• Dr. Geisler is a magna cum laude and Phi Beta Kappa graduate of the University of Tennessee in Knoxville and completed his doctor of medicine degree at the University of Tennessee in Memphis. He later earned a master of public health degree in epidemiology from the University of Washington School of Public Health and Community Medicine in Seattle. Following an internal medicine internship and residency at the University of Michigan in Ann Arbor, Dr. Geisler served a fellowship at the Division of Allergy and Infectious Diseases at the University of Washington. He is board certified in internal medicine and infectious diseases. In addition to his current teaching, clinical, and research activities at the University of Alabama at Birmingham, Dr. Geisler has also served as a consultant to the CDC for several projects, including development of the 2015 CDC STD Treatment Guidelines and he is the Clinical Associate Director of the UAB Medical Scientist Training Program.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American womenGenes and Immunity.  20:69-73. 2019
    2019 Mycoplasma genitalium infections with macrolide and fluoroquinolone resistance-Associated mutations in heterosexual african American couples in AlabamaSexually Transmitted Diseases.  46:18-24. 2019
    2019 Repeated Chlamydia trachomatis infections are associated with lower bacterial loadsEpidemiology and Infection.  147. 2019
    2019 Stimulated peripheral blood mononuclear cells from chlamydia-infected women release predominantly Th1-polarizing cytokinesCytokine.  113:458-461. 2019
    2019 Two cases of multidrug-resistant genitourinary Mycoplasma genitalium infection successfully eradicated with minocyclineInternational Journal of STD and AIDS2019
    2018 Advancing the public health applications of Chlamydia trachomatis serologyLancet Infectious Diseases.  18:e399-e407. 2018
    2018 An Adaptive chlamydia trachomatis-specific IFN-γ-producing CD4+ T cell response is associated with protection against chlamydia reinfection in womenFrontiers in Immunology.  9. 2018
    2018 Performance of chlamydia trachomatis OmcB enzyme-linked immunosorbent assay in serodiagnosis of chlamydia trachomatis infection in womenJournal of Clinical Microbiology.  56. 2018
    2018 Evaluation of a real-time PCR assay for detection of Mycoplasma genitalium and macrolide resistance-mediating mutations from clinical specimensDiagnostic Microbiology and Infectious Disease.  91:123-125. 2018
    2018 High prevalence of multidrug-resistant mycoplasma genitalium in human immunodeficiency virus-infected men who have sex with men in AlabamaClinical Infectious Diseases.  66:796-798. 2018
    2018 T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributionsMicrobes and Infection.  20:176-184. 2018
    2017 Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected womenAmerican Journal of Reproductive Immunology.  78. 2017
    2017 Population-attributable fraction of tubal factor infertility associated with chlamydiaAmerican Journal of Obstetrics and Gynecology.  217:336.e1-336.e16. 2017
    2017 Lower Levels of Cervicovaginal Tryptophan Are Associated with Natural Clearance of Chlamydia in WomenJournal of Infectious Diseases.  215:1888-1892. 2017
    2017 Immunoglobulin-based investigation of spontaneous resolution of chlamydia trachomatis infectionJournal of Infectious Diseases.  215:1653-1656. 2017
    2017 The predominant CD4+ Th1 cytokine elicited to chlamydia trachomatis infection in women is tumor necrosis factor alpha and not interferon gammaClinical and Diagnostic Laboratory Immunology.  24. 2017
    2016 Chlamydia trachomatis infection in African American women who exclusively have sex with womenInternational Journal of STD and AIDS.  27:978-983. 2016
    2016 Azithromycin versus Doxycycline for ChlamydiaNew England Journal of Medicine.  374:1787. 2016
    2015 Azithromycin versus doxycycline for urogenital chlamydia trachomatis infectionNew England Journal of Medicine.  373:2512-2521. 2015
    2015 Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment GuidelinesClinical Infectious Diseases.  61:S774-S784. 2015
    2015 Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisisJournal of Perinatology.  35:930-934. 2015
    2015 Resolution of Chlamydia trachomatis infection is associated with a distinct T cell response profileClinical and Diagnostic Laboratory Immunology.  22:1206-1218. 2015
    2015 The effect of valacyclovir on HIV and HSV-2 in HIV-infected persons on antiretroviral therapy with previously unrecognised HSV-2International Journal of STD and AIDS.  26:574-581. 2015
    2015 Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubesFertility and Sterility.  104:1522-1526. 2015
    2015 Investigating the epidemiology of repeat chlamydia trachomatis detection after treatment by Using C. trachomatis OmpA genotypingJournal of Clinical Microbiology.  53:546-549. 2015
    2014 Azithromycin for rectal chlamydia: Is it time to leave azithromycin on the shelf?..Not yetSexually Transmitted Diseases.  41:86-88. 2014
    2014 A case of syphilitic osteitis in a patient with HIV infectionInternational Journal of STD and AIDS.  25:765-767. 2014
    2014 Dysuria in the emergency department: Missed diagnosis of Chlamydia trachomatisWestern Journal of Emergency Medicine : Integrating Emergency Care with Population Health.  15:227-230. 2014
    2014 Lower sexually transmissible infection prevalence among lifetime exclusive women who have sex with women compared with women who have sex with women and menSexual Health.  11:592-593. 2014
    2014 Lymphogranuloma venereum proctitis and clostridium difficile colitis in an HIV-infected patientInfectious Diseases in Clinical Practice.  22. 2014
    2014 Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in womenAntimicrobial Agents and Chemotherapy.  58:4014-4019. 2014
    2013 Spontaneous resolution of genital chlamydia trachomatis infection in women and protection from reinfectionJournal of Infectious Diseases.  207:1850-1856. 2013
    2013 Chlamydia trachomatis infection among women 26 to 39 years of age in the united states, 1999 to 2010Sexually Transmitted Diseases.  40:335-337. 2013
    2012 Immunoglobulin-specific responses to chlamydia elementary bodies in individuals with and at risk for genital chlamydial infectionJournal of Infectious Diseases.  206:1836-1843. 2012
    2012 Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital chlamydia trachomatis infection: A randomized, double-blind, double-dummy, active-controlled, multicenter trialClinical Infectious Diseases.  55:82-88. 2012
    2012 Chronic rectal bleeding due to lymphogranuloma venereum proctocolitisAmerican Journal of Gastroenterology.  107:488-489. 2012
    2012 Predictors of high chlamydia and gonorrhea positivity rates among men in the southern United StatesJournal of the National Medical Association.  104:20-27. 2012
    2011 Diagnosis and management of uncomplicated chlamydia trachomatis infections in adolescents and adults: Summary of evidence reviewed for the 2010 centers for disease control and prevention sexually transmitted diseases treatment guidelinesClinical Infectious Diseases.  53. 2011
    2010 Duration of untreated, uncomplicated chlamydia trachomatis genital infection and factors associated with chlamydia resolution: A review of human studiesJournal of Infectious Diseases.  201. 2010
    2010 Spontaneous resolution of extragenital chlamydial and gonococcal infections prior to therapySexually Transmitted Diseases.  37:343-344. 2010
    2010 Herpes simplex virus in African American heterosexual males: The roles of age and male circumcisionSexually Transmitted Diseases.  37:217-222. 2010
    2010 Concordance of rectal and cervical chlamydia trachomatis OmpA genotypes infecting women in Birmingham, AlabamaSexually Transmitted Diseases.  37:32-33. 2010
    2008 Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infectionSexually Transmitted Infections.  84:541-544. 2008
    2008 Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein a genotypes infecting women and men who have sex with men in Birmingham, AlabamaSexually Transmitted Diseases.  35:856-858. 2008
    2008 Immunogenetic correlates of neisseria gonorrhoeae infection in adolescentsSexually Transmitted Diseases.  35:656-661. 2008
    2008 The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatmentSexually Transmitted Diseases.  35:119-123. 2008
    2008 Chlamydia trachomatis positivity rates among men tested in selected venues in the United States: a review of the recent literature.Sexually Transmitted Diseases.  35. 2008
    2008 Chlamydial and gonococcal infections in women seeking pregnancy testing at family-planning clinicsAmerican Journal of Obstetrics and Gynecology.  198:502.e1-502.e4. 2008
    2007 Pelvic examination findings and chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification testSexually Transmitted Diseases.  34:335-338. 2007
    2007 Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: Evidence reviewed for the 2006 centers for disease control and prevention sexually transmitted diseases treatment guidelinesClinical Infectious Diseases.  44. 2007
    2006 Association of Chlamydia trachomatis serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, AlabamaSexually Transmitted Diseases.  33:621-624. 2006
    2006 Two cases of pott disease associated with bilateral psoas abscesses: Case reportSpine.  31. 2006
    2006 Health insurance coverage, health care-seeking behaviors, and genital chlamydial infection prevalence in sexually active young adultsSexually Transmitted Diseases.  33:389-396. 2006
    2006 Evaluating eosinophilia in the primary care setting.Journal of the American Academy of Physician Assistants.  19:34-38. 2006
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescentsClinical and Experimental Immunology.  142:548-554. 2005
    2005 Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: Implications for diagnostic approach and managementSexually Transmitted Diseases.  32:630-634. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescentsJournal of Infectious Diseases.  191:1084-1092. 2005
    2005 Phenytoin hypersensitivity syndrome masquerading as fever and systemic illness of unknown origin in an HIV-infected patientInternational Journal of STD and AIDS.  16:178-179. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescentsJournal of Infectious Diseases.  190:1723-1729. 2004
    2004 Vaginal leucocyte counts in women with bacterial vaginosis: Relation to vagina and cervical infectionsSexually Transmitted Infections.  80:401-405. 2004
    2004 The Prozone Phenomenon in Syphilis TestingSouthern Medical Journal.  97:327-328. 2004
    2004 Approaches to the management of uncomplicated genital Chlamydia trachomatis infectionsExpert Review of Anti-infective Therapy.  2:771-785. 2004
    2004 Assessing the impact of a comprehensive sexually transmitted disease curriculum on learning outcomesAmerican Journal of Obstetrics and Gynecology.  191:1822-1827. 2004
    2003 Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp.Antimicrobial Agents and Chemotherapy.  47:636-642. 2003
    2003 The relationship of serovar to clinical manifestations of urogenital Chlamydia trachomatis infectionSexually Transmitted Diseases.  30:160-165. 2003
    2002 Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantationTransplantation.  73:1002-1005. 2002
    2002 Broad spectrum of dermatologic manifestations caused by Mycobacterium haemophilum infectionArchives of Dermatology -Chicago-.  138:229-230. 2002
    2002 Epidemiology of anorectal chlamydial and gonococcal infections among men having sex with men in Seattle: Utilizing serovar and auxotype strain typingSexually Transmitted Diseases.  29:189-195. 2002
    2001 Pneumonia and sepsis due to fluoroquinolone-resistant Capnocytophaga gingivalis after autologous stem cell transplantationBone Marrow Transplantation.  28:1171-1173. 2001
    2001 Quantitative culture of Chlamydia trachomatis: Relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital diseaseJournal of Infectious Diseases.  184:1350-1354. 2001
    2001 Epidemiology and clinical manifestations of unique Chlamydia trachomatis isolates that occupy nonfusogenic inclusionsJournal of Infectious Diseases.  184:879-884. 2001
    1998 Septic arthritis caused by Neisseria sicca.Journal of Rheumatology.  25:826-828. 1998


    Year Title Altmetric
    2013 The immunologic response to urogenital infection.  97-114. 2013
    2013 Chlamydia control: A comparative review from the USA and UK.  401-430. 2013
    2011 Infections Caused by Chlamydia trachomatis, Including Lymphogranuloma Venereum.  335-343. 2011
    2011 Diseases Caused by Chlamydiae.  1916-1922. 2011

    Research Overview

  • His research program primarily investigates the influence of both biological characteristics of Chlamydia trachomatis and the human host immune-mediated responses and genetics on the clinical manifestations and outcomes of chlamydial infection. His research interests also include epidemiology, antibiotic resistance, and treatment of Mycoplasma genitalium infections. His clinical and teaching interests include the epidemiology, clinical manifestations, diagnosis, treatment, and prevention of sexually transmitted infections. Dr. Geisler is a teaching faculty for the AL-NC STD/HIV Prevention Training Center. Dr. Geisler is also Co-Director of the UAB Medical Scientist Training Program.

    Chlamydia trachomatis and Mycoplasma genitalium infections
  • Education And Training

  • Master of Public Health in Epidemiology, University of Washington 2000
  • Doctor of Medicine, University of Tennessee System : Memphis 1996
  • University of Michigan Hospitals & Health Centers, Internship 1997
  • University of Washington Medical Center, Residency 2002
  • University of Michigan Hospitals & Health Centers, Residency 1999
  • Full Name

  • William Geisler