Selected Publications

Academic Article

Year Title Altmetric
2018 Combined analysis of antigen presentation and T-cell recognition reveals restricted immune responses in melanomaCancer Discovery.  8:1366-1375. 2018
2018 Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cellsRedox Biology.  18:54-64. 2018
2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in VitroACS Chemical Biology.  13:2048-2057. 2018
2018 Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell cultureRedox Biology.  17:59-69. 2018
2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
2018 Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's diseaseJournal of Neurochemistry.  144:691-709. 2018
2018 The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synucleinNeurobiology of Disease.  110:68-81. 2018
2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activationJournal of Biological Chemistry.  293:1218-1228. 2018
2017 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.Journal of Biological Chemistry.  293:1218-1228. 2017
2017 Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neuronsAutophagy.  13:1828-1840. 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cellsProceedings of the National Academy of Sciences.  114:E6371-E6380. 2017
2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's diseaseMolecular Brain.  10. 2017
2017 Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic miceJournal of Neurochemistry.  142:297-304. 2017
2017 Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart FailureCirculation: Heart Failure.  10. 2017
2017 O-GlcNAcylation and neurodegenerationBrain Research Bulletin.  133:80-87. 2017
2017 Oxidative stress and neurodegenerationBrain Research Bulletin.  133:1-3. 2017
2017 A central role for R7bp in the regulation of itch sensationPAIN.  158:931-944. 2017
2017 Autophagy and the redox connection: Virtual collection Vol 2Redox Biology.  11:620-621. 2017
2017 Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neuronsRedox Biology.  11:73-81. 2017
2017 Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrilsRedox Biology.  11:429-437. 2017
2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathwayJournal of Biological Chemistry.  292:3029-3038. 2017
2017 Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune functionAnnals of Oncology.  28:83-89. 2017
2017 Overexpression of SMOC2 attenuates the tumorigenicity of hepatocellular carcinoma cells and is associated with a positive postoperative prognosis in human hepatocellular carcinomaJournal of Cancer.  8:3812-3827. 2017
2017 Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-upAnnals of Oncology.  28:75-82. 2017
2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
2016 Differential regulation of autophagy and mitophagy in pulmonary diseasesAJP - Lung Cellular and Molecular Physiology.  311:L433-L452. 2016
2016 Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stressJournal of Translational Medicine.  14. 2016
2016 Metabolic, autophagic, and mitophagic activities in cancer initiation and progressionBiomedical Journal.  39:98-106. 2016
2016 The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases.Aging and Disease.  7:150-162. 2016
2016 Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse GliomaCell.  164:550-563. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinomaOncotarget.  7:6323-6334. 2016
2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
2015 Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355))Biochemical Journal.  471:431. 2015
2015 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicityBiochemical Journal.  469:347-355. 2015
2015 Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammationFree Radical Biology and Medicine.  85:83-94. 2015
2015 Teaching the basics of autophagy and mitophagy to redox biologists-Mechanisms and experimental approachesRedox Biology.  4:242-259. 2015
2015 Regulation of autophagy by protein post-translational modificationLaboratory Investigation.  95:14-25. 2015
2014 SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signalingCancer Research.  74:6318-6329. 2014
2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
2014 Bioenergetic adaptation in response to autophagy regulators during rotenone exposureJournal of Neurochemistry2014
2014 Autophagy as an essential cellular antioxidant pathway in neurodegenerative diseaseRedox Biology.  2:82-90. 2014
2014 Decreased expression of TRIM3 is associated with poor prognosis in patients with primary hepatocellular carcinomaMedical Oncology.  31. 2014
2014 Mitophagy mechanisms and role in human diseasesThe International journal of biochemistry.  53:127-133. 2014
2014 Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cellsJournal of Neurochemistry.  128:950-961. 2014
2014 Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeuticsFree Radical Biology and Medicine.  71:196-207. 2014
2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research.Clinical Science.  127:367-373. 2014
2014 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cellsAutophagy.  10:986-1003. 2014
2013 Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cellsAutophagy.  9:1996-2008. 2013
2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cellsAJP - Endocrinology and Metabolism.  305. 2013
2013 Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblastsBiochemical Journal.  454:249-257. 2013
2013 Impaired autophagy, defective t cell homeostasis, and a wasting syndrome in mice with a t cell-specific deletion of Vps34Journal of Immunology.  190:5086-5101. 2013
2013 Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1PLoS ONE.  8. 2013
2013 Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administrationNeuroscience Letters.  538:3-8. 2013
2013 ICAD Deficiency in Human Colon Cancer and Predisposition to Colon Tumorigenesis: Linkage to Apoptosis Resistance and Genomic InstabilityPLoS ONE.  8. 2013
2013 Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonucleasethat translocates to the nucleus during apoptosisJournal of Biological Chemistry.  288:3460-3468. 2013
2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeuticsBiochemical Society Transactions.  41:127-133. 2013
2013 Autophagy and mitophagy in cellular damage controlRedox Biology.  1:616-630. 2013
2013 Cellular metabolic and autophagic pathways: Traffic control by redox signalingFree Radical Biology and Medicine.  63:207-221. 2013
2013 Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neuronsFree Radical Biology and Medicine.  65:1215-1228. 2013
2013 Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation productsFree Radical Biology and Medicine.  59:56-68. 2013
2012 Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell DeathPLoS ONE.  7. 2012
2012 Genetically engineered mouse models of Parkinson's diseaseBrain Research Bulletin.  88:13-32. 2012
2012 Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy.  8:445-544. 2012
2012 Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagyAJP - Heart and Circulatory Physiology.  302. 2012
2012 Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver functionProceedings of the National Academy of Sciences.  109:2003-2008. 2012
2012 Autophagy, mitochondria and oxidative stress: Cross-talk and redox signallingBiochemical Journal.  441:523-540. 2012
2012 Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heartAutophagy.  8:707-708. 2012
2011 Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stressFree Radical Biology and Medicine.  51:2007-2017. 2011
2011 Assessing bioenergetic function in response to oxidative stress by metabolic profilingFree Radical Biology and Medicine.  51:1621-1635. 2011
2011 Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neuronsMolecular Neurodegeneration.  6. 2011
2011 Systems biology of the autophagy-lysosomal pathwayAutophagy.  7:477-489. 2011
2010 Alpha-synuclein gene structure, evolution, and protein aggregationNeural Regeneration Research.  5:1423-1428. 2010
2010 Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's diseaseMolecular Neurodegeneration.  5. 2010
2010 Lysosome dysfunction triggers Atg7-dependent neural apoptosisJournal of Biological Chemistry.  285:10497-10507. 2010
2009 Inhibition of lysosomal functions reduces proteasomal activityNeuroscience Letters.  456:15-19. 2009
2008 Fos regulates neuronal activity in the nucleus accumbensNeuroscience Letters.  448:157-160. 2008
2008 The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapyFrontiers in Bioscience.  13:718-736. 2008
2008 Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemiaJournal of Neuroscience Research.  86:1115-1124. 2008
2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
2007 Lack of self-administration of cocaine in dopamine D1 receptor knock-out miceJournal of Neuroscience.  27:13140-13150. 2007
2007 Dopamine D1 and D3 receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylationJournal of Neurochemistry.  103:840-848. 2007
2007 Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicinCell Research.  17:735-736. 2007
2007 The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotionPharmacology Biochemistry and Behavior.  86:718-726. 2007
2007 Kainic acid induces early and transient autophagic stress in mouse hippocampusNeuroscience Letters.  414:57-60. 2007
2007 The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosisInsect Molecular Biology.  16:93-105. 2007
2007 Effects of acute "binge" cocaine on mRNA levels of μ opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout miceSynapse.  61:50-59. 2007
2006 c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changesJournal of Neuroscience.  26:13287-13296. 2006
2006 Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamineSynapse.  60:399-405. 2006
2006 Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female miceNeuroscience Letters.  403:125-130. 2006
2006 c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neuronsNeuroscience Letters.  400:177-180. 2006
2005 Repeated cocaine administration induces gene expression changes through the dopamine D1 receptorsNeuropsychopharmacology.  30:1443-1454. 2005
2005 Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1Cardiovascular Research.  65:719-727. 2005
2004 Neural system-enriched gene expression: Relationship to biological pathways and neurological diseasesPhysiological Genomics.  18:167-183. 2004
2004 Molecular genetic probing of dopamine receptors in drug addictionCurrent Opinion in Drug Discovery and Development.  7:703-708. 2004
2004 Role of endonuclease G in neuronal excitotoxicity in miceNeuroscience Letters.  364:203-207. 2004
2004 c-fos regulates neuropeptide Y expression in mouse dentate gyrusNeuroscience Letters.  363:6-10. 2004
2004 Cocaine-Induced Intracellular Signaling and Gene Expression Are Oppositely Regulated by the Dopamine D1 and D3 ReceptorsJournal of Neuroscience.  24:3344-3354. 2004
2003 Endonuclease G is required for early embryogenesis and normal apoptosis in miceProceedings of the National Academy of Sciences.  100:15782-15787. 2003
2003 Function of γ-Aminobutyric Acid Receptor/Channel ρ1 Subunits in Spinal CordJournal of Biological Chemistry.  278:48321-48329. 2003
2003 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environmentNeuropsychopharmacology.  28:100-107. 2003
2003 Generating gene knockout mice for studying mechanisms underlying drug addiction.Methods in Molecular Medicine.  79:351-363. 2003
2002 Hippocampal expression of c-fos is not essential for spatial learningSynapse.  46:91-99. 2002
2002 c-fos-deficient mouse hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitabilityNeuroscience Letters.  331:151-154. 2002
2002 Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditionsBiochemical and Biophysical Research Communications.  297:537-544. 2002
2002 The dopamine D1 receptor is a critical mediator for cocaine-induced gene expressionJournal of Neurochemistry.  82:1453-1464. 2002
2002 DNA fragmentation factor 45 knockout mice exhibit longer memory retention in the novel object recognition task compared to wild-type micePhysiology and Behavior.  76:315-320. 2002
2002 Apoptotic DNA fragmentation and tissue homeostasisTrends in Cell Biology.  12:84-89. 2002
2002 c-fos regulates neuronal excitability and survivalNature Genetics.  30:416-420. 2002
2001 Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injuryMolecular Medicine.  7:205-216. 2001
2001 Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systemsJournal of Addictive Diseases.  20:7-18. 2001
2001 DNA fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell deathBiochemical and Biophysical Research Communications.  285:1143-1149. 2001
2000 Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosisBiochemical and Biophysical Research Communications.  274:225-229. 2000
2000 DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control miceBrain Research.  867:70-79. 2000
2000 Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptorBrain Research.  852:198-207. 2000
2000 DNA fragmentation in apoptosisCell Research.  10:205-211. 2000
2000 Probing the role of the dopamine D1 receptor in psychostimulant addictionAnnals of the New York Academy of Sciences.  914:13-21. 2000
1999 DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cellsJournal of Biological Chemistry.  274:37450-37454. 1999
1998 Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45Proceedings of the National Academy of Sciences.  95:12480-12485. 1998
1995 Association of an activator with an RNA polymerase II holoenzymeGenes and Development.  9. 1995


Year Title Altmetric
2013 Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease, Redox Biology 2 (2014) 82–90 2013


Year Title Altmetric
2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
2012 Mitochondrial dysfunction in neurodegenerative disease: Protein aggregation, autophagy, and oxidative stress.  95-111. 2012
2009 Apoptosis in neurodegenerative diseases.  479-504. 2009

Research Overview

  • My research focus is to understand the cellular and molecular mechanisms responsible for autophagy, mitophagy and lysosomal functions, how these are linked to redox biology and bioenergetics, and how these mechanisms play important roles in Parkinson’s disease pathogenesis and provide opportunities for therapeutics development. These mechanisms are also important for understanding cell differentiation, proliferation, function and survival, in the context of cancer, diabetes, aging, cardiovascular, lung, liver and Alzheimer’s diseases. We are approaching this by using state of the art genetic models and advanced biochemical, omics, metabolic and redox related technologies.
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Texas System : Southwestern Medical Center at Dallas 1991
  • Full Name

  • Jianhua Zhang