Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart FailureCirculation Research.  124:161-169. 2019
2019 Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistanceInternational Journal of Cancer2019
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.Blood Adv.  2:2829-2836. 2018
2018 AKT-independent activation of p38 MAP kinase promotes vascular calcificationRedox Biology.  16:97-103. 2018
2017 Dietary potassium regulates vascular calcification and arterial stiffness.JCI insight.  2. 2017
2017 The interplay between calmodulin and membrane interactions with the pleckstrin homology domain of aktJournal of Biological Chemistry.  292:251-263. 2017
2017 The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligandJournal of Biological Chemistry.  292:10390-10397. 2017
2016 Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cellsRedox Biology.  9:244-253. 2016
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiationEMBO Reports.  17:887-900. 2016
2016 Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancerBioorganic and Medicinal Chemistry Letters.  26:1237-1244. 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signalingFrontiers in Bioscience.  21:397-409. 2016
2015 Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the VasculatureCurrent Osteoporosis Reports.  13:206-215. 2015
2015 Inhibition of FOXO1/3 promotes vascular calcificationArteriosclerosis, Thrombosis, and Vascular Biology.  35:175-183. 2015
2015 Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancerOncotarget.  6:25308-25319. 2015
2014 Activation of AKT by O-linked N-Acetylglucosamine induces vascular calcification in diabetes mellitusCirculation Research.  114:1094-1102. 2014
2013 PARP-1 regulates resistance of pancreatic cancer to trail therapyClinical Cancer Research.  19:4750-4759. 2013
2013 Structural and biophysical characterization of the interactions between the death domain of fas receptor and calmodulinJournal of Biological Chemistry.  288:21898-21908. 2013
2012 Vascular smooth muscle cell smad4 gene is important for mouse vascular developmentArteriosclerosis, Thrombosis, and Vascular Biology.  32:2171-2177. 2012
2012 Smooth muscle cell-specific runx2 deficiency inhibits vascular calcificationCirculation Research.  111:543-552. 2012
2012 Serum response factor regulates bone formation via IGF-1 and Runx2 signalsJournal of Bone and Mineral Research.  27:1659-1668. 2012
2012 Reduced CaM/FLIP binding by a single point mutation in c-FLIP L modulates Fas-mediated apoptosis and decreases tumorigenesisLaboratory Investigation.  92:82-90. 2012
2011 Trifluoperazine regulation of calmodulin binding to Fas: A computational studyProteins.  79:2543-2556. 2011
2011 Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-Extracellular Signal-regulated Kinase (ERK)Journal of Biological Chemistry.  286:24776-24784. 2011
2011 Runx2-upregulated receptor activator of nuclear factor κb ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophagesArteriosclerosis, Thrombosis, and Vascular Biology.  31:1387-1396. 2011
2011 Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesisLaboratory Investigation.  91:896-904. 2011
2011 Mechanisms and consequences of salt sensitivity and dietary salt intakeCurrent Opinion in Nephrology and Hypertension.  20:37-43. 2011
2010 RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesisJournal of Biological Chemistry.  285:36315-36321. 2010
2009 Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4Laboratory Investigation.  89:1221-1228. 2009
2009 Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulinClinical Cancer Research.  15:1288-1296. 2009
2008 A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesinMicrobiological sciences.  70:1094-1104. 2008
2008 The effect of plasminogen activator inhibitor type 1 on apoptosisThrombosis and Haemostasis.  100:1037-1040. 2008
2008 Phospholipase Cγ2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisJournal of Biological Chemistry.  283:29593-29601. 2008
2008 Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signallingBiochemical Journal.  412:459-468. 2008
2008 Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signalingJournal of Biological Chemistry.  283:15319-15327. 2008
2008 Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cellsJournal of Cellular Biochemistry.  103:788-799. 2008
2007 Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinomaInternational Journal of Oncology.  31:843-850. 2007
2006 Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinomaInternational Journal of Oncology.  29:1319-1329. 2006
2006 Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1Arteriosclerosis, Thrombosis, and Vascular Biology.  26:1777-1783. 2006
2006 Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory proteinAmerican Journal of Pathology.  169:1833-1842. 2006
2004 Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1Journal of Cellular Biochemistry.  92:178-188. 2004
2002 Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1Nutrition, Metabolism and Cardiovascular Diseases.  12:325-330. 2002
2002 The independence of signaling pathways mediating increased expression of plasminogen activator inhibitor type 1 in HepG2 cells exposed to free fatty acids or triglyceridesInternational journal of experimental diabetes research.  3:109-118. 2002
2000 Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 geneArteriosclerosis, Thrombosis, and Vascular Biology.  20:2696-2701. 2000

Education And Training

  • Master of Business Administration in Business Administration and Management, University of Vermont 2001
  • Doctor of Philosophy Level Degree in Zoology / Animal Biology, Xiamen University 1997
  • Full Name

  • Yabing Chen