Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Myocardial tissue characterization by combining late gadolinium enhancement imaging and percent edema mapping: a novel T2 map-based MRI method in canine myocardial infarctionEuropean Radiology Experimental.  2. 2018
2018 In the absence of central pre-B cell receptor selection, peripheral selection attempts to optimize the antibody repertoire by enriching for CDR-H3 Y101Frontiers in Immunology.  9. 2018
2017 Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3Autoimmunity.  50:42-51. 2017
2016 Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesisJournal of Allergy and Clinical Immunology.  138:1495-1498. 2016
2016 Age-independent myocardial infarct quantification by signal intensity percent infarct mapping in swineJournal of Magnetic Resonance Imaging.  43:911-920. 2016
2016 HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequenceImmunogenetics.  68:145-155. 2016
2015 Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodiesPLoS ONE.  10. 2015
2014 Infarct density distribution by MRI in the porcine model of acute and chronic myocardial infarction as a potential method transferable to the clinicInternational Journal of Cardiac Imaging.  30:937-948. 2014
2013 The link between antibodies to oxldl and natural protection against pneumococci depends on dh gene conservationJournal of Experimental Medicine.  210:875-890. 2013
2012 Determination of infarct size in Ex Vivo swine hearts by multidetector computed tomography using gadolinium as contrast mediumInvestigative Radiology.  47:277-283. 2012
2012 Acute infarct selective MRI contrast agentInternational Journal of Cardiac Imaging.  28:285-293. 2012
2011 Quantification of myocardial viability distribution with Gd(DTPA) bolus-enhanced, signal intensity-based percent infarct mappingMagnetic Resonance Imaging.  29:650-658. 2011
2010 Differentiation of acute and four-week old myocardial infarct with Gd(ABE-DTTA)-enhanced CMRJournal of Cardiovascular Magnetic Resonance.  12. 2010
2010 Percent infarct mapping for delayed contrast enhancement magnetic resonance imaging to quantify myocardial viability by Gd(DTPA).Journal of Magnetic Resonance Imaging.  32:859-868. 2010
2009 Virtual in vivo biopsy map of early prostate neoplasm in TRAMP mice by MRIProstate.  69:449-458. 2009
2009 Epigenetic Reprogramming: A Possible Etiological Factor in Bladder Pain Syndrome/Interstitial Cystitis?Journal of Urology, The.  181:980-984. 2009
2008 Head-to-head comparison between delayed enhancement and percent infarct mapping for assessment of myocardial infarct size in a canine modelJournal of Magnetic Resonance Imaging.  28:1386-1392. 2008
2007 Erratum: SIRT1 is significantly elevated in mouse and human prostate cancer (Cancer Research (2007) 67, (6612-6618))Cancer Research.  67:8423. 2007
2007 SIRT1 is significantly elevated in mouse and human prostate cancerCancer Research.  67:6612-6618. 2007
2007 In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agentMagnetic Resonance in Medicine.  58:55-64. 2007
2007 A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMRJournal of Cardiovascular Magnetic Resonance.  9:549-556. 2007
2007 Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intakeCancer Research.  67:417-424. 2007
2006 In vivo R1-enhancement mapping of canine myocardium using CeMRI with Gd(ABE-DTTA) in an acute ischemia-reperfusion modelJournal of Magnetic Resonance Imaging.  24:571-579. 2006
2006 Percent infarct mapping: An R1-map-based CE-MRI method for determining myocardial viability distributionMagnetic Resonance in Medicine.  56:535-545. 2006
2006 Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogsPharmacology.  77:188-194. 2006
2005 β1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contactsCancer Research.  65:6692-6700. 2005
2005 Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP)Journal of Nutrition.  135:989-995. 2005
2005 Association of a major protein antigen of Mycoplasma arthritidis with virulenceInfection and Immunity.  73:245-249. 2005
2004 Transgenic mouse with human mutant p53 expression in the prostate epitheliumProstate.  61:26-34. 2004
2004 The vir gene of bacteriophage MAV1 confers resistance to phage infection on Mycoplasma arthritidisJournal of Bacteriology.  186:5715-5720. 2004
2004 A hypothesis for the etiology of interstitial cystitisAdvances in Experimental Medicine and Biology.  539 B:683-712. 2004
2003 HIV Protease Inhibitor Ritonavir Induces Lipoatrophy in Male MiceAIDS Research and Human Retroviruses.  19:1141-1150. 2003
2002 Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and ratsJournal of Infectious Diseases.  186:432-435. 2002
2002 Genistein chemoprevention: Timing and mechanisms of action in murine mammary and prostateJournal of Nutrition.  132. 2002
2002 Evaluation of liver fatty acid oxidation in the leptin-deficient obese mouseMolecular Genetics and Metabolism.  75:219-226. 2002
2001 Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP)Cancer Research.  61:6777-6782. 2001
2000 NF-kappaB activation mediates the response of a subpopulation of basal uroepithelial cells to a cell wall component of Enterococcus faecalis.Journal of Cellular Physiology.  182:232-238. 2000
1998 Osteopontin stimulates a subpopulation of quiescent human prostate epithelial cells with high proliferative potential to divide in vitroProstate.  35:83-94. 1998
1997 Evidence for altered proliferative ability of progenitors of urothelial cells in interstitial cystitisJournal of Urology, The.  158:248-252. 1997
1996 I. A subpopulation of human urothelial cells is stimulated to proliferate by treatment in vitro with lipoteichoic acid, a cell wall component of Streptococcus faecalisJournal of Cellular Physiology.  169:42-51. 1996
1996 II. Long-term treatment with lipoteichoic acid from Streptococcus faecalis affects differentiation and expression and cellular distribution of β1 integrins in human urothelial cellsJournal of Cellular Physiology.  169:52-65. 1996
1996 III. Nitric oxide mediates the action of lipoteichoic acid on the function of human urothelial cellsJournal of Cellular Physiology.  169:66-77. 1996
1996 Long-term treatment with lipoteichoic acid from Streptococcus faecalis affects differentiation and expression and cellular distribution of beta 1 integrins in human urothelial cells.Journal of Cellular Physiology.  169:52-65. 1996
1996 Nitric oxide mediates the action of lipoteichoic acid on the function of human urothelial cells.Journal of Cellular Physiology.  169:66-77. 1996
1995 Recombinant adenovirus-mediated gene transfer to genitourinary epithelium in vitro and in vivo.Cancer Gene Therapy.  2:97-104. 1995
1994 Integrin-mediated adhesive properties of uroepithelial cells are inhibited by treatment with bacterial toxins.American Journal of Physiology.  266:C1552-C1559. 1994
1994 Integrin-mediated adhesive properties of uroepithelial cells are inhibited by treatment with bacterial toxinsAmerican Journal of Physiology - Cell Physiology.  266. 1994
1993 Effects of Escherichia coli and E. coli lipopolysaccharides on the function of human ureteral epithelial cells cultured in serum-free mediumInfection and Immunity.  61:3304-3312. 1993
1992 Altered sulfate transport via anion exchange in CFPAC is corrected by retrovirus-mediated CFTR gene transferAmerican Journal of Physiology.  263. 1992
1992 Effects of growth factors, hormones, bacterial lipopolysaccharides, and lipotechoic acids on the clonal growth of normal ureteral epithelial cells in serum‐free cultureJournal of Cellular Physiology.  150:52-58. 1992
1991 Carrier-mediated sulfate transport in human ureteral epithelial cells cultured in serum-free medium.American Journal of Physiology.  261:C916-C926. 1991
1991 High intracellular pH in CFPAC: A pancreas cell line from a patient with cystic fibrosis is lowered by retrovirus-mediated CFTR gene transferBiochemical and Biophysical Research Communications.  180:342-348. 1991
1991 Sulfation by human lung fibroblasts: SO42- and sulfur-containing amino acids as sources for macromolecular sulfationAmerican Journal of Physiology.  260. 1991
1989 Chinese Hamster Ovary Cell Mutants Deficient in an Anion Exchanger Functionally Similar to Erythroid Band 3Annals of the New York Academy of Sciences.  574:109-112. 1989
1989 Evidence for vasoactive intestinal peptide receptors in apical membranes from tracheal epitheliumLife Sciences.  44:1037-1042. 1989
1989 Sulfate transport in human lung fibroblasts (IMR-90): Effect of pH and anionsAmerican Journal of Physiology.  256. 1989
1988 Chinese hamster ovary cell mutants deficient in an anion exchanger functionally similar to the erythroid band 3Journal of Biological Chemistry.  263:18607-18613. 1988
1988 Binding and degradation of125I-insulin by isolated rat renal brush border membranes: Evidence for low affinity, high capacity insulin recognition sitesJournal of Membrane Biology.  105:113-129. 1988
1988 Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patientsBiochemical and Biophysical Research Communications.  152:99-106. 1988
1987 Sulfate transport in apical membrane vesicles isolated from tracheal epitheliumAmerican Journal of Physiology.  253. 1987
1987 Reaction of unsaturated uronic acid residues with mercuric salts. Cleavage of the hyaluronic acid disaccharide 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose.Biochemical Journal.  245:795-804. 1987
1986 Sulfate transport-deficient mutants of Chinese hamster ovary cells. Sulfation of glycosaminoglycans dependent on cysteineJournal of Biological Chemistry.  261:15725-15733. 1986
1985 In vitro ethanol effects on the transport properties of isolated renal brush-border membrane vesiclesJournal of Membrane Biology.  88:123-130. 1985
1985 Evidence from 23Na NMR studies for the existence of sodium-channels in the brush border membrane of the renal proximal tubuleBiochemical and Biophysical Research Communications.  128:746-753. 1985
1985 Evidence for the presence of an ATP transport system in brush-border membrane vesicles isolated from the kidney cortexBBA - Biomembranes.  812:595-599. 1985
1985 Small Proteins Affect Na+ Gradient‐Dependent d‐Glucose Transport in Isolated Renal Brush‐Border Membrane VesiclesAnnals of the New York Academy of Sciences.  456:101-104. 1985
1985 Sulfate transport in human lung fibroblasts (IMR‐90)Journal of Cellular Physiology.  125:243-250. 1985
1984 Polyamines stimulate d-glucose transport in isolated renal brush-border membrane vesiclesBBA - Biomembranes.  777:1-8. 1984
1984 Mg2+ATPase activity in isolated renal brush border membrane vesiclesFederation proceedings.  43. 1984
1984 Sulfate utilization in human lung fibroblasts (IMR-90)Federation proceedings.  43. 1984
1983 In vitro effects of vitamin D3 on the phospholipids of isolated renal brush border membranesJournal of Membrane Biology.  72:85-91. 1983
1980 Intracellular phosphorus pools in intact algal cells: 31P NMR and transmission electron microscopy studies.FEBS Letters.  117:137-142. 1980
1980 31P‐NMR DIFFERENTIATION BETWEEN INTRACELLULAR PHOSPHATE POOLS IN COSMARIUM (CHLOROPHYTA)Journal of Phycology.  16:368-374. 1980
1980 PHOSPHORUS UTILIZATION AND STORAGE IN BATCH CULTURES OF THE DINOFLAGELLATE PERIDINIUM CINCTUM F. WESTIIJournal of Phycology.  16:626-633. 1980
1980 The effect of photochemical treatment of water on algal growthWater Research.  14:539-543. 1980
1979 An indication to the role of intracellular phosphorus for the development of the dinoflagellate peridinium bloom in Lake KinneretWater Research.  13:585-588. 1979

Chapter

Year Title Altmetric
2009 978-1-4200-4579-6.  197-214. 2009
2003 A Hypothesis for the Etiology of Interstitial Cystitis.  683-712. 2003

Research Overview

  • My main scientific interests have been in the biology of the genitourinary tract. Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) is a chronic inflammatory disease of the bladder wall. More than 100 years after first being described, the diagnosis of BPS/IC is still associated with controversy. Given the difficulties associated with the diagnosis of BPS/IC, it is not surprising that the etiology of this syndrome is poorly understood.
    In vitro studies in my laboratory have been consistent with the possibility that BPS/IC may develop in response to noxious stimuli in the bladder lumen. Thus, lipoteichoic acid (LT-2), a cell wall component of the gram-positive bacterium Streptococcus faecalis, stimulated the proliferation rate of a subpopulation of basal uroepithelial cells with high proliferative potential (possibly stem cells), their progeny differentiated at a higher rate and displayed abnormal expression and cellular distribution of β1 integrins, and LT-2 required activation of iNOS and NFκB. Moreover, our studies provided evidence for altered proliferative ability of progenitors of urothelial cells in cell cultures isolated from patients with BPS/IC. These studies raised a number of questions: What are the mechanisms by which noxious stimuli in the bladder lumen may trigger abnormal function of the muscle and nerve tissue underlying the uroepithelium, causing pain and persistent urge to void? In addition, how is it possible that chronic symptoms similar to those characteristic of bacterial cystitis persist for years in patients with BPS/IC in whom no infectious agent is detected at the time of diagnosis? Based on emerging data from several laboratories, I postulated in a review that epigenetic reprogramming mechanisms in the bladder may provide an explanation for uroepithelial, mast cells and nerve cell abnormalities in BPS/IC, as well as propagation of this altered state in the absence of the signal that may have triggered it. Data supporting this hypothesis would provide a rationale for new diagnostic, treatment and dietary intervention options for BPS/IC.
    My second scientific interest is dietary prevention of prostate cancer (PC). PC is the most commonly diagnosed cancer in North American men. Findings of latent or clinically insignificant PC occur in a large proportion, and at equal rates, in autopsy studies among men from Asian countries and the United States. In contrast, the incidence of clinically significant PC is an order of magnitude higher in the United States. Epidemiological studies suggest that this might be attributable to differences in environmental factors and life style, including nutrition. Aggressive PC is less prevalent among Asian men where the intake of soy products is very high. However, with Westernization and loss of traditional eating habits, the pattern of disease incidence is also changing in Asian men. On the basis of these findings, it has been postulated that phytoestrogens, including genistein, may have a preventive role in PC. Studies in my laboratory in a transgenic mouse model of prostate cancer (TRAMP mice), supported this hypothesis
    Prostate cancer fatalities are rarely due to primary tumors, but rather to widespread metastatic disease. The preferential colonization of bone by prostatic adenocarcinomas has been attributed to the passage of prostate epithelial cells from the prostate to the spine via paravertebral blood vessels. However, molecular mechanisms that facilitate retention of metastatic cells in bone and, their subsequent unrestricted proliferation, are poorly understood. In my laboratory, in vitro studies in cell cultures isolated from the human prostate and in vivo studies in the transgenic mouse model of prostate cancer focused on cell adhesion-mediated molecular mechanisms that: (i) May underlie progression of slow growing prostate tumors to metastatic growth; and that (ii) May be the target of preventive strategies that delay progression of indolent prostate tumors to metastatic growth.
    In the past few years, in collaborative studies with Harry W. Schroeder, Jr., my interests have expanded to the link between natural protection against infectious agents and D(H) gene conservation.
  • Teaching Overview

  • My teaching efforts have focused on courses for graduate students. Over the years, I have taught segments in the courses Practical Pharmacology, Animal Models of Human Disease, Animal Use in Biomedical Research, Principles of Toxicology, Advanced Topics in Toxicology, Molecular Biology of Cell Adhesion, Principles of Genetics: Genetic basis of Disease, Advanced Genetics. I was the course master for two courses: Scientific Method in Biomedical Research and Basic Statistics. More recently, I have been involved in teaching a course for graduate students entitled "Topics in Professional Development".
  • Education And Training

  • NIH Laboratory of Molecular Aging, Postdoctoral Research 1981
  • Doctor of Philosophy in Biochemistry, Weizmann Institute of Science 1978
  • Master of Sciences or Mathematics in Physiology, Pathology and Related Sciences, Tel Aviv University 1972
  • Bachelor of Science or Mathematics in Biology, Tel Aviv University 1969
  • Full Name

  • Ada Elgavish