Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 MicroRNAs in depression and suicide: Recent insights and future perspectives.Journal of Affective Disorders.  240:146-154. 2018
2018 Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain.Molecular Neurobiology2018
2018 Linking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implications.Molecular Psychiatry2018
2018 Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment.International Journal of Neuropsychopharmacology.  21:461-472. 2018
2018 Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior.Molecular Neurobiology2018
2018 Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects.American Journal of Psychiatry.  175:262-274. 2018
2018 Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats.Psychoneuroendocrinology.  89:185-193. 2018
2018 Understanding the Neuroepigenetic Constituents of Suicide Brain.Progress in Molecular Biology and Translational Science.  157:233-262. 2018
2017 The concept of violent suicide, its underlying trait and neurobiology: A critical perspective.European Neuropsychopharmacology.  28:243-251. 2017
2017 Albumin Protein Cleavage Affects the Wear and Friction of Ultra-High Molecular Weight Polyethylene.Lubricants.  5. 2017
2017 Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis.Journal of Affective Disorders.  225:422-428. 2017
2017 The recent progress in animal models of depression.Progress in Neuro-Psychopharmacology and Biological Psychiatry.  77:99-109. 2017
2017 microRNA-124: a putative therapeutic target and biomarker for major depression.Expert Opinion on Therapeutic Targets.  21:653-656. 2017
2017 Altered miRNA expression network in locus coeruleus of depressed suicide subjects.Scientific Reports.  7:4387. 2017
2017 Animal models to improve our understanding and treatment of suicidal behavior.Translational Psychiatry.  7:e1092. 2017
2017 Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania.Neuroscience.  345:229-242. 2017
2017 Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder.Neuropsychopharmacology.  42:864-875. 2017
2017 DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation.Journal of Psychiatric Research.  89:115-124. 2017
2017 The Life Span Model of Suicide and Its Neurobiological Foundation.Frontiers in Neuroscience.  11:74. 2017
2017 Understanding epigenetic architecture of suicide neurobiology: A critical perspective.Neuroscience and Biobehavioral Reviews.  72:10-27. 2017
2016 Dissecting bipolar disorder complexity through epigenomic approach.Molecular Psychiatry.  21:1490-1498. 2016
2016 Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder.World Journal of Biological Psychiatry.  18:592-603. 2016
2016 Pathogenetic and therapeutic applications of microRNAs in major depressive disorder.Progress in Neuro-Psychopharmacology and Biological Psychiatry.  64:341-348. 2016
2016 Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression.Neural Plasticity.  2016:7383724. 2016
2015 Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology.Translational Psychiatry.  5:e682. 2015
2015 Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease.Molecular Psychiatry.  20:677-684. 2015
2015 Altered Expression of Endoplasmic Reticulum Stress Associated Genes in Hippocampus of Learned Helpless Rats: Relevance to Depression Pathophysiology.Frontiers in Pharmacology.  6:319. 2015
2015 Serotonergic and Noradrenergic Neurotransmitter Systems in SuicideAdvances in Biological Psychiatry -Basel-.  30:21-36. 2015
2014 Toll-like receptors in the depressed and suicide brain.Journal of Psychiatric Research.  53:62-68. 2014
2014 Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications.Dialogues in Clinical Neuroscience.  16:43-61. 2014
2014 Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia.Journal of Affective Disorders.  152-154:326-333. 2014
2014 Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness.Frontiers in Psychiatry.  5:6. 2014
2014 Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects.PLoS ONE.  9:e86469. 2014
2014 Hippocampal neurogenesis, neurotrophic factors and depression: possible therapeutic targets?Current Drug Targets -Cns and Neurological Disorders-.  13:1708-1721. 2014
2014 The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p.Cellular and Molecular Neurobiology.  34:17-30. 2014
2013 Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims.Psychoneuroendocrinology.  38:2628-2639. 2013
2013 Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease.Journal of Psychiatric Research.  47:1187-1191. 2013
2013 Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3β and β-catenin.International Journal of Neuropsychopharmacology.  16:945-955. 2013
2013 Involvement of brain-derived neurotrophic factor in late-life depression.American Journal of Geriatric Psychiatry.  21:433-449. 2013
2013 Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk.Cardiovascular Psychiatry and Neurology.  2013:796462. 2013
2013 MicroRNAs: fundamental regulators of gene expression in major affective disorders and suicidal behavior?Frontiers in Cellular Neuroscience.  7:208. 2013
2013 Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression.Current Pharmaceutical Design.  19:1898-1922. 2013
2013 The role of neuropeptides in suicidal behavior: a systematic review.BioMed Research International.  2013:687575. 2013
2013 microRNAs as Biomarker in Depression Pathogenesis.Annals of Psychiatry and Mental Health.  1:1003. 2013
2012 The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior.Neuroscience Research.  73:179-190. 2012
2012 MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects.PLoS ONE.  7:e33201. 2012
2012 Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims.Journal of Psychiatric Research.  46:57-63. 2012
2011 MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness.International Journal of Neuropsychopharmacology.  14:1315-1325. 2011
2011 Evidence demonstrating role of microRNAs in the etiopathology of major depression.Journal of Chemical Neuroanatomy.  42:142-156. 2011
2011 Elucidating biological risk factors in suicide: role of protein kinase A.Progress in Neuro-Psychopharmacology and Biological Psychiatry.  35:831-841. 2011
2011 Glycosides, depression and suicidal behaviour: the role of glycoside-linked proteins.Molecules.  16:2688-2713. 2011
2011 Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients.Psychiatry Research.  185:108-112. 2011
2010 Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder.Journal of Affective Disorders.  126:303-311. 2010
2010 What can post-mortem studies tell us about the pathoetiology of suicide?Future Neurology.  5:701-720. 2010
2010 Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects.Biological Psychiatry.  67:1017-1025. 2010
2010 Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects.Progress in Neuro-Psychopharmacology and Biological Psychiatry.  34:645-651. 2010
2010 Brain-derived neurotrophic factor and suicide pathogenesis.Annals of Medicine.  42:87-96. 2010
2010 Glycogen synthase kinase-3beta in the platelets of patients with mood disorders: effect of treatment.Journal of Psychiatric Research.  44:143-148. 2010
2009 Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1).International Journal of Neuropsychopharmacology.  12:1337-1354. 2009
2009 Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide.Biological Psychiatry.  65:319-328. 2009
2009 GSK-3beta gene expression in human postmortem brain: regional distribution, effects of age and suicide.Neurochemical Research.  34:274-285. 2009
2009 Brain-derived neurotrophic factor: role in depression and suicide.Neuropsychiatric Disease and Treatment.  5:433-449. 2009
2009 Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims.Prostaglandins and medicine.  80:19-26. 2009
2009 Pharmacological Characterization of Inositol 1,4,5-tris Phosphate Receptors in Human Platelet Membranes.Cardiovascular Psychiatry and Neurology.  2009:618586. 2009
2008 Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims.International Journal of Neuropsychopharmacology.  11:1047-1061. 2008
2008 Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response.Journal of the American Academy of Child and Adolescent Psychiatry.  47:1077-1085. 2008
2008 Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects.Neuropsychopharmacology.  33:2324-2340. 2008
2008 Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase ANeuropsychiatric Disease and Treatment.  4:161-176. 2008
2008 Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase.Journal of Neuroscience.  28:3042-3050. 2008
2008 Adenylyl cyclase-cyclicAMP signaling in mood disorders: role of the crucial phosphorylating enzyme protein kinase A.Neuropsychiatric Disease and Treatment.  4:161-176. 2008
2008 5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims.The open neuropsychopharmacology journal.  1:1-5. 2008
2008 Decreased protein kinase C (PKC) in platelets of pediatric bipolar patients: effect of treatment with mood stabilizing drugs.Journal of Psychiatric Research.  42:106-116. 2008
2007 Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects.Neuropsychopharmacology.  32:2338-2350. 2007
2007 Role of protein kinase A in the etiology of suicide: Evidence from human postmortem brain and preclinical studiesPrimary Psychiatry.  14:71-79. 2007
2007 Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus.International Journal of Neuropsychopharmacology.  10:621-629. 2007
2007 Noradrenergic function in suicide.Archives of Suicide Research.  11:235-246. 2007
2006 Hippocampal cell proliferation regulation by repeated stress and antidepressants.NeuroReport.  17:863-867. 2006
2006 Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims.Archives of General Psychiatry.  63:639-648. 2006
2006 Monoamine receptors and signal transduction mechanisms in suicideCurrent Psychiatry Reviews.  2:51-75. 2006
2006 Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide.Neurochemical Research.  31:167-176. 2006
2006 Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.Neuroscience.  139:1017-1029. 2006
2006 ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.Molecular Psychiatry.  11:86-98. 2006
2005 Suicide brain is associated with decreased expression of neurotrophins.Biological Psychiatry.  58:315-324. 2005
2005 Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims.Neuropsychopharmacology.  30:1548-1556. 2005
2005 The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system.Brain Research.  136:45-53. 2005
2005 Focus on protein kinase A and protein kinase C, critical components of signal transduction system, in mood disorders and suicide.International Journal of Neuropsychopharmacology.  8:1-4. 2005
2005 Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior.Neuropsychopharmacology.  30:473-483. 2005
2005 Differential regulation of serotonin (5HT)2A receptor mRNA and protein levels after single and repeated stress in rat brain: role in learned helplessness behavior.Neuropharmacology.  48:204-214. 2005
2005 Chapter 5.1 The intracellular signaling cascade and stressTechniques in the Behavioral and Neural Sciences.  15:643-663. 2005
2004 Altered protein kinase a in brain of learned helpless rats: effects of acute and repeated stress.Biological Psychiatry.  56:30-40. 2004
2004 Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study.Archives of General Psychiatry.  61:685-693. 2004
2004 Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits.Biological Psychiatry.  55:234-243. 2004
2003 Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment.Psychopharmacology.  170:115-123. 2003
2003 Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression.Journal of Psychiatric Research.  37:421-432. 2003
2003 Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects.Archives of General Psychiatry.  60:804-815. 2003
2003 Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects.Archives of General Psychiatry.  60:273-282. 2003
2002 Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain.Neuropharmacology.  43:1269-1279. 2002
2002 Erratum: mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims (Neuropsychopharmacology (October 2002) 27:4 (499-517) PII:S0893133X02003354)Neuropsychopharmacology.  27:1092. 2002
2002 mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims.Neuropsychopharmacology.  27:499-517. 2002
2002 Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain.Journal of Pharmacology and Experimental Therapeutics.  301:197-209. 2002
2002 Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims.American Journal of Psychiatry.  159:419-429. 2002
2002 Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients.Neuropsychopharmacology.  26:216-228. 2002
2002 [(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims.American Journal of Psychiatry.  159:66-73. 2002
2001 Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment.Psychiatry Research.  105:23-32. 2001
2001 Glucocorticoid receptors are required for up-regulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone.Federation proceedings.  15:1792-1794. 2001
2001 Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects.Journal of Neurochemistry.  77:916-928. 2001
2000 Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.Archives of General Psychiatry.  57:1061-1069. 2000
2000 Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in rat brain: focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphate.Journal of Pharmacology and Experimental Therapeutics.  295:244-254. 2000
2000 Adrenal glucocorticoids modulate [3H]cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain.Journal of Pharmacology and Experimental Therapeutics.  294:103-116. 2000
1999 Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects.American Journal of Psychiatry.  156:1895-1901. 1999
1999 Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain.Journal of Pharmacology and Experimental Therapeutics.  291:688-704. 1999
1999 Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain.Journal of Neurochemistry.  73:693-699. 1999
1999 Repeated administration of dexamethasone increases phosphoinositide-specific phospholipase C activity and mRNA and protein expression of the phospholipase C beta 1 isozyme in rat brain.Journal of Neurochemistry.  73:780-790. 1999
1999 The phenotypic characteristics of heterozygous reeler mouse.NeuroReport.  10:1329-1334. 1999
1999 Administration of dexamethasone up-regulates protein kinase C activity and the expression of gamma and epsilon protein kinase C isozymes in the rat brain.Journal of Neurochemistry.  72:380-387. 1999
1998 A decrease of reelin expression as a putative vulnerability factor in schizophrenia.Proceedings of the National Academy of Sciences.  95:15718-15723. 1998
1998 Quantitation of 5HT2A receptor mRNA in human postmortem brain using competitive RT-PCR.NeuroReport.  9:3761-3765. 1998
1998 Protein kinase C in platelets of depressed patients.Biological Psychiatry.  44:909-911. 1998
1998 Elevated [3H]inositol 1,4,5-trisphosphate binding sites and expressed inositol 1,4,5-trisphosphate receptor protein level in platelets of depressed patients.Psychopharmacology.  138:47-54. 1998
1997 Protein kinase C in the postmortem brain of teenage suicide victims.Neuroscience Letters.  228:111-114. 1997
1997 Effects of subchronic administration of antidepressants and anxiolytics on levels of the alpha subunits of G proteins in the rat brain.Journal of Neural Transmission.  104:747-760. 1997
1996 Pharmacological characterization of inositol 1,4,5trisphosphate receptors in human platelet membranes: Effects of calcium and cyclic ampFederation proceedings.  10. 1996
1995 Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior.American Journal of Psychiatry.  152:850-855. 1995
1993 Chronic ethanol consumption decreases the phorbol ester binding to membranal but not cytosolic protein kinase C in rat brain.Alcohol.  10:259-262. 1993

Chapter

Year Title Altmetric
2017 Genetics of suicidal behaviour.  73-90. 2017
2015 Neuropeptides: Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders.  409-442. 2015
2015 microRNAs as novel players in depression pathogenesis and in the mechanisms of action of fluoxetine and other antidepressants.  147-166. 2015
2014 MicroRNA function and dysregulation in depression and suicide.  273-294. 2014
2013 MicroRNAs, major affective disorders and suicidal behaviour.  39-64. 2013

Education And Training

  • Doctor of Science in Biochemistry, Foreign University
  • Full Name

  • Yogesh Dwivedi
  • Blazerid

  • ydwivedi