Positions

Overview

  • Dr. Ballesteros-Tato completed his Ph.D. in Molecular Biology at the Autonoma University of Madrid in Spain in July 2007. In his Ph.D. thesis work, he studied the role of the cell cycle inhibitor p21 and the apoptosis-inducing Fas receptor in controlling immunological tolerance in different murine and human autoimmune diseases. Beginning in March of 2008, he joined the laboratory of Dr. Troy Randall at Trudeau Institute as a postdoctoral fellow, and then later moved with Dr. Randall's lab to the University of Rochester. As a postdoc, he studied how dendritic cell (DC) subsets responded to influenza infection and how they controlled CD8+ T cell priming and promoted memory T cell differentiation. These previous studies have stimulated my interest in how cells of the innate immune system, particularly DCs, monocytes, and their progeny, control both early inflammation and ultimately T and B cell responses to pathogens. Since he joined UAB in 2015, his laboratory is studying the cellular interactions, the environmental cues and the molecular mechanisms that control the differential capacity of distinct populations of DCs to regulate T and B cells responses in different models of infection and autoimmune diseases.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B CellsImmunity.  50:1172-1187.e7. 2019
    2019 Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in InfantsImmunity.  50:225-240.e4. 2019
    2019 Dysregulation of T follicular helper cells in lupusJournal of Immunology.  202:1649-1658. 2019
    2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infectionNature Immunology.  18:1249-1260. 2017
    2017 Integrated STAT3 and ikaros zinc finger transcription factor activities regulate Bcl-6 expression in CD4+ Th cellsJournal of Immunology.  199:2377-2387. 2017
    2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene ProgramsImmunity.  47:251-267.e7. 2017
    2016 The Integrin LFA-1 Controls T Follicular Helper Cell Generation and MaintenanceImmunity.  45:831-846. 2016
    2016 T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust MiteImmunity.  44:259-273. 2016
    2016 IL-7 signalling represses Bcl-6 and the T FH gene programNature Communications.  7. 2016
    2015 Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ productionScientific Reports.  5. 2015
    2014 The biology of the interleukin-2 (IL-2)-Based immunotherapies in cancer and autoimmune diseaseInternational Journal of Cancer Research and Prevention.  7:213-234. 2014
    2014 Dendritic cells and B cells: Unexpected partners in Th2 developmentJournal of Immunology.  193:1531-1537. 2014
    2014 Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8+ T CellsImmunity.  41:127-140. 2014
    2014 FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availabilityNature Communications.  5. 2014
    2014 Innate IFNγ-producing B cellsCell Research.  24:135-136. 2014
    2014 Beyond regulatory T cells: The potential role for IL-2 to deplete T-follicular helper cells and treat autoimmune diseasesImmunotherapy.  6:1207-1220. 2014
    2014 Priming of T follicular helper cells by dendritic cellsImmunology and Cell Biology.  92:22-27. 2014
    2014 Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cellsJournal of Experimental Medicine.  211:1637-1655. 2014
    2013 CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell- mediated suppression of CD8+ T cell responses to influenzaJournal of Experimental Medicine.  210:1591-1601. 2013
    2012 Regulation of T H2 development by CXCR5 + dendritic cells and lymphotoxin-expressing B cellsNature Immunology.  13:681-690. 2012
    2012 Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell DifferentiationImmunity.  36:847-856. 2012
    2012 Unraveling effector functions of B cells during infection: The hidden world beyond antibody productionInfectious Disorders - Drug Targets.  12:213-221. 2012
    2011 Memory: The Incomplete Unhappening of DifferentiationImmunity.  35:496-498. 2011
    2010 Erratum: Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza (Nature Immunology (2010) 11 (216-224))Nature Immunology.  11:644. 2010
    2010 Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+T cell responses to influenzaNature Immunology.  11:216-224. 2010
    2007 p21CIP1/WAF1 controls proliferation of activated/memory T cells and affects homeostasis and memory T cell responsesJournal of Immunology.  178:2296-2306. 2007
    2007 Cell cycle inhibitors in T cell tolerance and autoimmunity controlInmunología.  26:184-192. 2007

    Chapter

    Year Title Altmetric
    2014 The biology of the interleukin-2 (IL-2)-based immunotherapies in cancer and autoimmune disease.  31-52. 2014

    Research Overview

  • T cell responses
    B cell responses
    Dendritic cell Biology
    Influenza
    Autoimmune diseases
    Vaccines
  • Teaching Activities

    Full Name

  • Andre Ballesteros-Tato