Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor FunctionsFrontiers in Immunology.  10. 2019
2019 Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidaseInternational Journal of Immunopathology and Pharmacology.  33. 2019
2019 Neutrophil and granulocytic myeloid-derived suppressor cell-mediated t cell suppression significantly contributes to immune dysregulation in common variable immunodeficiency disordersJournal of Immunology.  202:93-104. 2019
2018 Is a lower-dose, subcutaneous contraceptive injectable containing depot medroxyprogesterone acetate likely to impact women's risk of HIV?Contraception.  97:191-197. 2018
2018 Hormonal contraception and HIV-1 acquisition: Biological mechanisms 2018
2017 Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 InfectionPLoS Pathogens.  13. 2017
2016 Erratum: Corrigendum to “Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs” (Contraception (2014) 90(2) (123–129) (S0010782414000535) (10.1016/j.contraception.2014.02.006))Contraception.  94:578. 2016
2015 Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract 2015
2014 Altered Serum Cytokine Signature in Common Variable ImmunodeficiencyJournal of Clinical Immunology.  34:971-978. 2014
2014 Effect of progestins on immunity: Medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCsContraception.  90:123-129. 2014
2014 Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 PathwayPLoS Pathogens.  10. 2014
2013 The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial CellsPLoS Pathogens.  9. 2013
2013 Hormonal contraception and hiv-1 infection: Medroxyprogesterone acetate suppresses innate and adaptive immune mechanismsEndocrinology.  154:1282-1295. 2013
2013 Optimization of the transductional efficiency of lentiviral vectors: Effect of sera and polycationsMolecular Biotechnology.  53:308-314. 2013
2012 Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemiaClinical and Experimental Immunology.  170:321-332. 2012
2011 Menstrual blood as a potential source of endometrial derived CD3+ T cellsPLoS ONE.  6. 2011
2011 Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responsesPLoS ONE.  6. 2011
2010 Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection 2010
2009 Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen 2009
2009 A model for testing the immunogenicity of simian immunodeficiency virus and simian-human immunodeficiency virus vaccine candidates in miceJournal of Virological Methods.  158:70-76. 2009
2009 Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infectionJournal of Reproductive Immunology.  83:196-200. 2009
2008 Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responsesVaccine.  26:1541-1551. 2008
2006 HIV infection: first battle decides the war 2006
2006 Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levelsJournal of Virology.  80:3732-3742. 2006
2006 Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genesJournal of Immunology.  176:85-96. 2006
2005 Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional levelJournal of Biological Chemistry.  280:5750-5763. 2005
2002 Immune intervention strategies for HIV-1 infection of humans in the SIV macaque modelVaccine.  20. 2002
2002 Containment of simian immunodeficiency virus infection in vaccinated macaques: Correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responsesJournal of Immunology.  169:4778-4787. 2002
2002 Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapyJournal of Immunology.  169:5347-5357. 2002
2002 A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV/HIV vaccineVaccine.  20:3171-3186. 2002
2002 ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiencyJournal of Virology.  76:292-302. 2002
2002 Cervicovaginal lamina propria lymphocytes: Phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to simian immunodeficiency virus SIVmac251Journal of Virology.  76:9-18. 2002
2002 Design and in vivo immunogenicity of a polyvalent vaccine based on SIVmac regulatory genes 2002
2002 Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaquesVirology.  304:125-134. 2002
2001 Potentiation of Simian Immunodeficiency Virus (SIV)-specific CD4+ and CD8+ T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimenJournal of Immunology.  167:7180-7191. 2001
2001 Towards an improved AIDS vaccine: Enhancing the MHC class I and II antigen presentation of SIV proteins using ubiquitin and HLA-DM targeting sequences 2001
2001 Impairment of Gag-specific CD8+ T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaquesJournal of Virology.  75:11483-11495. 2001
2001 Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; A pilot studyBMC Infectious Diseases.  1. 2001
2001 Polymorphism in the 3′-untranslated region of TNFα mRNA impairs binding of the post-transcriptional regulatory protein HuR to TNFα mRNANucleic Acids Research.  29:863-871. 2001
2001 Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaquesNature Medicine.  7:1320-1326. 2001
2000 Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaquesNature Medicine.  6:1140-1146. 2000
1998 Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-α mRNANucleic Acids Research.  26:2803-2812. 1998
1998 Phenotypic difference between Bcg(r) and Bcg(s) macrophages is related to differences in protein-kinase-C-dependent signalling 1998
1996 Two distinct regions in the 3' untranslated region of tumor necrosis factor alpha mRNA form complexes with macrophage proteinsMolecular and Cellular Biology.  16:5579-5590. 1996

Education And Training

  • Doctor of Philosophy Level Degree in Medicine, McGill University 1997
  • Master's Level Degree in Medical Biochemistry, Charles University in Prague 1990
  • Full Name

  • Zdenek Hel