Selected Publications

Academic Article

Year Title Altmetric
2023 Syntaxin 1 Ser14 phosphorylation is required for nonvesicular dopamine release.Science Advances.  9:eadd8417. 2023
2022 The dopamine transporter gene SLC6A3: multidisease risksMolecular Psychiatry.  27:1031-1046. 2022
2021 Bile Acids Gate Dopamine Transporter Mediated CurrentsFrontiers in Chemistry.  9. 2021
2021 Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric diseaseJCI Insight.  6. 2021
2021 Bile acids gate dopamine transporter mediated currents 2021
2021 A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila MelanogasterMolecular Psychiatry.  26:4417-4430. 2021
2021 Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-DystoniaeLife.  10. 2021
2021 Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine ModelFrontiers in Psychiatry.  12. 2021
2020 A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brainJournal of Comparative Neurology.  528:2445-2470. 2020
2020 Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent 2020
2019 GLP-1: Molecular mechanisms and outcomes of a complex signaling system 2019
2019 Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviorsJournal of Clinical Investigation.  129:3407-3419. 2019
2019 Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3 2019
2018 Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivoJournal of Allergy and Clinical Immunology.  142:1515-1528.e8. 2018
2018 Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine rewardPLoS Biology.  16. 2018
2018 Brief exposure to obesogenic diet disrupts brain dopamine networksPLoS One.  13. 2018
2017 Gβγ 3 subunit activation promotes dopamine efflux through the dopamine transporterMolecular Psychiatry.  22:1673-1679. 2017
2017 Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporterJournal of Chemical Neuroanatomy.  83-84:69-74. 2017
2016 Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levelsTranslational Psychiatry.  6. 2016
2015 Insights in how amphetamine ROCKs (Rho-associated containing kinase) membrane protein trafficking 2015
2015 The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in micePhysiology and Behavior.  149:262-268. 2015
2015 Dual agonist occupancy of at 1 -R-α 2C -AR heterodimers results in atypical G s -PKA signalingNature Chemical Biology.  11:271-279. 2015
2015 Zn2+ reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorderMolecular Autism.  6. 2015
2015 Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and BehaviorsEBioMedicine.  2:135-146. 2015
2015 Impaired mTORC2 signaling in catecholaminergic neurons exaggerates high fat diet-induced hyperphagiaVaccine Reports.  1. 2015
2015 mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission 2015
2014 Striatal dopamine homeostasis is altered in mice following Roux-en-Y gastric bypass surgeryACS Chemical Neuroscience.  5:943-951. 2014
2014 Missense dopamine transporter mutations associate with adult parkinsonism and ADHDJournal of Clinical Investigation.  124:3107-3120. 2014
2014 Moving beyond energy homeostasis: New roles for glucagon-like peptide-1 in food and drug reward 2014
2014 Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function 2014
2014 PIP2 regulates psychostimulant behaviors through its interaction with a membrane proteinNature Chemical Biology.  10:582-589. 2014
2014 SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and traffickingTranslational Psychiatry.  4:e464. 2014
2013 De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorderMolecular Psychiatry.  18:1315-1323. 2013
2013 Drosophila melanogaster: A novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter geneMolecular Psychiatry.  18:1235. 2013
2013 GLP-1 analog attenuates cocaine rewardMolecular Psychiatry.  18:961-962. 2013
2013 Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate 2013
2013 Structural arrangement of the intracellular Ca2+ binding domains of the cardiac Na+/Ca2+ exchanger (NCX1.1): Effects of Ca2+ bindingJournal of Biological Chemistry.  288:4194-4207. 2013
2012 Phosphatidylinositol 4,5-biphosphate (PIP2) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structureBiochemistry.  51:7685-7698. 2012
2012 Exendin-4 decreases amphetamine-induced locomotor activityPhysiology and Behavior.  106:574-578. 2012
2012 Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation 2012
2012 Rescue of dopamine transporter function in hypoinsulinemic rats by a D 2 receptor-ERK-dependent mechanism 2012
2011 Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neuronsNeuron.  72:977-990. 2011
2011 Erratum: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT (Nature Neuroscience (2011) 14 (469-477))Nature Neuroscience.  14:1617. 2011
2011 Insulin signaling and addictionNeuropharmacology.  61:1123-1128. 2011
2011 Impaired striatal akt signaling disrupts dopamine homeostasis and increases feedingPLoS One.  6. 2011
2011 Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DATNature Neuroscience.  14:469-477. 2011
2011 Insulin regulation of monoamine signaling: Pathway to obesityNeuropsychopharmacology.  36:359-360. 2011
2010 Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis 2010
2010 Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expressionACS Chemical Neuroscience.  1:476-481. 2010
2010 Molecular mechanisms of amphetamine actions in caenorhabditis elegansMolecular Pharmacology.  78:151-156. 2010
2010 Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking 2010
2010 Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenialike behaviors in neuronal rictor null micePLoS Biology.  8. 2010
2010 Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder 2010
2009 Subcellular localization of the antidepressant-sensitive norepinephrine transporterBMC Neuroscience.  10. 2009
2009 A juxtamembrane mutation in the n terminus of the dopamine transporter induces preference for an inward-facing conformationMolecular Pharmacology.  75:514-524. 2009
2009 A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transportersMolecular Neurobiology.  39:73-80. 2009
2008 Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine effluxMolecular Pharmacology.  74:1101-1108. 2008
2008 Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male ratsEuropean Journal of Pharmacology.  592:109-115. 2008
2008 PI3K signaling supports amphetamine-induced dopamine effluxBiochemical and Biophysical Research Communications.  372:656-661. 2008
2008 Anomalous dopamine release associated with a human dopamine transporter coding variant 2008
2008 Behavioral effects of amphetamine in streptozotocin-treated ratsEuropean Journal of Pharmacology.  581:105-112. 2008
2008 Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function 2008
2007 Hypoinsulinemia regulates amphetamine-induced reverse transport of dopaminePLoS Biology.  5:2369-2378. 2007
2007 Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic ratsJournal of Neurochemistry.  101:151-159. 2007
2007 Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanismMolecular Pharmacology.  71:835-842. 2007
2007 Insulin replacement restores the behavioral effects of quinpirole and raclopride in streptozotocin-treated ratsJournal of Pharmacology and Experimental Therapeutics.  320:1216-1223. 2007
2007 Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1a/transporter complexesMolecular Pharmacology.  71:230-239. 2007
2006 Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-Induced Reverse TransportNeuron.  51:417-429. 2006
2006 Regulation of dopamine transporter trafficking by intracellular amphetamineMolecular Pharmacology.  70:542-548. 2006
2006 The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak currentNeuropharmacology.  50:354-361. 2006
2006 The dopamine transporter: A vigilant border control for psychostimulant actionHandbook of experimental pharmacology.  175:215-232. 2006
2005 Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamineJournal of Neurochemistry.  94:1402-1410. 2005
2005 Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistributionMolecular Pharmacology.  68:102-109. 2005
2005 Mechanisms of neurotransmitter release by amphetamines: A reviewProgress in Neurobiology.  75:406-433. 2005
2005 Amphetamine induces dopamine efflux through a dopamine transporter channel 2005
2005 Biogenic amine neurotransmitter transporters: Just when you thought you knew themPhysiology.  225-231. 2005
2004 N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced effluxPLoS Biology.  2. 2004
2004 Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporterMolecular Pharmacology.  66:137-143. 2004
2004 Amphetamine regulation of dopamine transport: Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrierJournal of Biological Chemistry.  279:8966-8975. 2004
2003 Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaineEuropean Journal of Pharmacology.  479:153-158. 2003
2003 Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity 2003
2003 Amphetamine-induced dopamine efflux: A voltage-sensitive and intracellular Na+-dependent mechanismJournal of Biological Chemistry.  278:12070-12077. 2003
2003 Dopamine transport currents are promoted from curiosity to physiologyTrends in Neurosciences.  26:173-176. 2003
2003 Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats 2003
2003 A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity 2003
2002 Cerulein-induced acute pancreatitis in the rat is significantly ameliorated by treatment with MEK1/2 inhibitors U0126 and PD98059Pancreas.  25:251-259. 2002
2002 PI 3-kinase regulation of dopamine uptakeJournal of Neurochemistry.  81:859-869. 2002
2002 Cocaine increases dopamine uptake and cell surface expression of dopamine transportersBiochemical and Biophysical Research Communications.  290:1545-1550. 2002
2000 Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism 2000
1999 L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain L-proline transporter 1999
1998 Acute regulation of norepinephrine transport: I. Protein kinase C- linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cellsJournal of Pharmacology and Experimental Therapeutics.  287:733-743. 1998
1998 Patch-clamp and amperometric recordings from norepinephrine transporters: Channel activity and voltage-dependent uptake 1998
1998 Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteinsBiological Psychiatry.  44:169-178. 1998
1998 Fluctuation analysis of norepinephrine and serotonin transporter currentsMethods in Enzymology.  296:578-593. 1998
1997 Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel 1997
1997 Electrophysiological Analysis of Transporter Function 1997
1997 Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression 1997
1996 Norepinephrine transporters have channel modes of conduction 1996
1996 Functional role of low-voltage-activated dihydropyridine-sensitive Ca channels during the action potential in adult rat sensory neurones 1996
1995 Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants 1995
1994 Inactivation of single Ca2+ channels in rat sensory neurons by extracellular Ca2+. 1994
1994 Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxolBiophysical Journal.  67:2296-2304. 1994
1992 Effect of firing rate on the calcium permeability in adult neurons during spontaneous action potentialsBiophysical Journal.  63:926-934. 1992


Year Title Altmetric
2021 Membrane transport.  1073-1075. 2021
2013 Neurotransmitter Transporters.  238-240. 2013

Education And Training

  • Doctor of Philosophy, University of Milan 1998
  • Doctor of Science in Medical Biochemistry, University of Milan 1991
  • Full Name

  • Aurelio Galli