Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune ResponsesImmunity.  51:155-168.e5. 2019
2019 Defining Barriers that Impede ChoicesImmunity.  50:542-544. 2019
2018 Connections between Metabolism and Epigenetics in Programming Cellular DifferentiationAnnual Review of Immunology.  36:221-246. 2018
2018 Metabolites, genome organization, and cellular differentiation gene programsCurrent Opinion in Immunology.  51:62-67. 2018
2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infectionNature Immunology.  18:1249-1260. 2017
2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene ProgramsImmunity.  47:251-267.e7. 2017
2017 Protein kinase CK2 controls the fate between Th17 cell and regulatory T cell differentiationJournal of Immunology.  198:4244-4254. 2017
2015 Transcriptional regulation of T cell metabolismMolecular Immunology.  68:520-526. 2015
2015 TCR-signaling events in cellular metabolism and specializationFrontiers in Immunology.  6. 2015
2014 Bcl-6 directly represses the gene program of the glycolysis pathwayNature Immunology.  15:957-964. 2014
2014 Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibilityImmunology and Cell Biology.  92:34-39. 2014
2014 Roles for helper T cell lineage-specifying transcription factors in cellular specializationAdvances in Immunology.  124:171-206. 2014
2013 Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx catsMammalian Genome.  24:400-408. 2013
2013 Toward an understanding of the gene-specific and global logic of inducible gene transcriptionCold Spring Harbor Symposia on Quantitative Biology.  78:61-68. 2013
2012 Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factorsNature Reviews Immunology.  12:799-804. 2012
2012 Molecular mechanisms that control the expression and activity of Bcl-6 in T H1 cells to regulate flexibility with a T FH-like gene profileNature Immunology.  13:405-411. 2012
2012 Transcriptional mechanisms that regulate T helper 1 cell differentiationCurrent Opinion in Immunology.  24:191-195. 2012
2012 Encoding stability versus flexibility: Lessons learned from examining epigenetics in T helper cell differentiationCurrent Topics in Microbiology and Immunology.  356:145-164. 2012
2012 T-bet employs diverse regulatory mechanisms to repress transcriptionImmunology Today.  33:78-83. 2012
2012 Ikaros changes the face of NuRD remodelingNature Immunology.  13:16-18. 2012
2011 The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsJournal of Experimental Medicine.  208:1001-1013. 2011
2011 Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infectionNature Immunology.  12:663-671. 2011
2010 Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate t-box family member-dependent gene expressionMolecular Cell.  40:594-605. 2010
2010 Molecular mechanisms by which T-bet regulates T-helper cell commitmentImmunological Reviews.  238:233-246. 2010
2009 T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrowJournal of Experimental Medicine.  206:2469-2481. 2009
2009 CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ LocusImmunity.  31:551-564. 2009
2009 Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR familiesImmunology.  126:306-315. 2009
2009 An essential interaction between T-box proteins and histone-modifying enzymesEpigenetics.  4:85-88. 2009
2008 Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expressionGenes and Development.  22:2980-2993. 2008
2007 T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domainMolecular and Cellular Biology.  27:8510-8521. 2007
2006 T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effectsJournal of Biological Chemistry.  281:11992-12000. 2006
2005 NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expressionProceedings of the National Academy of Sciences.  102:2016-2021. 2005
2004 T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cellsImmunity.  20:477-494. 2004
2004 Novel ChIP-based strategies to uncover transcription factor target genes in the immune systemNature Reviews Immunology.  4:381-386. 2004
2002 Identification of unknown target genes of human transcription factors using chromatin immunoprecipitationMethods.  26:37-47. 2002
2002 Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysisGenes and Development.  16:235-244. 2002
2001 Use of chromatin immunoprecipitation to clone novel E2F target promotersMolecular and Cellular Biology.  21:6820-6832. 2001
2001 Down-regulation of TDT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activatorGenes and Development.  15:1817-1832. 2001
2001 Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent eventNature Immunology.  2:51-57. 2001
1999 Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcriptionImmunity.  11:665-675. 1999

Education And Training

  • Doctor of Philosophy in Microbiology, University of California System : Los Angeles 2000
  • Bachelor of Arts in Biology, University of Minnesota System : Morris 1995
  • Full Name

  • Amy Weinmann