Positions

Overview

  • Dr. Gaggar obtained his medical degree from the University of Michigan in 2000 as a member of the prestigious Inteflex program. He then moved to Birmingham, AL where he completed his internship and residency in internal medicine at the University of Alabama at Birmingham (UAB) in 2003. Following residency training, he began fellowship training at UAB in pulmonary and critical care medicine. During the research phase of his fellowship training, he worked in the laboratories of Dr. JP Clancy (Chief, Pediatric Pulmonology) and Dr. J. Edwin Blalock (Professor, Department of Medicine). He completed his fellowship in 2006, with special emphasis in cystic fibrosis and lung transplantation.

    The following year, Dr. Gaggar completed a PhD in Molecular and Cellular Physiology at UAB. Dr. Gaggar was invited to joined the UAB Division of Pulmonary, Allergy & Critical Care Medicine in 2006 as instructor in medicine. He currently serves as a director of the Pulmonary Biospecimen Repository and the Cystic Fibrosis Inflammation Group at UAB. He continues to see patients as both an inpatient physician and in the clinic setting. In addition, his laboratory program continues to investigate the roles of proteases in lung disease.

    Dr. Gaggar currently sees patients after lung transplantation and individuals with cystic fibrosis at University Hospital. He also holds a staff position at the Birmingham VA Medical Center (BVAMC) where he sees individuals with chronic obstructive lung disease (COPD). In addition, he serves as an attending physician at both the UAB and the BVAMC intensive care units.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Reply to de Steenhuijsen Piters and BogaertAmerican Journal of Respiratory and Critical Care Medicine.  201:1311-1312. 2020
    2020 Immunomodulation in cystic fibrosis: Why and how?International Journal of Molecular Sciences.  21. 2020
    2020 Human Fetal Lungs Harbor a Microbiome SignatureAmerican Journal of Respiratory and Critical Care Medicine.  201:1002-1006. 2020
    2020 Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice 2020
    2020 Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosisJournal of Cystic Fibrosis.  19:40-48. 2020
    2019 Neutrophil-Targeted, protease-Activated pulmonary drug delivery blocks airway and systemic inflammationJCI insight.  4. 2019
    2019 An Ancient CFTR Ortholog Informs Molecular Evolution in ABC TransportersDevelopmental Cell.  51:421-430.e3. 2019
    2019 Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibitionBiochemical and Biophysical Research Communications.  517:691-696. 2019
    2019 What lies beneath: Preformed autoantibodies and lung transplantationAmerican Journal of Respiratory Cell and Molecular Biology.  60:613-614. 2019
    2019 Differences among cigarette-only smokers compared to dual users of cigarettes and little cigars/cigarillos in the criminal justice populationAddictive Behaviors.  90:236-240. 2019
    2019 Vitamin D for the Immune System in Cystic Fibrosis (DISC): A double-blind, multicenter, randomized, placebo-controlled clinical trialAmerican Journal of Clinical Nutrition.  109:554-565. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the LungCell.  176:113-126.e15. 2019
    2019 Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury 2019
    2019 Proline-glycine-proline peptides are critical in the development of smoke-induced emphysemaAmerican Journal of Respiratory Cell and Molecular Biology.  61:560-566. 2019
    2018 ADAM9: A damaging player in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  198:1465-1466. 2018
    2018 Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGeneJCI insight.  3. 2018
    2018 Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome. 2018
    2018 Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosisJournal of Leukocyte Biology.  104:665-675. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammationEuropean Respiratory Journal.  52. 2018
    2018 Systemic markers of adaptive and innate immunity are associated with chronic obstructive pulmonary disease severity and spirometric disease progressionAmerican Journal of Respiratory Cell and Molecular Biology.  58:500-509. 2018
    2018 Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infantsJCI insight.  3. 2018
    2018 Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patientsBMC Pulmonary Medicine.  18. 2018
    2017 The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fibrosisContemporary Clinical Trials Communications.  6:39-45. 2017
    2017 Doxycycline improves clinical outcomes during cystic fibrosis exacerbationsEuropean Respiratory Journal.  49. 2017
    2016 Bioactive extracellular matrix fragments in lung health and diseaseJournal of Clinical Investigation.  126:3176-3184. 2016
    2016 CXCR1 Regulates Pulmonary Anti- Pseudomonas Host DefenseJournal of Innate Immunity.  8:362-373. 2016
    2016 Matrix remodeling in pulmonary fibrosis and emphysemaAmerican Journal of Respiratory Cell and Molecular Biology.  54:751-760. 2016
    2016 Neutrophil fates in bronchiectasis and alpha-1 antitrypsin deficiencyAnnals of the American Thoracic Society.  13:S123-S129. 2016
    2016 Genetic regulation of expression of leukotriene A4 hydrolaseERJ Open Research.  2. 2016
    2016 Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosisJournal of Cystic Fibrosis.  15:227-233. 2016
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomesAmerican Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftorJournal of Cystic Fibrosis.  15:67-73. 2016
    2016 Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury 2016
    2016 There is blood in the water: Hemolysis, hemoglobin, and heme in acute lung injury 2016
    2015 A fragment in time: Elastin peptides and progression of emphysemaAmerican Journal of Respiratory and Critical Care Medicine.  192:1141-1143. 2015
    2015 The matrikine PGP as a potential biomarker in COPD 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2015 A randomized, placebo-controlled trial of roflumilast effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  192:934-942. 2015
    2014 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  190:51-61. 2014
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virusEuropean Respiratory Journal.  43:1086-1096. 2014
    2014 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patientsClinical and Translational Science.  7:336-341. 2014
    2014 Fibrosis: Ultimate and proximate causesJournal of Clinical Investigation.  124:4673-4677. 2014
    2014 L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human NeutrophilsInflammation.  37:1401-1412. 2014
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPDChest.  144:498-506. 2013
    2012 Innate immunity in cystic fibrosis lung diseaseJournal of Cystic Fibrosis.  11:363-382. 2012
    2012 CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung diseaseEuropean Respiratory Journal.  39:1385-1390. 2012
    2012 Extensive surgical and comprehensive postoperative medical management for cystic fibrosis chronic rhinosinusitis 2012
    2011 Series "matrix metalloproteinases in lung health and disease": The role of matrix metalloproteinases in cystic fibrosis lung diseaseEuropean Respiratory Journal.  38:721-727. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2010 Is there a doctor in the house? The downside of 24/7 attending coverage in academic intensive care unitsAmerican Journal of Respiratory and Critical Care Medicine.  181:1280-1281. 2010
    2010 Incidence, relevance and response for Ralsfonia respiratory infections.Clinical Laboratory Science.  23:99-106. 2010
    2009 Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagenJournal of Neuroimmunology.  217:51-54. 2009
    2009 The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantationJournal of Immunology.  182:4423-4431. 2009
    2008 Potential role of high-mobility group box 1 in cystic fibrosis airway diseaseAmerican Journal of Respiratory and Critical Care Medicine.  178:822-831. 2008
    2008 Inhibition of airway proteases in cystic fibrosis lung diseaseEuropean Respiratory Journal.  32:783-795. 2008
    2008 TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung diseaseJournal of Immunology.  181:2753-2763. 2008
    2008 Interfering with extracellular matrix degradation to blunt inflammationCurrent Opinion in Pharmacology.  8:242-248. 2008
    2008 A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in Chronic neutrophilic inflammationJournal of Immunology.  180:5662-5669. 2008
    2008 Genetic and reproductive knowledge among adolescents and adults with cystic fibrosisChest.  133:1533. 2008
    2007 Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients 2007
    2007 Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensisJournal of Immunology.  178:1013-1020. 2007
    2007 The ups and downs of peer reviewAdvances in Physiology Education.  31:145-152. 2007
    2006 Biologic markers of mortality in acute lung injuryClinica Chimica Acta.  372:24-32. 2006

    Chapter

    Year Title Altmetric
    2010 Neutrophil elastase-mediated modulation of pathophysiology in cystic fibrosis lung disease.  87-111. 2010

    Research Overview

  • Dr. Gaggar's laboratory interests focus on the roles proteases play in modulation of lung disease. Dr. Gaggar utilizes a combination of cell-based systems, unique murine models, and clinical specimens, leading to research which is truly "translational" in nature. The Gaggar lab's interests focus on 3 major arenas: proteases and neutrophilic airway inflammation, proteases and ion transportation, and the Regulation of Surfactant Protein D by Airway Proteases.

    Recently, Dr. Gaggar's laboratory and Dr. J. Edwin Blalock's laboratory have worked together to describe the proteolytic pathways involved in the generation of a novel neutrophil chemoattractant, proline-glycine-proline (PGP). Dr. Gaggar's group has shown that this chemoattractant is generated by the cleavage of collagen by matrix metalloprotease (MMP)-8 and MMP-9, in conjunction with a novel serine protease, prolyl endopeptidase (PE). Dr. Gaggar's group has also highlighted the relative contribution of PGP in development of BOS, demonstrating for the first time the impact this peptide might play in clinical lung disease. Ongoing efforts are now being focused in further delineation of the biological roles PGP may induce in the airway beyond neutrophil recruitment.
  • Investigator On

  • Influenza Regulation of Epithelial Pneumococcal Host Defense  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2020 - 2024
  • Mechanisms and Correlates of Immune Protection against Genital Chlamydia in Humans  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2020 - 2024
  • Mechanisms of Pulmonary Microbiota-Induced Inflammation and Vascular Dysfunction in Neonatal Lung Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2024
  • A Novel Exosomal Inflammatory Pathway  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • UAB Research and Development Program  awarded by Cystic Fibrosis Foundation 2019 - 2023
  • Environmental Cadmium and COPD  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Standardized Treatment of Pulmonary Exacerbations II  awarded by SEATTLE CHILDREN'S HOSPITAL 2016 - 2019
  • Cellular Lipids and Leukocyte Function  awarded by National Institute of General Medical Sciences/NIH/DHHS 2015 - 2019
  • Genetics of Smoke-Altered LTA4H in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • Matrix Metalloproteinase Driven Lung Inflammation in RSV Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2019
  • Targeted Cell Therapy for Acute Lung Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Private Grant  awarded by CELTAXSYS, INC. 2016 - 2018
  • Proof of Principal Evaluation of IV Gallium Nitrate (Ganite) in Patients with Cystic Fibrosis  awarded by SEATTLE CHILDREN'S HOSPITAL 2013 - 2018
  • UAB Cystic Fibrosis Center for Care, Teaching, and Research (Adult)  awarded by Cystic Fibrosis Foundation 2011 - 2017
  • Private Grant  awarded by NIVALIS THERAPEUTICS, INC. - NEW 2016 - 2017
  • Private Grant  awarded by PROQR THERAPEUTICS 2015 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2013 - 2016
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2014 - 2016
  • Private Grant  awarded by INSMED PHARMACEUTICALS, INC. 2012 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2015
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2010 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2014
  • Pediatric Critical Care Scientist Development Program: "RSV-Induced Respiratory Failure: Role of MMP-9 in Lung Injury Through Generation of PGP"  awarded by University of Utah 2012 - 2013
  • Education And Training

  • Doctor of Philosophy in Molecular Physiology, University of Alabama at Birmingham 2007
  • Doctor of Medicine, University of Michigan System : Ann Arbor 2000
  • UAB Hospital, Internship 2001
  • UAB Hospital, Residency 2003
  • UAB Hospital, Postdoctoral Fellowship 2006
  • Full Name

  • Amit Gaggar