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Harris, William
Associate Professor
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E-mail
wtharris@uab.edu
Office Address
ACC 620
AMBULATORY CARE CENTER
Birmingham, AL 35233-0000
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Harris, William
Associate Professor
Positions
Associate Professor (P)
,
Pediatric - Pulmonary & Sleep Medicine
,
Pediatrics
2008 -
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2009 -
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
2011 -
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
2015 -
Overview
Publications
Research
Background
Contact
Overview
Overview
CF researcher
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2019
CFTR dysfunction increases endoglin and TGF-β signaling in airway epithelia
.
Physiological Reports
. 7.
2019
2019
Objective versus self-reported adherence to airway clearance therapy in cystic fibrosis
.
Respiratory Care
. 64:176-181.
2019
2019
An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2–5 years (KLIMB)
.
Journal of Cystic Fibrosis
.
2019
2019
Reply to Finotti et al.
.
American Journal of Respiratory and Critical Care Medicine
. 199:1444-1445.
2019
2018
MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway Epithelia
.
American Journal of Respiratory and Critical Care Medicine
. 197:632-643.
2018
2017
Airway microbiota across age and disease spectrum in cystic fibrosis.
.
European Respiratory Journal
. 50.
2017
2017
Pulmonary complications post hematopoietic stem cell transplant in dyskeratosis congenita: Analysis of oxidative stress in lung fibroblasts
.
Bone Marrow Transplantation
. 52:765-768.
2017
2017
Effect of prenatal versus postnatal Vitamin D deficiency on pulmonary structure and function in mice
.
American Journal of Respiratory Cell and Molecular Biology
. 56:383-392.
2017
2016
Constrictive bronchiolitis in cystic fibrosis adolescents with refractory pulmonary decline
.
Annals of the American Thoracic Society
. 13:2174-2183.
2016
2016
Risk stratification model to detect early pulmonary disease in infants with cystic fibrosis diagnosed by newborn screening
.
Pediatric Pulmonology
. 51:1168-1176.
2016
2016
Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-years with cystic fibrosis and a CFTR gating mutation (KIWI): An open-label, single-arm study
.
Lancet Respiratory Medicine
. 4:107-115.
2016
2016
Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor
.
Journal of Cystic Fibrosis
. 15:67-73.
2016
2015
Adherence to airway clearance therapy in pediatric cystic fibrosis: Socioeconomic factors and respiratory outcomes
.
Pediatric Pulmonology
. 50:1244-1252.
2015
2015
Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis
.
Pediatric Nephrology
. 30:1879-1888.
2015
2015
Acute Kidney Injury in Hospitalized Children With Cystic Fibrosis
.
Journal of Clinical Pediatric Nephrology
. 2:5-5.
2015
2014
TGF-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia
.
PLoS ONE
. 9.
2014
2014
Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients
.
Clinical and Translational Science
. 7:336-341.
2014
2013
Erratum: Myofibroblast differentiation and enhanced Tgf-B signaling in cystic fibrosis lung disease (PLoS ONE (2013) 8 (8))
.
PLoS ONE
. 8.
2013
2013
IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary Exacerbations
.
PLoS ONE
. 8.
2013
2013
Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease
.
PLoS ONE
. 8.
2013
2013
Crohn's disease with pulmonary manifestations in children: 2 case reports and review of the literature
.
Journal of Crohn's and Colitis
. 7.
2013
2011
Plasma TGF-β
1
in pediatric cystic fibrosis: Potential biomarker of lung disease and response to therapy
.
Pediatric Pulmonology
. 46:688-695.
2011
2010
Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas
.
Pediatric Pulmonology
. 45:281-290.
2010
2009
Transforming growth factor-β
1
in bronchoalveolar lavage fluid from children with cystic fibrosis
.
Pediatric Pulmonology
. 44:1057-1064.
2009
2009
Experience of the school-aged child with tracheostomy
.
International Journal of Pediatric Otorhinolaryngology
. 73:975-980.
2009
2009
Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis
.
Pediatric Pulmonology
. 44:503-511.
2009
2006
Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough
.
Pediatric Pulmonology
. 41:709-719.
2006
Research
Research Overview
Cystic Fibrosis, Pediatric Lung Disease, TGF-beta signaling, Airway Remodeling, miRNA
Principal Investigator On
Oligotherapeutics to Enhance CFTR Correction
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2021
Overcoming Barriers to F508del CFTR Correction
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2017 - 2020
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2018 - 2020
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2016 - 2020
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2017 - 2019
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2017 - 2019
Losartan as Anti-Inflammatory Therapy to Augment F508del CFTR Recovery
awarded by
University of Miami
2017 - 2019
MiR-145 Mediated TGF-Beta Pathobiology in CF
awarded by
Cystic Fibrosis Foundation
2017 - 2019
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2015 - 2018
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2015 - 2017
Private Grant
awarded by
Gilead Sciences
2015 - 2017
Mechanisms of Pulmonary Fibrosis in CF Lung Disease
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
2015 - 2016
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2015 - 2016
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2016
Effect of Vitamin D Deficiency on Murine Lung Development and Function
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
2013 - 2015
Myofibroblast Differentiation in Cystic Fibrosis
awarded by
Cystic Fibrosis Foundation
2012 - 2015
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2014
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2014
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2012 - 2013
Bronchoalveolar Lavage Fluid (BALF) Specimen Bank and Lower Airway Microbiome Analysis in Children and Adults With and Without Cystic Fibrosis (CF)
awarded by
University of Colorado
2011 - 2013
Myofibroblast Proliferation in Cystic Fibrosis: A Novel Mechanism of Disease Modification
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
2010 - 2012
Investigator On
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation
2019 - 2020
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2018 - 2020
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation
2018 - 2019
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2015 - 2018
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation
2017 - 2018
Prevalence and Significance of Staphylococcus Aureus Small–Colony Variants
awarded by
SEATTLE CHILDREN'S RESEARCH INSTITUTE
2014 - 2018
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation
2016 - 2017
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2015 - 2017
UAB Therapeutic Development Network Center
awarded by
Cystic Fibrosis Foundation
2015 - 2016
Private Grant
awarded by
PROQR THERAPEUTICS
2015 - 2016
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2016
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation
2015 - 2016
The Genetic Contribution to Drug Induced Renal lnjury:The Drug Induced Renal Injury Consortium (DIRECT)
awarded by
INTERNATIONAL SAE CONSORTIOUM, LTD
2013 - 2016
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2016
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2012 - 2015
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation
2014 - 2015
Translational Therapeutic Development Center
awarded by
Cystic Fibrosis Foundation
2013 - 2014
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2013 - 2014
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation
2013 - 2014
Private Grant
awarded by
N30 PHARMACEUTICALS, LLC
2013 - 2014
Private Grant
awarded by
GRIFOLS, INC
2012 - 2014
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
2012 - 2014
Pediatric Physician Training in Translational Research
awarded by
National Institute of Child Health and Human Development/NIH/DHHS
2008 - 2013
Private Grant
awarded by
N30 PHARMACEUTICALS, LLC
2013
Background
Education And Training
Doctor of Medicine,
Southwestern University
1999
Bachelor of Engineering in Materials Engineering,
Rice University
1994
Johns Hopkins Hospital, Residency
2003
University of North Carolina Hospital, Postdoctoral Fellowship
2007
Contact
Full Name
William
Harris