Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Epsins in vascular development, function and disease.  Cellular and Molecular Life Sciences.  78:833-842. 2021
2020 Redox Signaling and Cardiovascular Disease: New Paradigms and discoveries.  Redox Biology.  37. 2020
2020 Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation.  Laboratory Investigation.  100:777-785. 2020
2020 Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization 2020
2020 Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm 2020
2020 Transcriptional Programming in Arteriosclerotic Disease: A Multifaceted Function of the Runx2 2020
2019 Metabolic stress and cardiovascular disease in diabetes mellitus: The role of protein O -GlcNAc modification 2019
2019 Cytoplasmic PARP-1 promotes pancreatic cancer tumorigenesis and resistance.  International Journal of Cancer.  145:474-483. 2019
2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.  Circulation Research.  124:161-169. 2019
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.  Blood Advances.  2:2829-2836. 2018
2018 AKT-independent activation of p38 MAP kinase promotes vascular calcification.  Redox Biology.  16:97-103. 2018
2017 Dietary potassium regulates vascular calcification and arterial stiffness..  JCI insight.  2. 2017
2017 The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand.  Journal of Biological Chemistry.  292:10390-10397. 2017
2017 The interplay between calmodulin and membrane interactions with the pleckstrin homology domain of akt.  Journal of Biological Chemistry.  292:251-263. 2017
2016 Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells.  Redox Biology.  9:244-253. 2016
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.  EMBO Reports.  17:887-900. 2016
2016 Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer.  Bioorganic and Medicinal Chemistry Letters.  26:1237-1244. 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signaling.  Frontiers in Bioscience.  21:397-409. 2016
2015 Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the Vasculature.  Current Osteoporosis Reports.  13:206-215. 2015
2015 Inhibition of FOXO1/3 promotes vascular calcification 2015
2015 Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer.  Oncotarget.  6:25308-25319. 2015
2014 Activation of AKT by O-linked N-Acetylglucosamine induces vascular calcification in diabetes mellitus.  Circulation Research.  114:1094-1102. 2014
2013 PARP-1 regulates resistance of pancreatic cancer to trail therapy.  Clinical Cancer Research.  19:4750-4759. 2013
2013 Structural and biophysical characterization of the interactions between the death domain of fas receptor and calmodulin.  Journal of Biological Chemistry.  288:21898-21908. 2013
2012 Vascular smooth muscle cell smad4 gene is important for mouse vascular development 2012
2012 Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification.  Circulation Research.  111:543-552. 2012
2012 Serum response factor regulates bone formation via IGF-1 and Runx2 signals.  Journal of Bone and Mineral Research.  27:1659-1668. 2012
2012 Reduced CaM/FLIP binding by a single point mutation in c-FLIP L modulates Fas-mediated apoptosis and decreases tumorigenesis.  Laboratory Investigation.  92:82-90. 2012
2011 Trifluoperazine regulation of calmodulin binding to Fas: A computational study 2011
2011 Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-Extracellular Signal-regulated Kinase (ERK).  Journal of Biological Chemistry.  286:24776-24784. 2011
2011 Runx2-upregulated receptor activator of nuclear factor κb ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages 2011
2011 Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.  Laboratory Investigation.  91:896-904. 2011
2011 Mechanisms and consequences of salt sensitivity and dietary salt intake.  Current Opinion in Nephrology and Hypertension.  20:37-43. 2011
2010 RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.  Journal of Biological Chemistry.  285:36315-36321. 2010
2009 Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4.  Laboratory Investigation.  89:1221-1228. 2009
2009 Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: Role of calmodulin.  Clinical Cancer Research.  15:1288-1296. 2009
2008 A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin 2008
2008 The effect of plasminogen activator inhibitor type 1 on apoptosis.  Thrombosis and Haemostasis.  100:1037-1040. 2008
2008 Phospholipase Cγ2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.  Journal of Biological Chemistry.  283:29593-29601. 2008
2008 Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling.  Biochemical Journal.  412:459-468. 2008
2008 Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.  Journal of Biological Chemistry.  283:15319-15327. 2008
2008 Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells.  Journal of Cellular Biochemistry.  103:788-799. 2008
2007 Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma.  International Journal of Oncology.  31:843-850. 2007
2006 Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1 2006
2006 Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.  American Journal of Pathology.  169:1833-1842. 2006
2006 Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma.  International Journal of Oncology.  29:1319-1329. 2006
2004 Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1.  Journal of Cellular Biochemistry.  92:178-188. 2004
2002 Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1 2002
2002 The independence of signaling pathways mediating increased expression of plasminogen activator inhibitor type 1 in HepG2 cells exposed to free fatty acids or triglycerides.  International journal of experimental diabetes research.  3:109-118. 2002
2000 Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene 2000
1998 Cloning and functional expression of CPP32 cDNA in E. coli 1998

Principal Investigator On

Investigator On

Education And Training

  • Master of Business Administration in Business Administration and Management, University of Vermont 2001
  • Doctor of Philosophy Level Degree in Zoology / Animal Biology, Xiamen University 1997

    • Full Name

  • Yabing Chen