Positions

Overview

  • His research program investigates the influence of both biological characteristics of Chlamydia trachomatis and the human host immune-mediated responses and genetics on the clinical manifestations and outcomes of urogenital chlamydial infection. His clinical and teaching interests include the epidemiology, clinical manifestations, diagnosis, treatment, and prevention of sexually transmitted infections. Dr. Geisler is a teaching faculty for the AL-NC STD/HIV Prevention Training Center. Dr. Geisler is also the Clinical Associate Director of the UAB Medical Scientist Training Program.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Repeated Chlamydia trachomatis infections are associated with lower bacterial loads.Epidemiology and Infection.  1-3. 2018
    2018 Performance of Chlamydia trachomatis OmcB Enzyme-Linked Immunosorbent Assay in Serodiagnosis of Chlamydia trachomatis Infection in Women.Journal of Clinical Microbiology.  56. 2018
    2018 Advancing the public health applications of Chlamydia trachomatis serology.Lancet Infectious Diseases2018
    2018 Mycoplasma genitalium Infections with Macrolide and Fluoroquinolone Resistance-Associated Mutations in Heterosexual African American Couples in Alabama.Sexually Transmitted Diseases2018
    2018 Stimulated peripheral blood mononuclear cells from chlamydia-infected women release predominantly Th1-polarizing cytokines.Cytokine2018
    2018 Evaluation of a real-time PCR assay for detection of Mycoplasma genitalium and macrolide resistance-mediating mutations from clinical specimens.Diagnostic Microbiology and Infectious Disease.  91:123-125. 2018
    2018 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women.Genes and Immunity2018
    2018 High Prevalence of Multidrug-Resistant Mycoplasma genitalium in Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in Alabama.Clinical Infectious Diseases.  66:796-798. 2018
    2018 An Adaptive Chlamydia trachomatis-Specific IFN-γ-Producing CD4+ T Cell Response Is Associated With Protection Against Chlamydia Reinfection in Women.Frontiers in Immunology.  9:1981. 2018
    2017 T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions.Microbes and Infection.  20:176-184. 2017
    2017 Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women.American Journal of Reproductive Immunology.  78. 2017
    2017 Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women.Journal of Infectious Diseases.  215:1888-1892. 2017
    2017 Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection.Journal of Infectious Diseases.  215:1653-1656. 2017
    2017 Population-attributable fraction of tubal factor infertility associated with chlamydia.American Journal of Obstetrics and Gynecology.  217:336.e1-336.e16. 2017
    2017 The Predominant CD4+ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma.Clinical and Diagnostic Laboratory Immunology.  24. 2017
    2016 Azithromycin versus Doxycycline for Chlamydia.New England Journal of Medicine.  374:1787. 2016
    2015 Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection.New England Journal of Medicine.  373:2512-2521. 2015
    2015 Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines.Clinical Infectious Diseases.  61 Suppl 8:S774-S784. 2015
    2015 Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes.Fertility and Sterility.  104:1522-1526. 2015
    2015 Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis.Journal of Perinatology.  35:930-934. 2015
    2015 Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile.Clinical and Diagnostic Laboratory Immunology.  22:1206-1218. 2015
    2015 Chlamydia trachomatis infection in African American women who exclusively have sex with women.International Journal of STD and AIDS.  27:978-983. 2015
    2015 The effect of valacyclovir on HIV and HSV-2 in HIV-infected persons on antiretroviral therapy with previously unrecognised HSV-2.International Journal of STD and AIDS.  26:574-581. 2015
    2015 Investigating the epidemiology of repeat Chlamydia trachomatis detection after treatment by using C. trachomatis OmpA genotyping.Journal of Clinical Microbiology.  53:546-549. 2015
    2014 Lower sexually transmissible infection prevalence among lifetime exclusive women who have sex with women compared with women who have sex with women and men.Sexual Health.  11:592-593. 2014
    2014 A case of syphilitic osteitis in a patient with HIV infection.International Journal of STD and AIDS.  25:765-767. 2014
    2014 Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women.Antimicrobial Agents and Chemotherapy.  58:4014-4019. 2014
    2014 Dysuria in the emergency department: missed diagnosis of Chlamydia trachomatis.Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health.  15:227-230. 2014
    2014 Azithromycin for rectal chlamydia: is it time to leave azithromycin on the shelf?...Not yet.Sexually Transmitted Diseases.  41:86-88. 2014
    2014 Lymphogranuloma venereum proctitis and clostridium difficile colitis in an HIV-infected patientInfectious Diseases in Clinical Practice.  22. 2014
    2013 Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection.Journal of Infectious Diseases.  207:1850-1856. 2013
    2013 Chlamydia trachomatis infection among women 26 to 39 years of age in the United States, 1999 to 2010.Sexually Transmitted Diseases.  40:335-337. 2013
    2012 Immunoglobulin-specific responses to Chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection.Journal of Infectious Diseases.  206:1836-1843. 2012
    2012 Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital Chlamydia trachomatis infection: a randomized, double-blind, double-dummy, active-controlled, multicenter trial.Clinical Infectious Diseases.  55:82-88. 2012
    2012 Chronic rectal bleeding due to Lymphogranuloma venereum proctocolitis.American Journal of Gastroenterology.  107:488-489. 2012
    2012 Predictors of high chlamydia and gonorrhea positivity rates among men in the southern United States.Journal of the National Medical Association.  104:20-27. 2012
    2011 Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines.Clinical Infectious Diseases.  53 Suppl 3:S92-S98. 2011
    2010 Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies.Journal of Infectious Diseases.  201 Suppl 2:S104-S113. 2010
    2010 Spontaneous resolution of extragenital chlamydial and gonococcal infections prior to therapy.Sexually Transmitted Diseases.  37:343-344. 2010
    2010 Herpes simplex virus in African American heterosexual males: the roles of age and male circumcision.Sexually Transmitted Diseases.  37:217-222. 2010
    2010 Concordance of rectal and cervical Chlamydia trachomatis OmpA genotypes infecting women in Birmingham, Alabama.Sexually Transmitted Diseases.  37:32-33. 2010
    2008 Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infection.Sexually Transmitted Infections.  84:541-544. 2008
    2008 Chlamydia trachomatis positivity rates among men tested in selected venues in the United States: a review of the recent literature.Sexually Transmitted Diseases.  35:S8-S18. 2008
    2008 Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein A genotypes infecting women and men who have sex with men in Birmingham, Alabama.Sexually Transmitted Diseases.  35:856-858. 2008
    2008 Immunogenetic correlates of Neisseria gonorrhoeae infection in adolescents.Sexually Transmitted Diseases.  35:656-661. 2008
    2008 Chlamydial and gonococcal infections in women seeking pregnancy testing at family-planning clinics.American Journal of Obstetrics and Gynecology.  198:502.e1-502.e4. 2008
    2008 The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment.Sexually Transmitted Diseases.  35:119-123. 2008
    2007 Pelvic examination findings and Chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification test.Sexually Transmitted Diseases.  34:335-338. 2007
    2007 Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: evidence reviewed for the 2006 Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines.Clinical Infectious Diseases.  44 Suppl 3:S77-S83. 2007
    2006 Association of Chlamydia trachomatis Serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, Alabama.Sexually Transmitted Diseases.  33:621-624. 2006
    2006 Two cases of pott disease associated with bilateral psoas abscesses: case report.Spine.  31:E561-E564. 2006
    2006 Evaluating eosinophilia in the primary care setting.Journal of the American Academy of Physician Assistants.  19:34-38. 2006
    2006 Health insurance coverage, health care-seeking behaviors, and genital chlamydial infection prevalence in sexually active young adults.Sexually Transmitted Diseases.  33:389-396. 2006
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescents.Clinical and Experimental Immunology.  142:548-554. 2005
    2005 Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: implications for diagnostic approach and management.Sexually Transmitted Diseases.  32:630-634. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents.Journal of Infectious Diseases.  191:1084-1092. 2005
    2005 Phenytoin hypersensitivity syndrome masquerading as fever and systemic illness of unknown origin in an HIV-infected patient.International Journal of STD and AIDS.  16:178-179. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents.Journal of Infectious Diseases.  190:1723-1729. 2004
    2004 Assessing the impact of a comprehensive sexually transmitted disease curriculum on learning outcomes.American Journal of Obstetrics and Gynecology.  191:1822-1827. 2004
    2004 Approaches to the management of uncomplicated genital Chlamydia trachomatis infections.Expert Review of Anti-infective Therapy.  2:771-785. 2004
    2004 Vaginal leucocyte counts in women with bacterial vaginosis: relation to vaginal and cervical infections.Sexually Transmitted Infections.  80:401-405. 2004
    2004 The prozone phenomenon in syphilis testing.Southern Medical Journal.  97:327-328. 2004
    2003 Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp.Antimicrobial Agents and Chemotherapy.  47:636-642. 2003
    2003 The relationship of serovar to clinical manifestations of urogenital Chlamydia trachomatis infection.Sexually Transmitted Diseases.  30:160-165. 2003
    2002 Epidemiology of anorectal chlamydial and gonococcal infections among men having sex with men in Seattle: utilizing serovar and auxotype strain typing.Sexually Transmitted Diseases.  29:189-195. 2002
    2002 Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation.Transplantation.  73:1002-1005. 2002
    2002 Broad spectrum of dermatologic manifestations caused by Mycobacterium haemophilum infection.Archives of Dermatology -Chicago-.  138:229-230. 2002
    2001 Pneumonia and sepsis due to fluoroquinolone-resistant Capnocytophaga gingivalis after autologous stem cell transplantation.Bone Marrow Transplantation.  28:1171-1173. 2001
    2001 Quantitative culture of Chlamydia trachomatis: relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital disease.Journal of Infectious Diseases.  184:1350-1354. 2001
    2001 Epidemiology and clinical manifestations of unique Chlamydia trachomatis isolates that occupy nonfusogenic inclusions.Journal of Infectious Diseases.  184:879-884. 2001
    1998 Septic arthritis caused by Neisseria sicca.Journal of Rheumatology.  25:826-828. 1998

    Chapter

    Year Title Altmetric
    2013 The immunologic response to urogenital infection.  97-114. 2013
    2013 Chlamydia control: A comparative review from the USA and UK.  401-430. 2013
    2011 Infections Caused by Chlamydia trachomatis, Including Lymphogranuloma Venereum.  335-343. 2011
    2011 Diseases Caused by Chlamydiae.  1916-1922. 2011

    Principal Investigator On

  • Immunogenetic Determinants of Chlamydia Reinfection and Chlamydia-Associated Infertility in Women  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2021
  • Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia Trachomatis Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • CITY Health II - The Center for the Study of Community Health - SIP 14-034 - Prospective Study of Immune Response to Chlamydial Infection to Inform Development of Rational Prevention Strategies  awarded by National Center for Chronic Disease Prevention & Health Promo./CDC/DHHS 2014 - 2019
  • Transfer of Stored Specimens from Women with CT Infection  awarded by Indiana University 2018 - 2019
  • The UAB STI CRC - Project 3: Effect of Trichomonas and BV on Chlamydia Concordance and Treatment Outcomes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Private Grant  awarded by ROCHE DIAGNOSTICS OPERATIONS INC 2018 - 2019
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2016 - 2017
  • Mechanisms and Correlates of Immune Protection Against Genital Chlamydia in Humans  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2017
  • Private Grant  awarded by ACTIVBIOTICS, INC. 2012 - 2014
  • CITY Health - Center for the Study of Community Health SIP 11-048: Case Control Study of Chlamydia and Infertility Among Women Assessed for Tubal Disease or Treated by Assisted Reproductive Technology  awarded by National Center for Chronic Disease Prevention & Health Promo./CDC/DHHS 2011 - 2014
  • Private Grant  awarded by SANOFI PASTEUR LIMITED 2009 - 2013
  • Private Grant  awarded by WARNER CHILCOTT 2010 - 2013
  • Private Grant  awarded by SANOFI DIAGNOSTICS PASTEUR, INC. 2008 - 2012
  • Private Grant  awarded by MERCK & COMPANY, INC. 2012
  • Role of Immunogenetic Determinants on Human Genital Chlamydial Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2012
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2008 - 2011
  • Private Grant  awarded by MERCK & COMPANY, INC. 2010
  • Investigator On

  • Private Grant  awarded by ABBOTT MOLECULAR 2018 - 2020
  • HHSN27200010 Task Area 1 Task Order 9 - Sexually Transmitted Infections Clinical Trials Group (STI CTG) TASK AREA 1 TASK ORDER 9 Protocol Development, Implementation and Analysis for Mycoplasma Genitalium Among Men with Urethritis Attending STD Clinics in the US: Assessing Burden, Risk Factors and Co-Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2020
  • HHSN27200004 Task Area 2 Task Order 2 - Case Control Study Implementation (STI CTG)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2020
  • HHSN27200007 Task Area 2 Task Order 5 - Clinical Trial Modification and Implementation - DMID Protocol #07-0012  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2020
  • Sexually Transmitted Infections Clinical Trials Group (STI CTG)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2020
  • Medical Scientist Training Program  awarded by National Institute of General Medical Sciences/NIH/DHHS 2015 - 2020
  • HHSN27200003 Task Area 2 Task Order 1 - Clinical Trial Implementation-DMID (STI CTG)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2020
  • Private Grant  awarded by CEPHEID 2018 - 2019
  • Private Grant  awarded by RHEONIX, INC. 2014 - 2019
  • CITY Health II - The Center for the Study of Community Health  awarded by National Center for Chronic Disease Prevention & Health Promo./CDC/DHHS 2014 - 2019
  • Private Grant  awarded by ATLAS GENETICS 2017 - 2019
  • The UAB Sexually Transmitted Infections Cooperative Research Centers (STI CRC)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Private Grant  awarded by SPEEDX PTY. LTD. 2018 - 2019
  • Private Grant  awarded by ABBOTT MOLECULAR 2018 - 2019
  • Alabama/North Carolina STD/HIV Prevention Training Center Component A  awarded by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 2014 - 2019
  • Rectal and Oropharyngeal Swabs to Diagnose Gonococcal and Chlamydial Infection in Men and Women  awarded by University of California, San Francisco 2018 - 2019
  • Private Grant  awarded by LUMINEX CORPORATION 2018 - 2019
  • Private Grant  awarded by ROCHE MOLECULAR SYSTEMS, INC. 2017 - 2018
  • Private Grant  awarded by CURATEK PHARMACEUTICALS 2015 - 2018
  • JCDH Contract No: DC-29  awarded by JEFFERSON COUNTY DEPARTMENT OF HEALTH 2017 - 2018
  • Private Grant  awarded by HOLOGIC, INC. 2017 - 2018
  • Private Grant  awarded by CLICK DIAGNOSTICS 2016 - 2018
  • Private Grant  awarded by BECTON DICKINSON AND COMPANY 2016 - 2018
  • Trichomonas Vaginalis Repeat Infections Among HIV-Negative Women  awarded by TULANE UNIVERSITY 2013 - 2018
  • Private Grant  awarded by LUMINEX CORPORATION 2017
  • Private Grant  awarded by BECKMAN COULTER, INC. 2015 - 2017
  • Private Grant  awarded by ROCHE MOLECULAR SYSTEMS, INC. 2016 - 2017
  • Private Grant  awarded by LABORATORY CORPORATION OF AMERICA HOLDINGS 2016 - 2017
  • JCDH Contract No: DC-29  awarded by JEFFERSON COUNTY DEPARTMENT OF HEALTH 2016 - 2017
  • Private Grant  awarded by STARPHARMA 2014 - 2017
  • Private Grant  awarded by HOLOGIC, INC. 2016 - 2017
  • Private Grant  awarded by BD DIAGNOSTICS 2015 - 2017
  • Private Grant  awarded by FLORA BIOSCIENCE 2016 - 2017
  • Private Grant  awarded by HOLOGIC, INC. 2014 - 2016
  • Private Grant  awarded by VIAMET PHARMACEUTICALS, INC. - NEW 2014 - 2016
  • JCDH Contract No: DC-29  awarded by JEFFERSON COUNTY DEPARTMENT OF HEALTH 2015 - 2016
  • Private Grant  awarded by ELITECH GROUP MOLECULAR 2014 - 2016
  • Private Grant  awarded by QUIDEL CORPORATION 2015 - 2016
  • Private Grant  awarded by CEPHEID 2014 - 2016
  • Self-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing: Concurrence in Non-Clinical Settings vs. Clinical Settings  awarded by University of California, San Francisco 2014 - 2015
  • Private Grant  awarded by SYMBIOMIX THERAPEUTICS, LLC 2015
  • Private Grant  awarded by BIOHELIX CORPORATION 2013 - 2015
  • JCDH Contract NO: DC-29  awarded by JEFFERSON COUNTY DEPARTMENT OF HEALTH 2014 - 2015
  • Private Grant  awarded by BD DIAGNOSTICS 2012 - 2015
  • Private Grant  awarded by ROCHE MOLECULAR SYSTEMS, INC. 2013 - 2015
  • Sexually Transmitted Infections Clinical Trials Group (STI CTG)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2004 - 2015
  • Medical Scientist Training Program  awarded by National Institute of General Medical Sciences/NIH/DHHS 2010 - 2015
  • Private Grant  awarded by BD DIAGNOSTICS 2014 - 2015
  • Private Grant  awarded by HOLOGIC, INC. 2014
  • Private Grant  awarded by SYMBIOMIX THERAPEUTICS, LLC 2014
  • Private Grant  awarded by CEPHEID 2013 - 2014
  • CITY Health - Center for Study of Community Health  awarded by National Center for Chronic Disease Prevention & Health Promo./CDC/DHHS 2009 - 2014
  • STD/HIV Prevention Training Center  awarded by CDC - NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STDS AND TB PREVENTION 2011 - 2014
  • Private Grant  awarded by GEN-PROBE, INC. 2013 - 2014
  • Private Grant  awarded by BD DIAGNOSTICS 2011 - 2014
  • Private Grant  awarded by CEPHEID 2014
  • Private Grant  awarded by ROCHE MOLECULAR SYSTEMS, INC. 2012 - 2014
  • Private Grant  awarded by BD DIAGNOSTICS 2012 - 2014
  • Private Grant  awarded by GEN-PROBE, INC. 2012 - 2013
  • Education And Training

  • Doctor of Medicine, University of Tennessee System : Memphis
  • Master of Public Health in Epidemiology, University of Washington
  • Full Name

  • William Geisler
  • Blazerid

  • wgeisler