Positions

Overview

  • Dr. Bansal's research interest focuses on adaptive T-cell responses in HIV-1 transmission and pathogenesis. She's especially interested in understanding the role of HIV-1 specific CD8 and CD4 T-cells and their interplay with the host genetics in influencing the course of HIV-1 disease. This basic information is imperative for HIV-1 vaccine design as the correlates of immune protection are yet unknown. She is also interested in studying the role of T cell in HIV associated cancers.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infectionJournal of Clinical Investigation.  131. 2021
    2021 HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent mannerAutophagy.  17:553-577. 2021
    2020 Rates and Correlates of Incident Type 2 Diabetes Mellitus Among Persons Living With HIV-1 InfectionFrontiers in Endocrinology.  11. 2020
    2019 HLA-I Associated Adaptation Dampens CD8 T-Cell Responses in HIV Ad5-Vectored Vaccine RecipientsJournal of Infectious Diseases.  220:1620-1628. 2019
    2018 Tetraspanin blockage reduces exosome-mediated HIV-1 entryArchives of Virology.  163:1683-1689. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.Frontiers in Public Health.  6:70. 2018
    2017 Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cellsInternational Journal of Nanomedicine.  12:4823-4833. 2017
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progressionJournal of Experimental Medicine.  213:2049-2063. 2016
    2016 HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infectionJournal of Immunology.  196:3276-3286. 2016
    2015 Normal T-cell activation in elite controllers with preserved CD4 + T-cell countsAIDS.  29:2245-2254. 2015
    2015 Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA Class I alleles associated with a favorable clinical outcome 2015
    2014 Human Immunodeficiency Virus VaccinesInfectious Disease Clinics of North America.  28:615-631. 2014
    2014 Characterization of T-Cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 Vaccine 2014
    2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patientsAIDS.  28:2627-2631. 2014
    2011 Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression 2011
    2011 CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection 2011
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionJournal of Experimental Medicine.  207:51-59. 2010
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsJournal of Experimental Medicine.  205:1009-1017. 2008
    2008 Treatment response in acute/early infection versus advanced AIDS: Equivalent first and second phases of HIV RNA declineAIDS.  22:957-962. 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescentsAIDS.  21:2387-2397. 2007
    2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatmentJournal of Infectious Diseases.  195:108-117. 2007
    2006 Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patientsAIDS.  20:353-360. 2006
    2005 CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptidesAIDS.  19:241-250. 2005
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I AllelesAIDS Research and Human Retroviruses.  19:1017-1026. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities 2003
    1997 Expression of lacZ reporter gene under the control of the polyhedrin promoter of Spodoptera litura nuclear polyhedrosis virusGene.  190:145-150. 1997

    Research Overview

  • HIV-1, Vaccines, Infectious Diseases, T cell immunology
  • Investigator On

  • Vaccine and Treatment Evaluation Units  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER 2014 - 2023
  • Defining the Biological Relevance of HIV-1 Adaptation to CD4 T Cell Responses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2022
  • The Impact of HIV Adaptation to CD8 T Cells on Infection and Viral Control  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2020 - 2021
  • Immunologic Health in Aging PLWH  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2021
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2015 - 2021
  • Multidisciplinary Evaluation of Accelerated Aging in HIV-1 Infection  awarded by National Institute on Aging/NIH/DHHS 2017 - 2020
  • A Rational Approach for HIV Vaccine T Cell Epitope Selection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2016 - 2017
  • Oxidative Stress and T Cell Balance: Effect on Pulmonary Tuberculosis During HIV  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • HIV-1 Cryptic Epitopes: Implications for Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2015
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2010 - 2015
  • Analysis of Variant Epitope Specific CD8 T-Cells to Optimize HIV Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2014
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Mapping Novel Subdominant B*5701 Epitopes in Conserved Regions of the HIV Proteome  awarded by UNIVERSITY OF TEXAS 2009 - 2013
  • Teaching Overview

  • I have taught HIV-1 virology and immunology to undergraduate and graduate students working in an Infectious Diseases Laboratory.
  • Education And Training

  • Doctor of Philosophy in Virology, 1996
  • University of Alabama University of Alabama, Postdoctoral Fellowship 2001
  • Full Name

  • Anju Bansal