Selected Publications

Academic Article

Year Title Altmetric
2020 MRLR: unraveling high-resolution meiotic recombination by linked readsComputer applications in the biosciences : CABIOS.  36:10-16. 2020
2019 Multi-platform discovery of haplotype-resolved structural variation in human genomesNature Communications.  10. 2019
2019 Scalable De Novo Genome Assembly Using a Pregel-Like Graph-Parallel System.IEEE/ACM Transactions on Computational Biology and Bioinformatics2019
2019 Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2Cell.  176:1310-1324.e10. 2019
2018 Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detectionGenome Biology.  19:188. 2018
2018 Identification of meiotic recombination through gamete genome reconstruction using whole genome linked-reads 2018
2018 Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypesHuman Mutation.  39:939-946. 2018
2018 Regenerative potential of neonatal porcine heartsCirculation.  138:2809-2816. 2018
2018 Structural variant breakpoint detection with novoBreakMethods in Molecular Biology.  1833:129-141. 2018
2017 A murine preclinical syngeneic transplantation model for breast cancer precision medicineScience Advances.  3:e1600957-e1600957. 2017
2017 Integrated genomic and molecular characterization of cervical cancerNature.  543:378-384. 2017
2017 A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell LinesCell Systems.  5:485-497.e3. 2017
2017 An Organismal CNV Mutator Phenotype Restricted to Early Human DevelopmentCell.  168:830-842. 2017
2016 Functional annotation of rare gene aberration drivers of pancreatic cancerNature Communications.  7. 2016
2016 Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer typesBMC Genomics.  17:394-394. 2016
2016 Single-cell isolation by a modular single-cell pipette for RNA-sequencingLab on a Chip.  16:4742-4748. 2016
2016 novoBreak: local assembly for breakpoint detection in cancer genomesNature methods2016
2015 An integrated map of structural variation in 2,504 human genomesNature.  526:75-81. 2015
2015 A global reference for human genetic variationNature.  526:68-74. 2015
2015 ClinSeK: a targeted variant characterization framework for clinical sequencingGenome Medicine.  7:34-34. 2015
2015 Clinical actionability enhanced through deep targeted sequencing of solid tumorsClinical Chemistry.  61:544-553. 2015
2015 Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermiaOncotarget.  6:6535-6535. 2015
2015 Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutationsCancer Research.  75:5341-5354. 2015
2015 TransVar: a multilevel variant annotator for precision genomicsNature methods.  12:1002-1003. 2015
2014 Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombinationCell Research.  24:532-541. 2014
2014 Towards accurate characterization of clonal heterogeneity based on structural variationBMC Bioinformatics.  15:299-299. 2014
2014 Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisionsCell Stem Cell.  14:632-643. 2014
2013 Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammalsJournal of the American Chemical Society.  135:10396-10403. 2013
2013 Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technologyBMC Genomics.  14:711-711. 2013
2013 Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanismNucleic Acids Research.  gkt1090-gkt1090. 2013
2013 The evolution of small insertions and deletions in the coding genes of Drosophila melanogasterMolecular Biology and Evolution.  30:2699-2708. 2013
2012 Rainbow: an integrated tool for efficient clustering and assembling RAD-seq readsBioinformatics2012
2011 Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.Proceedings of the National Academy of Sciences.  108:12042-12047. 2011

Education And Training

  • Doctor of Social or Behavioral Sciences in Genome Sciences / Genomics, Chinese Academy of Medical Sciences and Peking Union Medical College 2013
  • Univeristy of Texas MD Anderson Cancer Center Bioinformatics and Computational Biology, Postdoctoral Fellowship 2017
  • Full Name

  • Zechen Chong