Selected Publications

Academic Article

Year Title Altmetric
2019 Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance.International Journal of Cancer2019
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.Blood Adv.  2:2829-2836. 2018
2018 AKT-independent activation of p38 MAP kinase promotes vascular calcification.Redox Biology.  16:97-103. 2018
2017 Dietary potassium regulates vascular calcification and arterial stiffness.JCI insight.  2. 2017
2017 The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand.Journal of Biological Chemistry.  292:10390-10397. 2017
2017 The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.Journal of Biological Chemistry.  292:251-263. 2017
2016 Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells.Redox Biology.  9:244-253. 2016
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.EMBO Reports.  17:887-900. 2016
2016 Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer.Bioorganic and Medicinal Chemistry Letters.  26:1237-1244. 2016
2016 TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling.Frontiers in Bioscience.  21:397-409. 2016
2015 Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer.Oncotarget.  6:25308-25319. 2015
2015 Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the Vasculature.Current Osteoporosis Reports.  13:206-215. 2015
2015 Inhibition of FOXO1/3 promotes vascular calcification.Arteriosclerosis, Thrombosis, and Vascular Biology.  35:175-183. 2015
2014 Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.Circulation Research.  114:1094-1102. 2014
2013 PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy.Clinical Cancer Research.  19:4750-4759. 2013
2013 Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.Journal of Biological Chemistry.  288:21898-21908. 2013
2012 Vascular smooth muscle cell Smad4 gene is important for mouse vascular development.Arteriosclerosis, Thrombosis, and Vascular Biology.  32:2171-2177. 2012
2012 Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.Circulation Research.  111:543-552. 2012
2012 Serum response factor regulates bone formation via IGF-1 and Runx2 signals.Journal of Bone and Mineral Research.  27:1659-1668. 2012
2012 Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis.Laboratory Investigation.  92:82-90. 2012
2011 Trifluoperazine regulation of calmodulin binding to Fas: a computational study.Proteins.  79:2543-2556. 2011
2011 Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK).Journal of Biological Chemistry.  286:24776-24784. 2011
2011 Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages.Arteriosclerosis, Thrombosis, and Vascular Biology.  31:1387-1396. 2011
2011 Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.Laboratory Investigation.  91:896-904. 2011
2011 Mechanisms and consequences of salt sensitivity and dietary salt intake.Current Opinion in Nephrology and Hypertension.  20:37-43. 2011
2010 RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.Journal of Biological Chemistry.  285:36315-36321. 2010
2009 Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4.Laboratory Investigation.  89:1221-1228. 2009
2009 Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.Clinical Cancer Research.  15:1288-1296. 2009
2008 A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin.Microbiological sciences.  70:1094-1104. 2008
2008 The effect of plasminogen activator inhibitor type 1 on apoptosis.Thrombosis and Haemostasis.  100:1037-1040. 2008
2008 Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.Journal of Biological Chemistry.  283:29593-29601. 2008
2008 Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling.Biochemical Journal.  412:459-468. 2008
2008 Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.Journal of Biological Chemistry.  283:15319-15327. 2008
2008 Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells.Journal of Cellular Biochemistry.  103:788-799. 2008
2007 Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma.International Journal of Oncology.  31:843-850. 2007
2006 Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.American Journal of Pathology.  169:1833-1842. 2006
2006 Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma.International Journal of Oncology.  29:1319-1329. 2006
2006 Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1.Arteriosclerosis, Thrombosis, and Vascular Biology.  26:1777-1783. 2006
2004 Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1.Journal of Cellular Biochemistry.  92:178-188. 2004
2002 Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1.Nutrition, Metabolism and Cardiovascular Diseases.  12:325-330. 2002
2002 The independence of signaling pathways mediating increased expression of plasminogen activator inhibitor type 1 in HepG2 cells exposed to free fatty acids or triglycerides.International journal of experimental diabetes research.  3:109-118. 2002
2000 Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene.Arteriosclerosis, Thrombosis, and Vascular Biology.  20:2696-2701. 2000

Education And Training

  • Doctor of Philosophy Level Degree in Zoology / Animal Biology, Xiamen University
  • Master of Business Administration in Business Administration and Management, University of Vermont
  • Full Name

  • Yabing Chen
  • Blazerid

  • ybchen