Positions

Overview

  • Angelo L. Gaffo is the section chief of Rheumatology at the Birmingham VA Medical Center and Associate Professor of Medicine in the Division of Rheumatology at the University of Alabama at Birmingham (UAB). He graduated from Medical School in 1999 in his native Lima, Peru and moved to the United States to complete training in Internal Medicine (UAB), Rheumatology (UAB), Public Health (earning a master’s degree at the UAB School of Public Health), and Quality Improvement science (Birmingham VA) in 2009. After joining the Birmingham VA and UAB he has developed his research interest in genetics, pathogenesis, clinical, and therapeutic aspects of gout and hyperuricemia. He was been in charge of the effort to develop a definition for flares in patients with gout, which was validated and published in 2017. He continues to be active in the research of how gout flares are reported and analyzed in clinical research. He has been the leading investigator in a R01-level grant as part of a NIAMS funded P50 program and UAB Center of Research Translation in gout and hyperuricemia. He maintains a busy gout clinical practice at the Birmingham VA Medical Center and a second clinical practice focused on complex autoimmunity at UAB. In addition, he has a long-standing interest in rheumatology education. As the associate director for UAB Rheumatology fellowship program, he collaborates and mentors rheumatology fellows and internal medicine residents to conduct quality improvement projects and pursue a variety of research clinical interests at the Birmingham VA and UAB.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Coexistent Hyperuricemia and Gout in Rheumatoid Arthritis: Associations With Comorbidities, Disease Activity, and MortalityArthritis Care and Research.  72:950-958. 2020
    2020 Gout epidemiology and comorbiditiesSeminars in Arthritis and Rheumatism.  50:S11-S16. 2020
    2020 Flare rate thresholds for patient assessment of gout disease activity states.Journal of Rheumatology2020
    2020 Gout is associated with an increased risk for incident heart failure among older adults: The REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study 2020
    2020 How flare prevention outcomes are reported in gout studies: A systematic review and content analysis of randomized controlled trialsSeminars in Arthritis and Rheumatism.  50:303-313. 2020
    2020 Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort StudyHypertension.  75:246-256. 2020
    2019 Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of goutAnnals of the Rheumatic Diseases.  78:1592-1600. 2019
    2019 Web Exclusive. Annals On Call - Understanding Gout PathophysiologyAnnals of Internal Medicine.  170:OC1. 2019
    2018 An Exercise in Clinical Reasoning: Do You Unpack?Journal of General Internal Medicine.  33:1196-1200. 2018
    2018 Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities 2018
    2018 Brief Report: Validation of a Definition of Flare in Patients With Established GoutArthritis and Rheumatology.  70:462-467. 2018
    2017 Rituximab in ANCA-Associated VasculitisCurrent Rheumatology Reports.  19. 2017
    2017 Renal dosing of allopurinol results in suboptimal gout careAnnals of the Rheumatic Diseases.  76. 2017
    2016 The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationaleContemporary Clinical Trials.  50:238-244. 2016
    2016 Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implicationsTherapeutic Advances in Musculoskeletal Disease.  8:145-159. 2016
    2016 Allopurinol Dose Reductions Based on Creatinine Alert Redesign SystemAmerican Journal of Medicine.  129:e95. 2016
    2015 Serum urate and incident cardiovascular disease: The Coronary Artery Risk Development in Young Adults (CARDIA) studyPLoS ONE.  10. 2015
    2015 Vascular calcifications on hand radiographs in rheumatoid arthritis and associations with autoantibodies, cardiovascular risk factors and mortalityRheumatology.  54:1587-1595. 2015
    2014 A qualitative assessment of internal medicine resident perceptions of graduate medical education following implementation of the 2011 ACGME duty hour standardsBMC Medical Education.  14. 2014
    2014 Comorbidities in patients with crystal diseases and hyperuricemiaRheumatic Disease Clinics of North America.  40:251-278. 2014
    2013 Longitudinal association between serum urate and subclinical atherosclerosis: The Coronary Artery Risk Development in Young Adults (CARDIA) studyJournal of Internal Medicine.  274:594-609. 2013
    2013 A Delphi exercise to identify characteristic features of gout - Opinions from patients and physicians, the first stage in developing new classification criteria (Journal of Rheumatology (2013) 40, (498-505))Journal of Rheumatology.  40:1634. 2013
    2013 Serum urate association with hypertension in young adults: Analysis from the Coronary Artery Risk Development in Young Adults cohortAnnals of the Rheumatic Diseases.  72:1321-1327. 2013
    2013 Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populationsAmerican Journal of Epidemiology.  177:923-932. 2013
    2013 A Delphi exercise to identify characteristic features of gout - Opinions from patients and physicians, the first stage in developing new classification criteriaJournal of Rheumatology.  40:498-505. 2013
    2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsNature Genetics.  45:145-154. 2013
    2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsNature Genetics.  45:145-154. 2013
    2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsNature Genetics.  45:145-154. 2013
    2013 Thrombosis in vasculitisBest Practice and Research: Clinical Rheumatology.  27:57-67. 2013
    2012 Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African AmericansArthritis and Rheumatism.  64:655-664. 2012
    2012 Drug treatment of hyperuricemia to prevent cardiovascular outcomes: Are we there yet?American Journal of Cardiovascular Drugs.  12:1-6. 2012
    2012 Association between being African-American, serum urate levels and the risk of developing hyperuricemia: Findings from the Coronary Artery Risk Development in Young Adults cohort 2012
    2012 Developing a provisional definition of flare in patients with established goutArthritis and Rheumatism.  64:1508-1517. 2012
    2011 Bringing it all together: A novel approach to the development of response criteria for chronic gout clinical trialsJournal of Rheumatology.  38:1467-1470. 2011
    2011 Patient-reported outcomes in chronic gout: A report from OMERACT 10Journal of Rheumatology.  38:1452-1457. 2011
    2011 Serum urate in chronic gout - Will it be the first validated soluble biomarker in rheumatology?Journal of Rheumatology.  38:1462-1466. 2011
    2011 Tophus measurement as an outcome measure for clinical trials of chronic gout: Progress and research prioritiesJournal of Rheumatology.  38:1458-1461. 2011
    2010 Serum urate and its relationship with alcoholic beverage intake in men and women: Findings from the Coronary Artery Risk Development in Young Adults (CARDIA) cohortAnnals of the Rheumatic Diseases.  69:1965-1970. 2010
    2010 Diagnostic Approach to ANCA-associated VasculitidesRheumatic Disease Clinics of North America.  36:491-506. 2010
    2009 Febuxostat: The evidence for its use in the treatment of hyperuricemia and goutCore Evidence.  4:25-36. 2009
    2009 Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? 2009
    2009 Are glucocorticoids equivalent to NSAIDs for the treatment of gout flares?Nature Clinical Practice Rheumatology.  5:12-13. 2009
    2008 Management of Hyperuricemia and Gout in CKDAmerican Journal of Kidney Diseases.  52:994-1009. 2008
    2008 Methotrexate is not associated with progression of interstitial lung disease in rheumatoid arthritisArchives of Internal Medicine.  168:1927-1928. 2008
    2008 Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine. 2008
    2007 Treatment of acute gout-like arthritis in an emergency setting: Prednisolone versus indomethacin: CommentaryNature Clinical Practice Rheumatology.  3:604-605. 2007
    2007 Pulmonary manifestations of rheumatoid arthritis 2007
    2006 Treatment of rheumatoid arthritisAmerican Journal of Health-System Pharmacy.  63:2451-2465. 2006
    2005 A group randomized trial to improve safe use of nonsteroidal anti-inflammatory drugsAmerican Journal of Managed Care.  11:537-543. 2005
    2004 Cysticercosis as the main cause of partial seizures in children in PeruRevista de Neurologia.  39:924-926. 2004
    1997 The role of menopause in the development of chronic mountain sickness.American Journal of Physiology.  272:R90-R94. 1997

    Chapter

    Year Title Altmetric
    2014 Crystal Diseases.  1935-1949. 2014
    2013 Asymptomatic hyperuricemia and its clinical implications for extra-articular disease.  132-147. 2013
    2012 Diagnosis of gout.  94-104. 2012

    Research Overview

  • Gout and other crystalline arthritis
    Vasculitis
    Epidemiology of Rheumatic diseases
  • Education And Training

  • Doctor of Medicine in Internal Medicine Residency Program, 1999
  • UAB Hospital, Internship 2003
  • UAB Hospital, Residency 2005
  • UAB Hospital, Postdoctoral Fellowship 2009
  • UAB Hospital, Postdoctoral Fellowship 2007
  • Full Name

  • Angelo Gaffo