
    2017 Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury.  American Journal of Kidney Diseases.  69:531-545. 2017
    2017 Mononuclear phagocyte subpopulations in the mouse kidney 2017
    2016 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management 2016
    2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype.  Scientific Reports.  6. 2016
    2016 Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC 2016
    2016 Heme oxygenases in cardiovascular health and disease.  Physiological Reviews.  96:1449-1508. 2016
    2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.  American Journal of Pathology.  186:2637-2649. 2016
    2016 A Festschrift Honoring Dr. David G. Warnock 2016
    2016 Heme oxygenase-1 in kidney health and disease.  Antioxidants and Redox Signaling.  25:165-183. 2016
    2016 Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot study.  PLoS ONE.  11. 2016
    2016 Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging 2016
    2016 Cellular and molecular mechanisms of AKI.  Journal of the American Society of Nephrology.  27:1288-1299. 2016
    2016 Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury 2016
    2016 Hemodiafiltration and hemodialysis differently affect P wave duration and dispersion on the surface electrocardiogram.  International Urology and Nephrology.  48:271-277. 2016
    2016 Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells.  Journal of Cellular and Molecular Medicine.  20:217-230. 2016
    2016 Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury.  Antioxidants and Redox Signaling.  24:99-112. 2016
    2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections 2016
    2016 Heme oxygenase-1 gene polymorphisms-toward precision medicine for AKI.  Journal of the American Society of Nephrology.  27:3229-3231. 2016
    2016 Heme oxygenase-1 regulates mitochondrial quality control in the heart..  JCI insight.  1:e85817. 2016
    2016 Targeting Iron Homeostasis in Acute Kidney Injury.  Seminars in Nephrology.  36:62-70. 2016
    2015 Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney Injury 2015
    2015 Quality control measures over 30 years in a multicenter clinical study: Results from the Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.  PLoS ONE.  10. 2015
    2015 Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.  Human Molecular Genetics.  24:4078-4093. 2015
    2015 Macrophage and epithelial cell H-ferritin expression regulates renal inflammation.  Kidney International.  88:95-108. 2015
    2015 Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across species.  PLoS ONE.  10. 2015
    2015 Heme oxygenase-1 regulates myeloid cell trafficking in AKI.  Journal of the American Society of Nephrology.  26:2139-2151. 2015
    2015 Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice 2015
    2014 Erratum to: Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis [Clinical and Experimental Nephrology, DOI 10.1007/s10157-014-0950-9].  Clinical and Experimental Nephrology.  18:960. 2014
    2014 Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis.  Clinical and Experimental Nephrology.  18:952-959. 2014
    2014 Nitric oxide and carbon monoxide antagonize TGF-β through ligandindependent internalization of TβR1/ALK5 2014
    2014 The mononuclear phagocyte system in homeostasis and disease: A role for heme oxygenase-1.  Antioxidants and Redox Signaling.  20:1770-1788. 2014
    2014 A small molecule β2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy.  Frontiers in Medicine.  1. 2014
    2014 Bilirubin: A potential biomarker and therapeutic target for diabetic nephropathy.  Diabetes.  63:2613-2616. 2014
    2014 Changing paradigms in acute kidney injury: From mechanisms to management - Proceedings of the 5th annual UAB-UCSD O'Brien center symposium (San Diego, Calif., USA, March 4, 2014) 2014
    2013 Proximal tubule h-ferritin mediates iron trafficking in acute kidney injury.  Journal of Clinical Investigation.  123:4423-4434. 2013
    2013 Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.  Laboratory Investigation.  93:868-879. 2013
    2013 Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells 2013
    2013 Hemodialysis and hemodiafiltration differently modulate left ventricular diastolic function.  BMC Nephrology.  14. 2013
    2013 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury.  American Journal of Pathology.  182:1239-1247. 2013
    2013 Adaptive responses to tissue injury: role of heme oxygenase-1. 2013
    2012 Superoxide in AVF dysfunction: A new target for intervention 2012
    2012 A reproducible mouse model of chronic allograft nephropathy with vasculopathy.  Kidney International.  82:1231-1235. 2012
    2012 Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice.  Arthritis and Rheumatism.  64:4114-4124. 2012
    2012 Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria.  Laboratory Investigation.  92:1541-1552. 2012
    2012 In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice.  Kidney International.  82:278-291. 2012
    2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function.  Kidney International.  82:304-313. 2012
    2012 Heme Oxygenase-1 as a Target for TGF-β in Kidney Disease.  Seminars in Nephrology.  32:277-286. 2012
    2012 Enabling Innovative Translational Research in Acute Kidney Injury.  Clinical and Translational Science.  5:93-101. 2012
    2012 Orthotopic aortic transplantation in mice for the study of vascular disease..  Journal of Visualized Experiments.  2012
    2011 Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells.  Kidney International.  80:731-739. 2011
    2011 Identification of a microRNA signature in renal fibrosis: Role of miR-21 2011
    2011 Sepsis and acute kidney injury.  Journal of the American Society of Nephrology.  22:999-1006. 2011
    2011 Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1 2011
    2011 Urine albumin as a biomarker in acute kidney injury 2011
    2011 ATP as a death factor: Purinergic signaling in renal epithelial-fibroblast cross talk 2011
    2011 Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy.  American Journal of Pathology.  178:2573-2586. 2011
    2011 Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1 2011
    2010 Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy MitoQ.  Biochemical Journal.  432:9-19. 2010
    2010 Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.  Journal of Biological Chemistry.  285:16476-16486. 2010
    2010 Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ12,14- prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.  Biochemical Journal.  426:31-41. 2010
    2010 Heme oxygenase-1 expression in murine dendritic cell subpopulations: Effect on CD8+ dendritic cell differentiation in vivo.  American Journal of Pathology.  176:2831-2839. 2010
    2010 Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury.  Journal of the American Society of Nephrology.  21:1702-1712. 2010
    2010 Hydrogen: Another gas with therapeutic potential.  Kidney International.  77:85-87. 2010
    2009 Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury.  Circulation Research.  105:965-972. 2009
    2009 Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions.  Biochemical Journal.  422:353-361. 2009
    2009 Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells.  Journal of the American Society of Nephrology.  20:1254-1263. 2009
    2009 The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells.  Biochemical Journal.  419:427-436. 2009
    2009 Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.  Free Radical Biology and Medicine.  46:866-875. 2009
    2009 Heme oxygenase and renal disease.  Current Hypertension Reports.  11:56-62. 2009
    2009 Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism 2009
    2009 Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation.  American Journal of Pathology.  175:422-429. 2009
    2009 Neutrophils in acute kidney injury: Not neutral any more.  Kidney International.  75:674-676. 2009
    2008 Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the diabetes control and complications trial.  JAMA Ophthalmology.  126:1707-1715. 2008
    2008 Heme oxygenase-1 and the vascular bed: From molecular mechanisms to therapeutic opportunities.  Antioxidants and Redox Signaling.  10:1767-1812. 2008
    2008 Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: Evidence for blunted responsiveness in diabetes.  Diabetes.  57:2488-2494. 2008
    2008 Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis.  Journal of the American Society of Nephrology.  19:1681-1691. 2008
    2008 Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation technique 2008
    2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.  Journal of Biological Chemistry.  283:18032-18039. 2008
    2008 Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis.  Circulation.  117:231-241. 2008
    2008 Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.  American Journal of Pathology.  173:154-160. 2008
    2007 Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury 2007
    2007 Growth factors and heme oxygenase-1: Perspectives in physiology and pathophysiology.  Antioxidants and Redox Signaling.  9:2197-2207. 2007
    2007 Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: Role of hydronephrosis 2007
    2007 Subclinical kidney injury incites endotoxin hyperresponsiveness 2007
    2007 Haem oxygenase-1 - A culprit in vascular and renal damage?.  Nephrology Dialysis Transplantation.  22:1495-1499. 2007
    2007 Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis.  Circulation Research.  100:1703-1711. 2007
    2007 Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.  American Journal of Transplantation.  7:1112-1120. 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism.  Journal of Experimental Medicine.  204:605-618. 2007
    2007 JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells.  Journal of Biological Chemistry.  282:6875-6886. 2007
    2007 Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo 2007
    2007 HOpe for contrast-induced acute kidney injury.  Kidney International.  72:907-909. 2007
    2007 Rhabdomyolysis and acute renal failure after fire ant bites.  Journal of General Internal Medicine.  22:145-147. 2007
    2006 Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators.  Journal of Biological Chemistry.  281:35686-35698. 2006
    2006 Epithelial cell polarity and hypoxia influence heme oxygenase-1 expression by heme in renal epithelial cells 2006
    2006 Mechanism of action of sulforaphane: Inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.  Cancer Research.  66:8804-8813. 2006
    2006 Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells.  Journal of Biological Chemistry.  281:24423-24430. 2006
    2006 Freeze-thaw increases adeno-associated virus transduction of cells 2006
    2006 Response to p-Cresol for better or worse: But what are we measuring? [5].  Kidney International.  70:232-233. 2006
    2006 Carbon monoxide: From silent killer to potential remedy 2006
    2006 Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney 2006
    2006 Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.  Free Radical Biology and Medicine.  40:952-959. 2006
    2006 Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression 2006
    2006 Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension.  Laboratory Investigation.  86:62-71. 2006
    2006 Hemodialysis reduces inhibitory effect of plasma ultrafiltrate on LDL oxidation and subsequent endothelial reactions.  Kidney International.  69:144-151. 2006
    2005 Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains.  BMC Nephrology.  6. 2005
    2005 IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.  Journal of the American Society of Nephrology.  16:3651-3660. 2005
    2005 Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cells.  Cellular and Molecular Biology.  51:357-362. 2005
    2005 A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia 2005
    2005 Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP 2005
    2005 Measuring Δψm in isolated tubules 2005
    2005 The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.  Cancer Research.  65:4789-4798. 2005
    2005 Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway 2005
    2005 An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.  Journal of Immunology.  174:5181-5186. 2005
    2005 Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney 2005
    2005 Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.  Human Gene Therapy.  16:235-247. 2005
    2005 Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: Effect of HO-1 knockout.  Biochemical and Biophysical Research Communications.  326:670-676. 2005
    2005 Adeno-associated virus vector-mediated gene delivery to the vasculature and kidney.  Acta Biochimica Polonica.  52:293-299. 2005
    2005 Heme oxygenase-1 expression in disease states.  Acta Biochimica Polonica.  52:273-284. 2005
    2004 Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.  Biochemical Journal.  383:209-218. 2004
    2004 Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase: Evolutionary conservation of product inhibition.  Journal of Biological Chemistry.  279:12769-12776. 2004
    2004 Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity 2004
    2004 "Lumen digestion" technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice 2004
    2004 Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1-deficient mouse.  American Journal of Pathology.  165:1045-1053. 2004
    2004 Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells.  Kidney International.  65:139-147. 2004
    2004 The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury 2004
    2003 An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1 2003
    2003 An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1. 2003
    2003 Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver 2003
    2003 Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis.  Transplantation.  76:650-656. 2003
    2003 A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cells 2003
    2003 Intimal exuberance: Veins in jeopardy.  American Journal of Pathology.  162:1759-1761. 2003
    2003 Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain.  Biochemical Journal.  371:877-885. 2003
    2003 Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.  Journal of the American Society of Nephrology.  14:947-958. 2003
    2003 Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.  Diabetes.  52:708-716. 2003
    2003 Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: Implications in the antiproliferative response to rapamycin.  Circulation.  107:911-916. 2003
    2002 Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.  Methods.  28:276-285. 2002
    2002 Heme oxygenase and the kidney 2002
    2002 Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response.  Journal of Biological Chemistry.  277:1933-1940. 2002
    2002 Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector.  Molecular Therapy.  5:154-160. 2002
    2001 Manganese superoxide dismutase attenuates cisplatin-induced renal injury: Importance of superoxide.  Journal of the American Society of Nephrology.  12:2683-2690. 2001
    2001 Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells. 2001
    2001 Geneticin induces endogenous heme oxygenase-1 expression: Implication in transfection studies.  Analytical Biochemistry.  289:303-305. 2001
    2001 Beneficial effects of intensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT).  Journal of Pediatrics.  139:804-812. 2001
    2001 Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.  Diabetes.  50:515-520. 2001
    2001 Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells 2001
    2000 Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-β in human renal epithelial cells.  Journal of Biological Chemistry.  275:40904-40909. 2000
    2000 Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. 2000
    2000 Renal response to tissue injury: Lessons from heme oxygenase-1 gene ablation and expression.  Journal of the American Society of Nephrology.  11:965-973. 2000
    2000 Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis 2000
    1999 Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells.  American Journal of Respiratory Cell and Molecular Biology.  20:797-804. 1999
    1998 Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells.  Journal of the American Society of Nephrology.  9:1990-1997. 1998
    1997 Temporal Induction of Clusterin in Cisplatin Nephrotoxicity.  Journal of the American Society of Nephrology.  8:302-305. 1997
    1997 Glomerular and vascular tissues do not down-regulate nitric oxide synthesis during protracted endotoxemia.  Kidney International.  52:460-467. 1997
    1996 Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL..  American Journal of Physiology.  271:F814-F823. 1996
    1996 Gas-generating systems in acute renal allograft rejection in the rat: Co-induction of heme oxygenase and nitric oxide synthase.  Transplantation.  61:93-98. 1996
    1996 Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL 1996
    1995 Recurrent hemolytic uremic syndrome in an adult renal allograft recipient: Current concepts and management.  Journal of the American Society of Nephrology.  6:1160-1169. 1995
    1995 Effect of quinidine on kidney biochemistry and function in male sprague-dawley rats.  Food and Chemical Toxicology.  33:203-207. 1995
    1995 Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat.  Kidney International.  48:1298-1307. 1995
    1994 Comparative in vitro renal damage due to stereoisomeric cinchona alkaloids.  Research communications in chemical pathology and pharmacology.  83:103-112. 1994
    1994 Pharmacologic Management of Shock-Induced Renal Dysfunction.  Advances in Pharmacology.  30:129-198. 1994
    1994 Protection of carbon tetrachloride hepatotoxicity by cinchona alkaloids.  Research communications in chemical pathology and pharmacology.  84:223-232. 1994
    1994 Susceptibility of ageing kidney to quinidine.  Pharmacological Research.  29:145-154. 1994
    1993 Effect of proteinuria on renal interstitium: Effect of products of nitrogen metabolism.  American Journal of Nephrology.  13:376-384. 1993
    1993 In vitro and in vivo effects of quinidine on the kidneys in Fischer-344 rats.  Research communications in chemical pathology and pharmacology.  82:143-150. 1993

    Book

    Year Title Altmetric
    2005 Gene therapy for kidney diseases.  Ed. 31.  2005

    Chapter

    Year Title Altmetric
    2012 Ferritin/ferroxidase activity: A potent inhibitor of vascular calcification, osteoblastic transdifferentiation of vascular smooth muscle cells and osteoblast activity.  83-100. 2012

    Research Overview

  • Acute kidney injury, critical care nephrology, progression of kidney disease

    • Principal Investigator On

  • ASN Ben J. Lipps Research Fellowship Award  awarded by American Society of Nephrology
  • Acute Kidney Injury Associated with Immune Checkpoint Inhibitors  awarded by PARTNERS HEALTHCARE
  • Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Evaluation of the Efficacy of Novel Heme Oxygenase-1 Inducers on the Innate Protective Response Against Viral Infections  awarded by Food & Drug Administration
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Immunoparalysis after Acute Kidney Injury  awarded by CHILDREN'S HOSPITAL COLORADO
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • LDHA Contributes to Acute Kidney Injury by Facilitating Glycolytic Switch  awarded by American Heart Association
  • Lymphatics and Lymphangiogenesis in Kidney Function and Inflammation  awarded by Texas A&M University
  • Myeloid Expression of Heme Oxygenase-1 in the AKI to CKD Transition  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Myeloid HO-1 Expression in the AKI to CKD Transition  awarded by American Heart Association
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by ASTELLAS PHARMA US, INC.
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by COMPLEXA, INC.
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by GlaxoSmithKline
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by Baxter Healthcare Corporation
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by AMAG PHARMACEUTICALS, INC.
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by AMICUS THERAPEUTICS, INC
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by AMAG PHARMACEUTICALS, INC.
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by OTSUKA AMERICA PHARMACEUTICAL, INC.
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by HORIZON PHARMA USA, INC.
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by ASTRAZENECA AB
  • Private Grant  awarded by OTSUKA AMERICA PHARMACEUTICAL, INC.
  • Private Grant  awarded by ANGION INC.
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by GOLDILOCKS THERAPEUTICS INC. ^
  • Private Grant  awarded by Sanofi US Services Inc
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core A (UCSD)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Pilot Project 4  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core A (UCSD)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

    • Investigator On

  • C-Reactive Protein Mediated Signals in Renal Injury and Repair  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • C-Reactive Protein in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • COMPLETED - UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Central Role of Heme Oxygenase in Reversing Bromine Morbidity and Mortality  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Effects of Thioredoxin Reductase Inhibition in the Lung: Regulation and Contribution of Heme-Oxygenase-1  awarded by American Heart Association
  • Ferritin Mediates Epithelial Cell-Macrophage Cross Talk in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Heme Oxygenase–1 and the Bioenergetic Threshold of Latent TB and HIV Co-Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population  awarded by National Human Genome Research Institute/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Laboratory Automation: Enhancing Biochemical Genetic Clinical and Research Services  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR
  • Mechanisms in Hypertension and Cardiovascular Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mononuclear Phagocytes in Acute Kidney Injury  awarded by American Heart Association
  • Mononuclear Phagocytes in the Pathogenesis of Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Protective Effects of Thioredoxin Reductase Inhibtion in the Lung: Regulation and Contribution of Heme-Oxygenase-1  awarded by American Heart Association
  • Role of C-Reactive Protein in Acute Kidney Injury  awarded by American Heart Association
  • Role of Heme Oxygenase-1 in Doxorubicin-Induced Cardiac Toxicity  awarded by American Heart Association
  • Targeting Ferritin in Vascular Calcification Associated With CKD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary Dysplasia  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • The Role of Heme Oxygenase-1 in the Immune Response  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Alzheimer's Disease Research Center  awarded by National Institute on Aging/NIH/DHHS
  • UAB Alzheimer's Disease Research Center - Admin Core  awarded by NIH - National Institutes of Health/DHHS
  • UAB Research Center of Excellence in Arsenicals  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Enrichment Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Pilot Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease.  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

    • Teaching Activities

    Education And Training

  • Government Wenlock & Lady Goschen Hospit, Internship
  • Postgraduate Institute of Medical Education/Resear, Residency
  • ALABAMA MEDICAL LICENSURE COMMISSION, Postdoctoral Fellowship
  • Postgraduate Institute of Medical Education/Resear, Postdoctoral Fellowship
  • University of Florida/Shands Hospital, Postdoctoral Fellowship
  • Bachelor of Medicine & Surgery (MBBS), 1985

    • Full Name

  • Anupam Agarwal