Positions

Overview

  • Dr. Geisler is a magna cum laude and Phi Beta Kappa graduate of the University of Tennessee in Knoxville and completed his doctor of medicine degree at the University of Tennessee in Memphis. He later earned a master of public health degree in epidemiology from the University of Washington School of Public Health and Community Medicine in Seattle. Following an internal medicine internship and residency at the University of Michigan in Ann Arbor, Dr. Geisler served a fellowship at the Division of Allergy and Infectious Diseases at the University of Washington. He is board certified in internal medicine and infectious diseases. In addition to his current teaching, clinical, and research activities at the University of Alabama at Birmingham, Dr. Geisler has also served as a consultant to the CDC and WHO on several projects, including development of the STI Treatment Guidelines. He is the Director of the UAB STD Program and is the UAB Assistant Dean for Physician Scientist Development.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Prevalence of Mycoplasma genitalium infection and macrolide resistance in pregnant women receiving prenatal careInternational Journal of Gynecology and Obstetrics.  160:341-344. 2023
    2022 Omadacycline Is Highly Active in Vitro against Mycoplasma genitaliumMicrobiology Spectrum.  10. 2022
    2022 Chlamydia trachomatis Infection and Seropositivity in Women Reporting Sexual Contact to a Chlamydia-Infected PartnerSexually Transmitted Diseases.  49:E97-E99. 2022
    2022 Chlamydial Pgp3 Seropositivity and Population-Attributable Fraction among Women with Tubal Factor InfertilitySexually Transmitted Diseases.  49:527-533. 2022
    2022 Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches 2022
    2022 Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment GuidelinesClinical Infectious Diseases.  74:S112-S126. 2022
    2022 A novel curricular framework to develop grant writing skills among MD-PhD studentsJournal of Clinical and Translational Science.  6. 2022
    2022 Association of Bacterial Vaginosis with Higher Vaginal Indole LevelsSexually Transmitted Diseases.  49:E53-E55. 2022
    2022 Association between Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma genitalium, and Trichomonas vaginalis and Secondary Infertility in Cameroon: A case-control studyPLoS One.  17. 2022
    2022 Evaluation of Clinical, Gram Stain, and Microbiological Cure Outcomes in Men Receiving Azithromycin for Acute Nongonococcal Urethritis: Discordant Cures Are Associated with Mycoplasma genitalium InfectionSexually Transmitted Diseases.  49:67-75. 2022
    2022 Immunogenicity and Protective Capacity of a Virus-like Particle Vaccine against Chlamydia trachomatis Type 3 Secretion System Tip Protein, CT584Vaccines.  10. 2022
    2021 Mycoplasma genitalium infection in women reporting dysuria: A pilot study and review of the literatureInternational Journal of STD and AIDS.  32:1196-1203. 2021
    2021 Predicting the Probability of Chlamydia Reinfection in African American Women Using Immunologic and Genetic Determinants in a Bayesian ModelSexually Transmitted Diseases.  48:813-818. 2021
    2021 Tubal Factor Infertility, In Vitro Fertilization, and Racial Disparities: A Retrospective Cohort in Two US ClinicsSexually Transmitted Diseases.  48:748-753. 2021
    2021 A Commentary on Current Diagnostic Challenges and Research Needs for Evaluating Reproductive Sequelae of Sexually Transmitted InfectionsJournal of Infectious Diseases.  224:S72-S74. 2021
    2021 Host Genetic Risk Factors for Chlamydia trachomatis-Related Infertility in WomenJournal of Infectious Diseases.  224:S64-S71. 2021
    2021 What Can Serology Tell Us about the Burden of Infertility in Women Caused by Chlamydia?Journal of Infectious Diseases.  224:S80-S85. 2021
    2021 Prevalence of Chlamydia trachomatis Infection in Young Women and Associated PredictorsSexually Transmitted Diseases.  48:529-535. 2021
    2021 Mycoplasma genitalium Infection in Young Women Without Urogenital Symptoms Presenting to a Community-Based Emergency Department in Birmingham, AlabamaSexually Transmitted Diseases.  48:e27-e29. 2021
    2020 Prevalence of mycoplasma genitalium infection, antimicrobial resistance mutations, and symptom resolution following treatment of urethritisClinical Infectious Diseases.  71:E624-E632. 2020
    2020 High rates of persistent and recurrent chlamydia in pregnant women after treatment with azithromycin 2020
    2020 Antibodies to variable domain 4 linear epitopes of the chlamydia trachomatis major outer membrane protein are not associated with chlamydia resolution or reinfection in womenClinical and Vaccine Immunology.  5. 2020
    2019 Mycoplasma genitalium Coinfection in Women With Chlamydia trachomatis InfectionSexually Transmitted Diseases.  46:E101-E104. 2019
    2019 Gamification: an Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research YearsMedical Science Educator.  29:739-747. 2019
    2019 Two cases of multidrug-resistant genitourinary Mycoplasma genitalium infection successfully eradicated with minocyclineInternational Journal of STD and AIDS.  30:512-514. 2019
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American womenGenes and Immunity.  20:69-73. 2019
    2019 Mycoplasma genitalium infections with macrolide and fluoroquinolone resistance-Associated mutations in heterosexual african American couples in AlabamaSexually Transmitted Diseases.  46:18-24. 2019
    2019 Repeated Chlamydia trachomatis infections are associated with lower bacterial loadsEpidemiology and Infection.  147. 2019
    2019 Stimulated peripheral blood mononuclear cells from chlamydia-infected women release predominantly Th1-polarizing cytokinesCytokine.  113:458-461. 2019
    2018 Advancing the public health applications of Chlamydia trachomatis serologyLancet Infectious Diseases.  18:e399-e407. 2018
    2018 An Adaptive chlamydia trachomatis-specific IFN-γ-producing CD4+ T cell response is associated with protection against chlamydia reinfection in womenFrontiers in Immunology.  9. 2018
    2018 Performance of chlamydia trachomatis OmcB enzyme-linked immunosorbent assay in serodiagnosis of chlamydia trachomatis infection in womenJournal of Clinical Microbiology.  56. 2018
    2018 Evaluation of a real-time PCR assay for detection of Mycoplasma genitalium and macrolide resistance-mediating mutations from clinical specimensDiagnostic Microbiology and Infectious Disease.  91:123-125. 2018
    2018 High prevalence of multidrug-resistant mycoplasma genitalium in human immunodeficiency virus-infected men who have sex with men in AlabamaClinical Infectious Diseases.  66:796-798. 2018
    2018 T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions 2018
    2017 Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected womenEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  78. 2017
    2017 Population-attributable fraction of tubal factor infertility associated with chlamydiaAmerican Journal of Obstetrics and Gynecology.  217:336.e1-336.e16. 2017
    2017 Lower Levels of Cervicovaginal Tryptophan Are Associated with Natural Clearance of Chlamydia in WomenJournal of Infectious Diseases.  215:1888-1892. 2017
    2017 Immunoglobulin-based investigation of spontaneous resolution of chlamydia trachomatis infectionJournal of Infectious Diseases.  215:1653-1656. 2017
    2017 The predominant CD4+ Th1 cytokine elicited to chlamydia trachomatis infection in women is tumor necrosis factor alpha and not interferon gammaClinical and Vaccine Immunology.  24. 2017
    2016 Chlamydia trachomatis infection in African American women who exclusively have sex with womenInternational Journal of STD and AIDS.  27:978-983. 2016
    2016 Azithromycin versus doxycycline for Chlamydia: The authors replyNew England Journal of Medicine.  374:1787. 2016
    2015 Azithromycin versus doxycycline for urogenital chlamydia trachomatis infectionNew England Journal of Medicine.  373:2512-2521. 2015
    2015 Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment GuidelinesClinical Infectious Diseases.  61:S774-S784. 2015
    2015 Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisisJournal of Perinatology.  35:930-934. 2015
    2015 Resolution of Chlamydia trachomatis infection is associated with a distinct T cell response profileClinical and Vaccine Immunology.  22:1206-1218. 2015
    2015 The effect of valacyclovir on HIV and HSV-2 in HIV-infected persons on antiretroviral therapy with previously unrecognised HSV-2International Journal of STD and AIDS.  26:574-581. 2015
    2015 Investigating the epidemiology of repeat chlamydia trachomatis detection after treatment by Using C. trachomatis OmpA genotypingJournal of Clinical Microbiology.  53:546-549. 2015
    2015 Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubesFertility and Sterility.  104:1522-1526. 2015
    2014 Azithromycin for rectal chlamydia: Is it time to leave azithromycin on the shelf?..Not yetSexually Transmitted Diseases.  41:86-88. 2014
    2014 A case of syphilitic osteitis in a patient with HIV infectionInternational Journal of STD and AIDS.  25:765-767. 2014
    2014 Dysuria in the emergency department: Missed diagnosis of Chlamydia trachomatisWestern Journal of Emergency Medicine.  15:227-230. 2014
    2014 Lower sexually transmissible infection prevalence among lifetime exclusive women who have sex with women compared with women who have sex with women and menSexual Health.  11:592-593. 2014
    2014 Lymphogranuloma venereum proctitis and clostridium difficile colitis in an HIV-infected patientInfectious Diseases in Clinical Practice.  22. 2014
    2014 Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in womenAntimicrobial Agents and Chemotherapy.  58:4014-4019. 2014
    2013 Spontaneous resolution of genital chlamydia trachomatis infection in women and protection from reinfectionJournal of Infectious Diseases.  207:1850-1856. 2013
    2013 Chlamydia trachomatis infection among women 26 to 39 years of age in the united states, 1999 to 2010Sexually Transmitted Diseases.  40:335-337. 2013
    2012 Immunoglobulin-specific responses to chlamydia elementary bodies in individuals with and at risk for genital chlamydial infectionJournal of Infectious Diseases.  206:1836-1843. 2012
    2012 Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital chlamydia trachomatis infection: A randomized, double-blind, double-dummy, active-controlled, multicenter trialClinical Infectious Diseases.  55:82-88. 2012
    2012 Chronic rectal bleeding due to lymphogranuloma venereum proctocolitisAmerican Journal of Gastroenterology.  107:488-489. 2012
    2012 Predictors of high chlamydia and gonorrhea positivity rates among men in the southern United StatesJournal of the National Medical Association.  104:20-27. 2012
    2011 Diagnosis and management of uncomplicated chlamydia trachomatis infections in adolescents and adults: Summary of evidence reviewed for the 2010 centers for disease control and prevention sexually transmitted diseases treatment guidelinesClinical Infectious Diseases.  53. 2011
    2010 Duration of untreated, uncomplicated chlamydia trachomatis genital infection and factors associated with chlamydia resolution: A review of human studiesJournal of Infectious Diseases.  201. 2010
    2010 Spontaneous resolution of extragenital chlamydial and gonococcal infections prior to therapySexually Transmitted Diseases.  37:343-344. 2010
    2010 Herpes simplex virus in African American heterosexual males: The roles of age and male circumcisionSexually Transmitted Diseases.  37:217-222. 2010
    2010 Concordance of rectal and cervical chlamydia trachomatis OmpA genotypes infecting women in Birmingham, AlabamaSexually Transmitted Diseases.  37:32-33. 2010
    2008 Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infectionSexually Transmitted Infections.  84:541-544. 2008
    2008 Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein a genotypes infecting women and men who have sex with men in Birmingham, AlabamaSexually Transmitted Diseases.  35:856-858. 2008
    2008 Immunogenetic correlates of neisseria gonorrhoeae infection in adolescentsSexually Transmitted Diseases.  35:656-661. 2008
    2008 The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatmentSexually Transmitted Diseases.  35:119-123. 2008
    2008 Chlamydia trachomatis positivity rates among men tested in selected venues in the United States: a review of the recent literature.Sexually Transmitted Diseases.  35. 2008
    2008 Chlamydial and gonococcal infections in women seeking pregnancy testing at family-planning clinicsAmerican Journal of Obstetrics and Gynecology.  198:502.e1-502.e4. 2008
    2007 Pelvic examination findings and chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification testSexually Transmitted Diseases.  34:335-338. 2007
    2007 Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: Evidence reviewed for the 2006 centers for disease control and prevention sexually transmitted diseases treatment guidelinesClinical Infectious Diseases.  44. 2007
    2006 Association of Chlamydia trachomatis serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, AlabamaSexually Transmitted Diseases.  33:621-624. 2006
    2006 Two cases of pott disease associated with bilateral psoas abscesses: Case reportSpine.  31. 2006
    2006 Health insurance coverage, health care-seeking behaviors, and genital chlamydial infection prevalence in sexually active young adultsSexually Transmitted Diseases.  33:389-396. 2006
    2006 Evaluating eosinophilia in the primary care setting.Journal of the American Academy of Physician Assistants.  19:34-38. 2006
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescentsClinical and Experimental Immunology.  142:548-554. 2005
    2005 Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: Implications for diagnostic approach and managementSexually Transmitted Diseases.  32:630-634. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescentsJournal of Infectious Diseases.  191:1084-1092. 2005
    2005 Phenytoin hypersensitivity syndrome masquerading as fever and systemic illness of unknown origin in an HIV-infected patientInternational Journal of STD and AIDS.  16:178-179. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescentsJournal of Infectious Diseases.  190:1723-1729. 2004
    2004 Vaginal leucocyte counts in women with bacterial vaginosis: Relation to vagina and cervical infectionsSexually Transmitted Infections.  80:401-405. 2004
    2004 The Prozone Phenomenon in Syphilis TestingSouthern Medical Journal.  97:327-328. 2004
    2004 Approaches to the management of uncomplicated genital Chlamydia trachomatis infectionsExpert Review of Anti-infective Therapy.  2:771-785. 2004
    2004 Assessing the impact of a comprehensive sexually transmitted disease curriculum on learning outcomesAmerican Journal of Obstetrics and Gynecology.  191:1822-1827. 2004
    2003 Sexually transmitted diseasesInfections in medicine.  20:340-349. 2003
    2003 Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp.Antimicrobial Agents and Chemotherapy.  47:636-642. 2003
    2003 The relationship of serovar to clinical manifestations of urogenital Chlamydia trachomatis infectionSexually Transmitted Diseases.  30:160-165. 2003
    2002 Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantationTransplantation.  73:1002-1005. 2002
    2002 Broad spectrum of dermatologic manifestations caused by Mycobacterium haemophilum infectionJAMA Dermatology.  138:229-230. 2002
    2002 Epidemiology of anorectal chlamydial and gonococcal infections among men having sex with men in Seattle: Utilizing serovar and auxotype strain typingSexually Transmitted Diseases.  29:189-195. 2002
    2001 Pneumonia and sepsis due to fluoroquinolone-resistant Capnocytophaga gingivalis after autologous stem cell transplantationBone Marrow Transplantation.  28:1171-1173. 2001
    2001 Quantitative culture of Chlamydia trachomatis: Relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital diseaseJournal of Infectious Diseases.  184:1350-1354. 2001
    2001 Epidemiology and clinical manifestations of unique Chlamydia trachomatis isolates that occupy nonfusogenic inclusionsJournal of Infectious Diseases.  184:879-884. 2001
    1998 Septic arthritis caused by Neisseria sicca.Journal of Rheumatology.  25:826-828. 1998

    Chapter

    Year Title Altmetric
    2017 Chlamydia trachomatis Infection.  597-602.e1. 2017
    2013 The immunologic response to urogenital infection.  97-114. 2013
    2013 Chlamydia control: A comparative review from the USA and UK.  401-430. 2013
    2012 Diseases Caused by Chlamydiae.  1916-1922. 2012
    2012 Infections Caused by Chlamydia trachomatis, Including Lymphogranuloma Venereum.  335-343. 2012

    Research Overview

  • His research program primarily investigates the influence of both biological characteristics of Chlamydia trachomatis and the human host immune-mediated responses and genetics on the clinical manifestations and outcomes of chlamydial infection. A major goal of his research program is to contribute to the development of an effective chlamydia vaccine. His research interests also include epidemiology, antibiotic resistance, and treatment of Mycoplasma genitalium infections. His clinical and teaching interests include the epidemiology, clinical manifestations, diagnosis, treatment, and prevention of sexually transmitted infections. Dr. Geisler is a teaching faculty for the AL-NC STD/HIV Prevention Training Center.

    Chlamydia trachomatis and Mycoplasma genitalium infections
  • Teaching Activities

  • 28-401 - VISITING ELECTIVES IN MEDICINE (Fall Term 2007)
  • 28-517 - MEDICINE RESEARCH (Fall Term 2008)
  • 28-517 - MEDICINE RESEARCH (Fall Term 2008)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2018)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2018)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2018)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Spring Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Spring Term 2019)
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Spring Term 2020)
  • GBS727 - ADVANCE HUMAN GENETICS (Spring Term 2016)
  • MSTP795 - Continuing Clinical Education (Fall Term 2013)
  • MSTP795 - Continuing Clinical Education (Fall Term 2014)
  • MSTP795 - Continuing Clinical Education (Fall Term 2015)
  • MSTP795 - Continuing Clinical Education (Fall Term 2016)
  • MSTP795 - Continuing Clinical Education (Fall Term 2017)
  • MSTP795 - Continuing Clinical Education (Fall Term 2018)
  • MSTP795 - Continuing Clinical Education (Fall Term 2019)
  • MSTP795 - Continuing Clinical Education (Fall Term 2020)
  • MSTP795 - Continuing Clinical Education (Fall Term 2021)
  • MSTP795 - Continuing Clinical Education (Spring Term 2014)
  • MSTP795 - Continuing Clinical Education (Spring Term 2015)
  • MSTP795 - Continuing Clinical Education (Spring Term 2016)
  • MSTP795 - Continuing Clinical Education (Spring Term 2017)
  • MSTP795 - Continuing Clinical Education (Spring Term 2018)
  • MSTP795 - Continuing Clinical Education (Spring Term 2019)
  • MSTP795 - Continuing Clinical Education (Spring Term 2020)
  • MSTP795 - Continuing Clinical Education (Spring Term 2021)
  • MSTP795 - Continuing Clinical Education (Spring Term 2022)
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2020)
  • PSDO798 - PSDO Non-Dissertation Research (Fall Term 2019)
  • PSDO798 - PSDO Non-Dissertation Research (Fall Term 2020)
  • PSDO798 - PSDO Non-Dissertation Research (Fall Term 2021)
  • PSDO798 - PSDO Non-Dissertation Research (Spring Term 2020)
  • PSDO798 - PSDO Non-Dissertation Research (Spring Term 2021)
  • PSDO798 - PSDO Non-Dissertation Research (Spring Term 2022)
  • PSDO798 - PSDO Non-Dissertation Research (Summer Term 2019)
  • PSDO798 - PSDO Non-Dissertation Research (Summer Term 2020)
  • PSDO798 - PSDO Non-Dissertation Research (Summer Term 2021)
  • PSDO798 - PSDO Non-Dissertation Research (Summer Term 2022)
  • PSDO799 - PSDO Dissertation Research (Fall Term 2019)
  • PSDO799 - PSDO Dissertation Research (Fall Term 2020)
  • PSDO799 - PSDO Dissertation Research (Fall Term 2021)
  • PSDO799 - PSDO Dissertation Research (Fall Term 2022)
  • PSDO799 - PSDO Dissertation Research (Spring Term 2021)
  • PSDO799 - PSDO Dissertation Research (Spring Term 2022)
  • PSDO799 - PSDO Dissertation Research (Summer Term 2020)
  • PSDO799 - PSDO Dissertation Research (Summer Term 2021)
  • PSDO799 - PSDO Dissertation Research (Summer Term 2022)
  • PSDO799 - PSDO Dissertation Research (Summer Term 2022)
  • Education And Training

  • University of Michigan Hospitals & Health Centers, Internship
  • University of Michigan Hospitals & Health Centers, Residency
  • University of Washington Medical Center, Postdoctoral Fellowship
  • Master of Public Health in Epidemiology, University of Washington 2000
  • Doctor of Medicine, University of Tennessee System : Memphis 1996
  • Full Name

  • William Geisler